Proc Natl Acad Sci U S A February 2018 PMID 29432159

NAD supplementation normalizes key Alzheimer's features and DNA damage responses in a new AD mouse model with introduced DNA repair deficiency.

Yujun Hou, Sofie Lautrup, Stephanie Cordonnier, Yue Wang, Deborah L Croteau, Eduardo Zavala, Yongqing Zhang, Kanako Moritoh, Jennifer F O'Connell, Beverly A Baptiste, Tinna V Stevnsner, Mark P Mattson, Vilhelm A Bohr

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Mentions

47
Peak: 7 in Apr 2023
across 6 sources since May 2019

Extended reach

91,998
potential audience

Total likes

81

Video views

1,754

Mentions per month

May 2019 – Jan 2024

Where it's discussed

  • News15 articles
  • X / Twitter11 posts
  • Facebook8 posts
  • Blogs8 articles
  • Reddit3 posts
  • YouTube2 videos

AI synopsis

What people are saying

The overall tone suggests cautious optimism, with posts emphasizing the normalization of Alzheimer’s key features and memory benefits, using phrases like 'restored memory' and 'amazing' to reflect positive impacts. Words such as 'normalizes' and 'amazing' highlight the perceived significance of the findings, contributing to a generally optimistic outlook on the research's potential influence on future therapies.

AgreementModerate agreement

Most discussions acknowledge the positive findings, emphasizing NAD+ as a promising treatment approach.

InterestModerate interest

Posts show moderate curiosity, highlighting the significance of NAD+ and its potential benefits for Alzheimer’s, with some mentioning specific methods like nicotinamide riboside.

EngagementModerate engagement

Users engage by referencing the study’s details, such as the normalization of Alzheimer’s features and memory improvements, indicating active interest.

ImpactModerate impact

The discussions reflect recognition that this research could influence Alzheimer's treatment strategies, as many posts frame NAD+ supplementation as a promising therapy.

Abstract in brief

  • NAD supplementation can restore energy metabolism, reduce key Alzheimer’s features like tau pathology, DNA damage, and neuroinflammation, and improve cognitive function in a new mouse model with DNA repair deficiency.
  • The study shows that low NAD levels are linked to brain damage in Alzheimer’s, and boosting NAD with nicotinamide riboside (NR) helps protect neurons, reduce damage, and improve synaptic plasticity.
  • Overall, these findings suggest that maintaining NAD levels could be a promising therapeutic approach to combat Alzheimer’s disease by addressing underlying cellular damage and neurodegeneration.]

Top posts

Most liked on X and Bluesky
Agingdoc
@agingdoc1 · X

NAD+ supplementation normalizes key Alzheimer’s features and DNA damage responses in a new AD mouse model with introduced DNA repair deficiency (2018) https://t.co/z6vfkupZqG @PNASNews https://t.co/kcBSLAxsfj

Apr 5, 2023 · 33 likes · 3 shares · 42,570 followers View post →
Nicole Laurent, LMHC
@KetoCounselor · X

They used a form of NAD+ called nicotinamide riboside and kept at it for six months. And here's the amazing part: it totally restored their spatial, recognition, and contextual fear memory! (20/27) https://t.co/72wXDumH5u

Apr 23, 2023 · 20 likes · 3 shares · 9,110 followers View post →
Rene Sugar
@renesugar · X

@foundmyfitness @dr_bredesen @CharlesMBrenner NAD+ supplementation normalizes key Alzheimer’s features and DNA damage responses in a new AD mouse model with introduced DNA repair deficiency https://t.co/EU7MR6jhMc

May 19, 2019 · 2 likes · 3,970 followers View post →
Dr. Shashank Joshi
@AskDrShashank · X

RT @agingdoc1: NAD+ supplementation normalizes key Alzheimer’s features and DNA damage responses in a new AD mouse model with introduced DN…

Apr 5, 2023 · 3 shares · 32,576 followers View post →
Sinan Mellaart
@sinanmellaart · X

RT @KetoCounselor: They used a form of NAD+ called nicotinamide riboside and kept at it for six months. And here's the amazing part: it tot…

Apr 23, 2023 · 3 shares · 785 followers View post →
Angela Galieti
@AngelaGalieti · X

RT @KetoCounselor: They used a form of NAD+ called nicotinamide riboside and kept at it for six months. And here's the amazing part: it tot…

Apr 23, 2023 · 3 shares · 535 followers View post →

All mentions

Sinan Mellaart
@sinanmellaart · X

RT @KetoCounselor: They used a form of NAD+ called nicotinamide riboside and kept at it for six months. And here's the amazing part: it tot…

Apr 23, 2023 · 3 shares · 785 followers View post →
Angela Galieti
@AngelaGalieti · X

RT @KetoCounselor: They used a form of NAD+ called nicotinamide riboside and kept at it for six months. And here's the amazing part: it tot…

Apr 23, 2023 · 3 shares · 535 followers View post →
Nicole Laurent, LMHC
@KetoCounselor · X

They used a form of NAD+ called nicotinamide riboside and kept at it for six months. And here's the amazing part: it totally restored their spatial, recognition, and contextual fear memory! (20/27) https://t.co/72wXDumH5u

Apr 23, 2023 · 20 likes · 3 shares · 9,110 followers View post →
Makito Hayashi
@hayashi_makito · X

RT @agingdoc1: NAD+ supplementation normalizes key Alzheimer’s features and DNA damage responses in a new AD mouse model with introduced DN…

Apr 6, 2023 · 3 shares · 96 followers View post →
Antonio Giuliano
@AntoGiuliano81 · X

RT @agingdoc1: NAD+ supplementation normalizes key Alzheimer’s features and DNA damage responses in a new AD mouse model with introduced DN…

Apr 6, 2023 · 3 shares · 498 followers View post →
Dr. Shashank Joshi
@AskDrShashank · X

RT @agingdoc1: NAD+ supplementation normalizes key Alzheimer’s features and DNA damage responses in a new AD mouse model with introduced DN…

Apr 5, 2023 · 3 shares · 32,576 followers View post →
Agingdoc
@agingdoc1 · X

NAD+ supplementation normalizes key Alzheimer’s features and DNA damage responses in a new AD mouse model with introduced DNA repair deficiency (2018) https://t.co/z6vfkupZqG @PNASNews https://t.co/kcBSLAxsfj

Apr 5, 2023 · 33 likes · 3 shares · 42,570 followers View post →
Largavita Bioscience
@LargavitaB · X

NAD+ supplementation normalizes key Alzheimer’s features and DNA damage responses in a new AD mouse model with introduced DNA repair deficiency!

Mar 15, 2023 · 34 followers View post →
Appalachian Wellness
@AppWellness · X

New post (NAD+ supplementation normalizes key Alzheimer’s features and DNA damage responses in a new AD mouse model with introduced DNA repair deficiency) has been published on Appalachian Wellness - https://t.co/Qg4mZdANfK

Aug 14, 2019 · 22 followers View post →
Reversing-Age
@ReversingA · X

NAD+ Supplementation Normalizes Key Alzheimer’s Features and DNA Damage Responses. Read the full study on our website: https://t.co/uDs4NRXprs #alzheimer #health #reversingage https://t.co/6KGpEOhwAj

Aug 14, 2019 · 7 followers View post →
Rene Sugar
@renesugar · X

@foundmyfitness @dr_bredesen @CharlesMBrenner NAD+ supplementation normalizes key Alzheimer’s features and DNA damage responses in a new AD mouse model with introduced DNA repair deficiency https://t.co/EU7MR6jhMc

May 19, 2019 · 2 likes · 3,970 followers View post →