Mechanisms of Ketamine Action as an Antidepressant #neuroscience #neuropsychiatric #sciencie #Neurotwitter #Psychtwitter #INPST https://t.co/Ktf0lPIIRO
Mechanisms of ketamine action as an antidepressant.
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Aug 2020 – Mar 2025Where it's discussed
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Discussions reflect strong interest through mentions of complex mechanisms such as NMDAR inhibition, effects on brain circuits, and downstream processes like BDNF activation, indicating deep engagement. The tone is analytical and appreciative, highlighting the research’s potential to influence future treatments, but without expressions of controversy or skepticism, leading to moderate impact scores.
Most discussions recognize the significance of the article, with some explicitly supporting its findings about ketamine's mechanisms and therapeutic potential.
The posts exhibit high curiosity about ketamine’s molecular actions and its implications for treating severe depression.
Participants reference specific mechanisms and molecules like GABAergic neurons, BDNF, and mTOR, indicating meaningful engagement with the research content.
The discussions suggest awareness of the study's importance in advancing neuropsychiatric treatments, though they don't show immediate calls for action or widespread change.
Abstract in brief
- Ketamine induces rapid and sustained antidepressant effects at subanesthetic doses, but its abuse potential and dissociative properties limit widespread use.
- The review explores various molecular mechanisms behind ketamine’s antidepressant actions, including NMDAR inhibition, effects on brain circuits like GABAergic interneurons and the lateral habenula, and activation of AMPA receptors, which promote synaptic plasticity.
- It also discusses downstream processes involving BDNF, eEF2, mTOR, and GSK3, as well as alternative pathways involving ketamine metabolites like hydroxynorketamine, suggesting multiple interconnected mechanisms contribute to its antidepressant effects.]
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Most liked on X and BlueskyRT @Dra_TeraizaMesa: Mechanisms of Ketamine Action as an Antidepressant #neuroscience #neuropsychiatric #sciencie #Neurotwitter #Psychtwit…
Mechanisms of Ketamine Action as an Antidepressant [Panos Zanos, Todd D. Gould. Mol Psychiatry. 2018 Apr; 23(4): 801–811. doi:10.1038/mp.2017.255] https://t.co/8GTvXXGDbe Here a synapse + présynaptic GABAergic (inh) neuron + astrocyte (non neural cell, BBB maintenance role most.) https://t.co/hAA3DCvrGz
RT @Dra_TeraizaMesa: Mechanisms of Ketamine Action as an Antidepressant #neuroscience #neuropsychiatric #sciencie #Neurotwitter #Psychtwit…
RT @Dra_TeraizaMesa: Mechanisms of Ketamine Action as an Antidepressant #neuroscience #neuropsychiatric #sciencie #Neurotwitter #Psychtwit…
RT @Dra_TeraizaMesa: Mechanisms of Ketamine Action as an Antidepressant #neuroscience #neuropsychiatric #sciencie #Neurotwitter #Psychtwit…
All mentions
Understanding Ketamine's Neuropharmacology and Antidepressant Effects
Ketamine was initially developed as an anesthetic but is now also used as an analgesic and antidepressant. This video discusses how ketamine impacts neurotransmission, particularly through NMDA receptor antagonism, and…
Ketamine as a Rapid-Acting Treatment for Depression
Numerous studies show that ketamine can work as a fast-acting antidepressant alleviating symptoms in a matter of hours or days. It provides quick relief of depressive symptoms, especially within 24 hours of infusion…
Ketamine's Role in Rapid Depression Relief and Neural Rewiring
Ketamine induces rapid and sustained antidepressant effects at subanesthetic doses. This video explores how it rewires neural connections, enhances neuroplasticity, and acts through multiple molecular pathways, offering…
@evemitocondrial Hay bastante investigación al respecto, sobre el uso de 'drogas de abuso' y su potencial para tratar formas severas de depresión. Este es solo un ejemplo: «Mechanisms of Ketamine Action as an Antidepressant» https://t.co/ng0uenKGaa
RT @Dra_TeraizaMesa: Mechanisms of Ketamine Action as an Antidepressant #neuroscience #neuropsychiatric #sciencie #Neurotwitter #Psychtwit…
RT @Dra_TeraizaMesa: Mechanisms of Ketamine Action as an Antidepressant #neuroscience #neuropsychiatric #sciencie #Neurotwitter #Psychtwit…
RT @Dra_TeraizaMesa: Mechanisms of Ketamine Action as an Antidepressant #neuroscience #neuropsychiatric #sciencie #Neurotwitter #Psychtwit…
RT @Dra_TeraizaMesa: Mechanisms of Ketamine Action as an Antidepressant #neuroscience #neuropsychiatric #sciencie #Neurotwitter #Psychtwit…
Mechanisms of Ketamine Action as an #Antidepressant #neuroscience #neuropsychiatric https://t.co/KqyrPw5EL4
Mechanisms of Ketamine Action as an Antidepressant #neuroscience #neuropsychiatric #sciencie #Neurotwitter #Psychtwitter #INPST https://t.co/Ktf0lPIIRO
Mechanisms of Ketamine Action as an Antidepressant [Panos Zanos, Todd D. Gould. Mol Psychiatry. 2018 Apr; 23(4): 801–811. doi:10.1038/mp.2017.255] https://t.co/8GTvXXGDbe Here a synapse + présynaptic GABAergic (inh) neuron + astrocyte (non neural cell, BBB maintenance role most.) https://t.co/hAA3DCvrGz
مرجع: Mechanisms of Ketamine Action as an Antidepressant Panos Zanos, Ph.D. and Todd D. Gould, M.D. doi: 10.1038/mp.2017.255