Cell Metab September 2017 PMID 28877458

Ketogenic Diet Reduces Midlife Mortality and Improves Memory in Aging Mice.

John C Newman, Anthony J Covarrubias, Minghao Zhao, Xinxing Yu, Philipp Gut, Che-Ping Ng, Yu Huang, Saptarsi Haldar, Eric Verdin

Mentions

174
Peak: 3 in Oct 2019
across 5 sources since Oct 2019

Extended reach

445,714
potential audience

Total likes

973

Video views

20,013

Mentions per month

Oct 2019 – Aug 2024

Where it's discussed

  • News119 articles
  • Facebook33 posts
  • X / Twitter11 posts
  • Blogs9 articles
  • YouTube2 videos

AI synopsis

What people are saying

The discussions reflect a positive reception to the research, with individuals expressing curiosity about its implications for human health and longevity, evidenced by comments like 'a study with humans is needed' and mentions of pathways like IIS/PI3K/AKT/mTORC. The tone combines support, technical analysis, and future-oriented speculation, revealing both interest and engagement aimed at understanding broader impacts.

AgreementModerate agreement

Most discussions support the findings, with some emphasizing the potential applicability to humans, indicating general agreement with the research conclusions.

InterestHigh interest

The discussions demonstrate high interest, with mentions of health benefits, longevity, and cognitive improvements, reflecting curiosity and relevance.

EngagementModerate engagement

Participants actively analyze the study’s implications, reference related biological pathways, and debate the potential for human translation, showing thoughtful engagement.

ImpactModerate impact

The conversations highlight the potential significance of the diet's effects on health and aging, suggesting moderate to high perceived impact.

Abstract in brief

  • A cyclic ketogenic diet (KD), which involves alternating weekly with a control diet, can reduce midlife mortality and improve memory in aging mice, without extending their maximum lifespan.
  • The diet influences gene expression by downregulating insulin and fatty acid synthesis pathways, and uniquely upregulates PPAR target genes across tissues and in old age, contributing to health benefits.
  • Overall, the study suggests that a nonobesogenic ketogenic diet enhances survival, cognitive function, and healthspan in aging mice.]

Top posts

Most liked on X and Bluesky
Dr. Ilin Gilberto de la Torre M.
@IlindelatorreMD · X

Una dieta cetogénica prolonga la longevidad y mejora la memoria en ratones que envejecen | Cell Metabolism https://t.co/I59bbCS1wW https://t.co/8Qm8h7ClJ4

Oct 21, 2019 · 5 likes · 1 share · 45,851 followers View post →
P.D. Mangan Health & Freedom Maximalist
@Mangan150 · X

@ChristianAssad Neither rats nor humans: Ketogenic Diet Reduces Midlife Mortality and Improves Memory in Aging Mice https://t.co/LcTfDziq4x

Oct 31, 2019 · 4 likes · 291,278 followers View post →
Agingdoc
@agingdoc1 · X

Ketogenic Diet Reduces Midlife Mortality and Improves Memory in Aging Mice (2017) https://t.co/qKHSvp253V

Apr 17, 2022 · 1 like · 41,315 followers View post →
Silvers Rayleigh
@MesjaWybraniec · X

@NIIESLON @famemmatv Boxdel bo pewnie będą głównie pytania z socjologii i z substancji psychoaktywnych zmniejszających tkankę tłuszczową hahaha https://t.co/mbb6V9Sgl0

Dec 30, 2023 · 1 like · 1 share · 19 followers View post →
Agingdoc
@agingdoc1 · X

@Blagosklonny @kevinburch @foundmyfitness @prolonfmd Yes Misha,@prolonfmd is certainly tapping IIS/PI3K/AKT/mTORC & related nutrient-sensing pathways & network of hallmarks of aging. While SAA sensing is part of that picture too, on the VLCD (overlap) was most enamored by: 1) https://t.co/ICz9cSptDn & 2) https://t.co/pOWz7wr3rU

Aug 12, 2020 · 41,315 followers View post →
Brianna Stubbs
@BriannaStubbs · X

@ifbacongrewont1 @americanaging BHB lifespan (worms): https://t.co/9Yf0u2tRxT KD lifespan (mice) https://t.co/Mi6vgEsYfa KD lifespan (mice- replication) https://t.co/MWvL2YrzcZ Review discussing implications of ketones for longevity https://t.co/ISwXRMY67h

Jun 22, 2021 · 4,032 followers View post →

All mentions

RAO
@corpliazon · X

RT @drjamesdinic: A cyclical ketogenic diet reduces mortality and improves memory in mice https://t.co/VhTDc93mne https://t.co/wUBTy6E9wX

Aug 15, 2024 · 40 shares · 1,284 followers View post →
Joshua Andrade, BSc., CPT | Online Nutrition Coach
@madscixntist · X

Ketogenic Diet Reduces Midlife Mortality and Improves Memory in Aging Mice A study with humans is needed to make conclusions there, but it seems (really) possible there may be the same effect in humans https://t.co/7E4dVPGW3T #keto #ketodiet #fatloss #fatlosstips #carnivore

Jun 28, 2024 · 3 followers View post →
Alex
@AlexViKu · X

Ketogenic Diet Reduces Midlife Mortality and Improves Memory in Aging Mice: Cell Metabolism https://t.co/zeIzsaYXZ3

Jan 23, 2024 · 97 followers View post →
Silvers Rayleigh
@MesjaWybraniec · X

RT @MesjaWybraniec: @NIIESLON @famemmatv Boxdel bo pewnie będą głównie pytania z socjologii i z substancji psychoaktywnych zmniejszających…

Dec 30, 2023 · 1 share · 19 followers View post →
Silvers Rayleigh
@MesjaWybraniec · X

@NIIESLON @famemmatv Boxdel bo pewnie będą głównie pytania z socjologii i z substancji psychoaktywnych zmniejszających tkankę tłuszczową hahaha https://t.co/mbb6V9Sgl0

Dec 30, 2023 · 1 like · 1 share · 19 followers View post →
Agingdoc
@agingdoc1 · X

Ketogenic Diet Reduces Midlife Mortality and Improves Memory in Aging Mice (2017) https://t.co/qKHSvp253V

Apr 17, 2022 · 1 like · 41,315 followers View post →
Brianna Stubbs
@BriannaStubbs · X

@ifbacongrewont1 @americanaging BHB lifespan (worms): https://t.co/9Yf0u2tRxT KD lifespan (mice) https://t.co/Mi6vgEsYfa KD lifespan (mice- replication) https://t.co/MWvL2YrzcZ Review discussing implications of ketones for longevity https://t.co/ISwXRMY67h

Jun 22, 2021 · 4,032 followers View post →
Agingdoc
@agingdoc1 · X

@Blagosklonny @kevinburch @foundmyfitness @prolonfmd Yes Misha,@prolonfmd is certainly tapping IIS/PI3K/AKT/mTORC & related nutrient-sensing pathways & network of hallmarks of aging. While SAA sensing is part of that picture too, on the VLCD (overlap) was most enamored by: 1) https://t.co/ICz9cSptDn & 2) https://t.co/pOWz7wr3rU

Aug 12, 2020 · 41,315 followers View post →
P.D. Mangan Health & Freedom Maximalist
@Mangan150 · X

@ChristianAssad Neither rats nor humans: Ketogenic Diet Reduces Midlife Mortality and Improves Memory in Aging Mice https://t.co/LcTfDziq4x

Oct 31, 2019 · 4 likes · 291,278 followers View post →
meteora
@Meteorapersa · X

RT @IlindelatorreMD: Una dieta cetogénica prolonga la longevidad y mejora la memoria en ratones que envejecen | Cell Metabolism https://t.…

Oct 22, 2019 · 1 share · 401 followers View post →
Dr. Ilin Gilberto de la Torre M.
@IlindelatorreMD · X

Una dieta cetogénica prolonga la longevidad y mejora la memoria en ratones que envejecen | Cell Metabolism https://t.co/I59bbCS1wW https://t.co/8Qm8h7ClJ4

Oct 21, 2019 · 5 likes · 1 share · 45,851 followers View post →