Interesting to look at the history of metformin in this context: 1. It was used as treatment for influenza post WWII https://t.co/dKfnEjeG1T 2. Modern research seems to confirm positive impact on immunity in T2D https://t.co/OXvduP4kG6 3. Clinical trial https://t.co/sMzx6KqJHJ
Metformin: historical overview.
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Feb 2019 – Sep 2025Where it's discussed
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News95 articles
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X / Twitter70 posts
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YouTube5 videos
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Facebook4 posts
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Bluesky2 posts
AI synopsis
What people are saying
The overall tone is informative and supportive, with examples like mentions of metformin's origins in herbal medicine, its rediscovery as an antiviral, and its role in managing diabetes, showing curiosity and appreciation for its historical and medical significance. Words like 'fascinating' and 'wonder drug' reflect positive perceptions, emphasizing its broad impact over time.
Most discussions acknowledge metformin's long history, effectiveness, and low cost, expressing general support.
Posts show high curiosity about the drug's origins, involving historical facts and its rediscovery for different purposes.
Many users discuss scientific origins, alternative uses, and implications, indicating deep engagement.
While the discussions highlight metformin's significance, few posts suggest transformative change or policy influence, limiting impact.
Abstract in brief
- Metformin, originally linked to the herbal medicine Galega officinalis, was first synthesized and tested for blood glucose lowering in the early 20th century, but was discontinued due to toxicity concerns, with limited use resuming in the mid-20th century after its rediscovery.
- Despite initial limited attention because of its lower potency compared to other drugs and its association with toxic Biguanides, metformin gradually gained recognition for effectively countering insulin resistance without causing weight gain or hypoglycemia, leading to its widespread adoption in Europe and the USA by the 1990s.
- Long-term studies, like the UKPDS in 1998, revealed cardiovascular benefits of metformin, cementing its role as the most prescribed glucose-lowering medication globally and opening possibilities for further therapeutic applications.]
Top posts
Most liked on X and Bluesky“Eusebio Garcia in the Philippines, in 1949, found metformin to be helpful in treating a local influenza outbreak” https://t.co/dKfnEjeG1T
Metformin, the wonder diabetes drug, also implicated in protecting against cancer - has a fascinating backstory. - Thread! https://t.co/rV0niXUdwx https://t.co/ZKwZIP0VcW
@Muller_Lab Introduced in Europe in 1958 for #T2D https://t.co/fG3dOK7A5c
Metformin çok ilginç bir molekül. Bu makalede metforminin en az kendisi kadar ilginç olan öyküsünden ve molekülün hemen hemen bütün özelliklerinden bahsedilmiş. https://t.co/u2P73tOyoT
⏰2 hours until #NephJC chat From herb to hero, it took centuries to withdraw phenformin before metformin became the world’s most prescribed oral antidiabetic
All mentions
Exploring Metformin: Anti-Aging Potential and Current Research
Metformin is an old, inexpensive drug primarily used for diabetes management, now gaining attention for its potential anti-aging benefits. In this video, we discuss the research surrounding metformin, including its…
Can Metformin Be Used for Weight Loss Without Diabetes?
This video explores whether metformin, originally developed for type 2 diabetes, can be used for weight loss and other health benefits. It discusses research on its effects on aging, inflammation, and potential uses…
Metformin's Potential Benefits Against Severe COVID-19 Outcomes
Metformin and Glifage: Effects on Weight Loss and Longevity
This video explains the origin, composition, mechanisms, and scientific evidence behind Metformin and Glifage in weight loss and longevity, discussing classic studies, myths, risks, and who can benefit from these…
Immortality of Medusa and Modern Scientific Insights on Diabetes and Heart Health
In this episode, we discuss the final three chapters of The Immortal Medusa, covering topics like diabetes, cardiovascular and cerebrovascular diseases, insulin, metformin, cholesterol, myostatin, and the importance of…
RT @shawnwenzel: Metformin is cheap because it's been around since the 1940s and is long off-patent. It works and is low-risk, and I'm just…
Metformin is cheap because it's been around since the 1940s and is long off-patent. It works and is low-risk, and I'm just glad it works for me! 3/3 https://t.co/4ovoXCDeFu
Not sure if @karthik2k2 will stop prescribing metformin to his diabetes patient. As metformin has its root to some traditional medicines. So by his Modern building analogy, this will be called copyright infringement, unfortunately Ayush don't sue anyone. https://t.co/Q2jBisevY9
It's also worth pointing out that metformin was explored as an antimalarial and antiviral (against the flu) before it became widely adopted as a diabetes drug: pubmed.ncbi.nlm.nih.gov/28776081/
⏰2 hours until #NephJC chat From herb to hero, it took centuries to withdraw phenformin before metformin became the world’s most prescribed oral antidiabetic
@tamararivc @DavidFajgenbaum Some background here: https://t.co/vMbgCNpco2
Metformin: historical overview https://t.co/dlV39mXCzq
Metformin : A History https://t.co/XDIAvqEU3r "Metformin (dimethylbiguanide) has become the preferred first-line oral blood glucose-lowering agent to manage type 2 diabetes. Its history is linked to Galega officinalis (also known as goat's rue), a traditional herbal..."
【ふぅ~ん】 そうか,メトホルミンって抗老化も期待されとるんか... https://t.co/e0IyTpD3my
@LilRdVet2 @GwenDakota2 As I said, it doesn't cause low blood sugar in non-diabetics. It wasn't created for diabetes, they just realized at some point it worked for diabetes. https://t.co/jXX1QJJxsI.
@dianaberrent I think the GLP-1 hype has made people think every diabetes drug is like that, but Metformin just lowers blood glucose by altering liver function. Why mixing alcohol is a big risk. Some interesting history https://t.co/P0f4VMxbeC
@jessica_jnd9 @MamaToronto @SickKidsNews @BogochIsaac @RevivalCare Oh my apologies - I misunderstood what you were saying earlier. I didn’t know that it was initially re-discovered as an anti-malarial drug! Interesting. https://t.co/gu4YQVFIvd.
@amymitchellart @danaparish @WendyENThomas I found this one interesting too https://t.co/lToLw62HCj
RT @babiejenks: I know we think of Metformin as a diabetes drug, but it was originally in the search for an antimalarial that it was found…
I know we think of Metformin as a diabetes drug, but it was originally in the search for an antimalarial that it was found to lower blood sugar. Goat's rue, the traditional European herb Metformin is derived from is known for its antiviral properties. https://t.co/P0f4VMxbeC
Check out the wonder of metformin. https://t.co/qLpNbzf2sA
I love my curious Dr. Hong's Pharmacy Classroom Wonder Drug just got more wondrous? (Drug Review & New Study) https://t.co/SXd0TKKBuC via @YouTube
Wonder Drug just got more wondrous? (Drug Review & New Study) https://t.co/wV952k76B8 via @YouTube
RT @AgBioWorld: Metformin, the wonder diabetes drug, also implicated in protecting against cancer - has a fascinating backstory. - Thread!…
RT @AgBioWorld: Metformin, the wonder diabetes drug, also implicated in protecting against cancer - has a fascinating backstory. - Thread!…
RT @AgBioWorld: Metformin, the wonder diabetes drug, also implicated in protecting against cancer - has a fascinating backstory. - Thread!…
RT @AgBioWorld: Metformin, the wonder diabetes drug, also implicated in protecting against cancer - has a fascinating backstory. - Thread!…
RT @AgBioWorld: Metformin, the wonder diabetes drug, also implicated in protecting against cancer - has a fascinating backstory. - Thread!…
Metformin, the wonder diabetes drug, also implicated in protecting against cancer - has a fascinating backstory. - Thread! https://t.co/rV0niXUdwx https://t.co/ZKwZIP0VcW
RT @hernangraffe: https://t.co/GR9xMBUQa8
https://t.co/GR9xMBUQa8
"Metformin was rediscovered in the search for antimalarial agents in the 1940s and, during clinical tests, proved useful to treat influenza when it sometimes lowered blood glucose." https://t.co/P0f4VMxJ4a https://t.co/MGK4FnfJnn
"したがって、メトホルミンは私たちの体内から尿や便として環境中に排出されます(Metformin: historical overview. Diabetologia (2017) 60(9):1566–76) メトホルミンの主作用は、私たちの生命のフローを生み出すミトコンドリアの機能をストップすることです"
@sol_diabetica @DiazStrunz Goats Rue . https://t.co/agPL2KuRz7
@JohnCla999 @parthaskar @drpratikc @_diabetes101 @DiabeticDadUK @Anniecoops @Rezaidi @kamleshkhunti @JDRFUK @NHSDiabetesProg @DiabetesUK @ShivaniM_KC @LisWarren @Tims_Pants Seems it was discovered in 1918 but not specifically used as a diabetes treatment until 1957 https://t.co/9WrZej3Scn
@buzzard89 Should be trying to change to lower the risks of covid, influenza and cancer etc. https://t.co/DPr8wH747C
Metformin history. I see a study associating with muscle loss...... it may need to be quantified? https://t.co/O6KP38Z5sM
@pkedrosky “And we don't know why.” It’s as clear day. Keep pounding those carbs, folks. “Long-term cardiovascular benefits of metformin were identified by the UK Prospective Diabetes Study (UKPDS) in 1998, ” https://t.co/V1Ef7C4GjO
@curiosweetie Well, yes..and no. Was discovered while 'searching for malarial drugs' , not used for. Used for influenza. (Actually, I didn't know the traditional herbal use was for plagues and other infections.) https://t.co/xnm7NEDiMs https://t.co/nUYUndFADM
RT @QHPV_diabetes: https://t.co/McItHk9yFp https://t.co/q8RBPENRd8
https://t.co/McItHk9yFp https://t.co/q8RBPENRd8
@dgbyers22 @davidasinclair buyer beware in the U.S. where supplements & herbs are not FDA approved.... https://t.co/McItHk9yFp
RT @DanielJDrucker: @Muller_Lab Introduced in Europe in 1958 for #T2D https://t.co/fG3dOK7A5c
@Muller_Lab Introduced in Europe in 1958 for #T2D https://t.co/fG3dOK7A5c
RT @gfj1979: Interesting to look at the history of metformin in this context: 1. It was used as treatment for influenza post WWII https://t…
RT @gfj1979: Interesting to look at the history of metformin in this context: 1. It was used as treatment for influenza post WWII https://t…
RT @gfj1979: Interesting to look at the history of metformin in this context: 1. It was used as treatment for influenza post WWII https://t…
RT @drjohnmorley: Metformin: historical overview. - PubMed - NCBI An excellent history pointing out that it was consider an anti-influenza…
RT @drjohnmorley: Metformin: historical overview. - PubMed - NCBI An excellent history pointing out that it was consider an anti-influenza…
Metformin: historical overview. - PubMed - NCBI An excellent history pointing out that it was consider an anti-influenza drug https://t.co/qYKHnrO6Ig
RT @gfj1979: Interesting to look at the history of metformin in this context: 1. It was used as treatment for influenza post WWII https://t…
i would like to remember you that Metformin is closed to chloroquine, has antiviral properties, it's perhaps an opportunity to explore again Coronavirus : let's read the bailey's publication here. Keep safe.DOI 10.1007/s00125-017-4318-z
RT @gfj1979: Interesting to look at the history of metformin in this context: 1. It was used as treatment for influenza post WWII https://t…
RT @gfj1979: Interesting to look at the history of metformin in this context: 1. It was used as treatment for influenza post WWII https://t…
RT @gfj1979: Interesting to look at the history of metformin in this context: 1. It was used as treatment for influenza post WWII https://t…
RT @gfj1979: Interesting to look at the history of metformin in this context: 1. It was used as treatment for influenza post WWII https://t…
RT @gfj1979: Interesting to look at the history of metformin in this context: 1. It was used as treatment for influenza post WWII https://t…
RT @gfj1979: Interesting to look at the history of metformin in this context: 1. It was used as treatment for influenza post WWII https://t…
Interesting to look at the history of metformin in this context: 1. It was used as treatment for influenza post WWII https://t.co/dKfnEjeG1T 2. Modern research seems to confirm positive impact on immunity in T2D https://t.co/OXvduP4kG6 3. Clinical trial https://t.co/sMzx6KqJHJ
RT @gfj1979: “Eusebio Garcia in the Philippines, in 1949, found metformin to be helpful in treating a local influenza outbreak” https://t.c…
RT @gfj1979: “Eusebio Garcia in the Philippines, in 1949, found metformin to be helpful in treating a local influenza outbreak” https://t.c…
RT @gfj1979: “Eusebio Garcia in the Philippines, in 1949, found metformin to be helpful in treating a local influenza outbreak” https://t.c…
RT @gfj1979: “Eusebio Garcia in the Philippines, in 1949, found metformin to be helpful in treating a local influenza outbreak” https://t.c…
RT @gfj1979: “Eusebio Garcia in the Philippines, in 1949, found metformin to be helpful in treating a local influenza outbreak” https://t.c…
RT @gfj1979: “Eusebio Garcia in the Philippines, in 1949, found metformin to be helpful in treating a local influenza outbreak” https://t.c…
Metformin çok ilginç bir molekül. Bu makalede metforminin en az kendisi kadar ilginç olan öyküsünden ve molekülün hemen hemen bütün özelliklerinden bahsedilmiş. https://t.co/u2P73tOyoT
RT @gfj1979: “Eusebio Garcia in the Philippines, in 1949, found metformin to be helpful in treating a local influenza outbreak” https://t.c…
RT @gfj1979: “Eusebio Garcia in the Philippines, in 1949, found metformin to be helpful in treating a local influenza outbreak” https://t.c…
RT @gfj1979: “Eusebio Garcia in the Philippines, in 1949, found metformin to be helpful in treating a local influenza outbreak” https://t.c…
RT @gfj1979: “Eusebio Garcia in the Philippines, in 1949, found metformin to be helpful in treating a local influenza outbreak” https://t.c…
RT @gfj1979: “Eusebio Garcia in the Philippines, in 1949, found metformin to be helpful in treating a local influenza outbreak” https://t.c…
“Eusebio Garcia in the Philippines, in 1949, found metformin to be helpful in treating a local influenza outbreak” https://t.co/dKfnEjeG1T
@PeterAttiaMD "The value of such a favourably versatile medication requires that the contraindications (especially renal and hypoxaemic restrictions) are respected and that further potential therapeutic opportunities are explored."https://t.co/hxdday7e8F https://t.co/eux8peGvEt
RT @redGDPS: Gemma Garcia nos hablara de los clásicos como la #Biguanidas y las #alfaglicosidasas La #metformina. https://t.co/DRfDqtQYXW #…
RT @redGDPS: Gemma Garcia nos hablara de los clásicos como la #Biguanidas y las #alfaglicosidasas La #metformina. https://t.co/DRfDqtQYXW #…
Gemma Garcia nos hablara de los clásicos como la #Biguanidas y las #alfaglicosidasas La #metformina. https://t.co/DRfDqtQYXW #3RSredGDPS https://t.co/rVFlearzrB
Metformin is still an important agent concerning the treatment of diabetes. Here is a historical overview worth reading. https://t.co/an84z9acCy
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