PubHawk
Science January 2018 PMID 29371440

Spermidine in health and disease.

Frank Madeo, Tobias Eisenberg, Federico Pietrocola, Guido Kroemer

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Mentions

61
Peak: 3 in Aug 2023
across 6 sources since Apr 2020

Extended reach

152,591
potential audience

Total likes

2,419

Video views

115,730

Mentions per month

Apr 2020 – Jan 2026

Where it's discussed

  • News26 articles
  • X / Twitter15 posts
  • Blogs8 articles
  • Facebook6 posts
  • YouTube5 videos
  • Bluesky1 posts

AI synopsis

What people are saying

The discussions show a strong support for the potential health benefits of spermidine, with posts stating that it 'helps maintain mitochondrial health' and 'could be a game changer' in aging and disease prevention, highlighting excitement and curiosity about its applications. The tone and choice of words emphasize a positive outlook, with some references to scientific studies that bolster the perceived significance of the compound.

AgreementModerate agreement

Most discussions support the idea that spermidine has potential health benefits, with comments about its positive effects and references to supporting studies.

InterestHigh interest

Many posts express curiosity and enthusiasm for the topic, especially regarding its impact on aging and health, indicating high interest.

EngagementModerate engagement

Participants are referencing studies, suggesting a moderate level of engagement, but most comments are brief and not deeply analytical.

ImpactModerate impact

While some posts mention possible health improvements and the significance of spermidine, overall impact appears moderate, as discussions are mostly about potential rather than confirmed results.

Abstract in brief

  • Spermidine, a natural compound found in foods, is being studied for its potential to delay aging and protect against diseases like heart disease, neurodegeneration, and cancer by mimicking effects of caloric restriction.
  • It helps maintain mitochondrial health, reduces inflammation, and prevents stem cell aging by activating cellular processes like autophagy, which clean out damaged cell parts.
  • Because spermidine is already part of a regular diet, clinical trials to enhance its intake are considered feasible, and epidemiological studies suggest it may be linked to lower rates of cardiovascular disease and cancer in humans.]
Read the full abstract

Top posts

Most liked on X and Bluesky
文月宵(ケトン人)
@fumizukishou_bc · X

ポリアミンの中でも最も効果が高いのがスペルミジン 食品でスペルミジンがとにかく多いのが納豆な訳でね？ 機序はオートファジー誘導からだと言われる 食事によるポリアミンの摂取は、ヒトの疫学研究における心血管系および癌関連の死亡率の低下と相関しています。https://t.co/GtAKePsDcK

Apr 29, 2021 · 10 likes · 722 followers View post →
老化を遅らせることに成功しているかも
@roukaokurasu · X

”スペルミジンはミトコンドリアの機能を維持し、抗炎症特性を示し、幹細胞の老化を防ぎます。 機構的には、他のカロリー制限模倣物が関与する分子経路を共有します。これはタンパク質の脱アセチル化を誘導し、機能的なオートファジーに依存します。” https://t.co/u9CUj8SSli

Sep 30, 2023 · 4 likes · 1 share · 2,497 followers View post →
老化を遅らせることに成功しているかも
@roukaokurasu · X

”スペルミジンはオートファジーを誘導し、オートファジー阻害によりスペルミジンの効果のほとんどが抑制されますが、このポリアミンの健康改善作用には別のメカニズムも関与していると考えられています。” https://t.co/u9CUj8SSli

Aug 4, 2023 · 1 like · 2,497 followers View post →
老化を遅らせることに成功しているかも
@roukaokurasu · X

Aug 4, 2023 · 1 like · 2,497 followers View post →
Kat Fu, M.S., M.S.
@thekatfu · X

Nov 29, 2023 · 18,052 followers View post →
AmericasLastChance
@BeholdAmerica · X

@MikeOMara Have you tried hyperbaric oxygen chamber? IV amino acids? Spermidine supplement? https://t.co/1ue8F5iDXu

Jan 16, 2023 · 3,257 followers View post →

All mentions

Michael Raddatz
@michaelraddatz.bsky.social · Bluesky

3/ The authors hypothesized that spermidine could be used to augment mitochondrial function (

Mar 24, 2025 · 1 share View post →
Kat Fu, M.S., M.S.
@thekatfu · X

Nov 29, 2023 · 18,052 followers View post →
たまご普通
@tama5slot · X

RT @roukaokurasu: ”スペルミジンはミトコンドリアの機能を維持し、抗炎症特性を示し、幹細胞の老化を防ぎます。 機構的には、他のカロリー制限模倣物が関与する分子経路を共有します。これはタンパク質の脱アセチル化を誘導し、機能的なオートファジーに依存します。” ht…

Oct 5, 2023 · 1 share · 105 followers View post →
老化を遅らせることに成功しているかも
@roukaokurasu · X

”スペルミジンはミトコンドリアの機能を維持し、抗炎症特性を示し、幹細胞の老化を防ぎます。 機構的には、他のカロリー制限模倣物が関与する分子経路を共有します。これはタンパク質の脱アセチル化を誘導し、機能的なオートファジーに依存します。” https://t.co/u9CUj8SSli

Sep 30, 2023 · 4 likes · 1 share · 2,497 followers View post →
Andy Spark
@AndySpark25 · X

@Zero_Long_Covid @wodarg Einfach googeln Da sind Menge Artikeln und auch Studien https://t.co/PskRlkmw37

Aug 31, 2023 · 127 followers View post →
老化を遅らせることに成功しているかも
@roukaokurasu · X

”スペルミジンはオートファジーを誘導し、オートファジー阻害によりスペルミジンの効果のほとんどが抑制されますが、このポリアミンの健康改善作用には別のメカニズムも関与していると考えられています。” https://t.co/u9CUj8SSli

Aug 4, 2023 · 1 like · 2,497 followers View post →
老化を遅らせることに成功しているかも
@roukaokurasu · X

Aug 4, 2023 · 1 like · 2,497 followers View post →
SDpeggysue
@XpfG99 · X

Spermidine in health and disease https://t.co/o3TXzooRdM

May 7, 2023 · 1,349 followers View post →
AmericasLastChance
@BeholdAmerica · X

@MikeOMara Have you tried hyperbaric oxygen chamber? IV amino acids? Spermidine supplement? https://t.co/1ue8F5iDXu

Jan 16, 2023 · 3,257 followers View post →
fun nunn
@funnynunn · X

Spermidine in health and disease - PubMed https://t.co/AQDf2oqMYo

Jul 15, 2022 · 413 followers View post →
DrShem
@DrShem · X

Yes, you should swallow. You'll look younger. https://t.co/YCyRnhhAIj https://t.co/2P40cu6FYD

Feb 7, 2022 · 446 followers View post →
luis hernan graffe
@hernangraffe · X

"Spermidine in health and disease | Science" https://t.co/EtvU8Zl7Yc

Jul 26, 2021 · 3,119 followers View post →
文月宵(ケトン人)
@fumizukishou_bc · X

ポリアミンの中でも最も効果が高いのがスペルミジン 食品でスペルミジンがとにかく多いのが納豆な訳でね？ 機序はオートファジー誘導からだと言われる 食事によるポリアミンの摂取は、ヒトの疫学研究における心血管系および癌関連の死亡率の低下と相関しています。https://t.co/GtAKePsDcK

Apr 29, 2021 · 10 likes · 722 followers View post →
F.Yusufzai
@obsurfer84 · X

Spermidine in health and disease https://t.co/Uur8UAV8Vu outline of the mechanisms of spermidine-mediated health effects.

Feb 20, 2021 · 292 followers View post →
WE_ARE_2140
@WE_ARE_2140 · X

#aging Spermidine in health and disease https://t.co/WnYrStvn4Q

Apr 19, 2020 · 1,418 followers View post →
Wouter
@Wouter10698863 · X

@MiesBee Kijk maar: https://t.co/KPdlZHzQpm

Apr 18, 2020 · 66 followers View post →