PubHawk
March 2018 PMID 29249689

NAD Intermediates: The Biology and Therapeutic Potential of NMN and NR.

Jun Yoshino, Joseph A Baur, Shin-Ichiro Imai

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Mentions

19
Peak: 4 in Sep 2023
across 6 sources since Sep 2020

Extended reach

227,199
potential audience

Total likes

2,593

Video views

211,364

Mentions per month

Sep 2020 – Aug 2025

Where it's discussed

  • X / Twitter11 posts
  • Facebook3 posts
  • YouTube2 videos
  • Instagram1 posts
  • News1 articles
  • Blogs1 articles

AI synopsis

What people are saying

The discussions reveal strong enthusiasm and support for NAD intermediates like NMN and NR as promising anti-aging and neuroprotective agents, with users mentioning ongoing research, clinical trials, and the compounds' potential to revolutionize treatments. The tone reflects curiosity and optimistic anticipation, evidenced by phrases like 'important evidence' and 'excellent scheme,' which underscore both scientific interest and perceived impact.

AgreementModerate agreement

Most users agree that NAD intermediates like NMN and NR show promising potential, especially highlighting their relevance to aging and neurodegeneration.

InterestHigh interest

Discussions frequently mention specific compounds and their roles, indicating high interest in the scientific and therapeutic implications.

EngagementModerate engagement

Comments reference research, clinical trials, and potential therapies, showing moderate depth of engagement with technical details.

ImpactModerate impact

There is recognition that these NAD precursors could significantly influence aging research and treatment options, though it’s still an emerging topic.

Abstract in brief

  • Research on NAD, especially its intermediates NMN and NR, has advanced our understanding of aging and related diseases, showing potential for prevention and treatment.
  • Although their exact metabolic pathways and how they behave in different tissues are still being studied, NMN and NR have unique roles influenced by tissue-specific enzymes and transporters.
  • A comprehensive theory links NAD metabolism to aging and lifespan, and current efforts are focusing on translating these promising findings from animal studies into human health benefits.
Read the full abstract

Top posts

Most liked on X and Bluesky
Betterbrand Health
@trybetterbrand · X

@jitterbug212 @heather_kayne @TheCryptoDog @KoroushAK https://t.co/BbPRweGW4W Precursors to NAD+, which is involved in a large number of cellular processes in the body. NR is an ingredient that one company has a monopoly on and they fund clinical trials. NMN is an ingredients open to all and there are also RCTs.

Sep 28, 2020 · 3 likes · 7,049 followers View post →
Dr. Hernández-Reyes, A. RD, MSc, PhD
@albertohdez · X

Otro excelente esquema, para ampliar info (10.1016/j.cmet.2017.11.002) https://t.co/progAwzNAZ

Jan 21, 2023 · 2 likes · 2,022 followers View post →
みどたぬ
@pinset710 · X

結局風呂入らん方が肌バリアなくならんし強いな 悟ったわ https://t.co/4XlgfLwcQk

Nov 12, 2023 · 1 like · 2,707 followers View post →
虹色@ゾナテツ
@_nijiiro · X

セラミド入り化粧水や乳液は意味ないってこと？ https://t.co/SdDS6F4tkx 教えて北条元治先生！

Feb 17, 2024 · 1 like · 443 followers View post →
stever liu
@steverliu · X

@NaturallyFTW @ShaneyWright @seadale1 nicotinamide mononucleotide (NMN) is another NAD precursor https://t.co/CeuH3kDPs9

Mar 9, 2022 · 1 like · 103 followers View post →
juniorjuri
@juniorjuri · X

NAD+ Intermediates: The Biology and Therapeutic Potential of NMN and NR https://t.co/mkFLlIxzQU hey provide important evidence to complement traditional treatments for neurodegeneration.

Oct 3, 2024 · 1,486 followers View post →

All mentions

ジャム
@chiko_hokkori2 · X

【セラミド】続・肌再生の専門家が、天然でオーガニックで最高のスキンケア保湿剤を紹介します https://t.co/PPyEIOY6Ht @YouTubeより

Nov 14, 2024 · 50 followers View post →
juniorjuri
@juniorjuri · X

NAD+ Intermediates: The Biology and Therapeutic Potential of NMN and NR https://t.co/mkFLlIxzQU hey provide important evidence to complement traditional treatments for neurodegeneration.

Oct 3, 2024 · 1,486 followers View post →
虹色@ゾナテツ
@_nijiiro · X

セラミド入り化粧水や乳液は意味ないってこと？ https://t.co/SdDS6F4tkx 教えて北条元治先生！

Feb 17, 2024 · 1 like · 443 followers View post →
みどたぬ
@pinset710 · X

結局風呂入らん方が肌バリアなくならんし強いな 悟ったわ https://t.co/4XlgfLwcQk

Nov 12, 2023 · 1 like · 2,707 followers View post →
ryota*
@_crty_ · X

【セラミド】続・肌再生の専門家が、天然でオーガニックで最高のスキンケア保湿剤を紹介します https://t.co/uDq19hBaNE @YouTubeより

Sep 30, 2023 · 202 followers View post →
Dr. Hernández-Reyes, A. RD, MSc, PhD
@albertohdez · X

Otro excelente esquema, para ampliar info (10.1016/j.cmet.2017.11.002) https://t.co/progAwzNAZ

Jan 21, 2023 · 2 likes · 2,022 followers View post →
stever liu
@steverliu · X

@NaturallyFTW @ShaneyWright @seadale1 nicotinamide mononucleotide (NMN) is another NAD precursor https://t.co/CeuH3kDPs9

Mar 9, 2022 · 1 like · 103 followers View post →
Moises Hernandez MD
@drmoyhv · X

Therapeutic potential on boosting NAD+ with NMN and NR. https://t.co/Uh6YCSWspd #nad #nmn #nr #LONGEVITY #aging #research #scienceandtechnology

Dec 15, 2021 · 94 followers View post →
bladerunner
@bladerunner3049 · X

https://t.co/4CLlGna4RY

Nov 24, 2021 · 810 followers View post →
bladerunner
@bladerunner3049 · X

#aging #longevity #NMN #NR https://t.co/4CLlGna4RY

Sep 5, 2021 · 810 followers View post →
Betterbrand Health
@trybetterbrand · X

@jitterbug212 @heather_kayne @TheCryptoDog @KoroushAK https://t.co/BbPRweGW4W Precursors to NAD+, which is involved in a large number of cellular processes in the body. NR is an ingredient that one company has a monopoly on and they fund clinical trials. NMN is an ingredients open to all and there are also RCTs.

Sep 28, 2020 · 3 likes · 7,049 followers View post →
Mitochondrial DNA and Parkinson's disease | Neurology
Blogs

https://doi.org/10.1016/j.cmet.2018.05.011 · Crossref. Ahmad Saedisomeolia ... https://doi.org/10.1016/bs.afnr.2017.11.002 · Crossref. J. William Langston ...

Jan 4, 2026 View →
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Facebook

... J., Baur, J. A., & Imai, S. (2018). NAD⁺ intermediates: The ... https: //doi.org/10.1016/j.cmet.2017.11.002 ‼️ Recuerda que lo más ...

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Instagram

9 likes, 0 comments - funktion.id，May 24, 2025 : "Tired, Inflamed, and Gaining Fat? It's Not Just About Food.

May 27, 2025 View →
幫大家結論一下：市售貴仙仙的NMN都是敲盤子用的。 前幾天有廠商 ...
Facebook

doi: 10.1016/j.cmet.2017.11.002 3. Palmer RD, Elnashar MM, Vaccarezza M. Precursor comparisons for the upregulation of nicotinamide adenine ...

Sep 22, 2023 View →
主要對於抗老化可能有助益。 體內煙酰胺腺嘌呤二核苷酸(NAD+) 會隨 ...
Facebook

doi:10.1016/j.cmet. 2017.11.002 3. Palmer RD, Elnashar MM, Vaccarezza M. Precursor comparisons for the upregulation of nicotinamide adenine ...

Sep 22, 2023 View →
Nicotinamide mononucleotide increases muscle insulin sensitivity in ...
News

doi:10.1016/j.cmet.2017.11.002 Medline. 6. S. Imai, J. Yoshino, The importance of NAMPT/NAD/SIRT1 in the systemic regulation of metabolism ...

Apr 22, 2021 View →