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Nat Rev Genet June 2018 PMID 29643443

DNA methylation-based biomarkers and the epigenetic clock theory of ageing.

Steve Horvath, Kenneth Raj

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Mentions

123
Peak: 12 in Aug 2022
across 6 sources since Jan 2019

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690,618
potential audience

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314

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Jan 2019 – Sep 2025

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AI synopsis

What people are saying

Overall, the conversations reflect high interest and positive acknowledgment of the article's importance, exemplified by remarks like 'paradigm shift' and mentions of the potential to address fundamental aging questions. The tone and choice of words suggest a recognition of the study's significance without deep technical analysis, indicating moderate engagement and perceived impact.

AgreementModerate agreement

Most discussions recognize the significance of DNA methylation biomarkers and the epigenetic clock in understanding aging, shown by phrases like 'paradigm shift' and references to the work as foundational.

InterestHigh interest

The discussions display high interest, with many posts calling the research a 'paradigm shift' or exploring its potential applications, indicating engagement with its importance.

EngagementModerate engagement

Posts include references to specific concepts such as aging trajectories, single-cell technologies, and questions about why we age, showing a moderate level of detailed engagement.

ImpactModerate impact

There's a consensus that this research has meaningful implications for health and aging, with phrases like 'address long-standing questions' and emphasizing its revolutionary potential.

Abstract in brief

  • DNA methylation-based biomarkers and the epigenetic clock theory of aging have advanced our ability to estimate biological age accurately across different tissues.
  • These epigenetic clocks connect developmental processes with biological aging, offering a unified framework to understand how we age throughout life.
  • Such biomarkers could help answer fundamental questions about aging and assist in developing interventions to improve health span and lifespan.]
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Top posts

Most liked on X and Bluesky
Eduardo Calixto
@ecalixto · X

Referencia: DNA methylation-based biomarkers and the epigenetic clock theory of ageing. S. Horvath y K. Raj Nature Reviews Genetics, 2018. 19; 371-384.

Aug 2, 2022 · 97 likes · 15 shares · 185,936 followers View post →
Eduardo Calixto
@ecalixto · X

Referencia DNA methylation-based biomarkers and the epigenetic clock theory of ageing. S. Horvath y K. Raj Nature Reviews Genetics, 2018. 19; 371-384.

Dec 30, 2022 · 45 likes · 4 shares · 185,936 followers View post →
Agingdoc
@agingdoc1 · X

DNA methylation-based biomarkers and the epigenetic clock theory of ageing (2018) https://t.co/OAjtWKKKvw https://t.co/oFXe5A09MK

Dec 25, 2022 · 22 likes · 2 shares · 42,545 followers View post →
Nature Reviews Genetics
@NatureRevGenet · X

Related article: Horvath, S. & Raj, K. DNA methylation-based biomarkers and the epigenetic clock theory of ageing. Nat. Rev. Genet. 19, 371–384 (2018)

Jul 20, 2020 · 6 likes · 1 share · 92,785 followers View post →
Thomas Westbrook
@holykoolaid · X

Is Your Body Older Than You Are? (X10 on epigenetic clocks) https://t.co/mBMXXb39Ca

Jun 24, 2021 · 5 likes · 1 share · 14,162 followers View post →
NOMIX
@NOMIX_AI · X

The story behind #stevehorvath - DNA methylation-based biomarkers and the epigenetic clock theory of ageing - https://t.co/iDQy2hGa8G https://t.co/kgpuiYFuOa

Apr 10, 2022 · 4 likes · 4 shares · 595 followers View post →

All mentions

Jerome Scelza
@JScelza · X

Inflammation (IL-6, hs-CRP), cfDNA and HbA1c associate with accelerated epigenetic age. Paradigm shift: routine blood+methylation clocks reveal modifiable aging trajectories - act sooner to preserve function and longevity. (Horvath & Raj) https://t.co/fez66pgpnp

Sep 19, 2025 · 457 followers View post →
Aubrai
@Aubrai_ · X

@bihuynh_eth

Sep 12, 2025 · 1 like · 10,564 followers View post →
prosopocoilusun
@prosopocoilusun · X

Horvath, S., & Raj, K. (2018). DNA methylation-based biomarkers and the epigenetic clock theory of ageing. Nature reviews genetics, 19(6), 371-384. https://t.co/LDeOE41fVb

Jul 5, 2024 · 543 followers View post →
Alexander M. Wolf
@AlexanderMWolf7 · X

@Madam_Mito The clock tick faster in development. This is Fig. 2 from Horvaths "DNA methylation-based biomarkers and the epigenetic clock theory of ageing". And they do because proliferation rates are higher in early development. Each cell cycle is throwing darts because of mutations. https://t.co/o3USRmbrbE

Jun 13, 2024 · 1 like · 354 followers View post →
Manoj Mayogi Mishra
@mayogisense · X

RT @gglinskii: DNA methylation-based biomarkers and the epigenetic clock theory of ageing. https://t.co/9J7lh9V0lR

Mar 4, 2024 · 1 share · 575 followers View post →
Dr. Gennadi Glinsky, MD, Ph.D.
@gglinskii · X

DNA methylation-based biomarkers and the epigenetic clock theory of ageing. https://t.co/9J7lh9V0lR

Mar 3, 2024 · 2 likes · 1 share · 2,073 followers View post →
Dr Khalid
@rauf_khalid · X

RT @agingdoc1: DNA methylation-based biomarkers and the epigenetic clock theory of ageing (2018) https://t.co/OAjtWKKKvw https://t.co/oFXe…

May 21, 2023 · 2 shares · 2,490 followers View post →
Miguel Angel Ruiz
@Mars_777 · X

RT @ecalixto: Referencia DNA methylation-based biomarkers and the epigenetic clock theory of ageing. S. Horvath y K. Raj Nature Reviews Gen…

Jan 2, 2023 · 4 shares · 2,614 followers View post →
fraulrivera65
@paul_rivera831 · X

RT @ecalixto: Referencia DNA methylation-based biomarkers and the epigenetic clock theory of ageing. S. Horvath y K. Raj Nature Reviews Gen…

Jan 1, 2023 · 4 shares · 303 followers View post →
Abraham Pavón
@PavonAbraham · X

RT @ecalixto: Referencia DNA methylation-based biomarkers and the epigenetic clock theory of ageing. S. Horvath y K. Raj Nature Reviews Gen…

Dec 31, 2022 · 4 shares · 864 followers View post →
melvi adams
@m_adams74 · X

RT @ecalixto: Referencia DNA methylation-based biomarkers and the epigenetic clock theory of ageing. S. Horvath y K. Raj Nature Reviews Gen…

Dec 30, 2022 · 4 shares · 1,195 followers View post →
Eduardo Calixto
@ecalixto · X

Referencia DNA methylation-based biomarkers and the epigenetic clock theory of ageing. S. Horvath y K. Raj Nature Reviews Genetics, 2018. 19; 371-384.

Dec 30, 2022 · 45 likes · 4 shares · 185,936 followers View post →
BelgiumSpain8
@BelgiumSpain8 · X

RT @agingdoc1: DNA methylation-based biomarkers and the epigenetic clock theory of ageing (2018) https://t.co/OAjtWKKKvw https://t.co/oFXe…

Dec 25, 2022 · 2 shares · 2,312 followers View post →
Agingdoc
@agingdoc1 · X

DNA methylation-based biomarkers and the epigenetic clock theory of ageing (2018) https://t.co/OAjtWKKKvw https://t.co/oFXe5A09MK

Dec 25, 2022 · 22 likes · 2 shares · 42,545 followers View post →
luis hernan graffe
@hernangraffe · X

RT @hernangraffe: DNA methylation-based biomarkers and the epigenetic clock theory of ageing | Nature Reviews Genetics https://t.co/zSPyvRA…

Dec 3, 2022 · 2 shares · 3,153 followers View post →
luis hernan graffe
@hernangraffe · X

RT @hernangraffe: DNA methylation-based biomarkers and the epigenetic clock theory of ageing | Nature Reviews Genetics https://t.co/zSPyvRA…

Aug 24, 2022 · 2 shares · 3,153 followers View post →
wp1957
@wp1957 · X

RT @ecalixto: Referencia: DNA methylation-based biomarkers and the epigenetic clock theory of ageing. S. Horvath y K. Raj Nature Reviews Ge…

Aug 21, 2022 · 15 shares · 2,104 followers View post →
Miguel Angel Ruiz
@Mars_777 · X

RT @ecalixto: Referencia: DNA methylation-based biomarkers and the epigenetic clock theory of ageing. S. Horvath y K. Raj Nature Reviews Ge…

Aug 5, 2022 · 15 shares · 2,614 followers View post →
TONY MUÑOZ
@tipicidad · X

RT @ecalixto: Referencia: DNA methylation-based biomarkers and the epigenetic clock theory of ageing. S. Horvath y K. Raj Nature Reviews Ge…

Aug 3, 2022 · 15 shares · 774 followers View post →
Eduardo I .
@Eduardo39437508 · X

RT @ecalixto: Referencia: DNA methylation-based biomarkers and the epigenetic clock theory of ageing. S. Horvath y K. Raj Nature Reviews Ge…

Aug 3, 2022 · 15 shares · 41 followers View post →
reymoraleshernandez
@tlahuizquiyahui · X

RT @ecalixto: Referencia: DNA methylation-based biomarkers and the epigenetic clock theory of ageing. S. Horvath y K. Raj Nature Reviews Ge…

Aug 3, 2022 · 15 shares · 270 followers View post →
Isabel Martínez
@_IsaMtz · X

RT @ecalixto: Referencia: DNA methylation-based biomarkers and the epigenetic clock theory of ageing. S. Horvath y K. Raj Nature Reviews Ge…

Aug 3, 2022 · 15 shares · 483 followers View post →
Monce R
@Rbk_023 · X

RT @ecalixto: Referencia: DNA methylation-based biomarkers and the epigenetic clock theory of ageing. S. Horvath y K. Raj Nature Reviews Ge…

Aug 2, 2022 · 15 shares · 1,246 followers View post →
Pepe
@pepewam13 · X

RT @ecalixto: Referencia: DNA methylation-based biomarkers and the epigenetic clock theory of ageing. S. Horvath y K. Raj Nature Reviews Ge…

Aug 2, 2022 · 15 shares · 2,817 followers View post →
Jose Manuel Cordova
@JoseMan57943124 · X

RT @ecalixto: Referencia: DNA methylation-based biomarkers and the epigenetic clock theory of ageing. S. Horvath y K. Raj Nature Reviews Ge…

Aug 2, 2022 · 15 shares · 123 followers View post →
Oscar Surfer ® 
@WindsurfBCS · X

RT @ecalixto: Referencia: DNA methylation-based biomarkers and the epigenetic clock theory of ageing. S. Horvath y K. Raj Nature Reviews Ge…

Aug 2, 2022 · 15 shares · 953 followers View post →
Eduardo Calixto
@ecalixto · X

Referencia: DNA methylation-based biomarkers and the epigenetic clock theory of ageing. S. Horvath y K. Raj Nature Reviews Genetics, 2018. 19; 371-384.

Aug 2, 2022 · 97 likes · 15 shares · 185,936 followers View post →
Juan Carlos Rivillas
@RivillasJuanito · X

DNA methylation-based biomarkers and the epigenetic clock theory of ageing. Epigenetic biomarkers may help to address long-standing questions in many fields, including the central question: Why do we age? https://t.co/v9SqbJlTaq https://t.co/T3BGlM4IG6

May 21, 2022 · 2 likes · 988 followers View post →
mindfulrevolution
@mndflrvltn · X

RT @NOMIX_AI: The story behind #stevehorvath - DNA methylation-based biomarkers and the epigenetic clock theory of ageing - https://t.co/iD…

Apr 10, 2022 · 4 shares · 33 followers View post →
REJUVENS
@rejuvens · X

RT @NOMIX_AI: The story behind #stevehorvath - DNA methylation-based biomarkers and the epigenetic clock theory of ageing - https://t.co/iD…

Apr 10, 2022 · 4 shares · 68 followers View post →
Datarella
@Datarella · X

RT @NOMIX_AI: The story behind #stevehorvath - DNA methylation-based biomarkers and the epigenetic clock theory of ageing - https://t.co/iD…

Apr 10, 2022 · 4 shares · 1,935 followers View post →
michaelreuter
@michaelreuter · X

RT @NOMIX_AI: The story behind #stevehorvath - DNA methylation-based biomarkers and the epigenetic clock theory of ageing - https://t.co/iD…

Apr 10, 2022 · 4 shares · 4,325 followers View post →
NOMIX
@NOMIX_AI · X

The story behind #stevehorvath - DNA methylation-based biomarkers and the epigenetic clock theory of ageing - https://t.co/iDQy2hGa8G https://t.co/kgpuiYFuOa

Apr 10, 2022 · 4 likes · 4 shares · 595 followers View post →
bioZone
@thebiozone · X

new bioZone video from collaborator @StefanA80648338 on the true cost of being the top baboon

Jan 21, 2022 · 3 likes · 186 followers View post →
Single Cell Media
@SingleCellMedia · X

RT @immortal3127: "With the advent of single-cell technologies, which enable measurements of RNA and DNA methylation in individual cells, t…

Jan 10, 2022 · 1 share · 3,825 followers View post →
Shiva Agarwal
@immortal3127 · X

"With the advent of single-cell technologies, which enable measurements of RNA and DNA methylation in individual cells, the relationship between DNA methylation levels and transcriptional changes might be revealed"- by Steve Horvath :https://t.co/YvzJ9JTZQr @AlexandreTrapp #aging https://t.co/0dfICqnLnL

Jan 10, 2022 · 1 like · 1 share · 60 followers View post →
NewAgeHeretic
@NewAgeHeretics · X

RT @holykoolaid: Is Your Body Older Than You Are? (X10 on epigenetic clocks) https://t.co/mBMXXb39Ca

Jun 25, 2021 · 1 share · 94 followers View post →
Thomas Westbrook
@holykoolaid · X

Is Your Body Older Than You Are? (X10 on epigenetic clocks) https://t.co/mBMXXb39Ca

Jun 24, 2021 · 5 likes · 1 share · 14,162 followers View post →
Shakirah Namuli
@AfricanShakirah · X

RT @NatureRevGenet: DNA methylation-based biomarkers and the epigenetic clock theory of ageing https://t.co/EQFUmhCEsj #Review https://t.co…

Jun 8, 2021 · 153 shares · 154 followers View post →
Jari Jokela
@JariLeistera · X

RT @NatureRevGenet: DNA methylation-based biomarkers and the epigenetic clock theory of ageing https://t.co/EQFUmhCEsj #Review https://t.co…

Jun 8, 2021 · 153 shares · 68 followers View post →
Nature Reviews Genetics
@NatureRevGenet · X

RT @NatureRevGenet: DNA methylation-based biomarkers and the epigenetic clock theory of ageing https://t.co/EQFUmhCEsj #Review https://t.co…

Jun 8, 2021 · 153 shares · 92,785 followers View post →
UltimApe
@ultimape · X

@lolitsnotreal_ @orthonormalist "Epigenetic biomarkers may help to address long-standing questions in many fields, including the central question: why do we age?" https://t.co/Rjsy1zsbow

Mar 22, 2021 · 1 like · 6,711 followers View post →
dgavrile@yahoo.com
@dgavrile1 · X

DNA methylation-based biomarkers and the epigenetic clock theory of ageing on @ResearchGate: https://t.co/gyYSlQskxv

Mar 19, 2021 · 42 followers View post →
American Society for Investigative Pathology
@ASIPath · X

DNA methylation-based biomarkers and the epigenetic clock theory of ageing https://t.co/fkZ63bDHtF @MassEyeAndEar @StGeniezLab #ASIPWebinar #ASIPVirtual #PISA2020

Jan 28, 2021 · 1 like · 3,424 followers View post →
American Society for Investigative Pathology
@ASIPath · X

DNA methylation-based biomarkers and the epigenetic clock theory of ageing https://t.co/novfdUZLFo @shepens @MassEyeAndEar @StGeniezLab #ASIPWebinar #ASIPVirtual #PISA2020

Jan 28, 2021 · 1 like · 3,424 followers View post →
Anjan Barman
@anjbth · X

RT @NatureRevGenet: Related article: Horvath, S. & Raj, K. DNA methylation-based biomarkers and the epigenetic clock theory of ageing. Nat.…

Jul 20, 2020 · 1 share · 1,408 followers View post →
Nature Reviews Genetics
@NatureRevGenet · X

Related article: Horvath, S. & Raj, K. DNA methylation-based biomarkers and the epigenetic clock theory of ageing. Nat. Rev. Genet. 19, 371–384 (2018)

Jul 20, 2020 · 6 likes · 1 share · 92,785 followers View post →
luis hernan graffe
@hernangraffe · X

DNA methylation-based biomarkers and the epigenetic clock theory of ageing | Nature Reviews Genetics https://t.co/zSPyvRAY8t

Sep 8, 2019 · 2 shares · 3,153 followers View post →
Dr. M. Bernardo
@mbernardo321 · X

#DNA methylation-based #biomarkers and the #epigenetic clock theory of ageing - Nature https://t.co/nWxZuuO9L7 via @nuzzel

Jan 14, 2019 · 351 followers View post →