Synopsis of Social media discussions

The discussions frequently reference the article's findings, such as claims that 'replacing saturated fat with n-6 PUFA is unlikely to reduce CHD events, mortality, or total mortality.' Participants often use phrases like 'the evidence shows' or 'the suggestion of benefits is due to inadequately controlled trials,' indicating a serious consideration of the study's implications. This emphasis on scientific evidence helps frame the discussions as informative and respectful, aligning with the overall sentiment of inquiry and reevaluation of prior dietary guidelines.

A
Agreement
Moderate agreement

Overall, the discussions reveal a moderate level of support for the study's conclusions, with many users acknowledging the findings of adequately controlled trials.

I
Interest
High level of interest

The topic sparked strong interest, as many participants shared references to related studies and engaged in detailed discussions.

E
Engagement
Moderate level of engagement

While there are some dismissive comments, the majority of users engaged in thoughtful analysis, analyzing methodologies and presenting counterarguments.

I
Impact
High level of impact

Many users perceive the study as having a significant impact on dietary recommendations regarding fats in relation to heart disease, emphasizing the relevance of its findings.

Social Mentions

YouTube

15 Videos

Facebook

21 Posts

Twitter

135 Posts

News

6 Articles

Reddit

4 Posts

Metrics

Video Views

58,488

Total Likes

2,613

Extended Reach

1,895,276

Social Features

181

Timeline: Posts about article

Top Social Media Posts

Posts referencing the article

Evaluating Saturated Fat and Its Impact on Heart Health

Evaluating Saturated Fat and Its Impact on Heart Health

I explore the role of saturated fat in our health, reviewing historical context and key research. This analysis challenges the belief that saturated fat is harmful and examines its complex relationship with coronary heart disease, urging a reevaluation of common dietary recommendations.

January 29, 2024

11,823 views


Debunking Myths: Saturated Fat and Heart Disease

Debunking Myths: Saturated Fat and Heart Disease

The idea that saturated fat causes heart disease is one of the biggest myths in modern nutrition. Science shows that saturated fat is not associated with increased mortality, while refined carbohydrates and industrial vegetable oils contribute to health issues. This video explores these findings.

February 20, 2025

10,118 views


Lower Cardiovascular Risk Without Medication Using Lifestyle Strategies

Lower Cardiovascular Risk Without Medication Using Lifestyle Strategies

This video explores ways to reduce cardiovascular risk through lifestyle changes, including the benefits of fermented red rice, tomato juice as an aspirin alternative, herbal teas like green and hibiscus, and physical activities such as Tai Chi, which can improve mental health.

May 3, 2018

6,315 views


Impact of Dietary Fats on Cardiovascular Health Risks

Impact of Dietary Fats on Cardiovascular Health Risks

This video explores the relationship between dietary fats and cardiovascular disease, clarifying risk factors contributing to heart attacks and strokes. We analyze how replacing saturated fats with vegetable oils affects serum cholesterol and health outcomes, based on the Minnesota Coronary Experiment.

May 13, 2024

183 views


Which Oils Are Healthy?

Which Oils Are Healthy?

December 26, 2017

123 views


Debunking the Plant Oil Myth: The Truth About Omega-6 and Health Risks

Debunking the Plant Oil Myth: The Truth About Omega-6 and Health Risks

Since years, we are told to replace butter with plant oils. But what if this advice is based on flawed studies from the 1960s? This video uncovers the myth surrounding seed oils and explains why the real concern lies elsewhere, emphasizing the importance of balanced Omega-6 and Omega-3 levels.

October 6, 2025

123 views


Debunking the Seed Oil Myth and the Importance of PUFA Balance

Debunking the Seed Oil Myth and the Importance of PUFA Balance

For decades weve been told to replace butter with vegetable oils for a healthy heart. But what if this advice was based on flawed old studies? This video debunks the seed oil myth and emphasizes the importance of understanding PUFA species and balancing Omega6 to Omega3.

October 5, 2025

23 views


Exploring the Health Impacts of Seed Oils on Cardiovascular Risk Factors

Exploring the Health Impacts of Seed Oils on Cardiovascular Risk Factors

Seed oils, including canola oil, have sparked debate regarding their health effects. This video delves into research suggesting that canola oil may improve cardiometabolic risk factors like cholesterol levels and inflammation. Tune in for insights on whether these oils should be part of your diet.

July 10, 2025

6 views


  • Dr. John Furr (N=1)
    @JohnFurr561061 (Twitter)

    @reFleXiveLogiK @ScottAppliedSci @Blackswanson @gunsnrosesgirl3 Evidence from Randomized Controlled Trials (RCTs) & Meta-analyses of RCTs https://t.co/oybE31Xz4S https://t.co/3TIZYDgUbh https://t.co/Yw99QB2HqV https://t.co/a0hIK5UL2N https://t.co/lIudH7GAQU
    view full post

    October 2, 2025

    1

  • David Lloyd
    @davidlloyd (Twitter)

    @lporiginalg https://t.co/wxKxngdVCs
    view full post

    March 15, 2025

  • Steven M. Belknap, MD PGY43
    @StevenMBelknap (Twitter)

    @TuckerGoodrich @JesperLundbom @garytaubes @KingManninen @PeterFaberSP @BiggestComeback @mikeoniron @exfatloss Here's the Hamley SRMA: DOI 10.1186/s12937-017-0254-5 The code is a complete transcript of the Survival Function calculations using Mathematica. It's not published anywhere. I can send you the Mathematica file if you like.
    view full post

    August 27, 2024

    2

  • Travis Einertson
    @LowCarbVet (Twitter)

    @StevenMBelknap @hufcm @dylanarmbruste3 @GardnerPhD @American_Heart Thanks for this. Here is the link to the Hamley paper….. https://t.co/rub9orSy0e https://t.co/C2eQFnuu2E
    view full post

    August 26, 2024

  • Steven M. Belknap, MD PGY43
    @StevenMBelknap (Twitter)

    @hufcm @dylanarmbruste3 @GardnerPhD @American_Heart 1. The best SRMA of SatFat→ω6:PUFA is by Hamley. DOI 10.1186/s12937-017-0254-5 2. Present the research result(s) that you believe that I ignore. 3. Explain the flaw in my application of Taleb's method to meta-analysis of the high-quality RCTs. (Unpublished ≠ Wrong & Published https://t.co/zonC5QEqC8
    view full post

    August 25, 2024

  • Steven M. Belknap, MD PGY43
    @StevenMBelknap (Twitter)

    Not so much. Satfat does not increase total mortality compared to ω6 PUFA, based on the best available research results: adequately-controlled randomized clinical trials that compare satfat to ω6 PUFA. DOI 10.1186/s12937-017-0254-5 https://t.co/xfFmERmP5f https://t.co/jQNkhgAOYv
    view full post

    August 16, 2024

    3

  • Nzyen Renrey
    @NzyenR (Twitter)

    @BioLayne No https://t.co/nNyXwaLb5U https://t.co/RLGJzxPDug https://t.co/DNCPsAaA5j /biomedcentral.com/articles/10.1186/s12986-017-0186-2
    view full post

    July 18, 2024

    1

  • Triage
    @triagemethod (Twitter)

    @NzyenR The question was: For those who disagree with this perspective regarding "seed oils" / PUFAs / linoleic acid and heart disease, what's the most convincing human evidence of harm? Ref 1.) https://t.co/BB0lP3eMle The meta-analysis you just cited does not make any such conclusion,
    view full post

    June 24, 2024

    5

  • Nzyen Renrey
    @NzyenR (Twitter)

    @triagemethod That's easy bro https://t.co/OKhZPXu2di https://t.co/LJStgsQQTO https://t.co/RLGJzxPDug
    view full post

    June 24, 2024

    1

  • Miguel The Vegan
    @miguelthevegan (Twitter)

    @AsarCadyn This isn’t just Alice’s opinion. https://t.co/shSMgmqYOg https://t.co/BhhOykfXRf https://t.co/Wsmte4QbJn
    view full post

    April 19, 2024

  • Adolfo Neto
    @adolfont (Twitter)

    @LucianTritt @lincolixavier @ngtv_bg I don't care that much about that. The fact is that there is evidence that saturated fats are not harmful. https://t.co/LugQuVZtt2
    view full post

    April 7, 2024

  • GenevieveZzyzyx
    @GZzyzyx (Twitter)

    @bminn7660 @_sugaree_ @VPrasadMDMPH So this was used as a claim that saturated fat “doesn’t cause cardiovascular disease” https://t.co/tIucEuromh It was a rabbit hole from source 33 of THIS nonsense
    view full post

    March 21, 2024

  • Bryan Bargowski
    @GosuGains (Twitter)

    RT @StevenMBelknap: @MohammedAlo Not so much. There’s a lot of wrong to unpack here. Hamley’s meta-analysis of RCTs found no effect of rep…
    view full post

    March 13, 2024

    3

  • Steven M. Belknap, MD PGY43
    @StevenMBelknap (Twitter)

    RT @StevenMBelknap: @MohammedAlo Not so much. There’s a lot of wrong to unpack here. Hamley’s meta-analysis of RCTs found no effect of rep…
    view full post

    March 13, 2024

    3

  • Steven M. Belknap, MD PGY43
    @StevenMBelknap (Twitter)

    @JesperLundbom @KingManninen @TuckerGoodrich @garytaubes @PeterFaberSP @BiggestComeback @mikeoniron @exfatloss You are correct that an analysis published in a meta-analysis of well-controlled RCTs showed that swapping SFA → ω6 PUFA does not increase cardiovascular mortality or total mortality. DOI 10.1186/s12937-017-0254-5 However, the analytic method used in this meta-analysis (and
    view full post

    March 13, 2024

    1

  • .
    @_4_5_44 (Twitter)

    RT @HalukVAHABOLU: 8/ ortada dönen dolabı anlamak için şunu oku https://t.co/6CNPt7M3es şu makaleleri de incelemeni isterim https://t.co/g…
    view full post

    March 2, 2024

    4

  • Abdülkadir Geylani Şahan
    @agsahan1 (Twitter)

    RT @HalukVAHABOLU: 8/ ortada dönen dolabı anlamak için şunu oku https://t.co/6CNPt7M3es şu makaleleri de incelemeni isterim https://t.co/g…
    view full post

    March 2, 2024

    4

  • Prof. Dr. Haluk VAHABOGLU
    @HalukVAHABOLU (Twitter)

    8/ ortada dönen dolabı anlamak için şunu oku https://t.co/6CNPt7M3es şu makaleleri de incelemeni isterim https://t.co/gtsPpYTcRP https://t.co/rDuuIxFc1b
    view full post

    March 1, 2024

    7

    4

  • Samar Sheoran
    @samarsheoran (Twitter)

    @Appoota @shashiiyengar @TheNutrivore https://t.co/oukjavwWgz Here this one. Effect on CHD
    view full post

    December 30, 2023

  • Libertas
    @Libertas2008 (Twitter)

    RT @raphaels7: https://t.co/v7gcZyOA5e “The suggestion of benefits reported [SFA => N6] in earlier meta-analyses is due to the inclusion of…
    view full post

    November 16, 2023

    3

  • Lauri Kärnä
    @LauriKrn (Twitter)

    @TuckerGoodrich @foundmyfitness @AnthonyLewayne @fmfclips @WHO Well meta-analysis says you’re wrong about the CVD: https://t.co/CnnKgXIcJK ” the pooled results from all trials, including the inadequately controlled trials, suggested that replacing SFA with mostly n-6 PUFA would significantly reduce the risk of total CHD events”
    view full post

    October 25, 2023

  • Max Lugavere
    @maxlugavere (Twitter)

    @MiocanDanijel Here’s one. 2017 meta-analysis: n-6 PUFA replacement shows no benefit to CHD events, mortality, or total mortality. Hamley, 2017 https://t.co/2xvQnOZTcg
    view full post

    October 18, 2023

  • Carnivore is Vegan
    @CarnivoreIs (Twitter)

    @TarbuckSam @BHBEnjoyer @EarthlingAus This is a metanalysis of RCTs. "Available evidence from adequately controlled randomised controlled trials suggest replacing SFA with mostly n-6 PUFA is unlikely to reduce CHD events, CHD mortality or total mortality." https://t.co/JEwpNUENiX
    view full post

    September 8, 2023


  • @dingdongjapan (Twitter)

    @BadassDalit @shashiiyengar @dlifein We don't need to check our lipids you need to check more research papers. 1.https://t.co/W8uMNf8yS3 https://t.co/Zn7Mvr0pe0 2.https://t.co/6xnNEmqw5H 3.https://t.co/RuFhMlmQUd 4.https://t.co/jdkcVoOy39 https://t.co/oWIDaWbuzM
    view full post

    June 23, 2023

    2

  • Nzyen Renrey
    @NzyenR (Twitter)

    @raphaels7 https://t.co/iGgztyMR9f https://t.co/dQ506vffyg https://t.co/ylyKiqChD5 These ones too plus mendelian randomization. Not to mention other that show a trend in crp with high intakes, blood clotting rct, the rct in China with gut bacteria and one where it increases lpa and oxldl
    view full post

    June 21, 2023

  • Nzyen Renrey
    @NzyenR (Twitter)

    @SOfreeLifestyle @BioLayne https://t.co/ylyKiqChD5 https://t.co/BPzuL8IIGi https://t.co/RLGJzxPDug https://t.co/dQ506vffyg
    view full post

    June 20, 2023

    1

  • IFN Academy
    @IFNAcademy (Twitter)

    IFNCP Functional Nutritionists are trained to tailor diet recommendations to YOU based on your lifestyle, genetics, and disease condition. https://t.co/jMkfayte5Y #IFNAcademy https://t.co/q45qJQZ7fH
    view full post

    June 9, 2023

  • Linux O'Beardly
    @OBeardly (Twitter)

    RT @StevenMBelknap: @MohammedAlo Not so much. There’s a lot of wrong to unpack here. Hamley’s meta-analysis of RCTs found no effect of rep…
    view full post

    April 22, 2023

    3

  • Steven M. Belknap, MD PGY43
    @StevenMBelknap (Twitter)

    @MohammedAlo Not so much. There’s a lot of wrong to unpack here. Hamley’s meta-analysis of RCTs found no effect of replacing dietary satfats with ω6 PUFAs. https://t.co/0WbEpOni0l I re-analyzed the RCT data using a better statistical method, and found that ω6 PUFAs *increased* mortality. https://t.co/lZRPFPXrNb
    view full post

    April 21, 2023

    27

    3

  • Renato Dumbra
    @renatodumbra (Twitter)

    @raphaels7 @PeterAttiaMD @ZeroAcreFarms replacing saturated fats with PUFAs resulted in a small but statistically significant reduction in body weight. https://t.co/jc4gVdSB4c
    view full post

    March 12, 2023

  • Max Lugavere
    @maxlugavere (Twitter)

    @missiletech80 Not what the science says. 2017 meta-analysis: n-6 PUFA replacement shows no benefit to CHD events, mortality, or total mortality. https://t.co/2xvQnOZTcg
    view full post

    March 11, 2023

    1

  • Steven M. Belknap, MD PGY43
    @StevenMBelknap (Twitter)

    @IsmaelGalancho @exfatloss @sguyenet @bigfatsurprise The facts are otherwise. Swapping out Dietary SatFats for PolyUnSatFats does not reduce total mortality. (Fig 3.) https://t.co/Y4YL7bkpZt The Minnesota Coronary Survey found a 22% *higher* risk of death for each 30 mg/dL reduction in serum cholesterol. https://t.co/szA2uVW4b4 https://t.co/Wc1TfLcCsP
    view full post

    March 10, 2023

    1

  • Wei. Zhang
    @WeiZhangAtmos (Twitter)

    @ToYourHealth101 @NicolaiWorm @bigfatsurprise @drdairy50 @fleroy1974 Hamley 2017 https://t.co/LXBKJGoF1b
    view full post

    March 6, 2023

  • Carnivore is Vegan
    @CarnivoreIs (Twitter)

    @skydog576 @rodney_dever @jwolnizer @forktown385 Even a metanalysis of RCT's concluded "Available evidence from adequately controlled randomised controlled trials suggest replacing SFA with mostly n-6 PUFA is unlikely to reduce CHD events, CHD mortality or total mortality" https://t.co/PNsZfDbq3I
    view full post

    March 5, 2023

  • Carnivore is Vegan
    @CarnivoreIs (Twitter)

    @LucianTritt @F_Z_F_Z_F RCT's don't show any harm from SFA's either. "Available evidence from adequately controlled randomised controlled trials suggest replacing SFA with mostly n-6 PUFA is unlikely to reduce CHD events, CHD mortality or total mortality" https://t.co/PNsZfDbq3I
    view full post

    February 27, 2023

  • #WorkoutWarrior
    @WorkoutWarrior4 (Twitter)

    RT @StevenMBelknap: @ScepticalDoctor @susanwoledge @ButterFueled LDL-C is not a predictive biomarker for atherosclerosis or anything else.…
    view full post

    February 14, 2023

    2

  • Butter Fueled
    @ButterFueled (Twitter)

    RT @StevenMBelknap: @ScepticalDoctor @susanwoledge @ButterFueled LDL-C is not a predictive biomarker for atherosclerosis or anything else.…
    view full post

    February 14, 2023

    2

  • Steven M. Belknap, MD PGY43
    @StevenMBelknap (Twitter)

    @ScepticalDoctor @susanwoledge @ButterFueled LDL-C is not a predictive biomarker for atherosclerosis or anything else. Randomized controlled trials have shown that replacing SatFats with PUFAs is not beneficial and is probably harmful. https://t.co/Y4YL7bkpZt
    view full post

    February 14, 2023

    24

    2

  • A Cookie
    @flatmannn (Twitter)

    @Alex__Katz @simplulo @mattyglesias Here we have a meta analysis showing no benefit from replacing sat fat with n6 polyunsaturated (what is found in cooking oils): https://t.co/JvPEL88Bd4
    view full post

    February 2, 2023

  • Jack O'Connor
    @JackoJSY (Twitter)

    @FearZero4 @stopYouOut @SBakerMD https://t.co/vTUMbvcMPd We can do it all day.
    view full post

    January 22, 2023

  • Steven M. Belknap, MD PGY43
    @StevenMBelknap (Twitter)

    @GZzyzyx @LeomantVictoria @benandjerrys Cholesterol in diet doesn’t cause heart attack. Re: saturated fats, “Available evidence from adequately controlled randomised controlled trials suggest replacing SFA with mostly n-6 PUFA is unlikely to reduce CHD events, CHD mortality or total mortality” https://t.co/0WbEpOni0l
    view full post

    December 11, 2022

    2

  • Steven M. Belknap, MD PGY43
    @StevenMBelknap (Twitter)

    @nntaleb @boozifer99 I admire @nntaleb’s critical thinking & clever stats. But! He has yet to get facts straight on recent tweets on SFAs. Plz review relevant tweets & revise yr error. @bigfatsurprise presented @stevenhamley’s review on SFA restriction as best, not Cochrane’s. https://t.co/Y4YL7bkXP1 https://t.co/LZ1v4apxaW
    view full post

    December 9, 2022

    1

  • Steven M. Belknap, MD PGY43
    @StevenMBelknap (Twitter)

    @CaloriesProper @bigfatsurprise @nntaleb @LuisCLCorreia @DrDamluji @cochranecollab @nationallipid @NutritionMadeS3 @KCKlatt Steven Hamley performed a meta-analysis of RCTs that replace saturated fatty acids (SFA) with ω-6 polyunsaturated fatty acids (PUFA). The experimental intervention was different according to the RCT. Here’s the key data from Figure 4. Here’s the link: https://t.co/Y4YL7b2OAT https://t.co/7fAWUlWSQi
    view full post

    December 8, 2022

  • Nina Teicholz, PhD
    @bigfatsurprise (Twitter)

    @nntaleb @StevenMBelknap @LuisCLCorreia @DrDamluji @cochranecollab @nationallipid Your issue is with the paper, I guess. You should know this is one of many reviews of these data. IMHO, the clearest review of this data, and also most objective, is this one. Breaks out well-controlled trials and inadequately controlled trials. https://t.co/JROZTlbbgI
    view full post

    December 3, 2022

    8

  • alephh
    @alephh (Twitter)

    Replacing sat fat with vegetable oils vs coronary heart disease (RCT meta-analysis) —Seed oils harm/kill more in rigorous trials (not stat-sig RR): 1.06 (.86/1.31) major CHD events 1.02 (.84/1.23) total CHD 1.13 (.91/1.40) CHD deaths 1.07 (.90/1.26) deaths https://t.co/OeJ9gzSGfq
    view full post

    October 19, 2022

  • Jim
    @JimeeLiberty (Twitter)

    @krebiozen @richykirsh @WendyOrent @mcfunny @scottstocker4 @IdunsDaughter @ConsequentialBr @pawley_robert @AndrewLazarus4 @Pouldeau61 @Monstercoyliar @SkepticalMutant @newstranslate13 @barryjohnreid21 @TonyBaduy @jarbot15 @AspAlaAsnAsnTyr @JonathanHannah @MaureenStroud @ShockTraumaRN @JimBeam102 @Thskicksarefire @JKelleyK @swedishchf @provaxtexan @reacharoundu @ogilville1 @Alex_on_A14 @doom37455413 @AngryFleas @ShadowDroid616 @doritmi @tomsirolimus @TheDrJon @jtmayes3 @nuhope2022 @Adrian7745 @statsguyuk @CurfewX @JDCBurnhil @HupperichWerner @KStateTurk @BreezerGalway @Fornowago @Conservacat2 @zeetubes @AtomsksSanakan @MattMcInnis6 @Twitter https://t.co/gY0y7OQLHF https://t.co/eACNbOLBJZ
    view full post

    September 27, 2022

  • Butter Fueled
    @ButterFueled (Twitter)

    @Tellit007 @SamaHoole Many studies to show there's little to no concern with consuming animal products (meat or fat) and LDL https://t.co/gZuj1i6TEg https://t.co/EU10ASP73H https://t.co/jOf1nJYdWu https://t.co/7JxO5vQNjx https://t.co/lbVYVog484 https://t.co/fWeyIXcd7u https://t.co/AHlnUrPfpo
    view full post

    September 18, 2022

  • Gerardo Avelar
    @Gerave7 (Twitter)

    @CaloriesProper Lol, actually I believe you know well it's supposed to work the other way around; if they do any claim (which I'm not), they must provide the evidence to support it. Anyway, a couple about PUFA, which I think is the usual suspect: https://t.co/XRCpCeI920 https://t.co/nQtc1BFr60
    view full post

    June 16, 2022

  • Jakub Lenard
    @lenard_jakub (Twitter)

    @sguyenet @theproof @sguyenet @theproof What do you think about this meta-analysis of RCTs? https://t.co/fREL2mK7IN
    view full post

    April 22, 2022

  • Janet Wilkins
    @JanetWi83437512 (Twitter)

    RT @Mangan150: Evidence suggests replacing saturated fat with n-6 PUFA is unlikely to reduce CHD events, CHD mortality or total mortality.…
    view full post

    April 3, 2022

    1

  • P.D. Mangan Health & Freedom Maximalist
    @Mangan150 (Twitter)

    Evidence suggests replacing saturated fat with n-6 PUFA is unlikely to reduce CHD events, CHD mortality or total mortality. The suggestion of benefits reported in earlier meta-analyses is due to the inclusion of inadequately controlled trials. https://t.co/LbLpngyVwf
    view full post

    April 3, 2022

    18

    1

  • Carnivore is Vegan
    @CarnivoreIs (Twitter)

    @LesFleurs67 @kemminnick @bigfatsurprise "Available evidence from adequately controlled randomised controlled trials suggest replacing SFA with mostly n-6 PUFA is unlikely to reduce CHD events" https://t.co/PNsZfCTgPA
    view full post

    March 20, 2022

  • Carnivore is Vegan
    @CarnivoreIs (Twitter)

    @CapitalistV3GAN @OwlJoAJo "evidence from adequately controlled randomised controlled trials suggest replacing SFA w/ n-6 PUFA is unlikely to reduce CHD events or total mortality.The suggestion of benefits reported in earlier meta-analyses is due to inadequately controlled trials." https://t.co/PNsZfCTgPA
    view full post

    March 10, 2022

  • el snaxion⚡️
    @snaxion (Twitter)

    INTERESTING: Saturated fatty acid intake/ heart disease may not be linked
    view full post

    March 6, 2022

  • help for your conscience
    @conscience_help (Twitter)

    @ScepticalDoctor @ValtsuH @Max_Plaid Responding with “bro” voice is childish and shows you don’t understand the topic adequately to argue with concise points. PUFAs are not at all beneficial for improving CVD outcomes when your studies are designed properly. https://t.co/cAtqkZWWU5
    view full post

    March 4, 2022

    1

  • Harmless Frog
    @FrogHarmless (Twitter)

    @ScepticalDoctor Yes, these trials have a lot of confounding factors. https://t.co/1rPjBwHF6e
    view full post

    October 10, 2021

  • Anthony CHAD-DAD Knobbe
    @anthonysramblin (Twitter)

    @SecoraPearlRem They are not https://t.co/54Uav4d0lc https://t.co/gEI8YV69iR https://t.co/pvU9ytSB8U https://t.co/B2qsqw3Q2x https://t.co/CaxsuRgyin
    view full post

    September 28, 2021

  • jorf
    @eatyourfat (Twitter)

    @NoNotTheDrummer @kayleighisded @philly_taco @alliemarie777 @vssapaige @colormeboldly https://t.co/QKggdY4VvZ
    view full post

    September 19, 2021

  • Sheep Herder
    @WarriorLean (Twitter)

    @TuckerGoodrich @The_Nutrivore https://t.co/OpHIQsmXdf
    view full post

    August 19, 2021

  • Sheep Herder
    @WarriorLean (Twitter)

    RT @Mangan150: Much of the evidence used by the experts to recommend use of vegetable oils in place of saturated fat is shoddy. When adequ…
    view full post

    August 19, 2021

    4

  • DiscoStew
    @DiscoStew66 (Twitter)

    RT @Mangan150: Much of the evidence used by the experts to recommend use of vegetable oils in place of saturated fat is shoddy. When adequ…
    view full post

    August 19, 2021

    4

  • MorozkoForge
    @MorozkoForge (Twitter)

    RT @Mangan150: Much of the evidence used by the experts to recommend use of vegetable oils in place of saturated fat is shoddy. When adequ…
    view full post

    August 19, 2021

    4

  • Waterpenny
    @Waterpenny111 (Twitter)

    RT @Mangan150: Much of the evidence used by the experts to recommend use of vegetable oils in place of saturated fat is shoddy. When adequ…
    view full post

    August 19, 2021

    4

  • P.D. Mangan Health & Freedom Maximalist
    @Mangan150 (Twitter)

    Much of the evidence used by the experts to recommend use of vegetable oils in place of saturated fat is shoddy. When adequately controlled trials are used, benefits disappear. https://t.co/LbLpngyVwf
    view full post

    August 19, 2021

    41

    4

  • Marc Kinjet
    @MarcKinjet (Twitter)

    The effect of replacing saturated fat with n-6 polyunsaturated fat on coronary heart disease: a meta-analysis of randomised controlled trials - the best method in nutritional science and metabolism shows no difference between Saturated fat and omega-6 fat! https://t.co/hADgdwYbrk
    view full post

    August 1, 2021

  • Carl Thomas Ball
    @carltball122219 (Twitter)

    RT @Mangan150: @IvorGoodbody https://t.co/Awv00AOofO
    view full post

    July 28, 2021

    1

  • P.D. Mangan Health & Freedom Maximalist
    @Mangan150 (Twitter)

    @IvorGoodbody https://t.co/Awv00AOofO
    view full post

    July 28, 2021

    3

    1

  • DiscoStew
    @DiscoStew66 (Twitter)

    RT @raphaels7: https://t.co/v7gcZyOA5e “The suggestion of benefits reported [SFA => N6] in earlier meta-analyses is due to the inclusion of…
    view full post

    July 28, 2021

    3

  • Harmless Frog
    @FrogHarmless (Twitter)

    RT @raphaels7: https://t.co/v7gcZyOA5e “The suggestion of benefits reported [SFA => N6] in earlier meta-analyses is due to the inclusion of…
    view full post

    July 28, 2021

    3

  • Raphael Sirtoli
    @raphaels7 (Twitter)

    https://t.co/v7gcZyOA5e “The suggestion of benefits reported [SFA => N6] in earlier meta-analyses is due to the inclusion of inadequately controlled trials” https://t.co/EPqT5mDu0I
    view full post

    July 27, 2021

    5

    3

  • Jakub Lenard
    @lenard_jakub (Twitter)

    @NutritionMadeS3 @CarolHo03279746 Are you referring to this meta-analysis?
    view full post

    July 27, 2021

    2

  • Sky King
    @skyking171717 (Twitter)

    @Veganella_ @The_Nutrivore @MrDiefenbach @LoraJR72 @kirthurgan @FusionProgGuy @waseemkiani @mosca_matthew @MistyMum2 @Parallax9999 @JoeKerr57254356 @OofT74480205 @AnimalJustice6 @cerebralsymphoy @Rev0lvingDoor @ThatTennisVegan @bongxdylan @TheTrueCompton @Grahanimal @_Aloominati_ @NutritionMadeS3 @whsource @BioLayne And this one: Conclusion: “Available evidence from adequately controlled randomised controlled trials suggest replacing SFA with mostly n-6 PUFA is unlikely to reduce CHD events, CHD mortality or total mortality. https://t.co/x7W1qB6pgR
    view full post

    July 13, 2021

  • Sky King
    @skyking171717 (Twitter)

    @ElliottWins @The_Nutrivore @Plant_proof Here ya go, Elliott: "Conclusion: “Available evidence from adequately controlled randomised controlled trials suggest replacing SFA with mostly n-6 PUFA is unlikely to reduce CHD events, CHD mortality or total mortality." https://t.co/x7W1qB6pgR
    view full post

    July 13, 2021

  • JaysonSipress
    @jaysonsipress (Twitter)

    @Tom_Babington1 @nakedathletes @kevinnbass *cough cough* https://t.co/HpC54R8Kma
    view full post

    April 15, 2021

  • JaysonSipress
    @jaysonsipress (Twitter)

    @Tom_Babington1 @kevinnbass So, are we not taking into account this meta-analysis? https://t.co/HpC54R8Kma
    view full post

    April 15, 2021

    1

  • Dušan Ristić
    @dsnrstc (Twitter)

    @mosca_matthew @AmandaZZ100 And anoher one: https://t.co/USi9LWeT9y
    view full post

    April 4, 2021

  • Chris Palmer, MD
    @ChrisPalmerMD (Twitter)

    @joemclean95 This one published in 2017 suggests otherwise. Looks like the verdict is still out? https://t.co/Wf7tmkj1yV
    view full post

    March 18, 2021

  • Maurício Lima
    @dj_surfista (Twitter)

    As evidências disponíveis de ensaios clínicos randomizados controlados adequadamente sugerem que a substituição de SFA por PUFA n-6 provavelmente não reduzirá o risco de doença cardíaca coronária (DCC), a mortalidade por DCC ou a mortalidade total. https://t.co/aVBDB7URCi
    view full post

    February 15, 2021

    2

  • Amir Weiss
    @AmirWeiss1 (Twitter)

    @MyNutritionSci @WiswordBrasil @Travis_Statham @ScepticalDoctor I clicked on the link to read the abstract, then saw this more recent paper from 2017 which seems to contrdict the findings. I'm on the sidelines, not advocating for one side or another https://t.co/Ktt9ZF2MSm
    view full post

    February 15, 2021

  • dr roth
    @mrc314 (Twitter)

    @bohdyone @Travis_Statham @MyNutritionSci @ScepticalDoctor Moreover …  "The effect of replacing saturated fat with mostly n-6 polyunsaturated fat on coronary heart disease" ARE NOT THE ONLY EFFECTS. Dying from something PUFA-induced, earlier, isn't a win.
    view full post

    February 15, 2021

  • Travis Statham
    @Travis_Statham (Twitter)

    RT @bohdyone: @MyNutritionSci @Travis_Statham @ScepticalDoctor Interesting, but I saw another that appears to directly contradict those fin…
    view full post

    February 15, 2021

    1

  • Bogdan
    @bohdyone (Twitter)

    @MyNutritionSci @Travis_Statham @ScepticalDoctor Interesting, but I saw another that appears to directly contradict those findings. https://t.co/YyJv40vuZG
    view full post

    February 15, 2021

    3

    1

  • Simon Dankel
    @simondankel (Twitter)

    RT @PreKureOfficial: @MyNutritionSci @simondankel @zinocker @kariannesve The only CHD events decreased in the Cochrane meta, by a tiny exte…
    view full post

    February 14, 2021

    1

  • PREKURE
    @PREKUREOfficial (Twitter)

    @MyNutritionSci @simondankel @zinocker @kariannesve The only CHD events decreased in the Cochrane meta, by a tiny extent, are unblinded ones - angina and revascularization - where LDL level is a diagnostic criteria in uncertain cases. And if you remove the confounded studies you won't even see that. https://t.co/PJI48nKIBQ
    view full post

    February 14, 2021

    2

    1

  • Jevan
    @Jevan (Twitter)

    @Alecsplaining @MarieSpreckley @jaapseidell I was talking about the red meat/white meat/ pp study you posted. As for SFA vs. PUFA, I have no big dog in the fight, data is messy, in this meta - in adequately controlled trials comparing SFA vs n-6, there is no difference in CVD events or mortality https://t.co/9eQlOxoTe6
    view full post

    February 10, 2021

  • Carnivore is Vegan
    @CarnivoreIs (Twitter)

    @Plant_proof @OhhiyoGarmen Also from 2017. So much for an echo chamber, "Available evidence from adequately controlled randomised controlled trials suggest replacing SFA with mostly n-6 PUFA is unlikely to reduce CHD events, CHD mortality or total mortality. " https://t.co/Nh1yzWyiUy
    view full post

    January 12, 2021

  • Zack DiMattia
    @ZackDiMattia (Twitter)

    @FoodFirst_Ty @CarnivoreAntMan https://t.co/UMhFxeSPOY https://t.co/ZKkBntwOMF https://t.co/sS40p2WNOn https://t.co/c5sTcM00ro https://t.co/QgAo5JaDRY https://t.co/wLREegMaKm https://t.co/TY096o1CWZ
    view full post

    June 29, 2020

  • Jeffery Heileson
    @jheilesonRD (Twitter)

    @The_Nutrivore @TheAlanAragon @StolteThiago "Robust" may be overstating the evidence. https://t.co/ejaRgk5qcU https://t.co/7dYDOXlgWy https://t.co/d8gOfPRo6C https://t.co/M6523GE5dg Silverman (2016) also cites the same studies as the AHA meta-analysis that has been criticized: https://t.co/SbP22Iwhuo
    view full post

    June 7, 2020

    1

  • Alberto García
    @AGG7 (Twitter)

    RT @DiscoStew66: https://t.co/yV10JFpo6q
    view full post

    June 5, 2020

    2

  • Leave it to Beaver
    @espacetimeNOT (Twitter)

    RT @tjavanainen2018: ”Available evidence from adequately controlled randomised controlled trials suggest replacing SFA with mostly n-6 PUFA…
    view full post

    June 5, 2020

    1

  • Vaste
    @VasteOy (Twitter)

    ”Available evidence from adequately controlled randomised controlled trials suggest replacing SFA with mostly n-6 PUFA is unlikely to reduce CHD events, CHD mortality or total mortality” #rasva #SFA #PUFA #CHD https://t.co/WFzxo7OSSv
    view full post

    June 5, 2020

  • Tuomas Javanainen
    @tjavanainen2018 (Twitter)

    ”Available evidence from adequately controlled randomised controlled trials suggest replacing SFA with mostly n-6 PUFA is unlikely to reduce CHD events, CHD mortality or total mortality” #rasva #SFA #PUFA #CHD https://t.co/5cwsRmXNVl
    view full post

    June 5, 2020

    2

    1

  • Sugar
    @Sugar51976529 (Twitter)

    @GovCanHealth These findings have implications for current dietary recommendations https://t.co/IxUo187Cwf
    view full post

    June 5, 2020

  • David Diamond
    @LDLSkeptic (Twitter)

    RT @DiscoStew66: https://t.co/yV10JFpo6q
    view full post

    June 5, 2020

    2

  • Nick Eggleton
    @NickEggleton (Twitter)

    The Effect of Replacing Saturated Fat With Mostly n-6 Polyunsaturated Fat on Coronary Heart Disease: A Meta-Analysis of Randomised Controlled Trials. https://t.co/6QdhueARAm
    view full post

    June 5, 2020

  • DiscoStew
    @DiscoStew66 (Twitter)

    https://t.co/yV10JFpo6q
    view full post

    June 5, 2020

    14

    2

  • DiscoStew
    @DiscoStew66 (Twitter)

    “Available evidence from adequately controlled randomised controlled trials suggest replacing SFA with mostly n-6 PUFA is unlikely to reduce CHD events, CHD mortality or total mortality.” https://t.co/3VZQOzY3jp
    view full post

    May 24, 2020

    5

  • Ian McIntosh D.C.
    @IanMcIntosh1 (Twitter)

    @The_Nutrivore Hmmm.. https://t.co/ndbZhXjQbu https://t.co/tJQ6OQijTb https://t.co/4Q4t1nB8bU https://t.co/vxbR0zNHeB https://t.co/IZSQvehGRC https://t.co/SZTcifSP0V Which studies to believe..
    view full post

    May 8, 2020

  • Jakub Lenard
    @lenard_jakub (Twitter)

    @lowcarbGP When it comes to fats, it's worth keeping this meta-analysis in mind https://t.co/fREL2mK7IN
    view full post

    April 8, 2020

    4

  • George D. Henderson
    @puddleg (Twitter)

    @IngersolRobert @craigthomler @JorgeLarangeir1 @ClimateOfGavin Does an association of 0.97 across half-a-million people really support that claim? https://t.co/hjm46MMkW9 Does the RCT evidence for SFA replacement really support that claim? https://t.co/H80sxBNYqL This is not contradictory evidence. It's confirmation of a null hypothesis.
    view full post

    February 9, 2020

  • Tucker Goodrich
    @TuckerGoodrich (Twitter)

    @jheilesonRD @TheAlanAragon @KrisSkeggs @EndGame_HS You're got that backwards, for Hamley, at least. "...replacing SFA with mostly n-6 PUFA is unlikely to reduce CHD events, CHD mortality or total mortality." https://t.co/PgRQm3mQri
    view full post

    January 11, 2020

    1

  • George D. Henderson
    @puddleg (Twitter)

    @POhukainen @FatEmperor @TomPMarshall Really? This is a non-statin intervention. https://t.co/H80sxBNYqL
    view full post

    December 5, 2019

  • Daniel Rico
    @dnlrico (Twitter)

    RT @puddleg: @JimJohnsonSci The @stevenhamley meta-analysis, which tries to account for confounding by the mixed interventions included in…
    view full post

    November 13, 2019

    2

  • ZahcM
    @ZahcM (Twitter)

    RT @puddleg: @JimJohnsonSci The @stevenhamley meta-analysis, which tries to account for confounding by the mixed interventions included in…
    view full post

    November 12, 2019

    2

  • George D. Henderson
    @puddleg (Twitter)

    @JimJohnsonSci The @stevenhamley meta-analysis, which tries to account for confounding by the mixed interventions included in the diet-heart metas, should also be considered: https://t.co/H80sxBNYqL
    view full post

    November 12, 2019

    3

    2

  • power
    @AntonVilla34 (Twitter)

    RT @DiegoNSalman: Meta análisis de estudios aleatorios sobre reemplazo de grasas saturadas por ácidos grasos omega 6: No hay beneficio algu…
    view full post

    September 9, 2019

    3

  • Javier
    @Pollojavi (Twitter)

    RT @DiegoNSalman: Meta análisis de estudios aleatorios sobre reemplazo de grasas saturadas por ácidos grasos omega 6: No hay beneficio algu…
    view full post

    September 9, 2019

    3

  • Alberto García
    @AGG7 (Twitter)

    RT @DiegoNSalman: Meta análisis de estudios aleatorios sobre reemplazo de grasas saturadas por ácidos grasos omega 6: No hay beneficio algu…
    view full post

    September 8, 2019

    3

  • DiegoNS
    @DiegoNSalman (Twitter)

    Meta análisis de estudios aleatorios sobre reemplazo de grasas saturadas por ácidos grasos omega 6: No hay beneficio alguno en mortalidad o infartos al disminuir o reemplazar el consumo grasa saturada #LowCarbChile https://t.co/4zaJTYFeuB
    view full post

    September 8, 2019

    3

    3

  • MadPharmacist
    @DarthPharmacist (Twitter)

    Cahque jour on dit a mes patients de ne surtout pas manger de gras saturés et de manger des huiles végétales chimiques a la place pour santé cardiovasculaire. Logic much. https://t.co/yYRlxPz6lV
    view full post

    June 3, 2019

  • Karageorgos
    @Karageorgos15 (Twitter)

    @RChrisCC @kevinnbass And more recent 2017 review questions whether replacing SFs with n-6 PUFA would be of benefit: "Available evidence from adequately controlled RCTs suggest replacing SFA with...n-6 PUFA is unlikely to reduce CHD events, CHD mortality or total mortality." https://t.co/f2Xpuya0OH
    view full post

    May 5, 2019

    1

  • George D. Henderson
    @puddleg (Twitter)

    @Sadrien_GW2 @Smark_phd @ProfTimNoakes @FatEmperor @grantsnz @CarynZinn That's why we included a reference to the Steve Hamley meta-analysis, which does that (as far as it is possible;). https://t.co/H80sxBNYqL
    view full post

    April 23, 2019

    3

  • SystematicReviewBot
    @EvidenceRobot (Twitter)

    RT @DrSaripanidis: Μεγάλες αναλυτικές μελέτες δημοσιευμένων τυχαιοποιημένων κλινικών εργασιών απέδειξαν πως η κατανάλωση κορεσμένων λιπών σ…
    view full post

    March 26, 2019

    1

  • Stavros Saripanidis, MD
    @DrSaripanidis (Twitter)

    Μεγάλες αναλυτικές μελέτες δημοσιευμένων τυχαιοποιημένων κλινικών εργασιών απέδειξαν πως η κατανάλωση κορεσμένων λιπών στη διατροφή δεν αυξάνει τη θνησιμότητα! https://t.co/3tRjh7JBBP https://t.co/Jw5AU5vprz https://t.co/YSkKw5LaCp https://t.co/mIdA8E8qQG
    view full post

    March 26, 2019

    1

  • MMA and Boxing Fight Analyst
    @kostasfant (Twitter)

    Available evidence from adequately controlled randomized controlled trials suggest replacing saturated fatty acids (SFA) with mostly n-6 polyunsaturated fat is UNLIKELY to reduce CHD events, CHD mortality or total mortality. https://t.co/B1LCrnQYHp
    view full post

    March 25, 2019


  • @Nutrition1974 (Twitter)

    Interesting!
    view full post

    March 21, 2019

    1

  • SystematicReviewBot
    @EvidenceRobot (Twitter)

    RT @Khalzur: Niektóre metaanalizy pokazują, że zastąpienie nasyconych kwasów tłuszczowych kwasami omega 6 nie zmniejsza ryzyka choroby nied…
    view full post

    February 13, 2019

    1

  • Kamil Paprotny
    @Kamil_Paprotny (Twitter)

    Niektóre metaanalizy pokazują, że zastąpienie nasyconych kwasów tłuszczowych kwasami omega 6 nie zmniejsza ryzyka choroby niedokrwiennej serca ani nie zmniejsza śmiertelności z tego powodu i całkowitej. #zdrowie #dieta #fitluty #nutrition #dietetyka https://t.co/uAzAZMdkkO
    view full post

    February 13, 2019

    1

  • Dr Scott W Murray
    @DrScottMurray (Twitter)

    RT @MMindrumMD: “adequately controlled RCTs suggest replacing SFA w/ mostly n-6 PUFA is unlikely to reduce CHD events, CHD mortality or tot…
    view full post

    January 22, 2019

    15

  • Simon Dankel
    @simondankel (Twitter)

    RT @MMindrumMD: “adequately controlled RCTs suggest replacing SFA w/ mostly n-6 PUFA is unlikely to reduce CHD events, CHD mortality or tot…
    view full post

    January 22, 2019

    15

  • Ana Cláudia
    @Anawsantos (Twitter)

    RT @MMindrumMD: “adequately controlled RCTs suggest replacing SFA w/ mostly n-6 PUFA is unlikely to reduce CHD events, CHD mortality or tot…
    view full post

    January 22, 2019

    15

  • Ashwin Subbaraj
    @AshPT2018 (Twitter)

    RT @MMindrumMD: “adequately controlled RCTs suggest replacing SFA w/ mostly n-6 PUFA is unlikely to reduce CHD events, CHD mortality or tot…
    view full post

    January 22, 2019

    15

  • DiscoStew
    @DiscoStew66 (Twitter)

    RT @KurtLass1: @MMindrumMD @DiscoStew66 Open access location: https://t.co/82LzXPrcCo
    view full post

    January 22, 2019

    1

  • Peter Miles
    @PeterMilesMD (Twitter)

    https://t.co/7pMTsxz8UR https://t.co/PIZGN3HSJw
    view full post

    January 22, 2019

    1

  • Kurt Lass
    @KurtLass1 (Twitter)

    @MMindrumMD @DiscoStew66 Open access location: https://t.co/82LzXPrcCo
    view full post

    January 22, 2019

    2

    1

  • Ginger Sladky⌛☮️
    @dragin97 (Twitter)

    RT @MMindrumMD: “adequately controlled RCTs suggest replacing SFA w/ mostly n-6 PUFA is unlikely to reduce CHD events, CHD mortality or tot…
    view full post

    January 22, 2019

    15

  • Guðmundur Jóhannsson
    @gfj1979 (Twitter)

    RT @MMindrumMD: “adequately controlled RCTs suggest replacing SFA w/ mostly n-6 PUFA is unlikely to reduce CHD events, CHD mortality or tot…
    view full post

    January 22, 2019

    15

  • Erik Macholl
    @ErikMacholl (Twitter)

    RT @MMindrumMD: “adequately controlled RCTs suggest replacing SFA w/ mostly n-6 PUFA is unlikely to reduce CHD events, CHD mortality or tot…
    view full post

    January 22, 2019

    15

  • Natural Law Enforcer
    @BChinatti (Twitter)

    RT @MMindrumMD: “adequately controlled RCTs suggest replacing SFA w/ mostly n-6 PUFA is unlikely to reduce CHD events, CHD mortality or tot…
    view full post

    January 22, 2019

    15

  • SystematicReviewBot
    @EvidenceRobot (Twitter)

    RT @MMindrumMD: “adequately controlled RCTs suggest replacing SFA w/ mostly n-6 PUFA is unlikely to reduce CHD events, CHD mortality or tot…
    view full post

    January 22, 2019

    15

  • KetofasterUK
    @KetofasterU (Twitter)

    RT @MMindrumMD: “adequately controlled RCTs suggest replacing SFA w/ mostly n-6 PUFA is unlikely to reduce CHD events, CHD mortality or tot…
    view full post

    January 22, 2019

    15

  • DiscoStew
    @DiscoStew66 (Twitter)

    RT @MMindrumMD: “adequately controlled RCTs suggest replacing SFA w/ mostly n-6 PUFA is unlikely to reduce CHD events, CHD mortality or tot…
    view full post

    January 22, 2019

    15

  • AntonioC Martinez II
    @usambcuba (Twitter)

    RT @MMindrumMD: “adequately controlled RCTs suggest replacing SFA w/ mostly n-6 PUFA is unlikely to reduce CHD events, CHD mortality or tot…
    view full post

    January 22, 2019

    15

  • Michael Mindrum, MD
    @MichaelMindrum (Twitter)

    “adequately controlled RCTs suggest replacing SFA w/ mostly n-6 PUFA is unlikely to reduce CHD events, CHD mortality or total mortality. The suggestion of benefits reported in earlier meta-analyses is due to inclusion of inadequately controlled trials.” https://t.co/pv4KUChttp
    view full post

    January 22, 2019

    31

    15

  • the skeptical cardiologist
    @skepcard (Twitter)

    @PeterAttiaMD The RCTs and the meta-analyses of the RCTs are nicely summarized here https://t.co/LYHTstcGWk. Current "expert" wisdom still maintains that replacing saturated fat with omega-6 PUFAs reducies CV risk but the data is very weak and depends on which RCTs are included.
    view full post

    January 13, 2019

Abstract Synopsis

  • The study re-evaluates the recommendation to replace saturated fats (SFA) with n6 polyunsaturated fats (PUFA) to lower coronary heart disease (CHD) risk, highlighting flaws in earlier analyses.
  • When focusing solely on adequately controlled trials (where experimental and control groups were similar), no significant impact on major CHD events or mortality rates was found.
  • In contrast, including all trials suggested that substituting SFA with n6 PUFA might reduce total CHD events, but not necessarily major CHD events or overall mortality rates.