J Clin Pharm Ther June 2018 PMID 29524352

The role and mechanism of action of menthol in topical analgesic products.

J V Pergolizzi, R Taylor, J-A LeQuang, R B Raffa

Mentions

66
Peak: 2 in Jul 2022
across 3 sources since Mar 2020

Extended reach

84,576
potential audience

Total likes

663

Video views

74,357

Mentions per month

Mar 2020 – Jul 2025

Where it's discussed

  • News59 articles
  • X / Twitter4 posts
  • YouTube3 videos

AI synopsis

What people are saying

Discussions reflect a balanced curiosity about menthol’s molecular actions, such as its activation of TRPM8 channels, and its potential to develop new nonopioid pain medications. The tone varies from technical to speculative, demonstrating both interest and recognition of the research’s significance.

AgreementModerate agreement

Most posts acknowledge the scientific findings, with some expressing support for the implications of menthol's mechanisms.

InterestModerate interest

Discussions show moderate curiosity about menthol’s molecular effects and potential applications.

EngagementModerate engagement

Posts touch upon detailed mechanisms like TRPM8 channels and debates about its therapeutic impact, indicating a certain level of engagement.

ImpactModerate impact

Participants consider the research important, suggesting it could influence future pain relief strategies or medical treatments.

Abstract in brief

  • Menthol has been used as a nonopioid pain reliever throughout history, and recent research highlights its action on TRPM8 channels, which are involved in sensing cold and pain.
  • It works as a counterirritant by creating a cooling sensation, initially stimulating nociceptors (pain sensors) and then desensitizing them, which helps reduce pain.
  • Understanding menthol's molecular mechanism may help develop new nonopioid pain medications, especially topical treatments, as an alternative to opioids for managing pain.]

Top posts

Most liked on X and Bluesky
Rakesh Pandey (राकेश पाण्डेय)
@rpandeybhu · X

@manojpandey66 @tpchaturvedibhu @sankha_shubhra @DrVNMishraa Menthol युक्त एक्सटर्नल यूज़ के तमाम प्रोडक्ट के पर कुछ कार्य हुआ है। जैसे https://t.co/GDdGh0QYfv परंतु ब्रेन के स्नायुतंतुओं पर सीधे असर डाल कर neural degeneration/cerebral atrophy (नसों के कमजोर होने का यही अर्थ लगाया हूँ) कैसे करता है, इसको जानने का प्रयास कर रहा हूँ।

Oct 7, 2023 · 1 like · 605 followers View post →
Francis Jeffrey
@FrancisJeffrey7 · X

#Menthol is a selective activator of transient #receptor potential #melastatin_8 (#TRPM8) channels & a vasoactive compound. It acts as a counter‐irritant by imparting a cooling effect and by initially stimulating #nociceptors and then desensitizing them. [https://t.co/8F3W3jZEF0] https://t.co/3lLVrLaT5p

Mar 9, 2020 · 4,974 followers View post →
Houston Social Media
@houstonsocial · X

The role and mechanism of action of #menthol in topical analgesic products https://t.co/8SAeVwYapv

Jan 4, 2022 · 4,321 followers View post →
Phil Emenogu
@EmenoguPhillip1 · X

https://t.co/GTsm7ZU7Kz @Trump @DonaldJTrumpJr @EricTrump @GovernorPerry @EmenoguPhillip1 @jaredkushner

Jul 20, 2025 · 320 followers View post →

All mentions

Phil Emenogu
@EmenoguPhillip1 · X

https://t.co/GTsm7ZU7Kz @Trump @DonaldJTrumpJr @EricTrump @GovernorPerry @EmenoguPhillip1 @jaredkushner

Jul 20, 2025 · 320 followers View post →
Rakesh Pandey (राकेश पाण्डेय)
@rpandeybhu · X

@manojpandey66 @tpchaturvedibhu @sankha_shubhra @DrVNMishraa Menthol युक्त एक्सटर्नल यूज़ के तमाम प्रोडक्ट के पर कुछ कार्य हुआ है। जैसे https://t.co/GDdGh0QYfv परंतु ब्रेन के स्नायुतंतुओं पर सीधे असर डाल कर neural degeneration/cerebral atrophy (नसों के कमजोर होने का यही अर्थ लगाया हूँ) कैसे करता है, इसको जानने का प्रयास कर रहा हूँ।

Oct 7, 2023 · 1 like · 605 followers View post →
Houston Social Media
@houstonsocial · X

The role and mechanism of action of #menthol in topical analgesic products https://t.co/8SAeVwYapv

Jan 4, 2022 · 4,321 followers View post →
Francis Jeffrey
@FrancisJeffrey7 · X

#Menthol is a selective activator of transient #receptor potential #melastatin_8 (#TRPM8) channels & a vasoactive compound. It acts as a counter‐irritant by imparting a cooling effect and by initially stimulating #nociceptors and then desensitizing them. [https://t.co/8F3W3jZEF0] https://t.co/3lLVrLaT5p

Mar 9, 2020 · 4,974 followers View post →