A genetically encoded Ca indicator based on circularly permutated sea anemone red fluorescent protein eqFP578.

Yi Shen, Hod Dana, Ahmed S Abdelfattah, Ronak Patel, Jamien Shea, Rosana S Molina, Bijal Rawal, Vladimir Rancic, Yu-Fen Chang, Lanshi Wu, Yingche Chen, Yong Qian, Matthew D Wiens, Nathan Hambleton, Klaus Ballanyi

January 2018 BMC Biol

Synopsis of Social media discussions

The discussions reflect a generally positive attitude, with phrases like 'missed it,' indicating curiosity and recognition of the publication's importance, and mentions of the genetically encoded calcium indicator's advantages, implying anticipation of future research benefits.

A
Agreement
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Most discussions acknowledge the significance of the research, with some expressing enthusiasm about its potential improvements.

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Interest
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Participants show moderate interest, mentioning the technological advancements and potential applications.

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Comments include references to the methodological aspects and implications, indicating active engagement.

I
Impact
 Moderate level of impact

The conversations suggest an optimistic view of the publication's potential influence in neuroscience and cellular imaging.

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    In case you missed it: A genetically encoded Ca2+ indicator based on circularly permutated sea anemone red fluorescent protein eqFP578 https://t.co/WV5ZJ2cBYq
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    May 7, 2019

Abstract Synopsis

  • This text discusses a new genetically encoded calcium indicator (GECI) called KGECO1, made from a red fluorescent protein derived from sea anemone, which helps scientists track calcium activity in cells for neuroscience research.
  • KGECO1 offers advantages like deeper tissue imaging and multicolor options due to its red fluorescence, with performance already comparable or better than existing GECIs, and it works well in different cell types and live animal models.
  • Future improvements could make KGECO1 even more effective, potentially surpassing current top red GECIs by reducing issues like lysosomal buildup and enhancing sensitivity and kinetics.]