N Engl J Med July 2017 PMID 28700844

Follow-up of Prostatectomy versus Observation for Early Prostate Cancer.

Timothy J Wilt, Karen M Jones, Michael J Barry, Gerald L Andriole, Daniel Culkin, Thomas Wheeler, William J Aronson, Michael K Brawer

Mentions

142
Peak: 4 in Sep 2025
across 5 sources since Apr 2020

Extended reach

545,518
potential audience

Total likes

14,151

Video views

527,355

Mentions per month

Apr 2020 – Sep 2025

Where it's discussed

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  • YouTube9 videos
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AI synopsis

What people are saying

Participants express keen interest through questions like 'Maybe we need to wait 10 more years?' and references to ongoing trials, reflecting curiosity and concern about long-term outcomes. The tone varies from skepticism to analytical, with phrases like 'unable to make sense of these results' showing a desire for deeper understanding, contributing to a moderate engagement level and recognizing the potential impact on clinical decisions.

AgreementNeither agree nor disagree

The discussions show mixed reactions, with some users questioning the findings and others referencing related studies, indicating neither full agreement nor disagreement.

InterestHigh interest

The discussions reflect high interest, as users are engaging with the topic, questioning results, and referencing related research, demonstrating genuine curiosity.

EngagementModerate engagement

There is a moderate level of engagement with some comments questioning the implications and referencing other studies, but limited in-depth analysis.

ImpactModerate impact

The discussions may influence opinions among clinicians and patients, though no clear consensus suggests a significant shift in practice yet.

Abstract in brief

  • The study compared long-term outcomes of men with early prostate cancer who underwent radical prostatectomy versus those who were just observed, and found no significant difference in overall or prostate cancer-specific mortality over a follow-up of approximately 13 years.
  • While surgery was associated with a potentially lower risk of death from any cause in men with intermediate-risk disease, it did not significantly reduce mortality in men with low- or high-risk disease, and it also led to fewer treatments for disease progression.
  • The results suggest that the choice between surgery and observation should consider individual risk levels and patient preferences, as long-term survival was similar, but surgery might reduce the need for additional treatments in certain groups.

Top posts

Most liked on X and Bluesky
Drew Moghanaki
@DrewMoghanaki · X

Was there really more enthusiasm in 1994 to debate than determine the truth? #pcsm #radonc @VickersBiostats @BehfarEhdaieMD Final study results: https://t.co/vzm6wljf6e https://t.co/DYtXwylO5V

Jul 12, 2022 · 5 likes · 12,963 followers View post →
Chris Kowalewski MD
@C_KowalewskiMD · X

https://t.co/Zjvbjit43F https://t.co/w9A8EcUbDr Please share with the urologist community as I’m unable to make sense of these results. #prostatecancer

Dec 15, 2024 · 2 likes · 812 followers View post →
Dr. Andrew Loblaw
@DrAndrewLoblaw · X

Interesting that Wilt’s #PIVOT study (RP vs WW for screen detected ds) with >19y mFU, there was no difference in OS or CSS. Maybe we need to wait 10 more years? https://t.co/1TTNnwMSuN https://t.co/Gj4lz0vvFb

Oct 10, 2024 · 1 like · 3,625 followers View post →
S Mohammad Jafri
@MoAkbarJafri · X

CHIEF PIVOT Trial Prostate cancer intervention vs observation https://t.co/MtKi5hhnCl

Aug 28, 2022 · 363 followers View post →
Rad Onc Commentary
@radoncpub · X

Follow-up of Prostatectomy versus Observation for Early Prostate Cancer https://t.co/SnD4wI5IbH

Jul 2, 2021 · 120 followers View post →
Jasoncheng
@jasoncheng1977 · X

RT @NEJM: Original Article: Follow-up of Prostatectomy versus Observation for Early Prostate Cancer https://t.co/FiweawbSsu #VisualAbstract…

Apr 14, 2020 · 124 shares · 33 followers View post →

All mentions

Chris Kowalewski MD
@C_KowalewskiMD · X

https://t.co/Zjvbjit43F https://t.co/w9A8EcUbDr Please share with the urologist community as I’m unable to make sense of these results. #prostatecancer

Dec 15, 2024 · 2 likes · 812 followers View post →
Dr. Andrew Loblaw
@DrAndrewLoblaw · X

Interesting that Wilt’s #PIVOT study (RP vs WW for screen detected ds) with >19y mFU, there was no difference in OS or CSS. Maybe we need to wait 10 more years? https://t.co/1TTNnwMSuN https://t.co/Gj4lz0vvFb

Oct 10, 2024 · 1 like · 3,625 followers View post →
S Mohammad Jafri
@MoAkbarJafri · X

CHIEF PIVOT Trial Prostate cancer intervention vs observation https://t.co/MtKi5hhnCl

Aug 28, 2022 · 363 followers View post →
Drew Moghanaki
@DrewMoghanaki · X

Was there really more enthusiasm in 1994 to debate than determine the truth? #pcsm #radonc @VickersBiostats @BehfarEhdaieMD Final study results: https://t.co/vzm6wljf6e https://t.co/DYtXwylO5V

Jul 12, 2022 · 5 likes · 12,963 followers View post →
Rad Onc Commentary
@radoncpub · X

Follow-up of Prostatectomy versus Observation for Early Prostate Cancer https://t.co/SnD4wI5IbH

Jul 2, 2021 · 120 followers View post →
Jasoncheng
@jasoncheng1977 · X

RT @NEJM: Original Article: Follow-up of Prostatectomy versus Observation for Early Prostate Cancer https://t.co/FiweawbSsu #VisualAbstract…

Apr 14, 2020 · 124 shares · 33 followers View post →