Diabetologia September 2017 PMID 28776081

Metformin: historical overview.

Clifford J Bailey

Mentions

180
Peak: 27 in Mar 2020
across 6 sources since Feb 2019

Extended reach

1,961,631
potential audience

Total likes

36,273

Video views

1,501,998

Mentions per month

Feb 2019 – Sep 2025

Where it's discussed

  • News95 articles
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  • YouTube5 videos
  • Facebook4 posts
  • Blogs4 articles
  • Bluesky2 posts

AI synopsis

What people are saying

The overall tone is informative and supportive, with examples like mentions of metformin's origins in herbal medicine, its rediscovery as an antiviral, and its role in managing diabetes, showing curiosity and appreciation for its historical and medical significance. Words like 'fascinating' and 'wonder drug' reflect positive perceptions, emphasizing its broad impact over time.

AgreementModerate agreement

Most discussions acknowledge metformin's long history, effectiveness, and low cost, expressing general support.

InterestHigh interest

Posts show high curiosity about the drug's origins, involving historical facts and its rediscovery for different purposes.

EngagementHigh engagement

Many users discuss scientific origins, alternative uses, and implications, indicating deep engagement.

ImpactModerate impact

While the discussions highlight metformin's significance, few posts suggest transformative change or policy influence, limiting impact.

Abstract in brief

  • Metformin, originally linked to the herbal medicine Galega officinalis, was first synthesized and tested for blood glucose lowering in the early 20th century, but was discontinued due to toxicity concerns, with limited use resuming in the mid-20th century after its rediscovery.
  • Despite initial limited attention because of its lower potency compared to other drugs and its association with toxic Biguanides, metformin gradually gained recognition for effectively countering insulin resistance without causing weight gain or hypoglycemia, leading to its widespread adoption in Europe and the USA by the 1990s.
  • Long-term studies, like the UKPDS in 1998, revealed cardiovascular benefits of metformin, cementing its role as the most prescribed glucose-lowering medication globally and opening possibilities for further therapeutic applications.]

Top posts

Most liked on X and Bluesky
Guðmundur Jóhannsson
@gfj1979 · X

Interesting to look at the history of metformin in this context: 1. It was used as treatment for influenza post WWII https://t.co/dKfnEjeG1T 2. Modern research seems to confirm positive impact on immunity in T2D https://t.co/OXvduP4kG6 3. Clinical trial https://t.co/sMzx6KqJHJ

Mar 15, 2020 · 28 likes · 12 shares · 2,021 followers View post →
Guðmundur Jóhannsson
@gfj1979 · X

“Eusebio Garcia in the Philippines, in 1949, found metformin to be helpful in treating a local influenza outbreak” https://t.co/dKfnEjeG1T

Mar 2, 2020 · 22 likes · 11 shares · 2,021 followers View post →
Science, Not Ideology
@AgBioWorld · X

Metformin, the wonder diabetes drug, also implicated in protecting against cancer - has a fascinating backstory. - Thread! https://t.co/rV0niXUdwx https://t.co/ZKwZIP0VcW

Jan 27, 2023 · 15 likes · 6 shares · 37,039 followers View post →
Daniel J Drucker
@DanielJDrucker · X

@Muller_Lab Introduced in Europe in 1958 for #T2D https://t.co/fG3dOK7A5c

Jan 2, 2021 · 15 likes · 1 share · 34,067 followers View post →
Kuran K.F.
@KuranKF · X

Metformin çok ilginç bir molekül. Bu makalede metforminin en az kendisi kadar ilginç olan öyküsünden ve molekülün hemen hemen bütün özelliklerinden bahsedilmiş. https://t.co/u2P73tOyoT

Mar 4, 2020 · 8 likes · 2,413 followers View post →
Nephrology Journal Club
@nephjc.bsky.social · Bluesky

⏰2 hours until #NephJC chat From herb to hero, it took centuries to withdraw phenformin before metformin became the world’s most prescribed oral antidiabetic

Apr 15, 2025 · 8 likes · 5 shares View post →

All mentions

TStriq
@TStriq · X

RT @shawnwenzel: Metformin is cheap because it's been around since the 1940s and is long off-patent. It works and is low-risk, and I'm just…

Jul 21, 2025 · 1 share · 479 followers View post →
Shawn Wenzel
@shawnwenzel · X

Metformin is cheap because it's been around since the 1940s and is long off-patent. It works and is low-risk, and I'm just glad it works for me! 3/3 https://t.co/4ovoXCDeFu

Jul 16, 2025 · 1 like · 1 share · 2,668 followers View post →
Advaita Batika ( ଅଦ୍ୱୈତ ବାଟିକା ) (अद्वैत वाटिका)
@advaita_batika · X

Not sure if @karthik2k2 will stop prescribing metformin to his diabetes patient. As metformin has its root to some traditional medicines. So by his Modern building analogy, this will be called copyright infringement, unfortunately Ayush don't sue anyone. https://t.co/Q2jBisevY9

Jul 8, 2025 · 492 followers View post →
Andrew Sparling
@awsparling.bsky.social · Bluesky

It's also worth pointing out that metformin was explored as an antimalarial and antiviral (against the flu) before it became widely adopted as a diabetes drug: pubmed.ncbi.nlm.nih.gov/28776081/

Jul 4, 2025 · 2 likes · 2 shares View post →
Nephrology Journal Club
@nephjc.bsky.social · Bluesky

⏰2 hours until #NephJC chat From herb to hero, it took centuries to withdraw phenformin before metformin became the world’s most prescribed oral antidiabetic

Apr 15, 2025 · 8 likes · 5 shares View post →
Andrew Sparling
@awsparling · X

@tamararivc @DavidFajgenbaum Some background here: https://t.co/vMbgCNpco2

Aug 20, 2024 · 1 like · 2,643 followers View post →
Anup Shrestha
@23anupshrestha · X

Metformin: historical overview https://t.co/dlV39mXCzq

Aug 7, 2024 · 1 like · 114 followers View post →
jo abbess
@joabbess · X

Metformin : A History https://t.co/XDIAvqEU3r "Metformin (dimethylbiguanide) has become the preferred first-line oral blood glucose-lowering agent to manage type 2 diabetes. Its history is linked to Galega officinalis (also known as goat's rue), a traditional herbal..."

May 4, 2024 · 2,357 followers View post →
もりはるし
@hmori_tky · X

【ふぅ~ん】 そうか,メトホルミンって抗老化も期待されとるんか... https://t.co/e0IyTpD3my

Mar 26, 2024 · 4 likes · 956 followers View post →
JVN
@JennJVN · X

@LilRdVet2 @GwenDakota2 As I said, it doesn't cause low blood sugar in non-diabetics. It wasn't created for diabetes, they just realized at some point it worked for diabetes. https://t.co/jXX1QJJxsI.

Feb 2, 2024 · 6 likes · 1 share · 950 followers View post →
Jenka
@babiejenks · X

@dianaberrent I think the GLP-1 hype has made people think every diabetes drug is like that, but Metformin just lowers blood glucose by altering liver function. Why mixing alcohol is a big risk. Some interesting history https://t.co/P0f4VMxbeC

Jan 4, 2024 · 1 like · 3,884 followers View post →
Dr. Christine Guptill (she/her)
@HealthMusicPerf · X

@jessica_jnd9 @MamaToronto @SickKidsNews @BogochIsaac @RevivalCare Oh my apologies - I misunderstood what you were saying earlier. I didn’t know that it was initially re-discovered as an anti-malarial drug! Interesting. https://t.co/gu4YQVFIvd.

Jun 19, 2023 · 2 likes · 1,957 followers View post →
Evergreen143
@Evergreen1431 · X

@amymitchellart @danaparish @WendyENThomas I found this one interesting too https://t.co/lToLw62HCj

May 10, 2023 · 2 likes · 498 followers View post →
Negawatts are best
@JoelTH · X

RT @babiejenks: I know we think of Metformin as a diabetes drug, but it was originally in the search for an antimalarial that it was found…

Mar 6, 2023 · 1 share · 559 followers View post →
Jenka
@babiejenks · X

I know we think of Metformin as a diabetes drug, but it was originally in the search for an antimalarial that it was found to lower blood sugar. Goat's rue, the traditional European herb Metformin is derived from is known for its antiviral properties. https://t.co/P0f4VMxbeC

Mar 6, 2023 · 2 likes · 1 share · 3,884 followers View post →
Hai Nes
@Johaines8 · X

Check out the wonder of metformin. https://t.co/qLpNbzf2sA

Mar 2, 2023 · 593 followers View post →
Remember the fifth of November.
@rememberthefift · X

I love my curious Dr. Hong's Pharmacy Classroom Wonder Drug just got more wondrous? (Drug Review & New Study) https://t.co/SXd0TKKBuC via @YouTube

Feb 26, 2023 · 3,016 followers View post →
L. Wayne Mathison
@WayneMathison · X

Wonder Drug just got more wondrous? (Drug Review & New Study) https://t.co/wV952k76B8 via @YouTube

Feb 26, 2023 · 4,909 followers View post →
Science, Not Ideology
@AgBioWorld · X

RT @AgBioWorld: Metformin, the wonder diabetes drug, also implicated in protecting against cancer - has a fascinating backstory. - Thread!…

Jan 27, 2023 · 6 shares · 37,039 followers View post →
Alvaro Díaz Bedregal
@adiazbedregal · X

RT @AgBioWorld: Metformin, the wonder diabetes drug, also implicated in protecting against cancer - has a fascinating backstory. - Thread!…

Jan 27, 2023 · 6 shares · 818 followers View post →
Dr.L.K.Pandey
@lkp63 · X

RT @AgBioWorld: Metformin, the wonder diabetes drug, also implicated in protecting against cancer - has a fascinating backstory. - Thread!…

Jan 27, 2023 · 6 shares · 208 followers View post →
Daniele Cinti
@daniele_cinti · X

RT @AgBioWorld: Metformin, the wonder diabetes drug, also implicated in protecting against cancer - has a fascinating backstory. - Thread!…

Jan 27, 2023 · 6 shares · 28 followers View post →
manuel_bolio
@manuel_bolio · X

RT @AgBioWorld: Metformin, the wonder diabetes drug, also implicated in protecting against cancer - has a fascinating backstory. - Thread!…

Jan 27, 2023 · 6 shares · 3,004 followers View post →
Science, Not Ideology
@AgBioWorld · X

Metformin, the wonder diabetes drug, also implicated in protecting against cancer - has a fascinating backstory. - Thread! https://t.co/rV0niXUdwx https://t.co/ZKwZIP0VcW

Jan 27, 2023 · 15 likes · 6 shares · 37,039 followers View post →
luis hernan graffe
@hernangraffe · X

RT @hernangraffe: https://t.co/GR9xMBUQa8

Jan 21, 2023 · 1 share · 3,133 followers View post →
luis hernan graffe
@hernangraffe · X

https://t.co/GR9xMBUQa8

Jan 19, 2023 · 1 share · 3,133 followers View post →
Jenka
@babiejenks · X

"Metformin was rediscovered in the search for antimalarial agents in the 1940s and, during clinical tests, proved useful to treat influenza when it sometimes lowered blood glucose." https://t.co/P0f4VMxJ4a https://t.co/MGK4FnfJnn

Dec 25, 2022 · 1 like · 3,884 followers View post →
多情仏心
@jiangminjp · X

"したがって、メトホルミンは私たちの体内から尿や便として環境中に排出されます(Metformin: historical overview. Diabetologia (2017) 60(9):1566–76) メトホルミンの主作用は、私たちの生命のフローを生み出すミトコンドリアの機能をストップすることです"

Nov 24, 2022 · 1,758 followers View post →
Ricardo de La Espriella
@RicardodeLaEsp4 · X

@sol_diabetica @DiazStrunz Goats Rue . https://t.co/agPL2KuRz7

Jun 12, 2022 · 152 followers View post →
Dawnie
@Moodwife · X

@JohnCla999 @parthaskar @drpratikc @_diabetes101 @DiabeticDadUK @Anniecoops @Rezaidi @kamleshkhunti @JDRFUK @NHSDiabetesProg @DiabetesUK @ShivaniM_KC @LisWarren @Tims_Pants Seems it was discovered in 1918 but not specifically used as a diabetes treatment until 1957 https://t.co/9WrZej3Scn

Jan 3, 2022 · 1 like · 2,355 followers View post →
Ken E
@keneyjolfson11 · X

@buzzard89 Should be trying to change to lower the risks of covid, influenza and cancer etc. https://t.co/DPr8wH747C

Nov 14, 2021 · 1 like · 100 followers View post →
Eve Beavers
@espacetimeCO · X

Metformin history. I see a study associating with muscle loss...... it may need to be quantified? https://t.co/O6KP38Z5sM

Nov 4, 2021 · 903 followers View post →
Douglas Ritz
@douglasritz · X

@pkedrosky “And we don't know why.” It’s as clear day. Keep pounding those carbs, folks. “Long-term cardiovascular benefits of metformin were identified by the UK Prospective Diabetes Study (UKPDS) in 1998, ” https://t.co/V1Ef7C4GjO

Oct 6, 2021 · 5,134 followers View post →
AMARESH KUMAR
@amareshskumar · X

@curiosweetie Well, yes..and no. Was discovered while 'searching for malarial drugs' , not used for. Used for influenza. (Actually, I didn't know the traditional herbal use was for plagues and other infections.) https://t.co/xnm7NEDiMs https://t.co/nUYUndFADM

Jul 8, 2021 · 1,275 followers View post →
Eve Beavers-Fain BSN MPH
@espacetimeNOT · X

RT @QHPV_diabetes: https://t.co/McItHk9yFp https://t.co/q8RBPENRd8

Jul 5, 2021 · 1 share · 1,204 followers View post →
Eve Beavers-Fain BSN MPH
@espacetimeNOT · X

https://t.co/McItHk9yFp https://t.co/q8RBPENRd8

Jul 5, 2021 · 1 share · 1,204 followers View post →
Eve Beavers-Fain BSN MPH
@espacetimeNOT · X

@dgbyers22 @davidasinclair buyer beware in the U.S. where supplements & herbs are not FDA approved.... https://t.co/McItHk9yFp

Jul 5, 2021 · 1,204 followers View post →
☣️ Pleb Kruse = BTC foundationalist in exile
@DrJackKruse · X

RT @DanielJDrucker: @Muller_Lab Introduced in Europe in 1958 for #T2D https://t.co/fG3dOK7A5c

Jan 2, 2021 · 1 share · 122,992 followers View post →
Daniel J Drucker
@DanielJDrucker · X

@Muller_Lab Introduced in Europe in 1958 for #T2D https://t.co/fG3dOK7A5c

Jan 2, 2021 · 15 likes · 1 share · 34,067 followers View post →
vaskar mistri
@vaskar1104 · X

RT @gfj1979: Interesting to look at the history of metformin in this context: 1. It was used as treatment for influenza post WWII https://t…

Sep 28, 2020 · 12 shares · 1,786 followers View post →
Melchior Meijer
@PolderPaleo · X

RT @gfj1979: Interesting to look at the history of metformin in this context: 1. It was used as treatment for influenza post WWII https://t…

Mar 31, 2020 · 12 shares · 5,183 followers View post →
Jorge Riquelme
@RiquelmeJorge · X

RT @gfj1979: Interesting to look at the history of metformin in this context: 1. It was used as treatment for influenza post WWII https://t…

Mar 27, 2020 · 12 shares · 845 followers View post →
Ivan Aprahamian
@IAprahamian · X

RT @drjohnmorley: Metformin: historical overview. - PubMed - NCBI An excellent history pointing out that it was consider an anti-influenza…

Mar 24, 2020 · 2 shares · 490 followers View post →
Gibrán Pedraza V
@gibranwho · X

RT @drjohnmorley: Metformin: historical overview. - PubMed - NCBI An excellent history pointing out that it was consider an anti-influenza…

Mar 23, 2020 · 2 shares · 251 followers View post →
john morley
@drjohnmorley · X

Metformin: historical overview. - PubMed - NCBI An excellent history pointing out that it was consider an anti-influenza drug https://t.co/qYKHnrO6Ig

Mar 23, 2020 · 1 like · 2 shares · 8,327 followers View post →
Laurence_Tien75
@LearnedLarry · X

RT @gfj1979: Interesting to look at the history of metformin in this context: 1. It was used as treatment for influenza post WWII https://t…

Mar 23, 2020 · 12 shares · 688 followers View post →
claudedalle
@claudedalle · X

i would like to remember you that Metformin is closed to chloroquine, has antiviral properties, it's perhaps an opportunity to explore again Coronavirus : let's read the bailey's publication here. Keep safe.DOI 10.1007/s00125-017-4318-z

Mar 23, 2020 · 5 likes · 123 followers View post →
Mad
@MadPharmacist1 · X

RT @gfj1979: Interesting to look at the history of metformin in this context: 1. It was used as treatment for influenza post WWII https://t…

Mar 22, 2020 · 12 shares · 6,488 followers View post →
DrDeaRoberts
@DrDeaRoberts · X

RT @gfj1979: Interesting to look at the history of metformin in this context: 1. It was used as treatment for influenza post WWII https://t…

Mar 21, 2020 · 12 shares · 2,038 followers View post →
David Wyant
@wyadvd · X

RT @gfj1979: Interesting to look at the history of metformin in this context: 1. It was used as treatment for influenza post WWII https://t…

Mar 21, 2020 · 12 shares · 2,686 followers View post →
Alper Aydın (Dietitian )
@aydinnalper · X

RT @gfj1979: Interesting to look at the history of metformin in this context: 1. It was used as treatment for influenza post WWII https://t…

Mar 18, 2020 · 12 shares · 1,426 followers View post →
Ellen Wetherill
@afashionfan · X

RT @gfj1979: Interesting to look at the history of metformin in this context: 1. It was used as treatment for influenza post WWII https://t…

Mar 17, 2020 · 12 shares · 2,288 followers View post →
MorozkoForge
@MorozkoForge · X

RT @gfj1979: Interesting to look at the history of metformin in this context: 1. It was used as treatment for influenza post WWII https://t…

Mar 16, 2020 · 12 shares · 2,350 followers View post →
Guðmundur Jóhannsson
@gfj1979 · X

Interesting to look at the history of metformin in this context: 1. It was used as treatment for influenza post WWII https://t.co/dKfnEjeG1T 2. Modern research seems to confirm positive impact on immunity in T2D https://t.co/OXvduP4kG6 3. Clinical trial https://t.co/sMzx6KqJHJ

Mar 15, 2020 · 28 likes · 12 shares · 2,021 followers View post →
Globiance Live Chat & Support
@globiance_Desk · X

RT @gfj1979: “Eusebio Garcia in the Philippines, in 1949, found metformin to be helpful in treating a local influenza outbreak” https://t.c…

Mar 8, 2020 · 11 shares · 2,941 followers View post →
Spes Nostra
@YSalm_o_Fendith · X

RT @gfj1979: “Eusebio Garcia in the Philippines, in 1949, found metformin to be helpful in treating a local influenza outbreak” https://t.c…

Mar 7, 2020 · 11 shares · 912 followers View post →
Adi Setyawan MD
@AdiSObGyn · X

RT @gfj1979: “Eusebio Garcia in the Philippines, in 1949, found metformin to be helpful in treating a local influenza outbreak” https://t.c…

Mar 6, 2020 · 11 shares · 355 followers View post →
Gary Fettke
@FructoseNo · X

RT @gfj1979: “Eusebio Garcia in the Philippines, in 1949, found metformin to be helpful in treating a local influenza outbreak” https://t.c…

Mar 6, 2020 · 11 shares · 84,758 followers View post →
Amerikkka’s Existence is NAWT Morally Tenable!
@Tenji95 · X

RT @gfj1979: “Eusebio Garcia in the Philippines, in 1949, found metformin to be helpful in treating a local influenza outbreak” https://t.c…

Mar 6, 2020 · 11 shares · 3,117 followers View post →
Isegoria
@Isegoria · X

RT @gfj1979: “Eusebio Garcia in the Philippines, in 1949, found metformin to be helpful in treating a local influenza outbreak” https://t.c…

Mar 6, 2020 · 11 shares · 1,633 followers View post →
Kuran K.F.
@KuranKF · X

Metformin çok ilginç bir molekül. Bu makalede metforminin en az kendisi kadar ilginç olan öyküsünden ve molekülün hemen hemen bütün özelliklerinden bahsedilmiş. https://t.co/u2P73tOyoT

Mar 4, 2020 · 8 likes · 2,413 followers View post →
David Wyant
@wyadvd · X

RT @gfj1979: “Eusebio Garcia in the Philippines, in 1949, found metformin to be helpful in treating a local influenza outbreak” https://t.c…

Mar 4, 2020 · 11 shares · 2,686 followers View post →
Ally Houston
@AllyTransforms · X

RT @gfj1979: “Eusebio Garcia in the Philippines, in 1949, found metformin to be helpful in treating a local influenza outbreak” https://t.c…

Mar 3, 2020 · 11 shares · 5,820 followers View post →
Carnivore is Vegan
@CarnivoreIs · X

RT @gfj1979: “Eusebio Garcia in the Philippines, in 1949, found metformin to be helpful in treating a local influenza outbreak” https://t.c…

Mar 3, 2020 · 11 shares · 3,711 followers View post →
Understand then QUESTION science
@AbAnand9 · X

RT @gfj1979: “Eusebio Garcia in the Philippines, in 1949, found metformin to be helpful in treating a local influenza outbreak” https://t.c…

Mar 3, 2020 · 11 shares · 991 followers View post →
Vet Goed
@VetGoed · X

RT @gfj1979: “Eusebio Garcia in the Philippines, in 1949, found metformin to be helpful in treating a local influenza outbreak” https://t.c…

Mar 3, 2020 · 11 shares · 389 followers View post →
Guðmundur Jóhannsson
@gfj1979 · X

“Eusebio Garcia in the Philippines, in 1949, found metformin to be helpful in treating a local influenza outbreak” https://t.co/dKfnEjeG1T

Mar 2, 2020 · 22 likes · 11 shares · 2,021 followers View post →
VanHelllish.eth❤️ Memecoin
@MikeonNet · X

@PeterAttiaMD "The value of such a favourably versatile medication requires that the contraindications (especially renal and hypoxaemic restrictions) are respected and that further potential therapeutic opportunities are explored."https://t.co/hxdday7e8F https://t.co/eux8peGvEt

Jun 23, 2019 · 167 followers View post →
Antonieta Vidal
@AntonietaVidalT · X

RT @redGDPS: Gemma Garcia nos hablara de los clásicos como la #Biguanidas y las #alfaglicosidasas La #metformina. https://t.co/DRfDqtQYXW #…

Apr 5, 2019 · 2 shares · 1,235 followers View post →
Fco Carramiñana Barrera
@fcbzafra · X

RT @redGDPS: Gemma Garcia nos hablara de los clásicos como la #Biguanidas y las #alfaglicosidasas La #metformina. https://t.co/DRfDqtQYXW #…

Apr 5, 2019 · 2 shares · 2,753 followers View post →
redGDPS Diabetes
@redGDPS · X

Gemma Garcia nos hablara de los clásicos como la #Biguanidas y las #alfaglicosidasas La #metformina. https://t.co/DRfDqtQYXW #3RSredGDPS https://t.co/rVFlearzrB

Apr 5, 2019 · 1 like · 2 shares · 15,486 followers View post →
mpmd2019
@mpmd2019 · X

Metformin is still an important agent concerning the treatment of diabetes. Here is a historical overview worth reading. https://t.co/an84z9acCy

Feb 12, 2019 · 1 like · 3 followers View post →