Natasha Trzaskalski
@NatashaTrza · X
@DanielJDrucker @Cell_Metabolism Another interesting paper to add to the bunch with liver specific transgenic mice https://t.co/9j3MW7aUHq
Jun 5, 2022 · 585 followers
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Mol Metab October 2017 PMID 29031724
Elevated hepatic DPP4 activity promotes insulin resistance and non-alcoholic fatty liver disease.
Mentions
19
Peak: 2 in Aug 2023
across 4 sources since Sep 2021
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Sep 2021 – Aug 2023Where it's discussed
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AI synopsis
What people are saying
The overall tone reflects neutral curiosity and academic interest, as seen in the brief comment about adding the paper to a collection and referencing liver-specific transgenic mice; the words are straightforward, indicating factual acknowledgment rather than passionate debate or critique.
AgreementModerate agreement
The mention of adding this paper to the collection suggests a positive perception of its scientific value, though there's no strong endorsement or critique.
InterestModerate interest
The focus on liver-specific transgenic mice indicates moderate interest, especially among those familiar with experimental models.
EngagementNeutral engagement
The discussion appears somewhat superficial, with only a brief mention without deeper analysis or discussion of implications.
ImpactNeutral impact
The post implies recognition of the paper's relevance but does not suggest it has an immediate or transformative impact.
Abstract in brief
- Elevated hepatic DPP4 activity is associated with the development of nonalcoholic fatty liver disease (NAFLD) and insulin resistance, as shown in a mouse model where liver-specific DPP4 overexpression led to increased liver fat, inflammation, and metabolic disturbances.
- In humans, individuals with NAFLD and insulin resistance have higher plasma DPP4 activity, and experiments with liver-specific DPP4 transgenic mice demonstrate that increased DPP4 causes weight gain, liver fat accumulation, and impaired insulin sensitivity, partly due to reduced levels of active GLP1.
- In vitro studies confirmed that DPP4 directly impairs insulin signaling in liver cells, suggesting that elevated DPP4 promotes NAFLD and insulin resistance through mechanisms involving both systemic effects (like lower GLP1) and local effects on liver cell function.
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Natasha Trzaskalski
@NatashaTrza · X
@DanielJDrucker @Cell_Metabolism Another interesting paper to add to the bunch with liver specific transgenic mice https://t.co/9j3MW7aUHq
Jun 5, 2022 · 585 followers
View post →
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