PubHawk
Gerontology November 2018 PMID 29190625

mTOR as Regulator of Lifespan, Aging, and Cellular Senescence: A Mini-Review.

Thomas Weichhart

Full text PDF Download social card

Mentions

28
Peak: 7 in May 2022
across 5 sources since Feb 2022

Extended reach

62,845
potential audience

Total likes

335

Video views

10,127

Mentions per month

Feb 2022 – Jul 2024

Where it's discussed

  • News12 articles
  • X / Twitter8 posts
  • Facebook3 posts
  • Blogs3 articles
  • YouTube2 videos

AI synopsis

What people are saying

The overall tone reflects strong agreement and high interest, exemplified by comments about rapamycin being the 'only known pharmacological intervention' that can extend lifespan, and references to the research as a significant breakthrough. The tone and choice of words like 'reduces DNA damage' and 'highly conserved pathway' convey both enthusiasm and recognition of the research’s potential impact on aging therapies.

AgreementModerate agreement

Most comments clearly support the significance of mTOR in aging research, emphasizing its role and the potential of inhibitors like rapamycin.

InterestHigh interest

Discussions show high enthusiasm and curiosity, with posters referencing the article's implications for lifespan extension and aging therapies.

EngagementModerate engagement

While some posts briefly share reactions, others delve deeper into mechanisms and significance, indicating moderate but meaningful engagement.

ImpactHigh impact

The discussions recognize the profound implications of mTOR research, especially highlighting pharmacological interventions as potentially transformative.

Abstract in brief

  • mTOR is a highly conserved cellular signaling pathway that helps cells respond to nutrients and growth signals, coordinating growth, cell death, and inflammation depending on the context.
  • Research shows that mTOR activity influences aging and lifespan, with inhibiting mTOR complex 1 (mTORC1) using rapamycin being the only known drug that extends lifespan across multiple organisms.
  • The review explores how mTOR controls aging-related processes like cellular aging, metabolism, and stem cell function, which could lead to new therapies for aging and age-related diseases.]
Read the full abstract

Top posts

Most liked on X and Bluesky
Greenlandshark
@greenlandsharky · X

mTOR as Regulator of #Lifespan , Aging, and Cellular #Senescence : A Mini-Review - FullText - Gerontology 2018, Vol. 64, Karger Publishers #mTOR inhibitors are currently the “ONLY known pharmacological intervention that increases lifespan”, #Rapamycin https://t.co/DBtoIGL0oi

May 4, 2022 · 10 likes · 3 shares · 325 followers View post →
Agingdoc
@agingdoc1 · X

mTOR as Regulator of Lifespan, Aging, and Cellular Senescence: A Mini-Review (2018) https://t.co/bheioIyD1X https://t.co/jUvDzkEsOD

May 4, 2022 · 7 likes · 1 share · 42,567 followers View post →
Tavis Piattoly,MS,RD
@TavisPiattoly · X

@rafaellugomd @davidasinclair His objective for reducing protein is to inhibit mTOR signaling which reduces DNA damage and extends life. https://t.co/qazLNkGpIo.

Jul 11, 2022 · 6 likes · 2,331 followers View post →
Rapamycin News
@RapaNews · X

RT @healthspanhack: mTOR as Regulator of #Lifespan , Aging, and Cellular #Senescence : A Mini-Review - FullText - Gerontology 2018, Vol. 64…

May 5, 2022 · 3 shares · 5,345 followers View post →
Charles Nelson
@_Biohacking · X

RT @healthspanhack: mTOR as Regulator of #Lifespan , Aging, and Cellular #Senescence : A Mini-Review - FullText - Gerontology 2018, Vol. 64…

May 4, 2022 · 3 shares · 1,410 followers View post →
peter mossop
@mostol1 · X

mTOR as Regulator of Lifespan, Aging, and Cellular Senescence: A Mini-Review - FullText - Gerontology 2018, Vol. 64, No. 2 - Karger Publishers https://t.co/Bb9fGoDuxb

May 4, 2022 · 357 followers View post →

All mentions

Tavis Piattoly,MS,RD
@TavisPiattoly · X

@rafaellugomd @davidasinclair His objective for reducing protein is to inhibit mTOR signaling which reduces DNA damage and extends life. https://t.co/qazLNkGpIo.

Jul 11, 2022 · 6 likes · 2,331 followers View post →
Dr. Boopathi Seenivasan
@iamboopathi · X

RT @healthspanhack: mTOR as Regulator of #Lifespan , Aging, and Cellular #Senescence : A Mini-Review - FullText - Gerontology 2018, Vol. 64…

May 6, 2022 · 3 shares · 153 followers View post →
Rapamycin News
@RapaNews · X

RT @healthspanhack: mTOR as Regulator of #Lifespan , Aging, and Cellular #Senescence : A Mini-Review - FullText - Gerontology 2018, Vol. 64…

May 5, 2022 · 3 shares · 5,345 followers View post →
Vivia Sthel
@vivia_sthel · X

RT @agingdoc1: mTOR as Regulator of Lifespan, Aging, and Cellular Senescence: A Mini-Review (2018) https://t.co/bheioIyD1X https://t.co/jU…

May 5, 2022 · 1 share · 203 followers View post →
Charles Nelson
@_Biohacking · X

RT @healthspanhack: mTOR as Regulator of #Lifespan , Aging, and Cellular #Senescence : A Mini-Review - FullText - Gerontology 2018, Vol. 64…

May 4, 2022 · 3 shares · 1,410 followers View post →
Greenlandshark
@greenlandsharky · X

mTOR as Regulator of #Lifespan , Aging, and Cellular #Senescence : A Mini-Review - FullText - Gerontology 2018, Vol. 64, Karger Publishers #mTOR inhibitors are currently the “ONLY known pharmacological intervention that increases lifespan”, #Rapamycin https://t.co/DBtoIGL0oi

May 4, 2022 · 10 likes · 3 shares · 325 followers View post →
peter mossop
@mostol1 · X

mTOR as Regulator of Lifespan, Aging, and Cellular Senescence: A Mini-Review - FullText - Gerontology 2018, Vol. 64, No. 2 - Karger Publishers https://t.co/Bb9fGoDuxb

May 4, 2022 · 357 followers View post →
Agingdoc
@agingdoc1 · X

mTOR as Regulator of Lifespan, Aging, and Cellular Senescence: A Mini-Review (2018) https://t.co/bheioIyD1X https://t.co/jUvDzkEsOD

May 4, 2022 · 7 likes · 1 share · 42,567 followers View post →