NPJ Aging Mech Dis August 2016 PMID 28721271

It takes two to tango: NAD and sirtuins in aging/longevity control.

Shin-Ichiro Imai, Leonard Guarente

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Mentions

30
Peak: 5 in Feb 2025
across 4 sources since Jul 2019

Extended reach

14,301
potential audience

Total likes

91

Video views

1,895

Mentions per month

Jul 2019 – Jun 2025

Where it's discussed

  • Facebook12 posts
  • YouTube7 videos
  • X / Twitter6 posts
  • News5 articles

AI synopsis

What people are saying

The discussions demonstrate a strong recognition of the research's importance, with comments like 'slowing aging by design' and mentions of NAD supplements, emphasizing their potential impact. The tone varies from supportive enthusiasm to curiosity, highlighting both understanding of the scientific content and interest in its applications.

AgreementModerate agreement

Most discussions acknowledge the importance of the NAD-sirtuin connection in aging, reflecting general agreement on the article's significance.

InterestHigh interest

The high interest score indicates that people are actively engaging with the topic, likely due to the relevance of aging research and potential therapies.

EngagementModerate engagement

Posts show moderate engagement, with some referencing scientific terms and implications, but few delve deeply into mechanisms or critique.

ImpactModerate impact

Participants seem to believe the research could influence future studies or treatments, although it's still in the research phase.

Abstract in brief

  • The article explains how NAD (nicotinamide adenine dinucleotide) and sirtuins are closely linked in regulating aging and longevity, with this relationship being evolutionarily conserved across many organisms.
  • As humans age, NAD levels decrease, which reduces sirtuin activity and disrupts communication between different parts of cells and between organs like the brain and fat tissue, contributing to age-related decline and diseases.
  • Recent research has strengthened the understanding of the NAD-sirtuin connection, leading to interest in NAD supplements as a potential way to combat aging-related issues.]

Top posts

Most liked on X and Bluesky
Nicotinamide Mononucleotide (NMN) | NMN.com
@NMNdotcom · X

Journal Reference: "It takes two to tango: NAD+ and sirtuins in aging/longevity control" Authors: Shin-Ichiro Imai, PhD, Leonard Guarente, PhD Afilliations: @WUSTLmed , @kochinstitute , @MIT Source Publication: @nature

Dec 5, 2020 · 1 like · 231 followers View post →
npj Journals
@Nature_NPJ · X

It takes two to tango: NAD+ and sirtuins in aging/longevity control #npjAMD https://t.co/Ev2HmvyRmO https://t.co/K9QJr9MwY5

Jul 21, 2019 · 1 share · 9,046 followers View post →
8Eevert ✨
@8Eevert · X

> Lastly, sirtuins are major consumers of NAD and they require NAD to conduct their processes PMID 28721271: It takes two to tango: NAD+ and #sirtuins in aging/longevity control. NPJ Aging Mech Dis. 2016 https://t.co/O4mnFuiIEF PMID 27552971: Slowing ageing by design: the https://t.co/XbOCCzKHpa https://t.co/UrnZSrWsLj

Dec 25, 2023 · 1,144 followers View post →
NAD+Biology
@BiologyNad · X

It takes two to tango: NAD⁺ and sirtuins in aging/longevity control https://t.co/JrpLOQYFev

Jun 17, 2025 · 991 followers View post →
(M) // M’s Journey XYZ
@DiscoverWhatLie · X

It takes two to tango: NAD+ and sirtuins in aging/longevity control | npj Aging

Jan 22, 2025 · 616 followers View post →
John Doe
@JohnDoe47564694 · X

RT @Nature_NPJ: It takes two to tango: NAD+ and sirtuins in aging/longevity control #npjAMD https://t.co/Ev2HmvyRmO https://t.co/K9QJr9MwY5

Aug 1, 2019 · 1 share · 377 followers View post →

All mentions

NAD+Biology
@BiologyNad · X

It takes two to tango: NAD⁺ and sirtuins in aging/longevity control https://t.co/JrpLOQYFev

Jun 17, 2025 · 991 followers View post →
(M) // M’s Journey XYZ
@DiscoverWhatLie · X

It takes two to tango: NAD+ and sirtuins in aging/longevity control | npj Aging

Jan 22, 2025 · 616 followers View post →
8Eevert ✨
@8Eevert · X

> Lastly, sirtuins are major consumers of NAD and they require NAD to conduct their processes PMID 28721271: It takes two to tango: NAD+ and #sirtuins in aging/longevity control. NPJ Aging Mech Dis. 2016 https://t.co/O4mnFuiIEF PMID 27552971: Slowing ageing by design: the https://t.co/XbOCCzKHpa https://t.co/UrnZSrWsLj

Dec 25, 2023 · 1,144 followers View post →
Nicotinamide Mononucleotide (NMN) | NMN.com
@NMNdotcom · X

Journal Reference: "It takes two to tango: NAD+ and sirtuins in aging/longevity control" Authors: Shin-Ichiro Imai, PhD, Leonard Guarente, PhD Afilliations: @WUSTLmed , @kochinstitute , @MIT Source Publication: @nature

Dec 5, 2020 · 1 like · 231 followers View post →
John Doe
@JohnDoe47564694 · X

RT @Nature_NPJ: It takes two to tango: NAD+ and sirtuins in aging/longevity control #npjAMD https://t.co/Ev2HmvyRmO https://t.co/K9QJr9MwY5

Aug 1, 2019 · 1 share · 377 followers View post →
npj Journals
@Nature_NPJ · X

It takes two to tango: NAD+ and sirtuins in aging/longevity control #npjAMD https://t.co/Ev2HmvyRmO https://t.co/K9QJr9MwY5

Jul 21, 2019 · 1 share · 9,046 followers View post →