Several posts demonstrate interest in the research's potential, such as referencing the unique cold adaptation mechanisms of ground squirrels and the prospects for biomedical advances. The tone conveys curiosity and optimism, with mentions of the publication offering 'new perspectives' and 'potential medical breakthroughs,' illustrating both enthusiasm and recognition of its broader impact.
AgreementModerate agreement
Most discussions acknowledge the significance of the research, especially highlighting the potential medical benefits and the importance of understanding hibernation mechanisms.
InterestHigh interest
Posts express high interest, referencing specific details in the publication and emphasizing the novelty of using hibernator-derived iPSCs for medical applications.
EngagementModerate engagement
Discussions include mentions of cellular pathways, species-specific adaptations, and potential translational research, indicating active engagement.
ImpactModerate impact
Participants suggest that this research could lead to major advances in medicine, such as improved organ preservation or new therapies for cold-related injuries.
Abstract in brief
Hibernating mammals, like the 13-lined ground squirrel, can survive extremely low temperatures without cellular damage, presenting possible medical benefits.
Researchers identified key cellular pathways that help these mammals tolerate cold, particularly by comparing their stem cells to human ones.
Adjusting these cold resistance pathways in human cells and rat cells demonstrated improved cellular stability and could potentially enhance organ transplant preservation.
Wei Li @NIH Ground squirrel not only hibernate but they are one of the few mammals that have a cone dominated and cold adapted retina. Here is the paper:
https://t.co/g7eaYZ1Pdl #nonstandard2019
Insulin resistance often remains unnoticed until health issues like type 2 diabetes develop. This video explains the key causes, how to recognize it using HOMA-IR and ATP III criteria, and effective treatments including…
This video explains how stem cells from hibernating mammals, like ground squirrels, can help study cold tolerance and improve medical applications such as organ preservation and transplantation.
Wei Li @NIH Ground squirrel not only hibernate but they are one of the few mammals that have a cone dominated and cold adapted retina. Here is the paper:
https://t.co/g7eaYZ1Pdl #nonstandard2019
Recent cryonics accomplishments and potential mistakes in review
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... cell, cells of virtually every conceivable kind are successfully cryopreserved. ... 10.1016/j.cell.2018.03.010. iPSCs from a Hibernator Provide a ...
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