April 2018 PMID 29316249

The mitochondrial ATP synthase is a shared drug target for aging and dementia.

Joshua Goldberg, Antonio Currais, Marguerite Prior, Wolfgang Fischer, Chandramouli Chiruta, Eric Ratliff, Daniel Daugherty, Richard Dargusch, Kim Finley, Pau B Esparza-Moltó, José M Cuezva, Pamela Maher, Michael Petrascheck, David Schubert

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Mentions

Peak: 2 in Sep 2019

across 6 sources since Jul 2018

Extended reach

11,206

potential audience

Total likes

167

Video views

6,170

Mentions per month

Jul 2018 – May 2020

Where it's discussed

Facebook12 posts
News9 articles
Blogs4 articles
X / Twitter2 posts
YouTube2 videos
Reddit2 posts

AI synopsis

What people are saying

The collected discussions mainly consist of straightforward posts sharing the article's main message, such as recognizing ATP synthase as a shared drug target, with no detailed commentary or debate. The tone is neutral and factual, reflecting a general acknowledgment rather than active engagement or disagreement.

AgreementModerate agreement

The limited number of posts suggests mild support or acknowledgment of the article's findings, with no indication of disagreement.

InterestNeutral interest

The discussions show minimal curiosity or enthusiasm; the posts are mostly straightforward shares rather than detailed analysis.

EngagementLow engagement

Posts are brief and lack detailed comments or questions, indicating low depth of involvement.

ImpactModerate impact

The simplicity and brevity of the discussions imply a perceived moderate importance without widespread debate or substantial influence.

Abstract in brief

The study uncovers a molecular connection between aging and dementia by identifying mitochondrial ATP synthase (ATP5A) as the target of the Alzheimer's drug candidate J147, which influences cellular calcium and longevity pathways.
J147's action on ATP synthase modulates mitochondrial functions, preventing age-related changes in brain gene expression and metabolites in mice and extending lifespan in fruit flies, linking aging processes to dementia.
The findings suggest that developing drugs targeting aging mechanisms, like ATP synthase, could effectively treat age-associated dementia, highlighting a close molecular relationship between aging and neurodegenerative diseases.]

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All mentions

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J147 Alzheimer's Drug Targets Mitochondrial ATP Synthase to Extend Lifespan

The study uncovers a molecular connection between aging and dementia by identifying mitochondrial ATP synthase as the target of J147, an Alzheimer's drug candidate that influences cellular calcium and longevity pathways.

UCer Channel · Jul 11, 2018 57 views

Doctor Lâm - Chuyên gia tư vấn sức khỏe online

@tsnguyenthilam · X

Sep 23, 2019 · 5 followers View post →

Marcia S Newman

@marciasgreen · X

RT @_INPST: The mitochondrial ATP synthase is a shared drug target for aging and dementia https://t.co/nqWv4I2uY6 #INPST #Science #Health…

Sep 23, 2019 · 31 shares · 4,970 followers View post →