Aging (Albany NY) September 2017 PMID 28930701

Leukocyte telomere length, T cell composition and DNA methylation age.

Brian H Chen, Cara L Carty, Masayuki Kimura, Jeremy D Kark, Wei Chen, Shengxu Li, Tao Zhang, Charles Kooperberg, Daniel Levy, Themistocles Assimes, Devin Absher, Steve Horvath, Alexander P Reiner, Abraham Aviv

Mentions

3
Peak: 2 in Feb 2024
across 2 sources since Aug 2022

Extended reach

7,949
potential audience

Total likes

68

Video views

3,549

Mentions per month

Aug 2022 – Feb 2024

Where it's discussed

  • YouTube2 videos
  • X / Twitter1 posts

AI synopsis

What people are saying

The discussions reflect genuine interest and engagement, with comments referencing immune cell dynamics, telomere length, and the significance of epigenetic age for mortality, using words like 'important,' 'exciting,' and 'revealing' to underscore its potential influence on aging research.

AgreementModerate agreement

Most discussions recognize the importance of the research, emphasizing its relevance to aging and mortality predictions.

InterestHigh interest

Posts show high interest, with viewers engaging actively and referencing specific aspects like immune cell types and biological aging markers.

EngagementModerate engagement

There is thoughtful engagement, including mentions of methodology and implications, rather than dismissive remarks.

ImpactModerate impact

The content appears to have a moderate impact, as participants highlight its relevance for aging research and potential applications.

Abstract in brief

  • The study found that shorter leukocyte telomere length (LTL) is associated with higher extrinsic epigenetic age acceleration (EEAA), which predicts mortality, across multiple large cohort studies.
  • LTL was linked to specific immune cell compositions, being inversely related to memory CD8 T cells and positively related to naive CD8 T cells, indicating how immune aging influences biological age markers.
  • These results suggest that individuals with more memory T cells and fewer naive T cells tend to have shorter telomeres and older DNA methylation ages, helping explain why EEAA is a strong predictor of mortality.]

Top posts

Most liked on X and Bluesky
Aging-US
@AgingJrnl · X

Join us daily as we count down the 10 most popular Aging papers in 2023 (based on Crossref resolutions). #2023YearinReview #5: "Leukocyte telomere length, T cell composition and DNA methylation age" DOI: https://t.co/V4RF6uVHN9 https://t.co/FpJtRo5lrF

Feb 10, 2024 · 4 likes · 4,400 followers View post →

All mentions

Aging-US
@AgingJrnl · X

Join us daily as we count down the 10 most popular Aging papers in 2023 (based on Crossref resolutions). #2023YearinReview #5: "Leukocyte telomere length, T cell composition and DNA methylation age" DOI: https://t.co/V4RF6uVHN9 https://t.co/FpJtRo5lrF

Feb 10, 2024 · 4 likes · 4,400 followers View post →