Mol Psychiatry April 2018 PMID 29532791

Mechanisms of ketamine action as an antidepressant.

P Zanos, T D Gould

Mentions

29
Peak: 6 in Jul 2022
across 4 sources since Aug 2020

Extended reach

641,189
potential audience

Total likes

3,624

Video views

475,014

Mentions per month

Aug 2020 – Mar 2025

Where it's discussed

  • News14 articles
  • X / Twitter9 posts
  • YouTube3 videos
  • Facebook3 posts

AI synopsis

What people are saying

Discussions reflect strong interest through mentions of complex mechanisms such as NMDAR inhibition, effects on brain circuits, and downstream processes like BDNF activation, indicating deep engagement. The tone is analytical and appreciative, highlighting the research’s potential to influence future treatments, but without expressions of controversy or skepticism, leading to moderate impact scores.

AgreementModerate agreement

Most discussions recognize the significance of the article, with some explicitly supporting its findings about ketamine's mechanisms and therapeutic potential.

InterestHigh interest

The posts exhibit high curiosity about ketamine’s molecular actions and its implications for treating severe depression.

EngagementModerate engagement

Participants reference specific mechanisms and molecules like GABAergic neurons, BDNF, and mTOR, indicating meaningful engagement with the research content.

ImpactModerate impact

The discussions suggest awareness of the study's importance in advancing neuropsychiatric treatments, though they don't show immediate calls for action or widespread change.

Abstract in brief

  • Ketamine induces rapid and sustained antidepressant effects at subanesthetic doses, but its abuse potential and dissociative properties limit widespread use.
  • The review explores various molecular mechanisms behind ketamine’s antidepressant actions, including NMDAR inhibition, effects on brain circuits like GABAergic interneurons and the lateral habenula, and activation of AMPA receptors, which promote synaptic plasticity.
  • It also discusses downstream processes involving BDNF, eEF2, mTOR, and GSK3, as well as alternative pathways involving ketamine metabolites like hydroxynorketamine, suggesting multiple interconnected mechanisms contribute to its antidepressant effects.]

Top posts

Most liked on X and Bluesky
Dra. Teraiza Mesa R Cuenta Oficial ®
@Dra_TeraizaMesa · X

Mechanisms of Ketamine Action as an Antidepressant #neuroscience #neuropsychiatric #sciencie #Neurotwitter #Psychtwitter #INPST https://t.co/Ktf0lPIIRO

Jul 5, 2022 · 4 likes · 4 shares · 9,063 followers View post →
Atanas G. Atanasov
@_atanas_ · X

RT @Dra_TeraizaMesa: Mechanisms of Ketamine Action as an Antidepressant #neuroscience #neuropsychiatric #sciencie #Neurotwitter #Psychtwit…

Jul 6, 2022 · 4 shares · 123,761 followers View post →
Anastasie
@Psychanastasie · X

Mechanisms of Ketamine Action as an Antidepressant [Panos Zanos, Todd D. Gould. Mol Psychiatry. 2018 Apr; 23(4): 801–811. doi:10.1038/mp.2017.255] https://t.co/8GTvXXGDbe Here a synapse + présynaptic GABAergic (inh) neuron + astrocyte (non neural cell, BBB maintenance role most.) https://t.co/hAA3DCvrGz

Jun 16, 2021 · 12,053 followers View post →
International Natural Product Sciences Taskforce
@_INPST · X

RT @Dra_TeraizaMesa: Mechanisms of Ketamine Action as an Antidepressant #neuroscience #neuropsychiatric #sciencie #Neurotwitter #Psychtwit…

Jul 5, 2022 · 4 shares · 10,273 followers View post →
Digital Health and Patient Safety Platform
@DHPSP · X

RT @Dra_TeraizaMesa: Mechanisms of Ketamine Action as an Antidepressant #neuroscience #neuropsychiatric #sciencie #Neurotwitter #Psychtwit…

Jul 5, 2022 · 4 shares · 6,748 followers View post →
Science Communication
@ScienceCommuni2 · X

RT @Dra_TeraizaMesa: Mechanisms of Ketamine Action as an Antidepressant #neuroscience #neuropsychiatric #sciencie #Neurotwitter #Psychtwit…

Jul 5, 2022 · 4 shares · 2,880 followers View post →

All mentions

105Apologist
@105Apologist · X

@evemitocondrial Hay bastante investigación al respecto, sobre el uso de 'drogas de abuso' y su potencial para tratar formas severas de depresión. Este es solo un ejemplo: «Mechanisms of Ketamine Action as an Antidepressant» https://t.co/ng0uenKGaa

Jan 25, 2025 · 55 followers View post →
Atanas G. Atanasov
@_atanas_ · X

RT @Dra_TeraizaMesa: Mechanisms of Ketamine Action as an Antidepressant #neuroscience #neuropsychiatric #sciencie #Neurotwitter #Psychtwit…

Jul 6, 2022 · 4 shares · 123,761 followers View post →
Digital Health and Patient Safety Platform
@DHPSP · X

RT @Dra_TeraizaMesa: Mechanisms of Ketamine Action as an Antidepressant #neuroscience #neuropsychiatric #sciencie #Neurotwitter #Psychtwit…

Jul 5, 2022 · 4 shares · 6,748 followers View post →
Science Communication
@ScienceCommuni2 · X

RT @Dra_TeraizaMesa: Mechanisms of Ketamine Action as an Antidepressant #neuroscience #neuropsychiatric #sciencie #Neurotwitter #Psychtwit…

Jul 5, 2022 · 4 shares · 2,880 followers View post →
International Natural Product Sciences Taskforce
@_INPST · X

RT @Dra_TeraizaMesa: Mechanisms of Ketamine Action as an Antidepressant #neuroscience #neuropsychiatric #sciencie #Neurotwitter #Psychtwit…

Jul 5, 2022 · 4 shares · 10,273 followers View post →
NousTalk
@noustalk · X

Mechanisms of Ketamine Action as an #Antidepressant #neuroscience #neuropsychiatric https://t.co/KqyrPw5EL4

Jul 5, 2022 · 1,149 followers View post →
Dra. Teraiza Mesa R Cuenta Oficial ®
@Dra_TeraizaMesa · X

Mechanisms of Ketamine Action as an Antidepressant #neuroscience #neuropsychiatric #sciencie #Neurotwitter #Psychtwitter #INPST https://t.co/Ktf0lPIIRO

Jul 5, 2022 · 4 likes · 4 shares · 9,063 followers View post →
Anastasie
@Psychanastasie · X

Mechanisms of Ketamine Action as an Antidepressant [Panos Zanos, Todd D. Gould. Mol Psychiatry. 2018 Apr; 23(4): 801–811. doi:10.1038/mp.2017.255] https://t.co/8GTvXXGDbe Here a synapse + présynaptic GABAergic (inh) neuron + astrocyte (non neural cell, BBB maintenance role most.) https://t.co/hAA3DCvrGz

Jun 16, 2021 · 12,053 followers View post →
Yazeed
@flexyazeed · X

مرجع: Mechanisms of Ketamine Action as an Antidepressant Panos Zanos, Ph.D. and Todd D. Gould, M.D. doi: 10.1038/mp.2017.255

Aug 31, 2020 · 153 followers View post →