Engineering CAR-T cells.

CC

Cancer Cell

@Cancer_Cell · X

Engineering CAR-T Cells for Next-Generation Cancer Therapy https://t.co/oFfVrEhICA

GP

GSBS Immunology Program

@ImmunologyGSBS · X

CCIR Immunology - Distinguished Guest Speaker TOMORROW, Thu, 05/02, 12 noon Dr. Maksim Mamonkin @MaxMamonkin, from at Baylor College of Medicine @bcmhouston will be delivering his talk on, “Engineering CAR-T cells for challenging hematopoietic malignancies” See you there! https://t.co/CO3PlAbaEo

O

OncoDaily

@oncodaily · X

Engineering CAR-T cells for combination therapy with CD47 blockade - @molecular_elena @Nature @MackallLab @JTheruvath_MD @Heitzeneder_S @CynFP https://t.co/X7rWxHRDtz #Cancer #CancerResearch #OncoDaily #Oncology https://t.co/Vs00QV3WJp

CC

Cancer Cell

@Cancer_Cell · X

Online Now: Engineering CAR-T Cells for Next-Generation Cancer Therapy https://t.co/zLd7WppVcY

GM

Geoffrey von Maltzahn

@GVMaltzahn · X

A glimpse of our RNA Gene Writers @TesseraTx allowing RNA payloads to write entire genes into the genome of human cells — here we deliver two RNAs to T cells and write a CAR gene into their genome. Imagine engineering CAR-T cells in vivo with redosable lipid nanoparticles https://t.co/kAhwBqQSbz

RP

Rafael Kramann, MD PhD

@rkramann · X

Engineering CAR-T cells to activate small-molecule drugs in situ | Nature Chemical Biology https://t.co/Qyk48EHsXe

Inadequate CAR T-cell infiltration into solid tumors limits efficacy. The authors show that engineering CAR T cells to express osteopontin can overcome physical barriers in solid tumors, offering a promising strategy to improve CAR T-cell infiltration and efficacy. Read more: buff.ly/BeV3GQ4

CAR T cell therapy has achieved success in certain blood cancers, but adapting them for solid tumors remain a challenge. Join our new webinar to learn how researchers are engineering CAR T cells to enhance tumor infiltration, immune activation, and persistence. www.biocompare.com/622261-Engin...

MK

mishan41k

@mishan41kkk · X

5/ One vision is engineering CAR-T cells that hunt senescent cells precisely, like sharpshooters. Another is creating vaccines that teach the immune system to quietly clear out toxic aging cells over time.

A

AOKI木木

@AOKI_mumu · X

@Aubrai_ , engineering CAR-T cells for amyloid clearance—might that target plaques in Alzheimer's without triggering excessive neuroinflammation? @BioProtocol

YE

Yair Einhorn

@yaireinhorn · X

3/Capstan’s tLNP platform delivers an mRNA payload encoding for an anti-CD19 CAR to CD8-expressing T cells thus effectively engineering CAR-T cells in vivo. The goal of Capstan’s approach is to achieve a reset of the immune system through rapid deep B cell depletion in both blood https://t.co/teAL7q2zC5

PARP inhibitors damage the DNA of T cells as well as tumor cells, and engineering CAR T cells to resist this damage improves treatment efficacy www.science.org/doi/10.1126/...

Engineering CAR T cells to secrete TGFβtrap, IL15, or IL12 molecules fused to αPDL1 scFv improves tumor localized immunomodulation & CAR T cell functionality www.biorxiv.org/content/10.1...

Engineering CAR T cells to express IL-9 receptors enhances their anti-tumor efficacy by promoting expansion, persistence, and tumor infiltration. ​ In models of pancreatic cancer and prostate cancer, these cells showed superior tumor control and survival. www.biorxiv.org/content/10.1...

ET

Emory Technology Transfer

@EmoryOTT · X

Available for #License: @EmoryUniversity researchers have discovered a subset of T cells with low reactivity to self-antigens, and proposed focusing on selecting the optimal “starting material” for engineering CAR-T cells. Learn more: https://t.co/FPWSGCXPCw

ET

Emory Technology Transfer

@EmoryOTT · X

Available for #License: @EmoryUniversity researchers have proposed an invention focusing on selecting the optimal “starting material” for engineering CAR-T cells. Developed by Byron Au-Yeung. Learn more about this opportunity here: https://t.co/MMHcIyiTO5 https://t.co/g10Jj2pLHS

CM

Chidambara .ML.

@chidambara09 · X

RT @oncodaily: Engineering CAR-T cells for combination therapy with CD47 blockade - @molecular_elena @Nature @MackallLab @JTheruvath_MD @He…

CO

Cecilia Ugaz Olivares

@ceciugaz · X

RT @oncodaily: Engineering CAR-T cells for combination therapy with CD47 blockade - @molecular_elena @Nature @MackallLab @JTheruvath_MD @He…

RN

Rita Nahapetyan

@RitaNahapetyan · X

RT @oncodaily: Engineering CAR-T cells for combination therapy with CD47 blockade - @molecular_elena @Nature @MackallLab @JTheruvath_MD @He…

O

OncoDaily

@oncodaily · X

Engineering CAR-T cells for combination therapy with CD47 blockade - @molecular_elena @Nature @MackallLab @JTheruvath_MD @Heitzeneder_S @CynFP https://t.co/X7rWxHRDtz #Cancer #CancerResearch #OncoDaily #Oncology https://t.co/Vs00QV3WJp

ET

Emory Technology Transfer

@EmoryOTT · X

Open for #License: Discovery of a subset of CAR-T cells with low reactivity to self-antigens + increased reactivity to foreign antigens. The proposed invention focuses on selecting the optimal “starting material” for engineering CAR-T cells. Learn more: https://t.co/FPWSGCXPCw https://t.co/5sTfYeo1Lq

CT

Center for Cell and Gene Therapy

@CAGTHouston · X

RT @ImmunologyGSBS: CCIR Immunology - Distinguished Guest Speaker TOMORROW, Thu, 05/02, 12 noon Dr. Maksim Mamonkin @MaxMamonkin, from a…

MG

Matthew Gubin

@GubinMatthew · X

RT @ImmunologyGSBS: CCIR Immunology - Distinguished Guest Speaker TOMORROW, Thu, 05/02, 12 noon Dr. Maksim Mamonkin @MaxMamonkin, from a…

GP

GSBS Immunology Program

@ImmunologyGSBS · X

CCIR Immunology - Distinguished Guest Speaker TOMORROW, Thu, 05/02, 12 noon Dr. Maksim Mamonkin @MaxMamonkin, from at Baylor College of Medicine @bcmhouston will be delivering his talk on, “Engineering CAR-T cells for challenging hematopoietic malignancies” See you there! https://t.co/CO3PlAbaEo

MH

Mike.Halevy

@HalevyMike · X

RT @yaireinhorn: 3/CPTX2309, a product of Capstan’s tLNP platform, delivers an mRNA payload encoding for an anti-CD19 CAR to CD8-expressing…

YE

Yair Einhorn

@yaireinhorn · X

3/CPTX2309, a product of Capstan’s tLNP platform, delivers an mRNA payload encoding for an anti-CD19 CAR to CD8-expressing T cells, effectively engineering CAR-T cells in vivo. The goal of this approach is to achieve a reset of the immune system through rapid deep B cell https://t.co/JaM6vtt4sl

LI

Lipschultz Precision Immunology Institute

@SinaiImmunol · X

RT @IcahnMountSinai: A new study from PrIISM’s leadership turns chimeric #antigen receptor (CAR)-T cell therapy in a new direction by engin…

IS

Icahn School of Medicine at Mount Sinai

@IcahnMountSinai · X

A new study from PrIISM’s leadership turns chimeric #antigen receptor (CAR)-T cell therapy in a new direction by engineering CAR-T cells to kill #tumor macrophages rather than #cancer cells, killing a major cell type protecting the cancer cells. Read more: https://t.co/ukODHR9O3P https://t.co/Qhugkyhr7l

CN

C&EN (Chemical & Engineering News)

@cenmag · X

Engineering CAR-T cells is a slow and arduous process. In a new paper, a group of researchers has devised a solution to broaden the versatility of engineered CAR-T cells. https://t.co/1pU52yYzAM

CN

C&EN (Chemical & Engineering News)

@cenmag · X

Engineering CAR-T cells is a slow and arduous process, with each batch usually customized to recognize only one antigen. In a new paper, a group of researchers has devised a solution to broaden the versatility of engineered CAR-T cells. https://t.co/0cqNwIyaym

SS

Shawn Sullivan

@shawntsullivan · X

@Noahpinion Another approach some researchers and a few companies have been working on: engineering CAR-T cells in vivo using engineered viruses. Still work to do to see if it’s a workable therapy, but it would dramatically lower costs for immunotherapy

CH

Christine Heenan

@ChristineHeenan · X

RT @GVMaltzahn: A glimpse of our RNA Gene Writers @TesseraTx allowing RNA payloads to write entire genes into the genome of human cells — h…

GM

Geoffrey von Maltzahn

@GVMaltzahn · X

A glimpse of our RNA Gene Writers @TesseraTx allowing RNA payloads to write entire genes into the genome of human cells — here we deliver two RNAs to T cells and write a CAR gene into their genome. Imagine engineering CAR-T cells in vivo with redosable lipid nanoparticles https://t.co/kAhwBqQSbz

GB

Gaming Bot

@precisionmedbot · X

RT @CarinaBiotech: Our CEO @rathjen3 is in Brisbane for @ISCTglobal #ISCTANZ2022. Today she'll be speaking about precision, positioning & p…

CB

Carina Biotech

@CarinaBiotech · X

Our CEO @rathjen3 is in Brisbane for @ISCTglobal #ISCTANZ2022. Today she'll be speaking about precision, positioning & potency – engineering CAR-T cells for the treatment of #solidtumors. #immunotherapy #immunooncology #precisionmedicine https://t.co/6S3pmc0463

TS

Trends in Pharmacological Sciences

@TrendsinPharma · X

New spotlight article from Isabel Lane and Max Jan @janlabmgh @MGHCancerCenter @harvardmed highlighting @nchembio article on engineering CAR-T cells to activate small-molecule drugs in situ by Scheinberg and colleagues. @DASLab_MSKCC @MSKCancerCenter https://t.co/DqnaKD6Aeo

JB

Joni Bryant

@JoniBry76879541 · X

RT @rkramann: Engineering CAR-T cells to activate small-molecule drugs in situ | Nature Chemical Biology https://t.co/Qyk48EHsXe

AG

Antony_GEU

@UoM_GEU · X

This is difficult to detect, and really bad in our disease models, but worse for clinical applications such as engineering Car-T cells.

CK

Cory Kornowicz

@cory_jay44 · X

RT @chupvl: "Engineering CAR-T cells to activate small-molecule drugs in situ". So, folks created #CART cell line that expresses an artific…

CB

CompChemBio Bot

@CompChemBioBot · X

RT @chupvl: "Engineering CAR-T cells to activate small-molecule drugs in situ". So, folks created #CART cell line that expresses an artific…

VC

Vladimir Chupakhin

@chupvl · X

"Engineering CAR-T cells to activate small-molecule drugs in situ". So, folks created #CART cell line that expresses an artificial enzyme to active a prodrug right at the tumor tissue. Whoa... #medchem #synthbio #compchem https://t.co/XVVIkYjYYy

DA

Dr. Aviseka

@aviseka · X

Engineering CAR-T cells to activate small-molecule drugs in situ | Nature Chemical Biology https://t.co/61S90OQhnt

DA

Dr. Aviseka

@aviseka · X

Engineering CAR-T cells to activate small-molecule drugs in situ https://t.co/61S90OQhnt

DZ

Dr. Zoidberg

@psuvafan007 · X

Engineering CAR-T cells to activate small-molecule drugs in situ | Nature Chemical Biology https://t.co/hg4Og4G7NT

GD

Gabi Desdín

@GDesdin · X

RT @rkramann: Engineering CAR-T cells to activate small-molecule drugs in situ | Nature Chemical Biology https://t.co/Qyk48EHsXe

MC

Mauro Corrado

@MauroCorradoBio · X

RT @rkramann: Engineering CAR-T cells to activate small-molecule drugs in situ | Nature Chemical Biology https://t.co/Qyk48EHsXe

RP

Rafael Kramann, MD PhD

@rkramann · X

Engineering CAR-T cells to activate small-molecule drugs in situ | Nature Chemical Biology https://t.co/Qyk48EHsXe

MM

Manzanilla & Miel

@ManzanillaMiel5 · X

RT @apinedalucena: Nice!!! ⁦@nchembio⁩ Engineering CAR-T cells to activate small-molecule drugs in situ | Nature Chemical Biology https://…

AL

A. Pineda-Lucena

@apinedalucena · X

Nice!!! ⁦@nchembio⁩ Engineering CAR-T cells to activate small-molecule drugs in situ | Nature Chemical Biology https://t.co/XYZyl0zXTL

MD

Martin Denzel

@MartinD79 · X

When a brilliant idea and a brilliant acronym come together - SEAKER cells activate a toxin locally in tumors. Engineering CAR-T cells to activate small-molecule drugs in situ. https://t.co/UL05BtFDKb

ML

Montani semper liberi

@ecolibertas · X

Gardner, T.J., Lee, J.P., Bourne, C.M. et al. Engineering CAR-T cells to activate small-molecule drugs in situ. Nat Chem Biol (2021). https://t.co/2p5XZB6mrv

TC

Tam Stage IV Metastatic Breast Cancer

@tamara05679334 · X

RT @ErSOActivism: Let’s get them to release #ErSO on tumor cells Engineering CAR-T cells to activate small-molecule drugs in situ | Natu…

VM

Vali Barsan, MD

@vbarsan · X

Engineering CAR-T cells to activate small-molecule drugs in situ | early days for synthetic biology and the many clinical applications forthcoming https://t.co/DGAjakeP7O

DC

Dr. Rose Ching

@RegenRoseChing · X

RT @CARTTherapy: Engineering CAR-T cells to activate small-molecule drugs in situ https://t.co/ik30eobAF5 #CART #bmtsm #CARTcell #immunoth…

PM

P. A-M

@PAMJ84 · X

RT @CARTTherapy: Engineering CAR-T cells to activate small-molecule drugs in situ https://t.co/ik30eobAF5 #CART #bmtsm #CARTcell #immunoth…

KA

Kevin de Alvarenga

@dealvarengaonco · X

Engineering CAR-T cells to activate small-molecule drugs in situ | Nature Chemical Biology https://t.co/gmc6sZgGPY

CR

Chimeric Antigen Receptor T-Cell (CAR-T) & Gene Rx

@CARTTherapy · X

Engineering CAR-T cells to activate small-molecule drugs in situ https://t.co/ik30eobAF5 #CART #bmtsm #CARTcell #immunotherapy #tcellrx #CARTcells #CellTherapy #Gene #Genetherapy

RS

Rio Sugimura

@rio_sugimura · X

RT @ErSOActivism: Let’s get them to release #ErSO on tumor cells Engineering CAR-T cells to activate small-molecule drugs in situ | Natu…

EF

ErSO/TEQ103forBreastCancer

@ErSOActivism · X

Let’s get them to release #ErSO on tumor cells Engineering CAR-T cells to activate small-molecule drugs in situ | Nature Chemical Biology https://t.co/vR3cvFPlx8

A

A

@AnnaBajur · X

Engineering CAR-T cells to activate small-molecule drugs in situ | Nature Chemical Biology

MC

Manish Chamoli

@manish_chamoli · X

RT @agingdoc1: Engineering CAR-T cells to activate small-molecule drugs in situ https://t.co/KYZvKGoMP3

EM

Edward Melia

@edward_melia · X

Engineering CAR-T cells to activate small-molecule drugs in situ https://t.co/qU5P75amm5

A

Agingdoc

@agingdoc1 · X

Engineering CAR-T cells to activate small-molecule drugs in situ https://t.co/KYZvKGoMP3

IS

Isatou Sarr

@IsatouSarr4 · X

Engineering CAR-T cells: Design concepts https://t.co/WEaQ2BOuJ9

IS

Isatou Sarr

@IsatouSarr4 · X

https://t.co/OYUefWfKxv

PR

Peter Mac Research

@PeterMacRes · X

RT @CancerImmIdeas: Closing remarks @CancerImmIdeas by the wonderful @paulbeavis4 all the way from @PeterMacRes. in Melbourne! An amazing…

DD

Don Davis

@dondavisphdmba · X

RT @5280dondavis: Engineering CAR-T cells https://t.co/GIXvxq9I8K

DD

Don Davis

@dondavisphdmba · X

Engineering CAR-T cells https://t.co/GIXvxq9I8K

VH

Victoria Hendry

@HendryVictoria · X

Engineering CAR-T Cells for Next-Generation Cancer Therapy. https://t.co/aC3dFxeLgR. ⁦@alanlparker⁩ ⁦@SimonWad⁩

JP

Jongwhi Park

@JongwhiP · X

RT @Cancer_Cell: Engineering CAR-T Cells for Next-Generation Cancer Therapy https://t.co/oFfVrEhICA

VH

Victoria Hendry

@HendryVictoria · X

RT @Cancer_Cell: Engineering CAR-T Cells for Next-Generation Cancer Therapy https://t.co/oFfVrEhICA

RG

Reza A. Ghodsi

@ReGhodsi · X

RT @Cancer_Cell: Engineering CAR-T Cells for Next-Generation Cancer Therapy https://t.co/oFfVrEhICA

E

EllisLab_

@EllisLab_ · X

RT @Cancer_Cell: Engineering CAR-T Cells for Next-Generation Cancer Therapy https://t.co/oFfVrEhICA

SS

Sriganesh Srihari | Biomedical Data Science

@srigsri23 · X

RT @Cancer_Cell: Engineering CAR-T Cells for Next-Generation Cancer Therapy https://t.co/oFfVrEhICA

GN

Grigorii Nos

@GrigoriiNos · X

RT @Cancer_Cell: Engineering CAR-T Cells for Next-Generation Cancer Therapy https://t.co/oFfVrEhICA

I

IUOPA

@IUOPA · X

RT @Cancer_Cell: Engineering CAR-T Cells for Next-Generation Cancer Therapy https://t.co/oFfVrEhICA

TP

Ti’ara Griffen, PhD

@TiaraGPhD · X

RT @Cancer_Cell: Engineering CAR-T Cells for Next-Generation Cancer Therapy https://t.co/oFfVrEhICA

OE

Olivier Elemento

@ElementoLab · X

RT @Cancer_Cell: Engineering CAR-T Cells for Next-Generation Cancer Therapy https://t.co/oFfVrEhICA

AJ

Angel Juárez

@J_F_Angel · X

RT @Cancer_Cell: Engineering CAR-T Cells for Next-Generation Cancer Therapy https://t.co/oFfVrEhICA

C

Catherine

@CatherineZhang · X

RT @Cancer_Cell: Engineering CAR-T Cells for Next-Generation Cancer Therapy https://t.co/oFfVrEhICA

RC

Raj Chakraborty

@rajshekharucms · X

RT @Cancer_Cell: Engineering CAR-T Cells for Next-Generation Cancer Therapy https://t.co/oFfVrEhICA

DP

David Russler-Germain, MD/PhD

@dgermain21 · X

RT @Cancer_Cell: Engineering CAR-T Cells for Next-Generation Cancer Therapy https://t.co/oFfVrEhICA

CC

Cancer Cell

@Cancer_Cell · X

Engineering CAR-T Cells for Next-Generation Cancer Therapy https://t.co/oFfVrEhICA

S

Sayama

@Sayamabio · X

@uctelevision [Paper] Engineering CAR-T Cells for Next-Generation Cancer Therapy(@Cancer_Cell) https://t.co/y91F9BIkWN Also, Prof. Chen plans to start solid tumor trial in 2022 funded by CIRM - Team designed CAR respond to soluble antigens, like TGF-β - Other strategy described in their reivew

DM

Dr Manoj

@drmanojpgi · X

RT @VivekSubbiah: Engineering CAR-T Cells for Next-Generation Cancer Therapy @Cancer_Cell @CellPressNews https://t.co/lIFqo9PUqv

VM

Vivek Subbiah, MD

@VivekSubbiah · X

Engineering CAR-T Cells for Next-Generation Cancer Therapy @Cancer_Cell @CellPressNews https://t.co/lIFqo9PUqv

YO

Yu-Kyoung Oh

@YuKyoungOh1 · X

RT @Cancer_Cell: Online Now: Engineering CAR-T Cells for Next-Generation Cancer Therapy https://t.co/zLd7WppVcY

ML

minnlab_litbot

@MLitbot · X

Engineering CAR-T Cells for Next-Generation Cancer Therapy. https://t.co/ANJnRI0AdH

IV

Inti De La Rosa Velazquez

@IntiOmics · X

Todo lo que querian saber acerca de la #terapia con #Celulas #CAR__T en #cancer lo encuentran en esta revisión. #tumor #celulasT #CAR Engineering CAR-T Cells for Next-Generation Cancer Therapy https://t.co/d5EU91JbFy

KW

Kitsada Wudhikarn

@Kwudhikarn · X

Engineering CAR-T Cells for Next-Generation Cancer Therapy: Cancer Cell https://t.co/gVdcmB75yH

JR

Jin Rong

@JinRongOw · X

RT @Cancer_Cell: Online Now: Engineering CAR-T Cells for Next-Generation Cancer Therapy https://t.co/zLd7WppVcY

DP

David Russler-Germain, MD/PhD

@dgermain21 · X

RT @Cancer_Cell: Online Now: Engineering CAR-T Cells for Next-Generation Cancer Therapy https://t.co/zLd7WppVcY

CL

Cell Stress & Immunity (CSI) Lab

@AbhishekDGarg · X

RT @Cancer_Cell: Online Now: Engineering CAR-T Cells for Next-Generation Cancer Therapy https://t.co/zLd7WppVcY

VH

Victoria Hendry

@HendryVictoria · X

RT @Cancer_Cell: Online Now: Engineering CAR-T Cells for Next-Generation Cancer Therapy https://t.co/zLd7WppVcY

DR

David Cano Rodriguez

@dcano87 · X

RT @Cancer_Cell: Online Now: Engineering CAR-T Cells for Next-Generation Cancer Therapy https://t.co/zLd7WppVcY

TM

Trends in Molecular Medicine

@TrendsMolecMed · X

RT @Cancer_Cell: Online Now: Engineering CAR-T Cells for Next-Generation Cancer Therapy https://t.co/zLd7WppVcY

CC

Cancer Cell

@Cancer_Cell · X

Online Now: Engineering CAR-T Cells for Next-Generation Cancer Therapy https://t.co/zLd7WppVcY

DF

Damon Runyon Cancer Research Foundation

@DamonRunyon · X

RT @AtlanticLIVE: The first generations were made with a crude engineering tool with viruses, says @UCSF + @igisci’s @MarsonLab on the pro…

A

AtlanticLIVE

@AtlanticLIVE · X

The first generations were made with a crude engineering tool with viruses, says @UCSF + @igisci’s @MarsonLab on the process of engineering car-t cells. It was made in a way that was sloppy. It worked well but it was not precise, expensive and takes a long time #PeopleVCancer

LL

Lum Lab

@lum_lab · X

It's Friday again and everyone still busy in the lab. Is that PCR positive? Engineering CAR-T cells. -JJL https://t.co/OEIun4Li7c