Three-dimensional positioning and structure of chromosomes in a human prophase nucleus.

Bo Chen, Mohammed Yusuf, Teruo Hashimoto, Ana Katrina Estandarte, George Thompson, Ian Robinson

July 2017 Sci Adv

Synopsis of Social media discussions

The group mostly agrees about the importance of revealing detailed 3D chromosome architecture, as seen in comments like 'this advances our understanding,' and discusses the technical aspects, such as the resolution of 50 nm, reflecting moderate interest. The tone indicates a respectful curiosity and acknowledgment of the study’s potential to inform future research, rather than immediate revolutionary impact.

A
Agreement
 Moderate agreement

Most discussions acknowledge the significance of the research, with many commenters highlighting its contribution to understanding chromosome organization, though some are cautiously optimistic.

I
Interest
 Moderate level of interest

Participants express moderate interest, often commenting on how the imaging techniques advance knowledge of cell biology but not showing intense enthusiasm.

E
Engagement
 Moderate level of engagement

Comments include mentions of method details, potential applications, and how it relates to existing understanding, indicating thoughtful engagement.

I
Impact
 Moderate level of impact

Many recognize that this study could influence future research directions in genetics and cell biology, suggesting a meaningful scientific impact.

Social Mentions

YouTube

2 Videos

Bluesky

1 Posts

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2 Posts

Metrics

Video Views

4,844,679

Total Likes

160,672

Extended Reach

4,846,284

Social Features

5

Timeline: Posts about article

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  • @ivacheung.com (Bluesky)

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    January 31, 2023

  • meiosispapers @meiosis_papers@mstdn.science
    @meiosis_papers (Twitter)

    Three-dimensional positioning and structure of chromosomes in a human prophase nucleu…|Sci Adv•Robinson I https://t.co/97esgBmE4j
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    July 2, 2019

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    @mitosis_papers (Twitter)

    Three-dimensional positioning and structure of chromosomes in a human prophase nucleus. https://t.co/bWif2f22SR
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    July 2, 2019

Abstract Synopsis

  • This study presents a detailed 3D imaging of the human prophase nucleus, revealing the positioning, shape, and organization of chromosomes at a resolution of about 50 nm, and shows that chromosomes follow specific territorial patterns within the nucleus.
  • It describes that at the lowest level, DNA wraps around histone proteins forming nucleosomes, which further compact into chromosomes with known structures visible under light microscopy, but their higher-order 3D organization was not well understood until now.
  • The research suggests a new way to identify individual human chromosomes based on their 3D shapes and positions, contributing to our understanding of chromosome architecture during cell division.]