J Am Geriatr Soc October 2017 PMID 28869295

The Clinical Potential of Senolytic Drugs.

James L Kirkland, Tamara Tchkonia, Yi Zhu, Laura J Niedernhofer, Paul D Robbins

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Mentions

20
Peak: 3 in Feb 2019
across 5 sources since Mar 2018

Extended reach

95,894
potential audience

Total likes

946

Video views

37,829

Mentions per month

Mar 2018 – Jan 2026

Where it's discussed

  • X / Twitter9 posts
  • YouTube5 videos
  • News3 articles
  • Facebook2 posts
  • Reddit1 posts

AI synopsis

What people are saying

The collection centers on optimistic appraisal of the article, highlighting potential for senolytics to transform geriatrics by addressing multiple diseases and functional declines. Posts frequently quote or paraphrase the authors to underline the translational potential and trial design innovations, signaling careful, forward-looking interest rather than critique. Word choices like 'could transform', 'multimorbidity', and 'in parallel' reinforce a narrative of high impact and broad applicability.

AgreementModerate agreement

Overall positive stance; multiple posts echo potential benefits and transformative impact if proven safe/effective.

InterestModerate interest

Moderate interest evident through reiteration of key points and emphasis on clinical potential.

EngagementModerate engagement

Genuine engagement; quotes and paraphrase show the poster is processing the content rather than passively repeating.

ImpactModerate impact

Anticipatory optimism about broad, multi-disease benefits; some posts highlight systemic impact in geriatrics.

Abstract in brief

  • Senolytic drugs selectively remove senescent cells, which accumulate with aging and in many diseases, and have shown to delay or mitigate multiple age-related conditions in animals.
  • Clinical translation is progressing with new trial designs that focus on multimorbidity, accelerated aging, localized senescent cell buildup, and frailty, rather than long-term endpoints like lifespan.
  • If proven safe and effective, senolytics could transform geriatrics by preventing or treating multiple diseases and functional declines simultaneously, rather than one at a time.

Top posts

Most liked on X and Bluesky
Agingdoc
@agingdoc1 · X

The Clinical Potential of Senolytic Drugs (2017) https://t.co/d9SM4EAWzW

Dec 25, 2022 · 4 likes · 41,699 followers View post →
john morley
@drjohnmorley · X

The Clinical Potential of Senolytic Drugs. - PubMed - NCBI https://t.co/ffGXvcCClS

Mar 25, 2019 · 8,319 followers View post →
DrRPalmquist
@DrPalmquist · X

The Clinical Potential of Senolytic Drugs - Kirkland - 2017 - Journal of the American Geriatrics Society - Wiley Online Library https://t.co/VfsrgYwBoT

Sep 13, 2020 · 3,165 followers View post →
25% changes the social structure
@LyceumWC · X

“Senolytic drugs are agents that selectively induce apoptosis of senescent cells. These cells accumulate in many tissues with aging and at sites of pathology in multiple chronic diseases.“ The Clinical Potential of Senolytic Drugs - Kirkland - https://t.co/xnlfgd6yyB

Feb 22, 2019 · 883 followers View post →
25% changes the social structure
@LyceumWC · X

The Clinical Potential of Senolytic Drugs - Kirkland - 2017 - Journal of the American Geriatrics Society - Wiley Online Library https://t.co/s34gxIhxQz

Mar 23, 2019 · 883 followers View post →
25% changes the social structure
@LyceumWC · X

4/ Senolytic drugs are agents that selectively destroy senescent cells or induce cell death. https://t.co/U93vCzSfp3

Feb 25, 2019 · 883 followers View post →

All mentions

Agingdoc
@agingdoc1 · X

The Clinical Potential of Senolytic Drugs (2017) https://t.co/d9SM4EAWzW

Dec 25, 2022 · 4 likes · 41,699 followers View post →
DrRPalmquist
@DrPalmquist · X

The Clinical Potential of Senolytic Drugs - Kirkland - 2017 - Journal of the American Geriatrics Society - Wiley Online Library https://t.co/VfsrgYwBoT

Sep 13, 2020 · 3,165 followers View post →
Cardea/Chile +569 81394757 +569 84095586
@cardeacl · X

The Clinical Potential of Senolytic Drugs https://t.co/VkPczu7szP

Apr 24, 2019 · 409 followers View post →
john morley
@drjohnmorley · X

The Clinical Potential of Senolytic Drugs. - PubMed - NCBI https://t.co/ffGXvcCClS

Mar 25, 2019 · 8,319 followers View post →
25% changes the social structure
@LyceumWC · X

The Clinical Potential of Senolytic Drugs - Kirkland - 2017 - Journal of the American Geriatrics Society - Wiley Online Library https://t.co/s34gxIhxQz

Mar 23, 2019 · 883 followers View post →
25% changes the social structure
@LyceumWC · X

4/ Senolytic drugs are agents that selectively destroy senescent cells or induce cell death. https://t.co/U93vCzSfp3

Feb 25, 2019 · 883 followers View post →
25% changes the social structure
@LyceumWC · X

“Senolytic drugs are agents that selectively induce apoptosis of senescent cells. These cells accumulate in many tissues with aging and at sites of pathology in multiple chronic diseases.“ The Clinical Potential of Senolytic Drugs - Kirkland - https://t.co/xnlfgd6yyB

Feb 22, 2019 · 883 followers View post →
25% changes the social structure
@LyceumWC · X

“If senolytics prove to be effective and safe in clinical trials, they could transform geriatric medicine by enabling prevention or treatment of multiple diseases and functional deficits in parallel, instead of one at a time.“ https://t.co/EPUVUGlO08

Feb 21, 2019 · 883 followers View post →
25% changes the social structure
@LyceumWC · X

Mayo Clinic - The Clinical Potential of Senolytic Drugs https://t.co/U93vCzSfp3

Jan 17, 2019 · 883 followers View post →
CUANDO CHATGPT INTENTÓ EVITAR SU PROPIO ... - Facebook
Facebook

org/10.1111/jgs.14969 • Muñoz-Espín, D., & Serrano, M. (2014). Cellular senescence: from physiology to pathology. Nature Reviews Molecular ...

Jul 8, 2025 View →
Background reading on cellular senescence? : r/longevity - Reddit
Reddit

... Drugs https://doi.org/10.1111/jgs.14969. Markers of T Cell Senescence in Humans https://doi.org/10.3390/ijms18081742. [deleted]. •. 9y ago.

Mar 7, 2018 View →
Gealterte Zellen auflösen | PZ - Pharmazeutische Zeitung
News

... 10.1111/jgs.14969). Dabei haben die potenziellen Arzneistoffe sogenannte seneszente Zellen als Ziel. Das sind Zellen, die sich nicht mehr ...

Sep 12, 2017 View →
Senolytische Arzneistoffe: Wenn das Alter aufgelöst wird
News

DOI: 10.1111/jgs.14969 (Review im «Journal of the American Geriatrics Society») DOI: 10.1038/ncomms15691 (Publikation in «Aging Cell ...

Sep 6, 2017 View →
Researchers review the clinical potential of senolytic drugs on aging
News

Journal of the American Geriatrics Society, 2017; DOI: 10.1111/jgs.14969; Joshua N Farr, Ming Xu, Megan M Weivoda, David G Monroe, Daniel G ...

Sep 5, 2017 View →
https://www.nature.com/articles/s41467-017-00314-z - Facebook
Facebook

The Clinical Potential of Senolytic Drugs... http://onlinelibrary.wiley. com/doi/10.1111/jgs.14969/abstract; ...

Sep 5, 2017 View →