George Brooks, The Science and Translation of Lactate Shuttle Theory: Once thought to be a waste product of anaerobic metabolism lactate is now known to form continuously under aerobic conditions. 1-major energy source, 2-major gluconeogenic precursor, and 3-signaling molecule.
The Science and Translation of Lactate Shuttle Theory.
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Feb 2019 – Aug 2024Where it's discussed
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What people are saying
The overall sentiment shows strong agreement with the publication, as many posts praise its comprehensive review and highlight how it challenges old beliefs about lactate, including references to Brooks' work and statements like 'lactate is now known to form continuously under aerobic conditions.' The tone often uses words like 'excellent,' 'wild,' and 'game changer,' which convey excitement and highlight its transformative impact on metabolic understanding.
Most discussions emphasize the importance of the article, supporting the idea that lactate is a continuously produced and functional molecule, aligning with the article's main points.
The posts show a moderate interest, with some expressing excitement about the topic being 'wild' or 'interesting,' but others mostly referencing the research summaries without deep enthusiasm.
Many comments reference specific concepts, publications, and authors like George Brooks, indicating deep engagement and familiarity with the scientific discourse.
The discussions reflect recognition of a paradigm shift in understanding lactate, with users acknowledging its significant role in metabolism and signaling, thus highlighting high impact.
Abstract in brief
- Lactate is recognized as a continuous byproduct of both anaerobic and aerobic metabolism, serving multiple crucial roles in the body.
- It acts as a significant energy source, a precursor for gluconeogenesis (the creation of glucose), and plays a role in cell signaling through concepts known as the "lactate shuttle."
- Elevated blood lactate levels, traditionally seen as a sign of stress during illness or injury, are now being understood as an indicator of strain and are being explored in clinical settings for their potential therapeutic benefits.
Top posts
Most liked on X and Bluesky@stevemagness @washingtonpost Not to mention that perhaps lactic acid/lactate isn’t as bad as first thought. Important review from Brooks recently, https://t.co/LF9Ze4VBiD
Full text: https://t.co/EBlck9KH6s
From George Brooks' The Science and Translation of Lactate Shuttle Theory review: Once thought to be a waste product of anaerobic metabolism, lactate is now known to form continuously under aerobic conditions. Lactatemia seen as ‘‘strain’’ and not a ‘‘stress’’ biomarker to some
En el músculo en reposo, la glucosa que ingresa a la célula pasa a piruvato y se transporta a las mitocondrias como acetil-CoA para su uso en el ciclo de Krebs. La glucosa que no está completamente oxidada entra en la glucólisis y produce lactato. https://t.co/ArZUEPLSnK
@no_earthquake Honestly just read this abstract, it lays out the basics https://t.co/FXfJPeha3X Also lactate in brain is wild https://t.co/bb0cFOqUnM
All mentions
Understanding Lactate in Exercise Physiology and Metabolism
This video explains why we should stop referring to lactic acid and instead focus on lactate, a crucial energy and signaling molecule. It covers energy metabolism pathways and recent insights into lactate's vital role…
Understanding the Role of Lactate in Training and Performance
This video reviews what we know about lactate and its implications for training. Discover how lactate impacts athletic performance and training strategies. Gain valuable insights into optimizing your running, including…
Advanced Physiology: Lactate as a Key Molecule in Human Metabolism
Lactate is one of the most abundant metabolites in the human body and plays a vital role in performance and health. Despite being unfairly demonized, new research highlights its importance in mitochondrial function and…
Lactate: The Key Nutrient for Brain, Muscle, and Heart Health
Lactate is the body's preferred energy source, crucial for brain, muscle, and heart function. This video explores how lactate's role has been misunderstood, emphasizing its importance in performance and health…
Lactate's Role in Muscle Fatigue and Energy Metabolism
Lactate buildup does not cause muscular fatigue. Lactate is a valuable energy source, and measuring its levels indicates how well the body utilizes it. New research suggests that hydrogen accumulation, not lactate, may…
Understanding Lactate's Role in Energy Metabolism and Physiological Function
Lactate is a byproduct of both anaerobic and aerobic metabolism, serving as an energy source, a precursor for gluconeogenesis, and a signaling molecule via the lactate shuttle. Elevated levels indicate strain and…
RT @ainesanapulla: @no_earthquake Honestly just read this abstract, it lays out the basics https://t.co/FXfJPeha3X Also lactate in brain i…
@no_earthquake Honestly just read this abstract, it lays out the basics https://t.co/FXfJPeha3X Also lactate in brain is wild https://t.co/bb0cFOqUnM
Full text: https://t.co/EBlck9KH6s
@drcourtneyhunt https://t.co/u2zy9jaJm8
En el músculo en reposo, la glucosa que ingresa a la célula pasa a piruvato y se transporta a las mitocondrias como acetil-CoA para su uso en el ciclo de Krebs. La glucosa que no está completamente oxidada entra en la glucólisis y produce lactato. https://t.co/ArZUEPLSnK
@Mithreu @michaelmantzmd @RDValerie No that is not at all how lactate feeds neurons. Not at all. Something by Brooks on lactate shuttles might help you: https://t.co/XSX3i3Efnn
@Stew_CoachUK @GeorgeABrooks3 This is one of the many excellent reviews on lactate published by George Brooks https://t.co/a7mD2AX3k4
@AndyTurner132 Start with this
@sakuma33110207 同姓同名である可能性も否定できませんが、所属も名前も一致しているので、おそらくあの有名なBrooksだと思います。 https://t.co/CtKRmCP3Y5
@dr_a90zl @Trippin_0_ @ApresLaPub @Tanchouxx Brooks GA. The Science and Translation of Lactate Shuttle Theory. Cell Metab. 2018 Apr 3;27(4):757-785. doi: 10.1016/j.cmet.2018.03.008. PMID: 29617642.
@ck_eternity_ https://t.co/WAIeis20Mj
Closely followed by reading this in George Brooks' 2018 paper, The Science and Translation of Lactate Shuttle Theory: "An example of how loose usage of terminology leads to misunderstanding is illustrated by this (incorrect) Wikipedia entry [on fermentation]."
RT @D_Morales_Alamo: Completely agree... "The Science and Translation of Lactate Shuttle Theory" excellent review published by Prof. George…
RT @D_Morales_Alamo: Completely agree... "The Science and Translation of Lactate Shuttle Theory" excellent review published by Prof. George…
@JeroenSwart @TLexercise @iljukov Also see The Science and Translation of Lactate Shuttle Theory, Brooks, 2018. First paragraph: "lactate formed and utilized continuously in diverse cells under fully aerobic conditions"
Always love a good lactate paper. "O2 availability was classically considered to be a primary driver of lactate production, although there are numerous reasons to reconsider this simplistic view." The Science and Translation of Lactate Shuttle Theory https://t.co/svrLKHqTzc
“The Science and Translation of Lactate Shuttle Theory” #lactateshuttle https://t.co/0BRdP3kmlf
The Science and Translation of Lactate Shuttle Theory - ScienceDirect https://t.co/lVKVcb0gOh
RT @RodrigoZacca: The Science and Translation of Lactate Shuttle Theory https://t.co/qncAdCN2KX
The Science and Translation of Lactate Shuttle Theory https://t.co/qncAdCN2KX
Laktat hemmt die Leistung?
RT @RobbySeaborne: @stevemagness @washingtonpost Not to mention that perhaps lactic acid/lactate isn’t as bad as first thought. Important r…
RT @RobbySeaborne: @stevemagness @washingtonpost Not to mention that perhaps lactic acid/lactate isn’t as bad as first thought. Important r…
@stevemagness @washingtonpost Not to mention that perhaps lactic acid/lactate isn’t as bad as first thought. Important review from Brooks recently, https://t.co/LF9Ze4VBiD
RT @Coach_Alejo: George Brooks, The Science and Translation of Lactate Shuttle Theory: Once thought to be a waste product of anaerobic meta…
RT @Coach_Alejo: George Brooks, The Science and Translation of Lactate Shuttle Theory: Once thought to be a waste product of anaerobic meta…
RT @Coach_Alejo: George Brooks, The Science and Translation of Lactate Shuttle Theory: Once thought to be a waste product of anaerobic meta…
RT @Coach_Alejo: George Brooks, The Science and Translation of Lactate Shuttle Theory: Once thought to be a waste product of anaerobic meta…
RT @Coach_Alejo: George Brooks, The Science and Translation of Lactate Shuttle Theory: Once thought to be a waste product of anaerobic meta…
RT @Power_LiftSport: From George Brooks' The Science and Translation of Lactate Shuttle Theory review: Once thought to be a waste product o…
George Brooks, The Science and Translation of Lactate Shuttle Theory: Once thought to be a waste product of anaerobic metabolism lactate is now known to form continuously under aerobic conditions. 1-major energy source, 2-major gluconeogenic precursor, and 3-signaling molecule.
RT @Power_LiftSport: From George Brooks' The Science and Translation of Lactate Shuttle Theory review: Once thought to be a waste product o…
From George Brooks' The Science and Translation of Lactate Shuttle Theory review: Once thought to be a waste product of anaerobic metabolism, lactate is now known to form continuously under aerobic conditions. Lactatemia seen as ‘‘strain’’ and not a ‘‘stress’’ biomarker to some