Overall, the discussions reflect a balanced curiosity and involvement, with examples such as references to study names like CANVAS and CREDENCE, and concerns about safety signals like amputations, which show both analytical interest and cautious engagement. The tone ranges from clinical updates to safety debates, emphasizing the article's relevance in ongoing medical conversations.
AgreementNeither agree nor disagree
The discussions show mixed opinions, with some recognizing the benefits of canagliflozin but also raising safety concerns like amputation risks.
InterestModerate interest
The posts demonstrate moderate curiosity about the study's findings and implications, often referencing specific trials like CANVAS and CREDENCE.
EngagementModerate engagement
Many posts include detailed references to trial results, safety considerations, and ongoing debates, indicating a higher level of engagement.
ImpactModerate impact
The discussions highlight that the article influences clinical considerations and safety debates, suggesting a noteworthy but not transformative impact.
Abstract in brief
Canagliflozin, a drug that lowers blood sugar, blood pressure, body weight, and albumin in people with type 2 diabetes, was shown to reduce the risk of serious cardiovascular events like heart attack and stroke in high-risk patients.
Although renal benefits were observed, such as slowing kidney disease progression, these were not definitively statistically significant.
The treatment was associated with an increased risk of amputation, especially at the toes or feet, which is an important safety consideration.
#ISNWebinar: Diabetes and its cardiac outcomes in people with and without kidney disease (CV outcome trials)
Further reading: https://t.co/gZYEfZthJV https://t.co/pxg7VuTPmM https://t.co/TkL1bUZAzh https://t.co/jiReouHd2o https://t.co/afT6tGHSqa
https://t.co/0aWpT6gJc6 https://t.co/KSEVGqkcZD
Feb 24, 2021 · 13 likes · 7 shares · 29,552 followersView post →
EL
Edgar V. Lerma
@edgarvlermamd · X
CANVAS: Canagliflozin and CV & Renal events in Type 2 Diabetes ca. 2017 from @NEJM
#VisualAbstract by @kidney_boy
#Nephpearls #NephJC
#Canagliflozin and Cardiovascular and Renal Events in #T2D Available in France but I’m convinced that most #HCP forgot #CREDENCE and #CANVAS studies … https://t.co/uhrDb9aOiM
Nov 13, 2025 · 12 likes · 2 shares · 31,605 followersView post →
MF
Melissa Bregger, MD, FACP
@MelBreggs · X
1/3-Day 8:
Cardiology started an SGLT2 inhibitor on a patient for the first time.
Thought it would be good to give a brief overview of CANVAS & CREDENCE Trials to review why an SGLT2i was started.
CANVAS Trial: https://t.co/mfw2cI9buz
CREDENCE Trial: https://t.co/2rGjYf92WQ
Feb 17, 2020 · 12 likes · 4 shares · 1,702 followersView post →
EL
Edgar V. Lerma
@edgarvlermamd · X
Whether the increased risk of lower limb amputation in the CANVAS Program was due to differing trial populations or protocols, or to chance remains unclear
#NKFClinicals
May 10, 2019 · 8 likes · 3 shares · 33,994 followersView post →
Canagliflozin lowers blood sugar and blood pressure, reducing serious cardiovascular risks in high-risk type 2 diabetes patients. While it benefits kidney health, there is an increased risk of amputation. Learn about…
Dr. Bruce Neal, a leading cardiologist, explores the cardiovascular implications of low sodium and high potassium diets. He presents findings from the 2021 SSASS Study, which involved 20,995 high-risk patients assessing…
RT @SABOURETCardio: #Canagliflozin and Cardiovascular and Renal Events in #T2D Available in France but I’m convinced that most #HCP forgot…
Nov 25, 2025 · 2 shares · 500 followersView post →
JO
Juan Carlos Obaya
@jcobaya69 · X
RT @SABOURETCardio: #Canagliflozin and Cardiovascular and Renal Events in #T2D Available in France but I’m convinced that most #HCP forgot…
Nov 13, 2025 · 2 shares · 858 followersView post →
S
SABOURETCardiologist
@SABOURETCardio · X
#Canagliflozin and Cardiovascular and Renal Events in #T2D Available in France but I’m convinced that most #HCP forgot #CREDENCE and #CANVAS studies … https://t.co/uhrDb9aOiM
Nov 13, 2025 · 12 likes · 2 shares · 31,605 followersView post →
24b) Other #DPP4i, #basal #insulin, and α-GI are neutral but and @GLP1 RAs have modest benefit from meta-analysis. #SGLT2i show consistent and robust benefits. Consider
May 11, 2022 · 3 likes · 4,210 followersView post →
N
NG20194
@NG20194 · X
@abledoc
Why it would be increasing risk for amputation?
Canagliflozin lowers risk of CVD, but increases risk of amputation
https://t.co/f2DFRV7wbK
CANVAS: Among patients with T2D and high CV risk, canagliflozin was associated with lower CV and renal events but higher risk of amputation #UMKCRCT
https://t.co/SxOGWqDwtj
RT @ISNkidneycare: #ISNWebinar: Diabetes and its cardiac outcomes in people with and without kidney disease (CV outcome trials)
Further rea…
Feb 24, 2021 · 7 shares · 174 followersView post →
DO
Dr. Carlos Orantes
@nefrorantes · X
RT @ISNkidneycare: #ISNWebinar: Diabetes and its cardiac outcomes in people with and without kidney disease (CV outcome trials)
Further rea…
Feb 24, 2021 · 7 shares · 5,000 followersView post →
R
Rayhan
@Nephwizard · X
RT @ISNkidneycare: #ISNWebinar: Diabetes and its cardiac outcomes in people with and without kidney disease (CV outcome trials)
Further rea…
Feb 24, 2021 · 7 shares · 170 followersView post →
AO
Angel Cesar Ortiz
@AngelCesarOrtiz · X
RT @ISNkidneycare: #ISNWebinar: Diabetes and its cardiac outcomes in people with and without kidney disease (CV outcome trials)
Further rea…
Feb 24, 2021 · 7 shares · 1,004 followersView post →
CT
carmen torres
@tatatorres1515 · X
RT @ISNkidneycare: #ISNWebinar: Diabetes and its cardiac outcomes in people with and without kidney disease (CV outcome trials)
Further rea…
Feb 24, 2021 · 7 shares · 606 followersView post →
FE
Fundación Renal Española
@FundacionRenalE · X
RT @ISNkidneycare: #ISNWebinar: Diabetes and its cardiac outcomes in people with and without kidney disease (CV outcome trials)
Further rea…
Feb 24, 2021 · 7 shares · 3,941 followersView post →
IN
Int Society of Nephrology
@ISNkidneycare · X
#ISNWebinar: Diabetes and its cardiac outcomes in people with and without kidney disease (CV outcome trials)
Further reading: https://t.co/gZYEfZthJV https://t.co/pxg7VuTPmM https://t.co/TkL1bUZAzh https://t.co/jiReouHd2o https://t.co/afT6tGHSqa
https://t.co/0aWpT6gJc6 https://t.co/KSEVGqkcZD
Feb 24, 2021 · 13 likes · 7 shares · 29,552 followersView post →
JS
Juan Senior
@jsenior64 · X
https://t.co/PraSDuCNkG
Jan 11, 2021 · 1 like · 11,090 followersView post →
パ
パフェ
@rosye_shukuru · X
Canagliflozin and Cardiovascular and Renal Events in Type 2 Diabetes - PubMed https://t.co/JaZyj6KP3q
RT @MelBreggs: 1/3-Day 8:
Cardiology started an SGLT2 inhibitor on a patient for the first time.
Thought it would be good to give a bri…
Feb 17, 2020 · 4 shares · 522 followersView post →
MF
Melissa Bregger, MD, FACP
@MelBreggs · X
1/3-Day 8:
Cardiology started an SGLT2 inhibitor on a patient for the first time.
Thought it would be good to give a brief overview of CANVAS & CREDENCE Trials to review why an SGLT2i was started.
CANVAS Trial: https://t.co/mfw2cI9buz
CREDENCE Trial: https://t.co/2rGjYf92WQ
Feb 17, 2020 · 12 likes · 4 shares · 1,702 followersView post →
F
Firstclassessaywriters
@EssaysClass · X
[Solution]Canagliflozin and Cardiovascular and Renal Events in Type 2 Diabetes https://t.co/lM78LDCx4J
RT @NEJM: Original Article: Canagliflozin and Cardiovascular and Renal Events in Type 2 Diabetes (CANVAS) https://t.co/aEGa1ggSpw #ADA2017
May 27, 2019 · 94 shares · 49 followersView post →
CC
Cardiac Surgery Congress
@CongressCardiac · X
Canagliflozin and Cardiovascular and Renal Events in Type 2 Diabetes
To know more : https://t.co/rtMD0TxgHr
#cardiologyconference #cardiologymeeting #cardiologistsconference #cardiovascular #cardiacdisease #cardiacmuscle https://t.co/rmPUPgtzf0
RT @edgarvlermamd: Whether the increased risk of lower limb amputation in the CANVAS Program was due to differing trial populations or prot…
May 11, 2019 · 3 shares · 2,361 followersView post →
VC
veronica coro
@veronicacoro1 · X
RT @edgarvlermamd: Whether the increased risk of lower limb amputation in the CANVAS Program was due to differing trial populations or prot…
May 10, 2019 · 3 shares · 109 followersView post →
EL
Edgar V. Lerma
@edgarvlermamd · X
Whether the increased risk of lower limb amputation in the CANVAS Program was due to differing trial populations or protocols, or to chance remains unclear
#NKFClinicals
May 10, 2019 · 8 likes · 3 shares · 33,994 followersView post →
SA
Sara Asecas
@SaraKeru · X
RT @edgarvlermamd: CANVAS: Canagliflozin and CV & Renal events in Type 2 Diabetes ca. 2017 from @NEJM
#VisualAbstract by @kidney_boy
#Nephp…
@kidneydoc101 @DrGavinDreyer @toates_19 @OK_Kidney @Ashidotic Likely significantly underpowered. The excess risk of amputation w Canagliflozin was in the combined CANVAS trials, n=10,000 https://t.co/4HtuaLYrip
Canagliflozin and Cardiovascular and Renal Events in Type 2 Diabetes
—cited by Dr. Joel Topf, MD, FACP, St. Clair University @kidney_boy #KidneyCon
“There was an amputation signal... we’ll talk more about that later.” https://t.co/rkEebrP0h8
#CANVAS looks like a smaller effect size than Emma-ref but overall delighted to see a second outcome trial that's + http://www.nejm.org/doi/full/10.1056/NEJMoa1611925
SGLT2 inhibitors in Diabetic Kidney Disease | PPTX
News
DOI: 10.1056/NEJMoa1611925 “Canagliflozin and Cardiovascular and Renal Events in Type 2 Diabetes. Outcomes Patient characteristics DOI: 10.1056/NEJMoa1611925.
org/doi/full/10.1056/NEJMoa1611925 قناة جدد معلوماتك الدوائية على التليجرام T.me/FYIMs @FYIMs. Brak dostępnego opisu zdjęcia. Zouhour K Jouny i 11 innych ...