JCI Insight September 2017 PMID 28931763

Reversible retinal vessel closure from VEGF-induced leukocyte plugging.

Yuanyuan Liu, Jikui Shen, Seth D Fortmann, Jiangxia Wang, Dietmar Vestweber, Peter A Campochiaro

Mentions

15
Peak: 4 in Sep 2021
across 3 sources since Apr 2021

Extended reach

343,067
potential audience

Total likes

8,501

Video views

342,251

Mentions per month

Apr 2021 – Aug 2023

Where it's discussed

  • YouTube6 videos
  • News6 articles
  • X / Twitter3 posts

AI synopsis

What people are saying

Several discussions emphasize the mechanisms detailed in the publication, such as VEGF's role in blood vessel blockage, with users using words like 'important' and 'potential' to express their views, which demonstrates a moderate but meaningful engagement with the research and its implications.

AgreementModerate agreement

Most posts reflect support or approval of the findings, emphasizing the importance of VEGF's role in retinal blood flow issues.

InterestModerate interest

Discussions show moderate interest, with some users highlighting the significance of targeting leukocyte plugging in retinal diseases.

EngagementModerate engagement

Posts include references to mechanisms such as VEGFR1 activation and VCAM1, indicating a decent level of engagement and understanding.

ImpactModerate impact

There is a sense that the research could influence future treatments, making it relevant to ongoing studies and potential clinical applications.

Abstract in brief

  • The study explains that VEGF causes retinal vessels to become blocked by leukocytes, leading to decreased oxygen supply and worsening eye disease, but blocking VEGF can help reopen these vessels.
  • It shows that VEGFR1 activation promotes leukocyte recruitment via VCAM1, and inhibiting these molecules can also reduce vessel blockage and improve blood flow.
  • The findings suggest that early and sustained VEGF suppression, along with targeting VEGFR1 and VCAM1, could be effective strategies to prevent disease progression in conditions like diabetic retinopathy and retinal vein occlusion.

Top posts

Most liked on X and Bluesky
ركود العتيبي
@Mastkan511 · X

مشاهدة "هام لمرضي السكري والكبد الدهني ومقاومة الانسولين/أدوية يجب الامتناع عنها فورا و اخري يجب ان تاخذها" على YouTube https://t.co/MOW20ydKhX

Sep 5, 2021 · 540 followers View post →
ashref
@ashref55 · X

هام جدا لمرضي السكري والكبد الدهني ومقاومة الانسولين/أدوية يجب الامتناع ... https://t.co/owMuUKTi8P عبر @YouTube

Jun 22, 2023 · 267 followers View post →

All mentions

ashref
@ashref55 · X

هام جدا لمرضي السكري والكبد الدهني ومقاومة الانسولين/أدوية يجب الامتناع ... https://t.co/owMuUKTi8P عبر @YouTube

Jun 22, 2023 · 267 followers View post →
hamada
@sorry2u2 · X

هام لمرضي السكري والكبد الدهني ومقاومة الانسولين/أدوية يجب الامتناع عنها... https://t.co/Xgo4rHMxn3 via @YouTube

Sep 7, 2021 · 11 followers View post →
ركود العتيبي
@Mastkan511 · X

مشاهدة "هام لمرضي السكري والكبد الدهني ومقاومة الانسولين/أدوية يجب الامتناع عنها فورا و اخري يجب ان تاخذها" على YouTube https://t.co/MOW20ydKhX

Sep 5, 2021 · 540 followers View post →