The fundamental theorem of natural selection with mutations.

William F Basener, John C Sanford

June 2018

Synopsis of Social media discussions

The discussions reflect a critical stance toward the article, with users citing it as evidence that mutation alone causes fitness decline, challenging traditional interpretations of evolution, as seen in phrases like 'falsify & flip Fisher's evolution theorem'. The tone varies from skeptical to analytical, engaging with technical and philosophical implications of the research, which highlights its potential impact but also reveals ongoing debates and controversy.

A
Agreement
 Low agreement

Most discussions challenge or criticize traditional views supported by the publication, indicating a tendency toward disagreement or skepticism.

I
Interest
 High level of interest

Posts show high interest by referencing complex theories, experiments, and debates about mutations and evolution.

E
Engagement
 High engagement

Many users deeply analyze the article, citing specific concepts, mathematical models, and scientific debates, demonstrating significant engagement.

I
Impact
 Moderate level of impact

Reactions focus on fundamental challenges to existing theories, suggesting their potential to influence ongoing scientific discussions, albeit with some skepticism.

Social Mentions

YouTube

5 Videos

Twitter

22 Posts

Blogs

4 Articles

Metrics

Video Views

4,262

Total Likes

152

Extended Reach

42,782

Social Features

31

Timeline: Posts about article

Top Social Media Posts

Posts referencing the article

Revised Fundamental Theorem of Natural Selection Includes Mutations

Revised Fundamental Theorem of Natural Selection Includes Mutations

This video explains how mutations influence the fundamental theorem of natural selection, providing a more realistic view of evolution by incorporating mutational effects alongside genetic variance.

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April 17, 2019

3,186 views

Revised Fundamental Theorem of Natural Selection Incorporating Mutations

Revised Fundamental Theorem of Natural Selection Incorporating Mutations

This video explains the fundamental theorem of natural selection, which states that the change in a species' average fitness equals its genetic variance. It also discusses how mutations impact this process, providing a more complete understanding of evolution.

Jornal da Ciência

July 25, 2019

479 views

Revising Natural Selection Theory: Incorporating Mutations for Accurate Evolution Insights

Revising Natural Selection Theory: Incorporating Mutations for Accurate Evolution Insights

The fundamental theorem of natural selection states that the rate of change in a species' average fitness equals its genetic variance. This video discusses how including mutations offers a more realistic view of evolution, emphasizing their significant impact on fitness changes.

Jornal da Ciência

June 1, 2021

401 views

Revised Fundamental Theorem of Natural Selection Incorporating Mutations

Revised Fundamental Theorem of Natural Selection Incorporating Mutations

This video revisits Fisher's fundamental theorem of natural selection by including mutations, revealing how mutational effects influence evolutionary change beyond genetic variance alone, offering a more comprehensive understanding of natural selection processes.

Jornal da Ciência

September 25, 2019

141 views

Revised Fundamental Theorem of Natural Selection with Mutations Explained

Revised Fundamental Theorem of Natural Selection with Mutations Explained

A review of Fisher's original theorem and the impact of mutations on natural selection, highlighting a new model that incorporates mutational effects for a more realistic view of evolution.

Luca Medugno

July 26, 2022

56 views

  • Sidetracked
    @SDAFS56788141 (Twitter)

    @Barney02073101 @TheHistoryGuy07 @AiG and another https://t.co/WWLvMmDgDC
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    October 19, 2025

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    @SDAFS56788141 (Twitter)

    @Just1Atheist @WComing78932759 @joeandthegiant @AgainstAtheismX https://t.co/AdCowxFeg1
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    October 14, 2025

  • Protestant Nightcrawler
    @PNightcrawler (Twitter)

    @Obsidiansand9 @QuestionErythng @AiG Okay, my bad, read this one instead: https://t.co/lc11cRCegU
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    August 20, 2025

  • Sidetracked
    @SDAFS56788141 (Twitter)

    @_OKJ__ @NotEvolution1 @Jaydon225 Here's one which reconsiders mutation and selection. https://t.co/AdCowxFeg1
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    May 10, 2025

  • Sidetracked
    @SDAFS56788141 (Twitter)

    @MKSVPER @jphook87_JLewis @oliverburdick Net loss https://t.co/AdCowxFeg1
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    April 3, 2025

  • Boch Choi
    @RealBochChoi (Twitter)

    @GSpellchecker https://t.co/uWIUP3Tliy
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    March 25, 2025

  • Jan van Meerten
    @JanvanMeerten (Twitter)

    @Scylaxx @JongGerdien De paper waar op gereageerd wordt is eveneens verschenen in Journal of Mathematical Biology. Voor de volledigheid: https://t.co/uUls41rNtM.
    view full post

    August 28, 2024

  • نبيل
    @nobel650 (Twitter)

    @ALNYJD https://t.co/gcxtOsA7F3 وممكن ترفق لنا كيف استحالة التطور رياضيا ؟ لأن المبادئ الأساسية كلها مفسرة رياضيا ومرفق لك معادلاتها -مع العلم اننا ما نحتاج لدليل رياضي على أن الطيارة تطير- ومرة أخرى اقولك لا تنقل شيء ما تفهمه . https://t.co/TtpDoUBbPm
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    July 2, 2024

  • Kawai_Yusuke
    @fiddler_K (Twitter)

    創造論者によるフィッシャーの基本定理に対する誤読による批判論文（https://t.co/9xQFrAv8FB）への反論/Fisher, Fitness, and the Fundamentals of Population Genetics -Panda'sThumb-https://t.co/UOZ7wVWnnO
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    April 25, 2024

  • (Sichu Lu(Sichu.Lu218@proton.me)
    @lu_sichu (Twitter)

    https://t.co/hqLLWLGoHZ
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    July 19, 2023

    3

  • TheScienceSays….
    @ScientiaRerum (Twitter)

    The study of genetics and the emerging concept of entropy is fascinating! Check this... William F. Basener / John C. Sanford The Journal of Mathematical Biology https://t.co/LK1vUMZGGI #Genetics #ScienceTwitter #sciencefactsamazing
    view full post

    August 30, 2021

    1

  • FRANCISCO CHAVEZ
    @Fco_Chavez_ (Twitter)

    RT @tdibrasilorg: @biohackerslab @DurationHealth A Humanidade precisa urgente de biohackers "https://t.co/BxSCqwiZEl">https://t.co/BxSCqwiZ…
    view full post

    August 18, 2021

    1

  • Jornal da Ciência (jornaldaciencia.com.br)
    @tdibrasilorg (Twitter)

    @biohackerslab @DurationHealth A Humanidade precisa urgente de biohackers "https://t.co/BxSCqwiZEl">https://t.co/BxSCqwiZEl
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    June 1, 2021

    1

    1

  • Jornal da Ciência (jornaldaciencia.com.br)
    @tdibrasilorg (Twitter)

    A Humanidade precisa urgente de biohackers https://t.co/BxSCqwiZEl via @YouTube
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    June 1, 2021

  • Yohan J. John
    @DrYohanJohn (Twitter)

    "What we have discovered is that, contrary to Fisher’s claim, continuously increasing population fitness is not an inherent property of life. Mutations by themselves drive fitness down." https://t.co/6lwQ1uZR7e
    view full post

    February 9, 2021

    1

  • KSG4JESUS
    @Prince_Kindou (Twitter)

    @albynn2 @mizzati21 @SVimaire Pardon pour le retard, les aléas de la vie... Je l'ai trouvé : https://t.co/4twMOBZpb3 Via cette article https://t.co/6ClWSJlwfb
    view full post

    July 18, 2020

  • Hannington Bukomeko
    @hbukomeko (Twitter)

    @Viktor_shinski @cobbo3 As science advanced, mathematicians found the maths inadequate and have since written to expose the weakness in the theorem. Science is not a religion. Things change. Some know earlier than others and pass it on. https://t.co/a8aws8knXw now go and be ignorant no more
    view full post

    November 12, 2019

  • Hannington Bukomeko
    @hbukomeko (Twitter)

    @Viktor_shinski @cobbo3 Evolution assumes adaptation through the mutation-selection process and was mathematically supported by Fisher's theorem of natural selection. the theorem was debunked https://t.co/a8aws8knXw and the math does not add up. https://t.co/Vjp6cCPUl3
    view full post

    November 11, 2019

  • Curiosa Biología
    @CuriosaBiologia (Twitter)

    @JACKRODAS2 @Solof1sincirco @Hjorvik @DrBioblogo @VaronDSchrdngr @Papelicoblanco @VaryIngweion @loq_digalarubia @jamoncillos @carbonlump @octaup94 @_ShiroCC_ @laurabaguirre @GGallegos24 "The fundamental theorem of natural selection with mutations” "Using computer simulation to understand mutation accumulation dynamics and genetic load” "Expression of an antimicrobial peptide via the chloroplast genome to control phytopathogenic bacteria and fungi”.
    view full post

    May 15, 2019

    1

  • David Murdoch
    @DavidMurdochArt (Twitter)

    @JamesonCal After we re-formulated Fisher’s model...with a more realistic distribution of mutations the population often undergoes perpetual fitness decline. https://t.co/A8dDeNURD4
    view full post

    March 21, 2019

    1

  • David L. Hagen
    @DavidLHagen (Twitter)

    @EdDarrell You can't even have evolution until you solve abiogenesis. Now Basener & Sanford 2017 show mutations quantitatively degrade, not increase fitness. You bear the scientific burden of proof to overcome those barriers https://t.co/sMuIR2FpNm
    view full post

    February 26, 2019

  • David L. Hagen
    @DavidLHagen (Twitter)

    Yes Basener & Sanford 2017 falsify & flip Fisher's evolution theorem, showing mutations in real populations cause decreasing fitness. https://t.co/lv7DTJpLWA Michael J Behe cites & published peer reviewed literature. See Scholar https://t.co/uk4JILNIDW Why continue to smear Behe? https://t.co/O4KPpd4K3S
    view full post

    February 26, 2019

Abstract Synopsis

  • The text discusses the fundamental theorem of natural selection, originally proposed by R. A. Fisher in 1935, which states that the rate of change of a species' average fitness is equal to its genetic variance but does not consider mutations.
  • The authors reexamine Fisher's theorem by including mutations in their model, showing that the change in mean fitness is influenced by both genetic variance and mutational effects, leading to a revised version called the fundamental theorem of natural selection with mutations.
  • This new theorem provides a more realistic and detailed understanding of evolution, highlighting that mutations significantly impact the process, which differs from Fisher’s original vision that assumed mutations would continually increase fitness without limitations.