May 2018 PMID 29662164

Transcription factors operate across disease loci, with EBNA2 implicated in autoimmunity.

John B Harley, Xiaoting Chen, Mario Pujato, Daniel Miller, Avery Maddox, Carmy Forney, Albert F Magnusen, Arthur Lynch, Kashish Chetal, Masashi Yukawa, Artem Barski, Nathan Salomonis, Kenneth M Kaufman, Leah C Kottyan, Matthew T Weirauch

Mentions

161
Peak: 8 in Jan 2022
across 5 sources since Mar 2019

Extended reach

56,709
potential audience

Total likes

21

Video views

24

Mentions per month

Mar 2019 – Apr 2024

Where it's discussed

  • News117 articles
  • X / Twitter19 posts
  • Blogs14 articles
  • Facebook9 posts
  • YouTube2 videos

AI synopsis

What people are saying

The social discussions reflect a strong interest in the genetic and viral mechanisms underlying autoimmune diseases, with examples like references to the 2018 Cincinnati study and mentions of disease connections such as lupus, MS, and rheumatoid arthritis. The tone is scientific and somewhat optimistic about the potential implications, contributing to the overall positive agreement and moderate engagement scores.

AgreementModerate agreement

Most discussions acknowledge the significance of EBNA2's role in autoimmunity and support the findings of the publication.

InterestHigh interest

The discussions demonstrate high interest, with many posts mentioning specific diseases and mechanisms, indicating curiosity and engagement with the topic.

EngagementModerate engagement

Posts reference supportive studies and implications, such as the 2018 research linking EBV to lupus and other diseases, showing moderate in-depth discussion.

ImpactModerate impact

The discussions suggest that the research is seen as impactful, especially in understanding disease mechanisms and viral contributions to autoimmunity, though not universally seen as revolutionary.

Abstract in brief

  • Transcription factors (TFs) frequently bind to multiple regions associated with complex diseases, with EBNA2 playing a significant role in autoimmunity and other disorders.
  • The study found nearly half of systemic lupus erythematosus risk loci are bound by the Epstein-Barr virus protein EBNA2, highlighting gene-environment interactions and potential mechanisms involving viral proteins in disease development.
  • The research suggests that interactions between TFs like EBNA2 and genetic variants influence gene expression, providing new insights into the genetic and environmental factors contributing to diseases such as cancer, lupus, multiple sclerosis, and others.]

Top posts

Most liked on X and Bluesky
Meghan O'Rourke meghanor.bsky.social
@meghanor · X

John Harley's team at the Cincinnati Children's hospital published an important study in 2018 showing one potential part of a mechanism for how EBV might trigger lupus and other autoimmune diseases: https://t.co/wtMLJUfp3t /4

Jan 14, 2022 · 10 likes · 2 shares · 21,258 followers View post →
PwME 4 bioMEdical research
@ValeBodi · X

Transcription factors operate across disease loci, with EBNA2 implicated in autoimmunity #EBV #EBNA2 #Autoimmunity aka what doesn’t kill you, can trigger autoimmunity later in life and serious disabling chronic illnesses #MS #SLE a subgroup of #MECFS https://t.co/4r06snmywt

Apr 24, 2022 · 3 likes · 1 share · 4,541 followers View post →
PwME 4 bioMEdical research
@ValeBodi · X

Transcription factors operate across disease loci, with EBNA2 implicated in autoimmunity: Explaining the genetics of many diseases is challenging because most associations localize to incompletely characterized regulatory regions. #Genetics #EBNA2 #EBV https://t.co/4r06snEHKB

Feb 22, 2023 · 3 likes · 1 share · 4,541 followers View post →
Rene Sugar
@renesugar · X

Transcription factors operate across disease loci, with EBNA2 implicated in autoimmunity #EBV https://t.co/4Gkhdxg98d

Apr 11, 2024 · 3 likes · 1 share · 3,970 followers View post →
FBCB-UNL
@FBCB_UNL · X

#SeminarioFBCB sobre "Transcription factors operate across disease loci, with EBNA2 implicated in autoimmunity" + Info:

Mar 26, 2019 · 1 like · 1 share · 1,597 followers View post →
Jean francis MD,FASN
@jeanfrancis72 · X

From “Kissing disease” to SLE and many other AID, EBNA2 protein in EBV interacts with many risk loci in B lymphocytes leading to SLE Transcription factors operate across disease loci, with EBNA2 implicated in autoimmunity | Nature Genetics https://t.co/BUJTPeQMAB

Apr 26, 2019 · 1 like · 557 followers View post →

All mentions

Susan
@SusanLa69642683 · X

RT @renesugar: Transcription factors operate across disease loci, with EBNA2 implicated in autoimmunity #EBV https://t.co/4Gkhdxg98d

Apr 12, 2024 · 1 share · 1,065 followers View post →
Rene Sugar
@renesugar · X

Transcription factors operate across disease loci, with EBNA2 implicated in autoimmunity #EBV https://t.co/4Gkhdxg98d

Apr 11, 2024 · 3 likes · 1 share · 3,970 followers View post →
bisynaptic
@bisynaptic · X

RT @ValeBodi: Transcription factors operate across disease loci, with EBNA2 implicated in autoimmunity: Explaining the genetics of many dis…

Feb 23, 2023 · 1 share · 338 followers View post →
PwME 4 bioMEdical research
@ValeBodi · X

Transcription factors operate across disease loci, with EBNA2 implicated in autoimmunity: Explaining the genetics of many diseases is challenging because most associations localize to incompletely characterized regulatory regions. #Genetics #EBNA2 #EBV https://t.co/4r06snEHKB

Feb 22, 2023 · 3 likes · 1 share · 4,541 followers View post →
Finne.
@martinfinne · X

RT @ValeBodi: Transcription factors operate across disease loci, with EBNA2 implicated in autoimmunity #EBV #EBNA2 #Autoimmunity aka what…

Apr 24, 2022 · 1 share · 2,205 followers View post →
PwME 4 bioMEdical research
@ValeBodi · X

Transcription factors operate across disease loci, with EBNA2 implicated in autoimmunity #EBV #EBNA2 #Autoimmunity aka what doesn’t kill you, can trigger autoimmunity later in life and serious disabling chronic illnesses #MS #SLE a subgroup of #MECFS https://t.co/4r06snmywt

Apr 24, 2022 · 3 likes · 1 share · 4,541 followers View post →
Bob
@fluxcapdoodah · X

RT @meghanor: John Harley's team at the Cincinnati Children's hospital published an important study in 2018 showing one potential part of a…

Jan 18, 2022 · 2 shares · 689 followers View post →
BreakthroughMedicine&AdvancedResearchTools
@JayChance12 · X

RT @ValeBodi: Transcription factors operate across disease loci, with #EBNA2 implicated in autoimmunity https://t.co/4r06snmywt #EBV #Autoi…

Jan 16, 2022 · 1 share · 634 followers View post →
CRPSisaRealPain
@CRPSisaRealPain · X

RT @meghanor: John Harley's team at the Cincinnati Children's hospital published an important study in 2018 showing one potential part of a…

Jan 15, 2022 · 2 shares · 1,143 followers View post →
Rodolfo Gomez Bahamonde
@GomezBahamonde · X

#EpsteinBarrVirus recent link to #MultipleSclerosis is not new. Researchers from @CincyChildrens suggested in 2018 the association of risk genetic loci of this disease and several rheumatic diseases #lupus, #JIA, #RA with viral proteins. https://t.co/STzCvcJpOR

Jan 14, 2022 · 193 followers View post →
PwME 4 bioMEdical research
@ValeBodi · X

@surf4children Transcription factors operate across disease loci, with EBNA2 implicated in autoimmunity https://t.co/4r06snmywt

Jan 14, 2022 · 4,541 followers View post →
PwME 4 bioMEdical research
@ValeBodi · X

Transcription factors operate across disease loci, with #EBNA2 implicated in autoimmunity https://t.co/4r06snmywt #EBV #Autoimmunity

Jan 14, 2022 · 1 share · 4,541 followers View post →
PwME 4 bioMEdical research
@ValeBodi · X

rheumatoid arthritis, inflammatory bowel disease, type 1 diabetes, juvenile idiopathic arthritis and celiac disease.” Transcription factors operate across disease loci, with #EBNA2 implicated in #autoimmunity #EBV https://t.co/4r06snmywt

Jan 14, 2022 · 4,541 followers View post →
Meghan O'Rourke meghanor.bsky.social
@meghanor · X

John Harley's team at the Cincinnati Children's hospital published an important study in 2018 showing one potential part of a mechanism for how EBV might trigger lupus and other autoimmune diseases: https://t.co/wtMLJUfp3t /4

Jan 14, 2022 · 10 likes · 2 shares · 21,258 followers View post →
Knotallthere
@Knotallthere1 · X

@MichJak @SteveHofstetter exactly what most say, and extremely unexpected, from a DR. Remember I said not a perfect comparison but close each virus is it’s own thing but…..science https://t.co/9oGK9wKGeC https://t.co/97qbHvHFHq

Jun 24, 2021 · 107 followers View post →
Gris
@degogrim · X

Transcription factors operate across disease loci, with EBNA2 implicated in autoimmunity | Nature Genetics https://t.co/XjH5ASFkE4

Nov 30, 2020 · 59 followers View post →
Jean francis MD,FASN
@jeanfrancis72 · X

From “Kissing disease” to SLE and many other AID, EBNA2 protein in EBV interacts with many risk loci in B lymphocytes leading to SLE Transcription factors operate across disease loci, with EBNA2 implicated in autoimmunity | Nature Genetics https://t.co/BUJTPeQMAB

Apr 26, 2019 · 1 like · 557 followers View post →
Vanina Gisela Franco
@VaninaGFranco · X

RT @FBCB_UNL: #SeminarioFBCB sobre "Transcription factors operate across disease loci, with EBNA2 implicated in autoimmunity" + Info:

Mar 27, 2019 · 1 share · 134 followers View post →
FBCB-UNL
@FBCB_UNL · X

#SeminarioFBCB sobre "Transcription factors operate across disease loci, with EBNA2 implicated in autoimmunity" + Info:

Mar 26, 2019 · 1 like · 1 share · 1,597 followers View post →