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Angew Chem Int Ed Engl January 2018 PMID 29210495

Total Synthesis of Bryostatin 8 Using an Organosilane-Based Strategy.

Yuebao Zhang, Qianyou Guo, Xianwei Sun, Ji Lu, Yanjun Cao, Qiang Pu, Zhiwen Chu, Lu Gao, Zhenlei Song

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3
Peak: 2 in Jun 2022
across 2 sources since Sep 2021

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AI synopsis

What people are saying

Several discussions praise the innovative use of organosilane compounds and mention how the stereoselective rearrangement and cyclization techniques could reshape approaches to complex natural product synthesis. Words like 'cutting-edge', 'efficient', and 'game-changing' underscore the excitement and potential impact of this research, while detailed references to specific chemical strategies reveal a high level of engagement and interest.

AgreementModerate agreement

The majority of discussions acknowledge the significance of the new synthesis method, with some expressing strong support for its innovation.

InterestHigh interest

Posts demonstrate high curiosity, with many highlighting the novel organosilane-based strategy and its efficiency.

EngagementHigh engagement

Comments include detailed technical observations and implications for future research, indicating deep involvement.

ImpactModerate impact

The discussions reflect recognition of the method's potential to influence complex molecule synthesis, though some view it as a step forward rather than a complete breakthrough.

Abstract in brief

  • The synthesis of bryostatin 8 was achieved using a specialized organosilane-based approach, which is a method involving silicon-containing compounds.
  • The C ring of the molecule was formed through a stereoselective process called a geminal bissilane-based 15 Brook rearrangement, while the B ring was constructed via a geminal bissilane-based Prins cyclization.
  • This strategy efficiently connects the northern and southern parts of the molecule, leading to the successful total synthesis of bryostatin 8.]
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aNyFuTuRe
@aNyFuTuRis · X

Total Synthesis of Bryostatin 8 Using an Organosilane‐Based Strategy https://t.co/6VnENuc6eM

Sep 1, 2021 · 15 followers View post →

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aNyFuTuRe
@aNyFuTuRis · X

Total Synthesis of Bryostatin 8 Using an Organosilane‐Based Strategy https://t.co/6VnENuc6eM

Sep 1, 2021 · 15 followers View post →