Med Sci Sports Exerc August 2018 PMID 29509641

Caffeine, CYP1A2 Genotype, and Endurance Performance in Athletes.

Nanci Guest, Paul Corey, Jason Vescovi, Ahmed El-Sohemy

Mentions

63
Peak: 3 in Feb 2019
across 5 sources since Feb 2019

Extended reach

89,679
potential audience

Total likes

63

Video views

81

Mentions per month

Feb 2019 – Aug 2024

Where it's discussed

  • Facebook26 posts
  • X / Twitter17 posts
  • News14 articles
  • Blogs4 articles
  • YouTube2 videos

AI synopsis

What people are saying

The discussions reflect a positive reception toward the idea that caffeine impacts performance differently based on genetics, with phrases like 'really ignited interest' and references to 'science' indicating enthusiasm and curiosity. Some posts highlight the need for more research, while others emphasize the potential for personalized testing, demonstrating active engagement and recognition of the study's relevance.

AgreementModerate agreement

Most discussions acknowledge that caffeine's effects on performance are influenced by genetic factors, indicating general support for the study's findings.

InterestHigh interest

The group demonstrates high curiosity about how genetics affect caffeine's effectiveness, with many posts referencing specific studies and the importance of genetic testing.

EngagementModerate engagement

Participants interpret research results, debate implications, and mention the need for further studies, showing active participation and curiosity.

ImpactModerate impact

There is recognition that the findings could influence personalized approaches in sports, suggesting moderate significance for athletes and researchers.

Abstract in brief

  • The study investigated how genetic differences in the CYP1A2 gene, which affects caffeine metabolism, influence caffeine's impact on 10km cycling performance, with results showing that caffeine improved performance mainly in athletes with the AA genotype.
  • Caffeine at 2 and 4 mg/kg improved cycling times significantly for AA genotype athletes, while those with the CC genotype experienced no benefit or worse performance at higher doses, indicating a gene-dependent response.
  • The findings suggest that genetic testing for CYP1A2 may help athletes personalize caffeine intake to optimize endurance performance, as genetic variation influences how caffeine affects endurance outcomes.]

Top posts

Most liked on X and Bluesky
Jorn Trommelen, PhD
@JornTrommelen · X

Effects of caffeine depend on genetics? The presence of the CYP1A2 gene influences the performance-enhancing effect of caffeine. Full breakdown: https://t.co/7pdDeiNdHV Study by @NanciGuestRDPhD : https://t.co/UGPnfnb54t #coffee #caffeine #performance https://t.co/N7THhtK24U

Mar 30, 2020 · 36 likes · 3 shares · 7,616 followers View post →
Jorn Trommelen, PhD
@JornTrommelen · X

In conclusion, the effect of caffeine differs between people. In most people, it improves or has no effect on exercise performance. In contrast, it decreases performance in some people. Study: https://t.co/6lDftQajg2 Connect on insta: https://t.co/VBgqiI6Wp5 8/8 https://t.co/5vpRrBnlAf

Mar 31, 2022 · 7 likes · 1 share · 7,616 followers View post →
Nanci Guest PhD, RD, CSCS
@NanciGuestRDPhD · X

@SteAssent @PatrickElliott0 My 2018 study n=8 CCs or ' very slow metabolizers' & CAF was ergolytic. Most studies group AC/CC vs AA (fast) - most are null. Caveat: Need replication of a 'CC only' group but only 10% of pop=CYP1A2 CC so need >1000 subjects! I'm not convinced it matters! https://t.co/hT3weTT3vA

May 9, 2023 · 4 likes · 10,515 followers View post →
David Roche
@MountainRoche · X

@fabticc @HypeoxiaMedia @UltraRunner26 Here's a study that really ignited interest in it! Lots more since then looking at CYP1A2: https://t.co/p1s4ADRrlt

Aug 22, 2024 · 2 likes · 24,115 followers View post →
Brett Singer MS,RD,CSSD
@BSinger10 · X

While most studies show an overall improvement in performance, there are some individuals who may see no response, or perform even worse. Here is arecent article from @NanciGuestRD : Caffeine, CYP1A2 Genotype, and Endurance Performance in Athletes. https://t.co/NRtJuEhmaU

Jun 11, 2019 · 2 likes · 2,817 followers View post →
Ahmed El-Sohemy
@elsohemy · X

@PreventionMag @windycityRD A number of studies now show that the effects of coffee/caffeine depend on whether you're a fast or slow metabolizer. Examples: https://t.co/xRNlEebksM https://t.co/UubmBjLZ0s https://t.co/CJahKjat1t https://t.co/na9zIuOmdu https://t.co/Ge3jBpovZu

Feb 20, 2023 · 2 likes · 914 followers View post →

All mentions

David Roche
@MountainRoche · X

@fabticc @HypeoxiaMedia @UltraRunner26 Here's a study that really ignited interest in it! Lots more since then looking at CYP1A2: https://t.co/p1s4ADRrlt

Aug 22, 2024 · 2 likes · 24,115 followers View post →
Nanci Guest PhD, RD, CSCS
@NanciGuestRDPhD · X

@SteAssent @PatrickElliott0 My 2018 study n=8 CCs or ' very slow metabolizers' & CAF was ergolytic. Most studies group AC/CC vs AA (fast) - most are null. Caveat: Need replication of a 'CC only' group but only 10% of pop=CYP1A2 CC so need >1000 subjects! I'm not convinced it matters! https://t.co/hT3weTT3vA

May 9, 2023 · 4 likes · 10,515 followers View post →
Ahmed El-Sohemy
@elsohemy · X

@PreventionMag @windycityRD A number of studies now show that the effects of coffee/caffeine depend on whether you're a fast or slow metabolizer. Examples: https://t.co/xRNlEebksM https://t.co/UubmBjLZ0s https://t.co/CJahKjat1t https://t.co/na9zIuOmdu https://t.co/Ge3jBpovZu

Feb 20, 2023 · 2 likes · 914 followers View post →
Abdulaziz
@MzhaAl · X

Caffeine, CYP1A2 Genotype, and Endurance Performance in Athletes - PubMed https://t.co/tmKLxNNnYI

Apr 1, 2022 · 580 followers View post →
Argón
@metilargon · X

RT @JornTrommelen: In conclusion, the effect of caffeine differs between people. In most people, it improves or has no effect on exercise p…

Mar 31, 2022 · 1 share · 352 followers View post →
Jorn Trommelen, PhD
@JornTrommelen · X

In conclusion, the effect of caffeine differs between people. In most people, it improves or has no effect on exercise performance. In contrast, it decreases performance in some people. Study: https://t.co/6lDftQajg2 Connect on insta: https://t.co/VBgqiI6Wp5 8/8 https://t.co/5vpRrBnlAf

Mar 31, 2022 · 7 likes · 1 share · 7,616 followers View post →
Spencer
@thricethought · X

@stevemagness Example: caffeine generally aids performance, but might be useless or detrimental if you don't have particular genetics. In this case, the solution was more science, but sometimes the data doesn't exist yet. https://t.co/ZVSOqRO9RK

Jan 11, 2022 · 36 followers View post →
Weldon
@Rocker75W · X

RT @JornTrommelen: Effects of caffeine depend on genetics? The presence of the CYP1A2 gene influences the performance-enhancing effect of…

Mar 30, 2020 · 3 shares · 329 followers View post →
Nancy Clark MS RD
@nclarkrd · X

RT @JornTrommelen: Effects of caffeine depend on genetics? The presence of the CYP1A2 gene influences the performance-enhancing effect of…

Mar 30, 2020 · 3 shares · 13,503 followers View post →
Jorn Trommelen, PhD
@JornTrommelen · X

Effects of caffeine depend on genetics? The presence of the CYP1A2 gene influences the performance-enhancing effect of caffeine. Full breakdown: https://t.co/7pdDeiNdHV Study by @NanciGuestRDPhD : https://t.co/UGPnfnb54t #coffee #caffeine #performance https://t.co/N7THhtK24U

Mar 30, 2020 · 36 likes · 3 shares · 7,616 followers View post →
Eric Gaubert
@kalydeoo · X

RT @BoisseauN: Caffeine, CYP1A2 Genotype, and Endurance Performance in Athletes. ☕️☕️☕️ https://t.co/8E1Or1h7hV

Dec 14, 2019 · 1 share · 18,542 followers View post →
Boisseau Nathalie
@BoisseauN · X

Caffeine, CYP1A2 Genotype, and Endurance Performance in Athletes. ☕️☕️☕️ https://t.co/8E1Or1h7hV

Dec 14, 2019 · 1 share · 641 followers View post →
Brett Singer MS,RD,CSSD
@BSinger10 · X

While most studies show an overall improvement in performance, there are some individuals who may see no response, or perform even worse. Here is arecent article from @NanciGuestRD : Caffeine, CYP1A2 Genotype, and Endurance Performance in Athletes. https://t.co/NRtJuEhmaU

Jun 11, 2019 · 2 likes · 2,817 followers View post →
Minna Tervo
@MinnaTohtori · X

Kofeiini parantaa #kestävyyssuorituskyky , mutta ei kaikilla. Caffeine, CYP1A2 Genotype, and Endurance Performance in Athletes https://t.co/LJFiF7hMk0

Mar 30, 2019 · 1 like · 201 followers View post →
Dr Nitin Malekar
@malekarnitin · X

RT @AdamsGenetics: A very informative podcast on #Caffeine , #CYP1A2 Genotype and #endurance performance in athletes. https://t.co/GopJLhmh…

Feb 11, 2019 · 2 shares · 127 followers View post →
Shah Fahad
@shahnutrition · X

RT @AdamsGenetics: A very informative podcast on #Caffeine , #CYP1A2 Genotype and #endurance performance in athletes. https://t.co/GopJLhmh…

Feb 11, 2019 · 2 shares · 1,096 followers View post →
Adam's Genetics
@AdamsGenetics · X

A very informative podcast on #Caffeine , #CYP1A2 Genotype and #endurance performance in athletes. https://t.co/GopJLhmhmh

Feb 10, 2019 · 2 likes · 2 shares · 560 followers View post →