John Harley's team at the Cincinnati Children's hospital published an important study in 2018 showing one potential part of a mechanism for how EBV might trigger lupus and other autoimmune diseases: https://t.co/wtMLJUfp3t /4
Transcription factors operate across disease loci, with EBNA2 implicated in autoimmunity.
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Mar 2019 – Apr 2024Where it's discussed
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News117 articles
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X / Twitter19 posts
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Blogs14 articles
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Facebook9 posts
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YouTube2 videos
AI synopsis
What people are saying
The social discussions reflect a strong interest in the genetic and viral mechanisms underlying autoimmune diseases, with examples like references to the 2018 Cincinnati study and mentions of disease connections such as lupus, MS, and rheumatoid arthritis. The tone is scientific and somewhat optimistic about the potential implications, contributing to the overall positive agreement and moderate engagement scores.
Most discussions acknowledge the significance of EBNA2's role in autoimmunity and support the findings of the publication.
The discussions demonstrate high interest, with many posts mentioning specific diseases and mechanisms, indicating curiosity and engagement with the topic.
Posts reference supportive studies and implications, such as the 2018 research linking EBV to lupus and other diseases, showing moderate in-depth discussion.
The discussions suggest that the research is seen as impactful, especially in understanding disease mechanisms and viral contributions to autoimmunity, though not universally seen as revolutionary.
Abstract in brief
- Transcription factors (TFs) frequently bind to multiple regions associated with complex diseases, with EBNA2 playing a significant role in autoimmunity and other disorders.
- The study found nearly half of systemic lupus erythematosus risk loci are bound by the Epstein-Barr virus protein EBNA2, highlighting gene-environment interactions and potential mechanisms involving viral proteins in disease development.
- The research suggests that interactions between TFs like EBNA2 and genetic variants influence gene expression, providing new insights into the genetic and environmental factors contributing to diseases such as cancer, lupus, multiple sclerosis, and others.]
Top posts
Most liked on X and BlueskyTranscription factors operate across disease loci, with EBNA2 implicated in autoimmunity #EBV #EBNA2 #Autoimmunity aka what doesn’t kill you, can trigger autoimmunity later in life and serious disabling chronic illnesses #MS #SLE a subgroup of #MECFS https://t.co/4r06snmywt
Transcription factors operate across disease loci, with EBNA2 implicated in autoimmunity: Explaining the genetics of many diseases is challenging because most associations localize to incompletely characterized regulatory regions. #Genetics #EBNA2 #EBV https://t.co/4r06snEHKB
Transcription factors operate across disease loci, with EBNA2 implicated in autoimmunity #EBV https://t.co/4Gkhdxg98d
#SeminarioFBCB sobre "Transcription factors operate across disease loci, with EBNA2 implicated in autoimmunity" + Info:
From “Kissing disease” to SLE and many other AID, EBNA2 protein in EBV interacts with many risk loci in B lymphocytes leading to SLE Transcription factors operate across disease loci, with EBNA2 implicated in autoimmunity | Nature Genetics https://t.co/BUJTPeQMAB
All mentions
Transcription Factors and Disease Loci: Focus on EBNA2 in Autoimmunity
The study reveals that transcription factors, especially EBNA2, bind to multiple disease-related regions, influencing conditions like lupus and autoimmunity. Nearly half of systemic lupus erythematosus risk loci are…
Role of Transcription Factors and EBNA2 in Autoimmune Diseases
Transcription factors often bind to multiple disease-related regions, with EBNA2 notably involved in autoimmunity. The study highlights gene-environment interactions and viral protein influence in disease mechanisms…
RT @renesugar: Transcription factors operate across disease loci, with EBNA2 implicated in autoimmunity #EBV https://t.co/4Gkhdxg98d
Transcription factors operate across disease loci, with EBNA2 implicated in autoimmunity #EBV https://t.co/4Gkhdxg98d
RT @ValeBodi: Transcription factors operate across disease loci, with EBNA2 implicated in autoimmunity: Explaining the genetics of many dis…
Transcription factors operate across disease loci, with EBNA2 implicated in autoimmunity: Explaining the genetics of many diseases is challenging because most associations localize to incompletely characterized regulatory regions. #Genetics #EBNA2 #EBV https://t.co/4r06snEHKB
RT @ValeBodi: Transcription factors operate across disease loci, with EBNA2 implicated in autoimmunity #EBV #EBNA2 #Autoimmunity aka what…
Transcription factors operate across disease loci, with EBNA2 implicated in autoimmunity #EBV #EBNA2 #Autoimmunity aka what doesn’t kill you, can trigger autoimmunity later in life and serious disabling chronic illnesses #MS #SLE a subgroup of #MECFS https://t.co/4r06snmywt
RT @meghanor: John Harley's team at the Cincinnati Children's hospital published an important study in 2018 showing one potential part of a…
RT @ValeBodi: Transcription factors operate across disease loci, with #EBNA2 implicated in autoimmunity https://t.co/4r06snmywt #EBV #Autoi…
RT @meghanor: John Harley's team at the Cincinnati Children's hospital published an important study in 2018 showing one potential part of a…
#EpsteinBarrVirus recent link to #MultipleSclerosis is not new. Researchers from @CincyChildrens suggested in 2018 the association of risk genetic loci of this disease and several rheumatic diseases #lupus, #JIA, #RA with viral proteins. https://t.co/STzCvcJpOR
@surf4children Transcription factors operate across disease loci, with EBNA2 implicated in autoimmunity https://t.co/4r06snmywt
Transcription factors operate across disease loci, with #EBNA2 implicated in autoimmunity https://t.co/4r06snmywt #EBV #Autoimmunity
rheumatoid arthritis, inflammatory bowel disease, type 1 diabetes, juvenile idiopathic arthritis and celiac disease.” Transcription factors operate across disease loci, with #EBNA2 implicated in #autoimmunity #EBV https://t.co/4r06snmywt
John Harley's team at the Cincinnati Children's hospital published an important study in 2018 showing one potential part of a mechanism for how EBV might trigger lupus and other autoimmune diseases: https://t.co/wtMLJUfp3t /4
@MichJak @SteveHofstetter exactly what most say, and extremely unexpected, from a DR. Remember I said not a perfect comparison but close each virus is it’s own thing but…..science https://t.co/9oGK9wKGeC https://t.co/97qbHvHFHq
Transcription factors operate across disease loci, with EBNA2 implicated in autoimmunity | Nature Genetics https://t.co/XjH5ASFkE4
From “Kissing disease” to SLE and many other AID, EBNA2 protein in EBV interacts with many risk loci in B lymphocytes leading to SLE Transcription factors operate across disease loci, with EBNA2 implicated in autoimmunity | Nature Genetics https://t.co/BUJTPeQMAB
RT @FBCB_UNL: #SeminarioFBCB sobre "Transcription factors operate across disease loci, with EBNA2 implicated in autoimmunity" + Info:
#SeminarioFBCB sobre "Transcription factors operate across disease loci, with EBNA2 implicated in autoimmunity" + Info:
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