Synopsis of Social media discussions
The discussions frequently reference the article's findings, such as claims that 'replacing saturated fat with n-6 PUFA is unlikely to reduce CHD events, mortality, or total mortality.' Participants often use phrases like 'the evidence shows' or 'the suggestion of benefits is due to inadequately controlled trials,' indicating a serious consideration of the study's implications. This emphasis on scientific evidence helps frame the discussions as informative and respectful, aligning with the overall sentiment of inquiry and reevaluation of prior dietary guidelines.
Agreement
Moderate agreementOverall, the discussions reveal a moderate level of support for the study's conclusions, with many users acknowledging the findings of adequately controlled trials.
Interest
High level of interestThe topic sparked strong interest, as many participants shared references to related studies and engaged in detailed discussions.
Engagement
Moderate level of engagementWhile there are some dismissive comments, the majority of users engaged in thoughtful analysis, analyzing methodologies and presenting counterarguments.
Impact
High level of impactMany users perceive the study as having a significant impact on dietary recommendations regarding fats in relation to heart disease, emphasizing the relevance of its findings.
Social Mentions
YouTube
15 Videos
21 Posts
135 Posts
News
6 Articles
4 Posts
Metrics
Video Views
58,488
Total Likes
2,613
Extended Reach
1,895,276
Social Features
181
Timeline: Posts about article
Top Social Media Posts
Posts referencing the article
Evaluating Saturated Fat and Its Impact on Heart Health
I explore the role of saturated fat in our health, reviewing historical context and key research. This analysis challenges the belief that saturated fat is harmful and examines its complex relationship with coronary heart disease, urging a reevaluation of common dietary recommendations.
Debunking Myths: Saturated Fat and Heart Disease
The idea that saturated fat causes heart disease is one of the biggest myths in modern nutrition. Science shows that saturated fat is not associated with increased mortality, while refined carbohydrates and industrial vegetable oils contribute to health issues. This video explores these findings.
Lower Cardiovascular Risk Without Medication Using Lifestyle Strategies
This video explores ways to reduce cardiovascular risk through lifestyle changes, including the benefits of fermented red rice, tomato juice as an aspirin alternative, herbal teas like green and hibiscus, and physical activities such as Tai Chi, which can improve mental health.
Impact of Dietary Fats on Cardiovascular Health Risks
This video explores the relationship between dietary fats and cardiovascular disease, clarifying risk factors contributing to heart attacks and strokes. We analyze how replacing saturated fats with vegetable oils affects serum cholesterol and health outcomes, based on the Minnesota Coronary Experiment.
Debunking the Plant Oil Myth: The Truth About Omega-6 and Health Risks
Since years, we are told to replace butter with plant oils. But what if this advice is based on flawed studies from the 1960s? This video uncovers the myth surrounding seed oils and explains why the real concern lies elsewhere, emphasizing the importance of balanced Omega-6 and Omega-3 levels.
Debunking the Seed Oil Myth and the Importance of PUFA Balance
For decades weve been told to replace butter with vegetable oils for a healthy heart. But what if this advice was based on flawed old studies? This video debunks the seed oil myth and emphasizes the importance of understanding PUFA species and balancing Omega6 to Omega3.
Exploring the Health Impacts of Seed Oils on Cardiovascular Risk Factors
Seed oils, including canola oil, have sparked debate regarding their health effects. This video delves into research suggesting that canola oil may improve cardiometabolic risk factors like cholesterol levels and inflammation. Tune in for insights on whether these oils should be part of your diet.
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@reFleXiveLogiK @ScottAppliedSci @Blackswanson @gunsnrosesgirl3 Evidence from Randomized Controlled Trials (RCTs) & Meta-analyses of RCTs https://t.co/oybE31Xz4S https://t.co/3TIZYDgUbh https://t.co/Yw99QB2HqV https://t.co/a0hIK5UL2N https://t.co/lIudH7GAQU
view full postOctober 2, 2025
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David Lloyd
@davidlloyd (Twitter)@lporiginalg https://t.co/wxKxngdVCs
view full postMarch 15, 2025
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Steven M. Belknap, MD PGY43
@StevenMBelknap (Twitter)@TuckerGoodrich @JesperLundbom @garytaubes @KingManninen @PeterFaberSP @BiggestComeback @mikeoniron @exfatloss Here's the Hamley SRMA: DOI 10.1186/s12937-017-0254-5 The code is a complete transcript of the Survival Function calculations using Mathematica. It's not published anywhere. I can send you the Mathematica file if you like.
view full postAugust 27, 2024
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Travis Einertson
@LowCarbVet (Twitter)@StevenMBelknap @hufcm @dylanarmbruste3 @GardnerPhD @American_Heart Thanks for this. Here is the link to the Hamley paper….. https://t.co/rub9orSy0e https://t.co/C2eQFnuu2E
view full postAugust 26, 2024
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Steven M. Belknap, MD PGY43
@StevenMBelknap (Twitter)@hufcm @dylanarmbruste3 @GardnerPhD @American_Heart 1. The best SRMA of SatFat→ω6:PUFA is by Hamley. DOI 10.1186/s12937-017-0254-5 2. Present the research result(s) that you believe that I ignore. 3. Explain the flaw in my application of Taleb's method to meta-analysis of the high-quality RCTs. (Unpublished ≠ Wrong & Published https://t.co/zonC5QEqC8
view full postAugust 25, 2024
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Steven M. Belknap, MD PGY43
@StevenMBelknap (Twitter)Not so much. Satfat does not increase total mortality compared to ω6 PUFA, based on the best available research results: adequately-controlled randomized clinical trials that compare satfat to ω6 PUFA. DOI 10.1186/s12937-017-0254-5 https://t.co/xfFmERmP5f https://t.co/jQNkhgAOYv
view full postAugust 16, 2024
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Nzyen Renrey
@NzyenR (Twitter)@BioLayne No https://t.co/nNyXwaLb5U https://t.co/RLGJzxPDug https://t.co/DNCPsAaA5j /biomedcentral.com/articles/10.1186/s12986-017-0186-2
view full postJuly 18, 2024
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Triage
@triagemethod (Twitter)@NzyenR The question was: For those who disagree with this perspective regarding "seed oils" / PUFAs / linoleic acid and heart disease, what's the most convincing human evidence of harm? Ref 1.) https://t.co/BB0lP3eMle The meta-analysis you just cited does not make any such conclusion,
view full postJune 24, 2024
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Nzyen Renrey
@NzyenR (Twitter)@triagemethod That's easy bro https://t.co/OKhZPXu2di https://t.co/LJStgsQQTO https://t.co/RLGJzxPDug
view full postJune 24, 2024
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Miguel The Vegan
@miguelthevegan (Twitter)@AsarCadyn This isn’t just Alice’s opinion. https://t.co/shSMgmqYOg https://t.co/BhhOykfXRf https://t.co/Wsmte4QbJn
view full postApril 19, 2024
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Adolfo Neto
@adolfont (Twitter)@LucianTritt @lincolixavier @ngtv_bg I don't care that much about that. The fact is that there is evidence that saturated fats are not harmful. https://t.co/LugQuVZtt2
view full postApril 7, 2024
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GenevieveZzyzyx
@GZzyzyx (Twitter)@bminn7660 @_sugaree_ @VPrasadMDMPH So this was used as a claim that saturated fat “doesn’t cause cardiovascular disease” https://t.co/tIucEuromh It was a rabbit hole from source 33 of THIS nonsense
view full postMarch 21, 2024
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Bryan Bargowski
@GosuGains (Twitter)RT @StevenMBelknap: @MohammedAlo Not so much. There’s a lot of wrong to unpack here. Hamley’s meta-analysis of RCTs found no effect of rep…
view full postMarch 13, 2024
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Steven M. Belknap, MD PGY43
@StevenMBelknap (Twitter)RT @StevenMBelknap: @MohammedAlo Not so much. There’s a lot of wrong to unpack here. Hamley’s meta-analysis of RCTs found no effect of rep…
view full postMarch 13, 2024
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Steven M. Belknap, MD PGY43
@StevenMBelknap (Twitter)@JesperLundbom @KingManninen @TuckerGoodrich @garytaubes @PeterFaberSP @BiggestComeback @mikeoniron @exfatloss You are correct that an analysis published in a meta-analysis of well-controlled RCTs showed that swapping SFA → ω6 PUFA does not increase cardiovascular mortality or total mortality. DOI 10.1186/s12937-017-0254-5 However, the analytic method used in this meta-analysis (and
view full postMarch 13, 2024
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.
@_4_5_44 (Twitter)RT @HalukVAHABOLU: 8/ ortada dönen dolabı anlamak için şunu oku https://t.co/6CNPt7M3es şu makaleleri de incelemeni isterim https://t.co/g…
view full postMarch 2, 2024
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Abdülkadir Geylani Şahan
@agsahan1 (Twitter)RT @HalukVAHABOLU: 8/ ortada dönen dolabı anlamak için şunu oku https://t.co/6CNPt7M3es şu makaleleri de incelemeni isterim https://t.co/g…
view full postMarch 2, 2024
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Prof. Dr. Haluk VAHABOGLU
@HalukVAHABOLU (Twitter)8/ ortada dönen dolabı anlamak için şunu oku https://t.co/6CNPt7M3es şu makaleleri de incelemeni isterim https://t.co/gtsPpYTcRP https://t.co/rDuuIxFc1b
view full postMarch 1, 2024
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Samar Sheoran
@samarsheoran (Twitter)@Appoota @shashiiyengar @TheNutrivore https://t.co/oukjavwWgz Here this one. Effect on CHD
view full postDecember 30, 2023
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Libertas
@Libertas2008 (Twitter)RT @raphaels7: https://t.co/v7gcZyOA5e “The suggestion of benefits reported [SFA => N6] in earlier meta-analyses is due to the inclusion of…
view full postNovember 16, 2023
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Lauri Kärnä
@LauriKrn (Twitter)@TuckerGoodrich @foundmyfitness @AnthonyLewayne @fmfclips @WHO Well meta-analysis says you’re wrong about the CVD: https://t.co/CnnKgXIcJK ” the pooled results from all trials, including the inadequately controlled trials, suggested that replacing SFA with mostly n-6 PUFA would significantly reduce the risk of total CHD events”
view full postOctober 25, 2023
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Max Lugavere
@maxlugavere (Twitter)@MiocanDanijel Here’s one. 2017 meta-analysis: n-6 PUFA replacement shows no benefit to CHD events, mortality, or total mortality. Hamley, 2017 https://t.co/2xvQnOZTcg
view full postOctober 18, 2023
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Carnivore is Vegan
@CarnivoreIs (Twitter)@TarbuckSam @BHBEnjoyer @EarthlingAus This is a metanalysis of RCTs. "Available evidence from adequately controlled randomised controlled trials suggest replacing SFA with mostly n-6 PUFA is unlikely to reduce CHD events, CHD mortality or total mortality." https://t.co/JEwpNUENiX
view full postSeptember 8, 2023
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@dingdongjapan (Twitter)@BadassDalit @shashiiyengar @dlifein We don't need to check our lipids you need to check more research papers. 1.https://t.co/W8uMNf8yS3 https://t.co/Zn7Mvr0pe0 2.https://t.co/6xnNEmqw5H 3.https://t.co/RuFhMlmQUd 4.https://t.co/jdkcVoOy39 https://t.co/oWIDaWbuzM
view full postJune 23, 2023
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Nzyen Renrey
@NzyenR (Twitter)@raphaels7 https://t.co/iGgztyMR9f https://t.co/dQ506vffyg https://t.co/ylyKiqChD5 These ones too plus mendelian randomization. Not to mention other that show a trend in crp with high intakes, blood clotting rct, the rct in China with gut bacteria and one where it increases lpa and oxldl
view full postJune 21, 2023
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Nzyen Renrey
@NzyenR (Twitter)@SOfreeLifestyle @BioLayne https://t.co/ylyKiqChD5 https://t.co/BPzuL8IIGi https://t.co/RLGJzxPDug https://t.co/dQ506vffyg
view full postJune 20, 2023
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IFN Academy
@IFNAcademy (Twitter)IFNCP Functional Nutritionists are trained to tailor diet recommendations to YOU based on your lifestyle, genetics, and disease condition. https://t.co/jMkfayte5Y #IFNAcademy https://t.co/q45qJQZ7fH
view full postJune 9, 2023
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Linux O'Beardly
@OBeardly (Twitter)RT @StevenMBelknap: @MohammedAlo Not so much. There’s a lot of wrong to unpack here. Hamley’s meta-analysis of RCTs found no effect of rep…
view full postApril 22, 2023
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Steven M. Belknap, MD PGY43
@StevenMBelknap (Twitter)@MohammedAlo Not so much. There’s a lot of wrong to unpack here. Hamley’s meta-analysis of RCTs found no effect of replacing dietary satfats with ω6 PUFAs. https://t.co/0WbEpOni0l I re-analyzed the RCT data using a better statistical method, and found that ω6 PUFAs *increased* mortality. https://t.co/lZRPFPXrNb
view full postApril 21, 2023
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Renato Dumbra
@renatodumbra (Twitter)@raphaels7 @PeterAttiaMD @ZeroAcreFarms replacing saturated fats with PUFAs resulted in a small but statistically significant reduction in body weight. https://t.co/jc4gVdSB4c
view full postMarch 12, 2023
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Max Lugavere
@maxlugavere (Twitter)@missiletech80 Not what the science says. 2017 meta-analysis: n-6 PUFA replacement shows no benefit to CHD events, mortality, or total mortality. https://t.co/2xvQnOZTcg
view full postMarch 11, 2023
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Steven M. Belknap, MD PGY43
@StevenMBelknap (Twitter)@IsmaelGalancho @exfatloss @sguyenet @bigfatsurprise The facts are otherwise. Swapping out Dietary SatFats for PolyUnSatFats does not reduce total mortality. (Fig 3.) https://t.co/Y4YL7bkpZt The Minnesota Coronary Survey found a 22% *higher* risk of death for each 30 mg/dL reduction in serum cholesterol. https://t.co/szA2uVW4b4 https://t.co/Wc1TfLcCsP
view full postMarch 10, 2023
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Wei. Zhang
@WeiZhangAtmos (Twitter)@ToYourHealth101 @NicolaiWorm @bigfatsurprise @drdairy50 @fleroy1974 Hamley 2017 https://t.co/LXBKJGoF1b
view full postMarch 6, 2023
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Carnivore is Vegan
@CarnivoreIs (Twitter)@skydog576 @rodney_dever @jwolnizer @forktown385 Even a metanalysis of RCT's concluded "Available evidence from adequately controlled randomised controlled trials suggest replacing SFA with mostly n-6 PUFA is unlikely to reduce CHD events, CHD mortality or total mortality" https://t.co/PNsZfDbq3I
view full postMarch 5, 2023
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Carnivore is Vegan
@CarnivoreIs (Twitter)@LucianTritt @F_Z_F_Z_F RCT's don't show any harm from SFA's either. "Available evidence from adequately controlled randomised controlled trials suggest replacing SFA with mostly n-6 PUFA is unlikely to reduce CHD events, CHD mortality or total mortality" https://t.co/PNsZfDbq3I
view full postFebruary 27, 2023
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#WorkoutWarrior
@WorkoutWarrior4 (Twitter)RT @StevenMBelknap: @ScepticalDoctor @susanwoledge @ButterFueled LDL-C is not a predictive biomarker for atherosclerosis or anything else.…
view full postFebruary 14, 2023
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Butter Fueled
@ButterFueled (Twitter)RT @StevenMBelknap: @ScepticalDoctor @susanwoledge @ButterFueled LDL-C is not a predictive biomarker for atherosclerosis or anything else.…
view full postFebruary 14, 2023
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Steven M. Belknap, MD PGY43
@StevenMBelknap (Twitter)@ScepticalDoctor @susanwoledge @ButterFueled LDL-C is not a predictive biomarker for atherosclerosis or anything else. Randomized controlled trials have shown that replacing SatFats with PUFAs is not beneficial and is probably harmful. https://t.co/Y4YL7bkpZt
view full postFebruary 14, 2023
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A Cookie
@flatmannn (Twitter)@Alex__Katz @simplulo @mattyglesias Here we have a meta analysis showing no benefit from replacing sat fat with n6 polyunsaturated (what is found in cooking oils): https://t.co/JvPEL88Bd4
view full postFebruary 2, 2023
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Jack O'Connor
@JackoJSY (Twitter)@FearZero4 @stopYouOut @SBakerMD https://t.co/vTUMbvcMPd We can do it all day.
view full postJanuary 22, 2023
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Steven M. Belknap, MD PGY43
@StevenMBelknap (Twitter)@GZzyzyx @LeomantVictoria @benandjerrys Cholesterol in diet doesn’t cause heart attack. Re: saturated fats, “Available evidence from adequately controlled randomised controlled trials suggest replacing SFA with mostly n-6 PUFA is unlikely to reduce CHD events, CHD mortality or total mortality” https://t.co/0WbEpOni0l
view full postDecember 11, 2022
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Steven M. Belknap, MD PGY43
@StevenMBelknap (Twitter)@nntaleb @boozifer99 I admire @nntaleb’s critical thinking & clever stats. But! He has yet to get facts straight on recent tweets on SFAs. Plz review relevant tweets & revise yr error. @bigfatsurprise presented @stevenhamley’s review on SFA restriction as best, not Cochrane’s. https://t.co/Y4YL7bkXP1 https://t.co/LZ1v4apxaW
view full postDecember 9, 2022
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Steven M. Belknap, MD PGY43
@StevenMBelknap (Twitter)@CaloriesProper @bigfatsurprise @nntaleb @LuisCLCorreia @DrDamluji @cochranecollab @nationallipid @NutritionMadeS3 @KCKlatt Steven Hamley performed a meta-analysis of RCTs that replace saturated fatty acids (SFA) with ω-6 polyunsaturated fatty acids (PUFA). The experimental intervention was different according to the RCT. Here’s the key data from Figure 4. Here’s the link: https://t.co/Y4YL7b2OAT https://t.co/7fAWUlWSQi
view full postDecember 8, 2022
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Nina Teicholz, PhD
@bigfatsurprise (Twitter)@nntaleb @StevenMBelknap @LuisCLCorreia @DrDamluji @cochranecollab @nationallipid Your issue is with the paper, I guess. You should know this is one of many reviews of these data. IMHO, the clearest review of this data, and also most objective, is this one. Breaks out well-controlled trials and inadequately controlled trials. https://t.co/JROZTlbbgI
view full postDecember 3, 2022
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alephh
@alephh (Twitter)Replacing sat fat with vegetable oils vs coronary heart disease (RCT meta-analysis) —Seed oils harm/kill more in rigorous trials (not stat-sig RR): 1.06 (.86/1.31) major CHD events 1.02 (.84/1.23) total CHD 1.13 (.91/1.40) CHD deaths 1.07 (.90/1.26) deaths https://t.co/OeJ9gzSGfq
view full postOctober 19, 2022
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Jim
@JimeeLiberty (Twitter)@krebiozen @richykirsh @WendyOrent @mcfunny @scottstocker4 @IdunsDaughter @ConsequentialBr @pawley_robert @AndrewLazarus4 @Pouldeau61 @Monstercoyliar @SkepticalMutant @newstranslate13 @barryjohnreid21 @TonyBaduy @jarbot15 @AspAlaAsnAsnTyr @JonathanHannah @MaureenStroud @ShockTraumaRN @JimBeam102 @Thskicksarefire @JKelleyK @swedishchf @provaxtexan @reacharoundu @ogilville1 @Alex_on_A14 @doom37455413 @AngryFleas @ShadowDroid616 @doritmi @tomsirolimus @TheDrJon @jtmayes3 @nuhope2022 @Adrian7745 @statsguyuk @CurfewX @JDCBurnhil @HupperichWerner @KStateTurk @BreezerGalway @Fornowago @Conservacat2 @zeetubes @AtomsksSanakan @MattMcInnis6 @Twitter https://t.co/gY0y7OQLHF https://t.co/eACNbOLBJZ
view full postSeptember 27, 2022
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Butter Fueled
@ButterFueled (Twitter)@Tellit007 @SamaHoole Many studies to show there's little to no concern with consuming animal products (meat or fat) and LDL https://t.co/gZuj1i6TEg https://t.co/EU10ASP73H https://t.co/jOf1nJYdWu https://t.co/7JxO5vQNjx https://t.co/lbVYVog484 https://t.co/fWeyIXcd7u https://t.co/AHlnUrPfpo
view full postSeptember 18, 2022
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Gerardo Avelar
@Gerave7 (Twitter)@CaloriesProper Lol, actually I believe you know well it's supposed to work the other way around; if they do any claim (which I'm not), they must provide the evidence to support it. Anyway, a couple about PUFA, which I think is the usual suspect: https://t.co/XRCpCeI920 https://t.co/nQtc1BFr60
view full postJune 16, 2022
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Jakub Lenard
@lenard_jakub (Twitter)@sguyenet @theproof @sguyenet @theproof What do you think about this meta-analysis of RCTs? https://t.co/fREL2mK7IN
view full postApril 22, 2022
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Janet Wilkins
@JanetWi83437512 (Twitter)RT @Mangan150: Evidence suggests replacing saturated fat with n-6 PUFA is unlikely to reduce CHD events, CHD mortality or total mortality.…
view full postApril 3, 2022
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P.D. Mangan Health & Freedom Maximalist
@Mangan150 (Twitter)Evidence suggests replacing saturated fat with n-6 PUFA is unlikely to reduce CHD events, CHD mortality or total mortality. The suggestion of benefits reported in earlier meta-analyses is due to the inclusion of inadequately controlled trials. https://t.co/LbLpngyVwf
view full postApril 3, 2022
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Carnivore is Vegan
@CarnivoreIs (Twitter)@LesFleurs67 @kemminnick @bigfatsurprise "Available evidence from adequately controlled randomised controlled trials suggest replacing SFA with mostly n-6 PUFA is unlikely to reduce CHD events" https://t.co/PNsZfCTgPA
view full postMarch 20, 2022
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Carnivore is Vegan
@CarnivoreIs (Twitter)@CapitalistV3GAN @OwlJoAJo "evidence from adequately controlled randomised controlled trials suggest replacing SFA w/ n-6 PUFA is unlikely to reduce CHD events or total mortality.The suggestion of benefits reported in earlier meta-analyses is due to inadequately controlled trials." https://t.co/PNsZfCTgPA
view full postMarch 10, 2022
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el snaxion⚡️
@snaxion (Twitter)INTERESTING: Saturated fatty acid intake/ heart disease may not be linked
view full postMarch 6, 2022
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help for your conscience
@conscience_help (Twitter)@ScepticalDoctor @ValtsuH @Max_Plaid Responding with “bro” voice is childish and shows you don’t understand the topic adequately to argue with concise points. PUFAs are not at all beneficial for improving CVD outcomes when your studies are designed properly. https://t.co/cAtqkZWWU5
view full postMarch 4, 2022
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Harmless Frog
@FrogHarmless (Twitter)@ScepticalDoctor Yes, these trials have a lot of confounding factors. https://t.co/1rPjBwHF6e
view full postOctober 10, 2021
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Anthony CHAD-DAD Knobbe
@anthonysramblin (Twitter)@SecoraPearlRem They are not https://t.co/54Uav4d0lc https://t.co/gEI8YV69iR https://t.co/pvU9ytSB8U https://t.co/B2qsqw3Q2x https://t.co/CaxsuRgyin
view full postSeptember 28, 2021
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jorf
@eatyourfat (Twitter)@NoNotTheDrummer @kayleighisded @philly_taco @alliemarie777 @vssapaige @colormeboldly https://t.co/QKggdY4VvZ
view full postSeptember 19, 2021
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Sheep Herder
@WarriorLean (Twitter)@TuckerGoodrich @The_Nutrivore https://t.co/OpHIQsmXdf
view full postAugust 19, 2021
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Sheep Herder
@WarriorLean (Twitter)RT @Mangan150: Much of the evidence used by the experts to recommend use of vegetable oils in place of saturated fat is shoddy. When adequ…
view full postAugust 19, 2021
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DiscoStew
@DiscoStew66 (Twitter)RT @Mangan150: Much of the evidence used by the experts to recommend use of vegetable oils in place of saturated fat is shoddy. When adequ…
view full postAugust 19, 2021
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MorozkoForge
@MorozkoForge (Twitter)RT @Mangan150: Much of the evidence used by the experts to recommend use of vegetable oils in place of saturated fat is shoddy. When adequ…
view full postAugust 19, 2021
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Waterpenny
@Waterpenny111 (Twitter)RT @Mangan150: Much of the evidence used by the experts to recommend use of vegetable oils in place of saturated fat is shoddy. When adequ…
view full postAugust 19, 2021
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P.D. Mangan Health & Freedom Maximalist
@Mangan150 (Twitter)Much of the evidence used by the experts to recommend use of vegetable oils in place of saturated fat is shoddy. When adequately controlled trials are used, benefits disappear. https://t.co/LbLpngyVwf
view full postAugust 19, 2021
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Marc Kinjet
@MarcKinjet (Twitter)The effect of replacing saturated fat with n-6 polyunsaturated fat on coronary heart disease: a meta-analysis of randomised controlled trials - the best method in nutritional science and metabolism shows no difference between Saturated fat and omega-6 fat! https://t.co/hADgdwYbrk
view full postAugust 1, 2021
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Carl Thomas Ball
@carltball122219 (Twitter)RT @Mangan150: @IvorGoodbody https://t.co/Awv00AOofO
view full postJuly 28, 2021
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P.D. Mangan Health & Freedom Maximalist
@Mangan150 (Twitter)@IvorGoodbody https://t.co/Awv00AOofO
view full postJuly 28, 2021
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DiscoStew
@DiscoStew66 (Twitter)RT @raphaels7: https://t.co/v7gcZyOA5e “The suggestion of benefits reported [SFA => N6] in earlier meta-analyses is due to the inclusion of…
view full postJuly 28, 2021
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Harmless Frog
@FrogHarmless (Twitter)RT @raphaels7: https://t.co/v7gcZyOA5e “The suggestion of benefits reported [SFA => N6] in earlier meta-analyses is due to the inclusion of…
view full postJuly 28, 2021
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Raphael Sirtoli
@raphaels7 (Twitter)https://t.co/v7gcZyOA5e “The suggestion of benefits reported [SFA => N6] in earlier meta-analyses is due to the inclusion of inadequately controlled trials” https://t.co/EPqT5mDu0I
view full postJuly 27, 2021
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Jakub Lenard
@lenard_jakub (Twitter)@NutritionMadeS3 @CarolHo03279746 Are you referring to this meta-analysis?
view full postJuly 27, 2021
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Sky King
@skyking171717 (Twitter)@Veganella_ @The_Nutrivore @MrDiefenbach @LoraJR72 @kirthurgan @FusionProgGuy @waseemkiani @mosca_matthew @MistyMum2 @Parallax9999 @JoeKerr57254356 @OofT74480205 @AnimalJustice6 @cerebralsymphoy @Rev0lvingDoor @ThatTennisVegan @bongxdylan @TheTrueCompton @Grahanimal @_Aloominati_ @NutritionMadeS3 @whsource @BioLayne And this one: Conclusion: “Available evidence from adequately controlled randomised controlled trials suggest replacing SFA with mostly n-6 PUFA is unlikely to reduce CHD events, CHD mortality or total mortality. https://t.co/x7W1qB6pgR
view full postJuly 13, 2021
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Sky King
@skyking171717 (Twitter)@ElliottWins @The_Nutrivore @Plant_proof Here ya go, Elliott: "Conclusion: “Available evidence from adequately controlled randomised controlled trials suggest replacing SFA with mostly n-6 PUFA is unlikely to reduce CHD events, CHD mortality or total mortality." https://t.co/x7W1qB6pgR
view full postJuly 13, 2021
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JaysonSipress
@jaysonsipress (Twitter)@Tom_Babington1 @nakedathletes @kevinnbass *cough cough* https://t.co/HpC54R8Kma
view full postApril 15, 2021
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JaysonSipress
@jaysonsipress (Twitter)@Tom_Babington1 @kevinnbass So, are we not taking into account this meta-analysis? https://t.co/HpC54R8Kma
view full postApril 15, 2021
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Dušan Ristić
@dsnrstc (Twitter)@mosca_matthew @AmandaZZ100 And anoher one: https://t.co/USi9LWeT9y
view full postApril 4, 2021
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Chris Palmer, MD
@ChrisPalmerMD (Twitter)@joemclean95 This one published in 2017 suggests otherwise. Looks like the verdict is still out? https://t.co/Wf7tmkj1yV
view full postMarch 18, 2021
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Maurício Lima
@dj_surfista (Twitter)As evidências disponíveis de ensaios clínicos randomizados controlados adequadamente sugerem que a substituição de SFA por PUFA n-6 provavelmente não reduzirá o risco de doença cardíaca coronária (DCC), a mortalidade por DCC ou a mortalidade total. https://t.co/aVBDB7URCi
view full postFebruary 15, 2021
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Amir Weiss
@AmirWeiss1 (Twitter)@MyNutritionSci @WiswordBrasil @Travis_Statham @ScepticalDoctor I clicked on the link to read the abstract, then saw this more recent paper from 2017 which seems to contrdict the findings. I'm on the sidelines, not advocating for one side or another https://t.co/Ktt9ZF2MSm
view full postFebruary 15, 2021
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dr roth
@mrc314 (Twitter)@bohdyone @Travis_Statham @MyNutritionSci @ScepticalDoctor Moreover … "The effect of replacing saturated fat with mostly n-6 polyunsaturated fat on coronary heart disease" ARE NOT THE ONLY EFFECTS. Dying from something PUFA-induced, earlier, isn't a win.
view full postFebruary 15, 2021
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Travis Statham
@Travis_Statham (Twitter)RT @bohdyone: @MyNutritionSci @Travis_Statham @ScepticalDoctor Interesting, but I saw another that appears to directly contradict those fin…
view full postFebruary 15, 2021
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Bogdan
@bohdyone (Twitter)@MyNutritionSci @Travis_Statham @ScepticalDoctor Interesting, but I saw another that appears to directly contradict those findings. https://t.co/YyJv40vuZG
view full postFebruary 15, 2021
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Simon Dankel
@simondankel (Twitter)RT @PreKureOfficial: @MyNutritionSci @simondankel @zinocker @kariannesve The only CHD events decreased in the Cochrane meta, by a tiny exte…
view full postFebruary 14, 2021
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PREKURE
@PREKUREOfficial (Twitter)@MyNutritionSci @simondankel @zinocker @kariannesve The only CHD events decreased in the Cochrane meta, by a tiny extent, are unblinded ones - angina and revascularization - where LDL level is a diagnostic criteria in uncertain cases. And if you remove the confounded studies you won't even see that. https://t.co/PJI48nKIBQ
view full postFebruary 14, 2021
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Jevan
@Jevan (Twitter)@Alecsplaining @MarieSpreckley @jaapseidell I was talking about the red meat/white meat/ pp study you posted. As for SFA vs. PUFA, I have no big dog in the fight, data is messy, in this meta - in adequately controlled trials comparing SFA vs n-6, there is no difference in CVD events or mortality https://t.co/9eQlOxoTe6
view full postFebruary 10, 2021
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Carnivore is Vegan
@CarnivoreIs (Twitter)@Plant_proof @OhhiyoGarmen Also from 2017. So much for an echo chamber, "Available evidence from adequately controlled randomised controlled trials suggest replacing SFA with mostly n-6 PUFA is unlikely to reduce CHD events, CHD mortality or total mortality. " https://t.co/Nh1yzWyiUy
view full postJanuary 12, 2021
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Zack DiMattia
@ZackDiMattia (Twitter)@FoodFirst_Ty @CarnivoreAntMan https://t.co/UMhFxeSPOY https://t.co/ZKkBntwOMF https://t.co/sS40p2WNOn https://t.co/c5sTcM00ro https://t.co/QgAo5JaDRY https://t.co/wLREegMaKm https://t.co/TY096o1CWZ
view full postJune 29, 2020
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Jeffery Heileson
@jheilesonRD (Twitter)@The_Nutrivore @TheAlanAragon @StolteThiago "Robust" may be overstating the evidence. https://t.co/ejaRgk5qcU https://t.co/7dYDOXlgWy https://t.co/d8gOfPRo6C https://t.co/M6523GE5dg Silverman (2016) also cites the same studies as the AHA meta-analysis that has been criticized: https://t.co/SbP22Iwhuo
view full postJune 7, 2020
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Alberto García
@AGG7 (Twitter)RT @DiscoStew66: https://t.co/yV10JFpo6q
view full postJune 5, 2020
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Leave it to Beaver
@espacetimeNOT (Twitter)RT @tjavanainen2018: ”Available evidence from adequately controlled randomised controlled trials suggest replacing SFA with mostly n-6 PUFA…
view full postJune 5, 2020
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Vaste
@VasteOy (Twitter)”Available evidence from adequately controlled randomised controlled trials suggest replacing SFA with mostly n-6 PUFA is unlikely to reduce CHD events, CHD mortality or total mortality” #rasva #SFA #PUFA #CHD https://t.co/WFzxo7OSSv
view full postJune 5, 2020
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Tuomas Javanainen
@tjavanainen2018 (Twitter)”Available evidence from adequately controlled randomised controlled trials suggest replacing SFA with mostly n-6 PUFA is unlikely to reduce CHD events, CHD mortality or total mortality” #rasva #SFA #PUFA #CHD https://t.co/5cwsRmXNVl
view full postJune 5, 2020
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Sugar
@Sugar51976529 (Twitter)@GovCanHealth These findings have implications for current dietary recommendations https://t.co/IxUo187Cwf
view full postJune 5, 2020
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David Diamond
@LDLSkeptic (Twitter)RT @DiscoStew66: https://t.co/yV10JFpo6q
view full postJune 5, 2020
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Nick Eggleton
@NickEggleton (Twitter)The Effect of Replacing Saturated Fat With Mostly n-6 Polyunsaturated Fat on Coronary Heart Disease: A Meta-Analysis of Randomised Controlled Trials. https://t.co/6QdhueARAm
view full postJune 5, 2020
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DiscoStew
@DiscoStew66 (Twitter)https://t.co/yV10JFpo6q
view full postJune 5, 2020
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DiscoStew
@DiscoStew66 (Twitter)“Available evidence from adequately controlled randomised controlled trials suggest replacing SFA with mostly n-6 PUFA is unlikely to reduce CHD events, CHD mortality or total mortality.” https://t.co/3VZQOzY3jp
view full postMay 24, 2020
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Ian McIntosh D.C.
@IanMcIntosh1 (Twitter)@The_Nutrivore Hmmm.. https://t.co/ndbZhXjQbu https://t.co/tJQ6OQijTb https://t.co/4Q4t1nB8bU https://t.co/vxbR0zNHeB https://t.co/IZSQvehGRC https://t.co/SZTcifSP0V Which studies to believe..
view full postMay 8, 2020
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Jakub Lenard
@lenard_jakub (Twitter)@lowcarbGP When it comes to fats, it's worth keeping this meta-analysis in mind https://t.co/fREL2mK7IN
view full postApril 8, 2020
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George D. Henderson
@puddleg (Twitter)@IngersolRobert @craigthomler @JorgeLarangeir1 @ClimateOfGavin Does an association of 0.97 across half-a-million people really support that claim? https://t.co/hjm46MMkW9 Does the RCT evidence for SFA replacement really support that claim? https://t.co/H80sxBNYqL This is not contradictory evidence. It's confirmation of a null hypothesis.
view full postFebruary 9, 2020
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Tucker Goodrich
@TuckerGoodrich (Twitter)@jheilesonRD @TheAlanAragon @KrisSkeggs @EndGame_HS You're got that backwards, for Hamley, at least. "...replacing SFA with mostly n-6 PUFA is unlikely to reduce CHD events, CHD mortality or total mortality." https://t.co/PgRQm3mQri
view full postJanuary 11, 2020
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George D. Henderson
@puddleg (Twitter)@POhukainen @FatEmperor @TomPMarshall Really? This is a non-statin intervention. https://t.co/H80sxBNYqL
view full postDecember 5, 2019
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Daniel Rico
@dnlrico (Twitter)RT @puddleg: @JimJohnsonSci The @stevenhamley meta-analysis, which tries to account for confounding by the mixed interventions included in…
view full postNovember 13, 2019
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ZahcM
@ZahcM (Twitter)RT @puddleg: @JimJohnsonSci The @stevenhamley meta-analysis, which tries to account for confounding by the mixed interventions included in…
view full postNovember 12, 2019
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George D. Henderson
@puddleg (Twitter)@JimJohnsonSci The @stevenhamley meta-analysis, which tries to account for confounding by the mixed interventions included in the diet-heart metas, should also be considered: https://t.co/H80sxBNYqL
view full postNovember 12, 2019
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power
@AntonVilla34 (Twitter)RT @DiegoNSalman: Meta análisis de estudios aleatorios sobre reemplazo de grasas saturadas por ácidos grasos omega 6: No hay beneficio algu…
view full postSeptember 9, 2019
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Javier
@Pollojavi (Twitter)RT @DiegoNSalman: Meta análisis de estudios aleatorios sobre reemplazo de grasas saturadas por ácidos grasos omega 6: No hay beneficio algu…
view full postSeptember 9, 2019
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Alberto García
@AGG7 (Twitter)RT @DiegoNSalman: Meta análisis de estudios aleatorios sobre reemplazo de grasas saturadas por ácidos grasos omega 6: No hay beneficio algu…
view full postSeptember 8, 2019
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DiegoNS
@DiegoNSalman (Twitter)Meta análisis de estudios aleatorios sobre reemplazo de grasas saturadas por ácidos grasos omega 6: No hay beneficio alguno en mortalidad o infartos al disminuir o reemplazar el consumo grasa saturada #LowCarbChile https://t.co/4zaJTYFeuB
view full postSeptember 8, 2019
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MadPharmacist
@DarthPharmacist (Twitter)Cahque jour on dit a mes patients de ne surtout pas manger de gras saturés et de manger des huiles végétales chimiques a la place pour santé cardiovasculaire. Logic much. https://t.co/yYRlxPz6lV
view full postJune 3, 2019
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Karageorgos
@Karageorgos15 (Twitter)@RChrisCC @kevinnbass And more recent 2017 review questions whether replacing SFs with n-6 PUFA would be of benefit: "Available evidence from adequately controlled RCTs suggest replacing SFA with...n-6 PUFA is unlikely to reduce CHD events, CHD mortality or total mortality." https://t.co/f2Xpuya0OH
view full postMay 5, 2019
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George D. Henderson
@puddleg (Twitter)@Sadrien_GW2 @Smark_phd @ProfTimNoakes @FatEmperor @grantsnz @CarynZinn That's why we included a reference to the Steve Hamley meta-analysis, which does that (as far as it is possible;). https://t.co/H80sxBNYqL
view full postApril 23, 2019
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SystematicReviewBot
@EvidenceRobot (Twitter)RT @DrSaripanidis: Μεγάλες αναλυτικές μελέτες δημοσιευμένων τυχαιοποιημένων κλινικών εργασιών απέδειξαν πως η κατανάλωση κορεσμένων λιπών σ…
view full postMarch 26, 2019
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Stavros Saripanidis, MD
@DrSaripanidis (Twitter)Μεγάλες αναλυτικές μελέτες δημοσιευμένων τυχαιοποιημένων κλινικών εργασιών απέδειξαν πως η κατανάλωση κορεσμένων λιπών στη διατροφή δεν αυξάνει τη θνησιμότητα! https://t.co/3tRjh7JBBP https://t.co/Jw5AU5vprz https://t.co/YSkKw5LaCp https://t.co/mIdA8E8qQG
view full postMarch 26, 2019
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MMA and Boxing Fight Analyst
@kostasfant (Twitter)Available evidence from adequately controlled randomized controlled trials suggest replacing saturated fatty acids (SFA) with mostly n-6 polyunsaturated fat is UNLIKELY to reduce CHD events, CHD mortality or total mortality. https://t.co/B1LCrnQYHp
view full postMarch 25, 2019
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@Nutrition1974 (Twitter)Interesting!
view full postMarch 21, 2019
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SystematicReviewBot
@EvidenceRobot (Twitter)RT @Khalzur: Niektóre metaanalizy pokazują, że zastąpienie nasyconych kwasów tłuszczowych kwasami omega 6 nie zmniejsza ryzyka choroby nied…
view full postFebruary 13, 2019
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Kamil Paprotny
@Kamil_Paprotny (Twitter)Niektóre metaanalizy pokazują, że zastąpienie nasyconych kwasów tłuszczowych kwasami omega 6 nie zmniejsza ryzyka choroby niedokrwiennej serca ani nie zmniejsza śmiertelności z tego powodu i całkowitej. #zdrowie #dieta #fitluty #nutrition #dietetyka https://t.co/uAzAZMdkkO
view full postFebruary 13, 2019
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Dr Scott W Murray
@DrScottMurray (Twitter)RT @MMindrumMD: “adequately controlled RCTs suggest replacing SFA w/ mostly n-6 PUFA is unlikely to reduce CHD events, CHD mortality or tot…
view full postJanuary 22, 2019
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Simon Dankel
@simondankel (Twitter)RT @MMindrumMD: “adequately controlled RCTs suggest replacing SFA w/ mostly n-6 PUFA is unlikely to reduce CHD events, CHD mortality or tot…
view full postJanuary 22, 2019
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Ana Cláudia
@Anawsantos (Twitter)RT @MMindrumMD: “adequately controlled RCTs suggest replacing SFA w/ mostly n-6 PUFA is unlikely to reduce CHD events, CHD mortality or tot…
view full postJanuary 22, 2019
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Ashwin Subbaraj
@AshPT2018 (Twitter)RT @MMindrumMD: “adequately controlled RCTs suggest replacing SFA w/ mostly n-6 PUFA is unlikely to reduce CHD events, CHD mortality or tot…
view full postJanuary 22, 2019
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DiscoStew
@DiscoStew66 (Twitter)RT @KurtLass1: @MMindrumMD @DiscoStew66 Open access location: https://t.co/82LzXPrcCo
view full postJanuary 22, 2019
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Peter Miles
@PeterMilesMD (Twitter)https://t.co/7pMTsxz8UR https://t.co/PIZGN3HSJw
view full postJanuary 22, 2019
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Kurt Lass
@KurtLass1 (Twitter)@MMindrumMD @DiscoStew66 Open access location: https://t.co/82LzXPrcCo
view full postJanuary 22, 2019
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Ginger Sladky⌛☮️
@dragin97 (Twitter)RT @MMindrumMD: “adequately controlled RCTs suggest replacing SFA w/ mostly n-6 PUFA is unlikely to reduce CHD events, CHD mortality or tot…
view full postJanuary 22, 2019
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Guðmundur Jóhannsson
@gfj1979 (Twitter)RT @MMindrumMD: “adequately controlled RCTs suggest replacing SFA w/ mostly n-6 PUFA is unlikely to reduce CHD events, CHD mortality or tot…
view full postJanuary 22, 2019
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Erik Macholl
@ErikMacholl (Twitter)RT @MMindrumMD: “adequately controlled RCTs suggest replacing SFA w/ mostly n-6 PUFA is unlikely to reduce CHD events, CHD mortality or tot…
view full postJanuary 22, 2019
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Natural Law Enforcer
@BChinatti (Twitter)RT @MMindrumMD: “adequately controlled RCTs suggest replacing SFA w/ mostly n-6 PUFA is unlikely to reduce CHD events, CHD mortality or tot…
view full postJanuary 22, 2019
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SystematicReviewBot
@EvidenceRobot (Twitter)RT @MMindrumMD: “adequately controlled RCTs suggest replacing SFA w/ mostly n-6 PUFA is unlikely to reduce CHD events, CHD mortality or tot…
view full postJanuary 22, 2019
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KetofasterUK
@KetofasterU (Twitter)RT @MMindrumMD: “adequately controlled RCTs suggest replacing SFA w/ mostly n-6 PUFA is unlikely to reduce CHD events, CHD mortality or tot…
view full postJanuary 22, 2019
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DiscoStew
@DiscoStew66 (Twitter)RT @MMindrumMD: “adequately controlled RCTs suggest replacing SFA w/ mostly n-6 PUFA is unlikely to reduce CHD events, CHD mortality or tot…
view full postJanuary 22, 2019
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AntonioC Martinez II
@usambcuba (Twitter)RT @MMindrumMD: “adequately controlled RCTs suggest replacing SFA w/ mostly n-6 PUFA is unlikely to reduce CHD events, CHD mortality or tot…
view full postJanuary 22, 2019
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Michael Mindrum, MD
@MichaelMindrum (Twitter)“adequately controlled RCTs suggest replacing SFA w/ mostly n-6 PUFA is unlikely to reduce CHD events, CHD mortality or total mortality. The suggestion of benefits reported in earlier meta-analyses is due to inclusion of inadequately controlled trials.” https://t.co/pv4KUChttp
view full postJanuary 22, 2019
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the skeptical cardiologist
@skepcard (Twitter)@PeterAttiaMD The RCTs and the meta-analyses of the RCTs are nicely summarized here https://t.co/LYHTstcGWk. Current "expert" wisdom still maintains that replacing saturated fat with omega-6 PUFAs reducies CV risk but the data is very weak and depends on which RCTs are included.
view full postJanuary 13, 2019
Abstract Synopsis
- The study re-evaluates the recommendation to replace saturated fats (SFA) with n6 polyunsaturated fats (PUFA) to lower coronary heart disease (CHD) risk, highlighting flaws in earlier analyses.
- When focusing solely on adequately controlled trials (where experimental and control groups were similar), no significant impact on major CHD events or mortality rates was found.
- In contrast, including all trials suggested that substituting SFA with n6 PUFA might reduce total CHD events, but not necessarily major CHD events or overall mortality rates.








Dr. John Furr (N=1)
@JohnFurr561061 (Twitter)