Cancer Res June 2018 PMID 29610116

Network Modeling of microRNA-mRNA Interactions in Neuroblastoma Tumorigenesis Identifies miR-204 as a Direct Inhibitor of MYCN.

Chi Yan Ooi, Daniel R Carter, Bing Liu, Chelsea Mayoh, Anneleen Beckers, Amit Lalwani, Zsuzsanna Nagy, Sara De Brouwer, Bieke Decaesteker, Tzong-Tyng Hung, Murray D Norris, Michelle Haber, Tao Liu, Katleen De Preter, Frank Speleman

Mentions

16
Peak: 4 in Oct 2020
across 2 sources since Jun 2018

Extended reach

15,321
potential audience

Total likes

55

Video views

5,775

Mentions per month

Jun 2018 – Oct 2020

Where it's discussed

  • X / Twitter14 posts
  • YouTube2 videos

AI synopsis

What people are saying

The discussions emphasize the importance of open access for research visibility and cite the miR-204 study's citations and publication details, indicating awareness of its scholarly impact, whereas collective tone remains informational more than critically analytical, reflecting moderate engagement and impact.

AgreementModerate agreement

Most discussions highlight the importance of open access and the significance of miR-204 research, showing general support for the publication's themes.

InterestModerate interest

Posts express moderate curiosity about the research, focusing more on open access policies and citation mentions rather than detailed scientific content.

EngagementNeutral engagement

While some users share citations and summarize research highlights, there is limited deep discussion or technical analysis of the findings.

ImpactModerate impact

The dissemination of research through citations and open access promotion suggests a recognition of its potential influence, though discussions remain somewhat superficial.

Abstract in brief

  • The study used network modeling to analyze how microRNAs (miRNAs) and messenger RNAs (mRNAs) interact during neuroblastoma development, identifying miR204 as a key tumor suppressor that inhibits the oncogene MYCN.
  • MYCN can directly repress miR204 by binding to its promoter, while miR204, in turn, suppresses MYCN expression, forming a regulatory loop that affects tumor growth.
  • Overexpression of miR204 reduces neuroblastoma cell growth and tumors, highlighting its potential as a target for therapies aiming to control MYCN-driven neuroblastoma.]

Top posts

Most liked on X and Bluesky
Ooi Chi Yan | 黃 智 仁
@OoiChiYan · X

My paper on #tumour suppressor #microRNA miR-204 as inhibitor of #MYCN in #ChildhoodCancer #neuroblastoma was accepted a year ago in #AACR #CancerResearch and has been cited at least once. Check it out while you're at #AACR19 #AACR2019. #cancer https://t.co/ceAAncKIWa

Mar 29, 2019 · 9 likes · 1 share · 298 followers View post →
Ooi Chi Yan | 黃 智 仁
@OoiChiYan · X

#OpenAccess #OA is important for maximizing the impact of #research and scholarly #publications. #OpenAccessWeek #OAWeek #OAWeek2020 is going to take place on 19 - 25 October. Make sure you understand beforehand what Open Access is about with this video: https://t.co/RfCqcKukfa

Oct 8, 2020 · 3 likes · 2 shares · 299 followers View post →
Ooi Chi Yan | 黃 智 仁
@OoiChiYan · X

My paper on #tumour suppressor #microRNA miR-204 as inhibitor of #MYCN in #ChildhoodCancer #neuroblastoma was published in print a year ago in #AACR #CancerResearch and has been cited at least three times. #cancer https://t.co/ceAAncKIWa

Jun 15, 2019 · 3 likes · 1 share · 298 followers View post →
Ooi Chi Yan | 黃 智 仁
@OoiChiYan · X

I'm happy to announce that I received the very first citation for my #PhD #research on tumour suppressor #microRNA miR-204, which is first published online almost a year ago on #AACR #CancerResearch. You can read my article here: https://t.co/ceAAncKIWa #MYCN #neuroblastoma

Mar 17, 2019 · 2 likes · 298 followers View post →
Ooi Chi Yan | 黃 智 仁
@OoiChiYan · X

My first research article has been cited by 13 scientific publications since it was first published online in @AACR #CancerResearch 2 yrs ago, according to Google Scholar. Thanks to everyone involved #cancer #ChildhoodCancer #microRNA #neuroblastoma #AACR https://t.co/ceAAncKIWa

Apr 1, 2020 · 2 likes · 1 share · 298 followers View post →
UNSW ObGyn & Paeds
@UNSWObGyn_Paeds · X

RT @OoiChiYan: My paper on #tumour suppressor #microRNA miR-204 as inhibitor of #MYCN in #ChildhoodCancer #neuroblastoma was published in p…

Jun 16, 2019 · 1 share · 1,652 followers View post →

All mentions

Ooi Chi Yan | 黃 智 仁
@OoiChiYan · X

This week is #OpenAccessWeek #OAweek. Not all #OpenAccess #OA publications are created equal. Learn more in this video: https://t.co/RfCqcKukfa

Oct 19, 2020 · 299 followers View post →
Chris Winchester
@ChrisW_PharmaG · X

RT @OoiChiYan: #OpenAccess #OA is important for maximizing the impact of #research and scholarly #publications. #OpenAccessWeek #OAWeek #OA…

Oct 9, 2020 · 2 shares · 990 followers View post →
Open Pharma
@_OpenPharma · X

RT @OoiChiYan: #OpenAccess #OA is important for maximizing the impact of #research and scholarly #publications. #OpenAccessWeek #OAWeek #OA…

Oct 8, 2020 · 2 shares · 1,022 followers View post →
Ooi Chi Yan | 黃 智 仁
@OoiChiYan · X

#OpenAccess #OA is important for maximizing the impact of #research and scholarly #publications. #OpenAccessWeek #OAWeek #OAWeek2020 is going to take place on 19 - 25 October. Make sure you understand beforehand what Open Access is about with this video: https://t.co/RfCqcKukfa

Oct 8, 2020 · 3 likes · 2 shares · 299 followers View post →
SoGiAm
@H0U3 · X

RT @OoiChiYan: My first research article has been cited by 13 scientific publications since it was first published online in @AACR #Cancer…

Apr 2, 2020 · 1 share · 1,585 followers View post →
Ooi Chi Yan | 黃 智 仁
@OoiChiYan · X

My first research article has been cited by 13 scientific publications since it was first published online in @AACR #CancerResearch 2 yrs ago, according to Google Scholar. Thanks to everyone involved #cancer #ChildhoodCancer #microRNA #neuroblastoma #AACR https://t.co/ceAAncKIWa

Apr 1, 2020 · 2 likes · 1 share · 298 followers View post →
Ooi Chi Yan | 黃 智 仁
@OoiChiYan · X

For those without access to subscriptions, #OpenAccess is vital avenue for accessing #knowledge from scholarly publications. But not all #OA publications are created equal. Know more before #OpenAccessWeek #OAweek begins next week: https://t.co/RfCqcKukfa https://t.co/NhfuzuxIgA

Oct 13, 2019 · 299 followers View post →
Ooi Chi Yan | 黃 智 仁
@OoiChiYan · X

The last full week of #October is #OpenAccessWeek #OAweek. Learn about what #OpenAccess #OA of scholarly publications really means and its roles in maximizing the #impact and benefits of #research to the world: https://t.co/RfCqcKukfa https://t.co/NhfuzuxIgA #creativecommons

Oct 2, 2019 · 1 share · 299 followers View post →
UNSW ObGyn & Paeds
@UNSWObGyn_Paeds · X

RT @OoiChiYan: My paper on #tumour suppressor #microRNA miR-204 as inhibitor of #MYCN in #ChildhoodCancer #neuroblastoma was published in p…

Jun 16, 2019 · 1 share · 1,652 followers View post →
Ooi Chi Yan | 黃 智 仁
@OoiChiYan · X

My paper on #tumour suppressor #microRNA miR-204 as inhibitor of #MYCN in #ChildhoodCancer #neuroblastoma was published in print a year ago in #AACR #CancerResearch and has been cited at least three times. #cancer https://t.co/ceAAncKIWa

Jun 15, 2019 · 3 likes · 1 share · 298 followers View post →
Ooi Chi Yan | 黃 智 仁
@OoiChiYan · X

This year marks the 10th anniversary of #OpenAccessWeek. My @YouTube video on #OpenAccess can act as a primer to understand the policy of certain political party before you vote https://t.co/RfCqcKukfa

May 14, 2019 · 299 followers View post →
SoGiAm
@H0U3 · X

RT @OoiChiYan: My paper on #tumour suppressor #microRNA miR-204 as inhibitor of #MYCN in #ChildhoodCancer #neuroblastoma was accepted a yea…

Mar 29, 2019 · 1 share · 1,585 followers View post →
Ooi Chi Yan | 黃 智 仁
@OoiChiYan · X

My paper on #tumour suppressor #microRNA miR-204 as inhibitor of #MYCN in #ChildhoodCancer #neuroblastoma was accepted a year ago in #AACR #CancerResearch and has been cited at least once. Check it out while you're at #AACR19 #AACR2019. #cancer https://t.co/ceAAncKIWa

Mar 29, 2019 · 9 likes · 1 share · 298 followers View post →
Ooi Chi Yan | 黃 智 仁
@OoiChiYan · X

I'm happy to announce that I received the very first citation for my #PhD #research on tumour suppressor #microRNA miR-204, which is first published online almost a year ago on #AACR #CancerResearch. You can read my article here: https://t.co/ceAAncKIWa #MYCN #neuroblastoma

Mar 17, 2019 · 2 likes · 298 followers View post →