January 2018 PMID 29382913

Human Skeletal Muscle Possesses an Epigenetic Memory of Hypertrophy.

Robert A Seaborne, Juliette Strauss, Matthew Cocks, Sam Shepherd, Thomas D O'Brien, Ken A van Someren, Phillip G Bell, Christopher Murgatroyd, James P Morton, Claire E Stewart, Adam P Sharples

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Mentions

167

Peak: 10 in Aug 2021

across 7 sources since Feb 2019

Extended reach

319,421

potential audience

Total likes

1,571

Video views

53,034

Mentions per month

Feb 2019 – Feb 2025

Where it's discussed

News60 articles
X / Twitter48 posts
Facebook39 posts
Blogs12 articles
Bluesky3 posts
Reddit3 posts
YouTube2 videos

AI synopsis

What people are saying

Discussions overwhelmingly support the research, emphasizing its importance with words like 'existence of a memory' and 'significant findings'. Certain posts highlight the novelty and potential applications, such as improved training strategies, showing deep engagement and high interest through terms like 'epigenetic', 'hypertrophy', and 'muscle memory'. The tone is enthusiastic, reflecting consensus on the study's transformative impact.

AgreementStrong agreement

Most discussions confirm and support the findings, emphasizing the existence of a genetic memory in skeletal muscle.

InterestHigh interest

The posts demonstrate high curiosity and enthusiasm, mentioning key terms like 'epigenetic memory', 'hypertrophy', and 'training', which suggest strong interest.

EngagementHigh engagement

Many users delve into the implications, citing related studies and discussing mechanisms, indicating deep engagement.

ImpactHigh impact

The overall tone highlights the significance of the discovery, with phrases like 'game-changing' and noting potential applications in training and recovery, pointing to a high perceived impact.

Abstract in brief

The study discovers that adult human skeletal muscle retains an epigenetic "memory" of previous hypertrophy, shown through persistent DNA hypomethylation and increased gene expression after muscle growth episodes.
Genes like AXIN1, GRIK2, CAMK4, and TRAF1 exhibit hypomethylation and sustained expression even during muscle unloading, indicating these epigenetic changes are maintained beyond periods of growth.
These findings highlight the role of specific genes in muscle hypertrophy memory and suggest that epigenetic modifications could influence future muscle growth, with potential implications for training and recovery strategies.

Read the full abstract

All mentions

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Konstantinos Prokopidis

@kostasproko.bsky.social · Bluesky

Human skeletal muscle possesses an epigenetic memory of high-intensity interval training pubmed.ncbi.nlm.nih.gov/39570634/

Feb 1, 2025 View post →

BioVison

@davidleipi · X

Training, Detraining to muscle baseline and after that a retraining resulted in more gene expression DOI:10.1038/s41598-018-20287-3

Jul 17, 2024 · 13 followers View post →

bioRxiv Physiology

@biorxiv-physio.bsky.social · Bluesky

Human skeletal muscle possesses an epigenetic memory of high intensity interval training https://www.biorxiv.org/content/10.1101/2024.05.30.596458v1

Jun 3, 2024 View post →

bioRxivpreprint

@biorxivpreprint.bsky.social · Bluesky

Human skeletal muscle possesses an epigenetic memory of high intensity interval training https://www.biorxiv.org/content/10.1101/2024.05.30.596458v1

Jun 3, 2024 View post →

Dr. Craig Whitworth-Turner

@scibasedlifter_ · X

@HowellsDan @pacarroll_ https://t.co/0hx9hyfNJa Read this

Apr 6, 2024 · 1 like · 2,630 followers View post →

Adrián Sánchez

@23Adriansanchez · X

https://t.co/hiXupz02fo https://t.co/WIsrob7JUn https://t.co/Cn5YMEcNtV https://t.co/ma36QH9f0J https://t.co/v8xPorbrjv https://t.co/ivQAKbGhQR

Jun 2, 2023 · 1 like · 5,373 followers View post →

Fitia App Español

@fitia_espanol · X

Feb 7, 2023 · 1,540 followers View post →

Dani Reyes Olavarría

@Daniitota · X

RT @SaulNutri:

Oct 28, 2022 · 1 share · 463 followers View post →

Saúl Sánchez

@SaulNutri · X

Oct 28, 2022 · 23 likes · 1 share · 108,064 followers View post →

Raghav Agrawal

@impactology · X

[open access] Human Skeletal Muscle Possesses an Epigenetic Memory of Hypertrophy https://t.co/ZP6gxr9e6Y

Oct 25, 2022 · 3,403 followers View post →

♀️Ana -XX

@ana_iamhuman · X

si bien el estudio en 2018 y 2019 expusieron q la memoria genética existe El músculo esquelético humano posee una memoria epigenética de hipertrofia @ContraBorrado @Jose__Errasti @NuriaCSopena https://t.co/EtTQym1NVA

Jun 19, 2022 · 42,236 followers View post →

青鬼のふんどしを洗う男

@pediatrun · X

RT @Team_inspire: Human Skeletal Muscle Possesses an Epigenetic Memory of Hypertrophy https://t.co/jXCDv4q98X

Feb 1, 2022 · 1 share · 106 followers View post →

J-Shira

@Team_inspire · X

Human Skeletal Muscle Possesses an Epigenetic Memory of Hypertrophy https://t.co/jXCDv4q98X

Feb 1, 2022 · 1 share · 4,797 followers View post →