Cell Metab April 2018 PMID 29617641

Mechanisms of Action and Therapeutic Application of Glucagon-like Peptide-1.

Daniel J Drucker

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Mentions

90
Peak: 34 in Dec 2023
across 4 sources since Jan 2019

Extended reach

1,459,945
potential audience

Total likes

1,013

Video views

52,598

Mentions per month

Jan 2019 – Aug 2025

Where it's discussed

  • X / Twitter55 posts
  • News27 articles
  • Blogs5 articles
  • YouTube3 videos

AI synopsis

What people are saying

The discussions reflect high engagement and interest through mentions of GLP-1's role in reducing inflammation and improving metabolic conditions, highlighting the article’s influence on current scientific conversations. Words like 'important,' 'clinical value,' and phrases like 'mechanisms to improve results' indicate that the article is seen as highly relevant for advancing medical research and treatment strategies.

AgreementModerate agreement

Most discussions acknowledge the significance of GLP-1 in metabolic health and its therapeutic potential, with some referencing its roles in inflammation and disease management.

InterestHigh interest

Posts show high interest, with mentions of GLP-1's mechanisms, clinical applications, and implications for treatments, indicating active engagement.

EngagementModerate engagement

Participants reference specific aspects of the publication, such as inflammation reduction and recent clinical findings, demonstrating thoughtful engagement.

ImpactModerate impact

Discussions suggest the article's content is impactful, influencing considerations of GLP-1 in innovative therapies and understanding disease mechanisms.

Abstract in brief

  • GLP1, released from gut cells, helps regulate blood sugar by increasing insulin secretion, reducing glucagon, slowing gastric emptying, and decreasing food intake, which aids in nutrient absorption and weight control.
  • The review discusses how natural and drug-induced GLP1 actions involve specific cell types and pathways, including their roles in metabolic processes, as well as their impact on conditions like obesity, diabetes, inflammation, and cardiovascular health.
  • Advancements in GLP1-based therapies, such as oral drugs and multi-target agonists, are highlighted, along with ongoing challenges and future directions for optimizing these treatments for metabolic diseases.]

Top posts

Most liked on X and Bluesky
Bryan Johnson
@bryan_johnson · X

8/ Sources 1. https://t.co/GVw0L4EKTZ 2. https://t.co/2mb6TSsCXe 3. https://t.co/mZQLAudg5z 4. https://t.co/KO6KqCxdAU 5. https://t.co/gfWVhkRx8N 6. https://t.co/HR5LiXqs1a 7. https://t.co/GYP5fdTfCU 8. https://t.co/lNPeB4ML3b 9. https://t.co/XBQxDypITX 10.

Dec 19, 2024 · 128 likes · 4 shares · 658,811 followers View post →
Daniel J Drucker
@DanielJDrucker · X

Does reduction of #inflammation contribute to the glucose-and #weightloss independent actions of GLP-1RA to reduce complications? How might that happen given limited immune cell GLP-1R expression? https://t.co/uIf0moqLE2 https://t.co/ZTdr4RJp1u

Dec 17, 2023 · 104 likes · 34 shares · 34,303 followers View post →
Robert Lufkin MD
@robertlufkinmd · X

The physiological importance of GLP-1 for reduction of inflammation, independent of glucose control and weight loss, is highlighted by demonstration that GLP-1-secreting cells not only respond to nutrients, but also act as inflammation sensors. https://t.co/6XwTwF9tpz https://t.co/NZ4mmTgbfb

Dec 20, 2024 · 22 likes · 5 shares · 145,747 followers View post →
Daniel J Drucker
@DanielJDrucker · X

For those interested in how and where GLP-1 might control #inflammation, some thoughts here @Cell_Metabolism #diabetes #obesity https://t.co/AAH5cZAX6x

Apr 17, 2020 · 9 likes · 1 share · 34,303 followers View post →
Daniel J Drucker
@DanielJDrucker · X

In 2018, the real clinical value of GLP-1R agonists #diabetes #heartdisease was consolidated with multiple highly consistent outcome studies. The importance of understanding mechanisms to improve results remains clear https://t.co/5fX4ZE9Aio

Jan 26, 2019 · 8 likes · 2 shares · 34,303 followers View post →
Robert Lufkin MD
@robertlufkinmd · X

Bariatric surgery greatly improves glycemic control, often within days after surgery, independently of weight loss. This is through the action of incretin hormones GLP-1 and GIP. https://t.co/1E029puV5k @GatlanHealth https://t.co/ioV2PGuVcZ

Dec 20, 2024 · 5 likes · 145,747 followers View post →

All mentions

Horses for Everyone
@DarcyButcher · X

RT @bryan_johnson: 8/ Sources 1. https://t.co/GVw0L4EKTZ 2. https://t.co/2mb6TSsCXe 3. https://t.co/mZQLAudg5z 4. https://t.co/KO6KqCxdAU…

Jan 5, 2025 · 4 shares · 717 followers View post →
Devanaur
@DarkMassacres · X

RT @bryan_johnson: 8/ Sources 1. https://t.co/GVw0L4EKTZ 2. https://t.co/2mb6TSsCXe 3. https://t.co/mZQLAudg5z 4. https://t.co/KO6KqCxdAU…

Dec 21, 2024 · 4 shares · 715 followers View post →
kaya?
@revolt321 · X

RT @robertlufkinmd: The physiological importance of GLP-1 for reduction of inflammation, independent of glucose control and weight loss, is…

Dec 21, 2024 · 5 shares · 17 followers View post →
Ju Filomeno
@JujunaLuta · X

RT @robertlufkinmd: The physiological importance of GLP-1 for reduction of inflammation, independent of glucose control and weight loss, is…

Dec 21, 2024 · 5 shares · 126 followers View post →
wondering
@ecat3 · X

RT @robertlufkinmd: The physiological importance of GLP-1 for reduction of inflammation, independent of glucose control and weight loss, is…

Dec 20, 2024 · 5 shares · 1,101 followers View post →
Critical Magazine
@fiyyaz877 · X

RT @robertlufkinmd: The physiological importance of GLP-1 for reduction of inflammation, independent of glucose control and weight loss, is…

Dec 20, 2024 · 5 shares · 354 followers View post →
JOE FRIDAY
@JOEFRIDAY342213 · X

RT @robertlufkinmd: The physiological importance of GLP-1 for reduction of inflammation, independent of glucose control and weight loss, is…

Dec 20, 2024 · 5 shares · 192 followers View post →
Robert Lufkin MD
@robertlufkinmd · X

The physiological importance of GLP-1 for reduction of inflammation, independent of glucose control and weight loss, is highlighted by demonstration that GLP-1-secreting cells not only respond to nutrients, but also act as inflammation sensors. https://t.co/6XwTwF9tpz https://t.co/NZ4mmTgbfb

Dec 20, 2024 · 22 likes · 5 shares · 145,747 followers View post →
Robert Lufkin MD
@robertlufkinmd · X

Bariatric surgery greatly improves glycemic control, often within days after surgery, independently of weight loss. This is through the action of incretin hormones GLP-1 and GIP. https://t.co/1E029puV5k @GatlanHealth https://t.co/ioV2PGuVcZ

Dec 20, 2024 · 5 likes · 145,747 followers View post →
darcy darnoc
@darcydarnoc · X

RT @bryan_johnson: 8/ Sources 1. https://t.co/GVw0L4EKTZ 2. https://t.co/2mb6TSsCXe 3. https://t.co/mZQLAudg5z 4. https://t.co/KO6KqCxdAU…

Dec 20, 2024 · 4 shares · 3,141 followers View post →
QuantumAI+Crispr3D=QuInCy=QAI&C3D=LA
@1LEOOEL1 · X

RT @bryan_johnson: 8/ Sources 1. https://t.co/GVw0L4EKTZ 2. https://t.co/2mb6TSsCXe 3. https://t.co/mZQLAudg5z 4. https://t.co/KO6KqCxdAU…

Dec 19, 2024 · 4 shares · 2,959 followers View post →
Bryan Johnson
@bryan_johnson · X

8/ Sources 1. https://t.co/GVw0L4EKTZ 2. https://t.co/2mb6TSsCXe 3. https://t.co/mZQLAudg5z 4. https://t.co/KO6KqCxdAU 5. https://t.co/gfWVhkRx8N 6. https://t.co/HR5LiXqs1a 7. https://t.co/GYP5fdTfCU 8. https://t.co/lNPeB4ML3b 9. https://t.co/XBQxDypITX 10.

Dec 19, 2024 · 128 likes · 4 shares · 658,811 followers View post →
Mia
@mia3_rodriguez · X

RT @DanielJDrucker: Does reduction of #inflammation contribute to the glucose-and #weightloss independent actions of GLP-1RA to reduce comp…

Aug 7, 2024 · 34 shares · 448 followers View post →
Dr. Critical Care
@Felipe_8811 · X

@KeTerriblesIvan @EstebanMerchan7 Si es que sabe inglés, ahí le dejo para que lea !! Y aprenda a no hacer el ridículo … pendejo https://t.co/7zLA2rieit

Feb 24, 2024 · 16 followers View post →
Frankie D Heyward, Ph.D.
@FrankieDHeyward · X

RT @DanielJDrucker: Does reduction of #inflammation contribute to the glucose-and #weightloss independent actions of GLP-1RA to reduce comp…

Dec 27, 2023 · 34 shares · 5,266 followers View post →
Ljiljana Lukic
@ljikson17 · X

RT @DanielJDrucker: Does reduction of #inflammation contribute to the glucose-and #weightloss independent actions of GLP-1RA to reduce comp…

Dec 20, 2023 · 34 shares · 132 followers View post →
Georgina Dowsett
@gkcdowsett · X

RT @DanielJDrucker: Does reduction of #inflammation contribute to the glucose-and #weightloss independent actions of GLP-1RA to reduce comp…

Dec 20, 2023 · 34 shares · 305 followers View post →
Sharona Azriel
@SharonaAzriel · X

RT @DanielJDrucker: Does reduction of #inflammation contribute to the glucose-and #weightloss independent actions of GLP-1RA to reduce comp…

Dec 19, 2023 · 34 shares · 1,407 followers View post →
Juan Carlos Obaya
@jcobaya69 · X

RT @DanielJDrucker: Does reduction of #inflammation contribute to the glucose-and #weightloss independent actions of GLP-1RA to reduce comp…

Dec 19, 2023 · 34 shares · 858 followers View post →
Javier Escalada #Yoelijoendocrino
@fjavesc · X

RT @DanielJDrucker: Does reduction of #inflammation contribute to the glucose-and #weightloss independent actions of GLP-1RA to reduce comp…

Dec 19, 2023 · 34 shares · 3,623 followers View post →
The Science of Parkinson's
@ScienceofPD · X

RT @DanielJDrucker: Does reduction of #inflammation contribute to the glucose-and #weightloss independent actions of GLP-1RA to reduce comp…

Dec 19, 2023 · 34 shares · 10,904 followers View post →
Maria Jesus Gonzalez Rellan
@ChusaGzlzRellan · X

RT @DanielJDrucker: Does reduction of #inflammation contribute to the glucose-and #weightloss independent actions of GLP-1RA to reduce comp…

Dec 18, 2023 · 34 shares · 786 followers View post →
Miguel Turégano
@tureyedro · X

RT @DanielJDrucker: Does reduction of #inflammation contribute to the glucose-and #weightloss independent actions of GLP-1RA to reduce comp…

Dec 18, 2023 · 34 shares · 813 followers View post →
Ubong Ekperikpe, Ph.D.
@ubong_ekperikpe · X

RT @DanielJDrucker: Does reduction of #inflammation contribute to the glucose-and #weightloss independent actions of GLP-1RA to reduce comp…

Dec 18, 2023 · 34 shares · 365 followers View post →
Anirban Maitra
@Aiims1742 · X

RT @DanielJDrucker: Does reduction of #inflammation contribute to the glucose-and #weightloss independent actions of GLP-1RA to reduce comp…

Dec 18, 2023 · 34 shares · 31,422 followers View post →
Ranjan Nanda
@RanjanN2022 · X

RT @DanielJDrucker: Does reduction of #inflammation contribute to the glucose-and #weightloss independent actions of GLP-1RA to reduce comp…

Dec 18, 2023 · 34 shares · 383 followers View post →
M-Clotilde ALVES GUERRA
@ClotildeAlvesGu · X

RT @DanielJDrucker: Does reduction of #inflammation contribute to the glucose-and #weightloss independent actions of GLP-1RA to reduce comp…

Dec 18, 2023 · 34 shares · 93 followers View post →
Christian Peace
@ChristianGPeace · X

RT @DanielJDrucker: Does reduction of #inflammation contribute to the glucose-and #weightloss independent actions of GLP-1RA to reduce comp…

Dec 18, 2023 · 34 shares · 336 followers View post →
Cell Metabolism
@Cell_Metabolism · X

RT @DanielJDrucker: Does reduction of #inflammation contribute to the glucose-and #weightloss independent actions of GLP-1RA to reduce comp…

Dec 18, 2023 · 34 shares · 53,902 followers View post →
Raul Villar
@DrRaulvillar · X

RT @DanielJDrucker: Does reduction of #inflammation contribute to the glucose-and #weightloss independent actions of GLP-1RA to reduce comp…

Dec 18, 2023 · 34 shares · 410 followers View post →
Jorge “Coco” Del-Aguila
@Coco_Lucho2 · X

RT @DanielJDrucker: Does reduction of #inflammation contribute to the glucose-and #weightloss independent actions of GLP-1RA to reduce comp…

Dec 18, 2023 · 34 shares · 117 followers View post →
joana nicolau
@NicolauJoana · X

RT @DanielJDrucker: Does reduction of #inflammation contribute to the glucose-and #weightloss independent actions of GLP-1RA to reduce comp…

Dec 18, 2023 · 34 shares · 424 followers View post →
Dr Celestino Gutiérrez González MD
@CelestinoGutirr · X

RT @DanielJDrucker: Does reduction of #inflammation contribute to the glucose-and #weightloss independent actions of GLP-1RA to reduce comp…

Dec 18, 2023 · 34 shares · 11,308 followers View post →
Zamara
@zamara_mariam · X

RT @DanielJDrucker: Does reduction of #inflammation contribute to the glucose-and #weightloss independent actions of GLP-1RA to reduce comp…

Dec 18, 2023 · 34 shares · 33 followers View post →
Doc Gerry Tan
@docgerrytan · X

RT @DanielJDrucker: Does reduction of #inflammation contribute to the glucose-and #weightloss independent actions of GLP-1RA to reduce comp…

Dec 18, 2023 · 34 shares · 310 followers View post →
Marta Sanchez Perez
@Marta_SanP · X

RT @DanielJDrucker: Does reduction of #inflammation contribute to the glucose-and #weightloss independent actions of GLP-1RA to reduce comp…

Dec 18, 2023 · 34 shares · 83 followers View post →
Elena del Olmo
@eledelolmo · X

RT @DanielJDrucker: Does reduction of #inflammation contribute to the glucose-and #weightloss independent actions of GLP-1RA to reduce comp…

Dec 18, 2023 · 34 shares · 476 followers View post →
Hamdi Frikha
@frikha_hamdi · X

RT @DanielJDrucker: Does reduction of #inflammation contribute to the glucose-and #weightloss independent actions of GLP-1RA to reduce comp…

Dec 17, 2023 · 34 shares · 52 followers View post →
Gavin Bewick
@GavBew · X

RT @DanielJDrucker: Does reduction of #inflammation contribute to the glucose-and #weightloss independent actions of GLP-1RA to reduce comp…

Dec 17, 2023 · 34 shares · 1,251 followers View post →
Matt L
@LL41622309 · X

RT @DanielJDrucker: Does reduction of #inflammation contribute to the glucose-and #weightloss independent actions of GLP-1RA to reduce comp…

Dec 17, 2023 · 34 shares · 29 followers View post →
Johnny Galtar
@JohnnyGaltar · X

RT @DanielJDrucker: Does reduction of #inflammation contribute to the glucose-and #weightloss independent actions of GLP-1RA to reduce comp…

Dec 17, 2023 · 34 shares · 417 followers View post →
JULIO SOLIS-Bioinformatician & Molecular Biologist
@Jsolis_s · X

RT @DanielJDrucker: Does reduction of #inflammation contribute to the glucose-and #weightloss independent actions of GLP-1RA to reduce comp…

Dec 17, 2023 · 34 shares · 432 followers View post →
Danielle Belardo, MD
@DBelardoMD · X

RT @DanielJDrucker: Does reduction of #inflammation contribute to the glucose-and #weightloss independent actions of GLP-1RA to reduce comp…

Dec 17, 2023 · 34 shares · 77,365 followers View post →
jose Miguel Gonzalez Clemente
@josemiguelgclem · X

RT @DanielJDrucker: Does reduction of #inflammation contribute to the glucose-and #weightloss independent actions of GLP-1RA to reduce comp…

Dec 17, 2023 · 34 shares · 102 followers View post →
Neil Floch MD
@NeilFlochMD · X

RT @DanielJDrucker: Does reduction of #inflammation contribute to the glucose-and #weightloss independent actions of GLP-1RA to reduce comp…

Dec 17, 2023 · 34 shares · 130,090 followers View post →
Randy J. Seeley, Ph.D.
@seeleyrj · X

RT @DanielJDrucker: Does reduction of #inflammation contribute to the glucose-and #weightloss independent actions of GLP-1RA to reduce comp…

Dec 17, 2023 · 34 shares · 1,946 followers View post →
Daniel Martín
@DaniMartinENDO · X

RT @DanielJDrucker: Does reduction of #inflammation contribute to the glucose-and #weightloss independent actions of GLP-1RA to reduce comp…

Dec 17, 2023 · 34 shares · 109 followers View post →
Daniel J Drucker
@DanielJDrucker · X

Does reduction of #inflammation contribute to the glucose-and #weightloss independent actions of GLP-1RA to reduce complications? How might that happen given limited immune cell GLP-1R expression? https://t.co/uIf0moqLE2 https://t.co/ZTdr4RJp1u

Dec 17, 2023 · 104 likes · 34 shares · 34,303 followers View post →
Greg Timblin
@gtimblin · X

@Mamarchist @captKangol The compound classes you list would be considered small molecules. Semaglutide is actually a modified version of the endogenously produced peptide hormone GLP-1 (so a biologic). Great review on the biology > https://t.co/OlJxb4TQIL https://t.co/ppp829WXQR

Jun 5, 2021 · 810 followers View post →
Leave it to Beaver
@espacetimeNOT · X

RT @DanielJDrucker: For those interested in how and where GLP-1 might control #inflammation, some thoughts here @Cell_Metabolism #diabetes…

Apr 17, 2020 · 1 share · 1,200 followers View post →
Daniel J Drucker
@DanielJDrucker · X

For those interested in how and where GLP-1 might control #inflammation, some thoughts here @Cell_Metabolism #diabetes #obesity https://t.co/AAH5cZAX6x

Apr 17, 2020 · 9 likes · 1 share · 34,303 followers View post →
The Williams Lab
@thewilliamslab · X

https://t.co/D9oIXjSCHC

Sep 25, 2019 · 1,872 followers View post →
Alessandro Bartolomucci Lab
@BartolomucciLab · X

RT @DanielJDrucker: In 2018, the real clinical value of GLP-1R agonists #diabetes #heartdisease was consolidated with multiple highly consi…

Jan 26, 2019 · 2 shares · 1,520 followers View post →
Donato Angelino
@don_angelino · X

#Mechanisms of Action and -#Therapeutic Application of Glucagon-like Peptide-1. #GLP1 ⁦@CellPressNews⁩ https://t.co/ieOATntAFb

Jan 26, 2019 · 1 like · 905 followers View post →
Daniel J Drucker
@DanielJDrucker · X

In 2018, the real clinical value of GLP-1R agonists #diabetes #heartdisease was consolidated with multiple highly consistent outcome studies. The importance of understanding mechanisms to improve results remains clear https://t.co/5fX4ZE9Aio

Jan 26, 2019 · 8 likes · 2 shares · 34,303 followers View post →