April 2018 PMID 29676998

An epigenetic biomarker of aging for lifespan and healthspan.

Morgan E Levine, Ake T Lu, Austin Quach, Brian H Chen, Themistocles L Assimes, Stefania Bandinelli, Lifang Hou, Andrea A Baccarelli, James D Stewart, Yun Li, Eric A Whitsel, James G Wilson, Alex P Reiner, Abraham Aviv, Kurt Lohman

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Mentions

196
Peak: 31 in Mar 2022
across 4 sources since Jan 2019

Extended reach

342,900
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Total likes

826

Video views

23,622

Mentions per month

Jan 2019 – Jun 2026

Where it's discussed

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AI synopsis

What people are saying

Several discussions highlight the novel insights provided by the DNAm PhenoAge biomarker compared to past markers, with terms like 'outperforms' and 'strong correlation' being commonly mentioned. Additionally, phrases such as 'important 2018 paper' and references to specific blood tests enhance the discourse by applying a sense of urgency and highlighting the clinical relevance, indicating that contributors are both informed and engaged with the research.

AgreementModerate agreement

Many discussions show general support for the findings of the paper, indicating respect for its contributions.

InterestHigh interest

The tone reflects strong curiosity around the implications of the new biomarker, highlighting its significance in understanding aging.

EngagementModerate engagement

There are references to detailed aspects of the methodology and comparisons to previous biomarkers, showing a moderate level of engagement.

ImpactHigh impact

Participants express that this publication could greatly influence future research and practical applications in the field of aging.

Abstract in brief

  • The study identifies a new epigenetic biomarker of aging called DNAm PhenoAge, which is more effective than previous markers in predicting aging-related outcomes like mortality, cancer, and Alzheimer's disease.
  • This biomarker incorporates clinical measures of phenotypic age alongside chronological age, enabling a more comprehensive understanding of biological aging.
  • It is linked to specific biological pathways, such as proinflammatory responses and mitochondrial function, suggesting that it can reveal significant insights into the mechanisms of aging across various tissues.

Top posts

Most liked on X and Bluesky
Alexander Samuel
@AlexSamTG · X

Commençons donc. Premier intervenant à la barre "Morgane Levine" qui propose un test nommé "Horvath-Levine"... Il s'appuie sur une publication qu'elle a faite sous la direction de Steve Horvath : https://t.co/hYo0MYn31M ⬇️ https://t.co/rHeXEtTcYr

Dec 17, 2022 · 52 likes · 3 shares · 20,253 followers View post →
Ton Map U | Ⓜ️Ⓜ️T
@Tonmapu · X

#2 Scientific Tweet for @BioProtocol and @Aubrai_ "An epigenetic biomarker of aging for lifespan and healthspan" - DNAm PhenoAge, a DNA methylation (DNAm)-based biomarker that outperforms nearly all previous measures (Horvath, Hannum) in predicting morbidity and mortality https://t.co/MxwjBhIqHQ https://t.co/MWb41hlybM

Sep 23, 2025 · 40 likes · 2,208 followers View post →
Salvador Macip, MD, PhD
@DrMacip · X

Proud to have our paper on CUDC-907 as a new senolytic as one of @AgingJrnl's Top 10 Papers in 2023 https://t.co/4WPb3WuQlh

Feb 19, 2024 · 24 likes · 5 shares · 6,606 followers View post →
Agingdoc
@agingdoc1 · X

An epigenetic biomarker of aging for lifespan and healthspan (2018) https://t.co/gHH7SSbjha

Mar 17, 2022 · 8 likes · 4 shares · 41,700 followers View post →
Agingdoc
@agingdoc1 · X

@foundmyfitness GrimmAge esp. (Horvath pub) shows promise: https://t.co/1o2JVX1nF3 but the best clock will depend on precisely what this surrogate variable is targeting. @DrMorganLevine is doing some great comparative work here as well: https://t.co/yg4kslhS9C https://t.co/gHH7SSbjha -@agingdoc1

Dec 15, 2020 · 8 likes · 1 share · 41,700 followers View post →
Aging-US
@AgingJrnl · X

Join us daily as we count down the 10 most popular Aging papers in 2023 (based on Crossref resolutions). #2023YearinReview #2: "An epigenetic biomarker of aging for lifespan and healthspan" DOI: https://t.co/xYPTdJ83Qw https://t.co/1JpCQ30QyN

Feb 13, 2024 · 7 likes · 3 shares · 4,377 followers View post →

All mentions

Ton Map U | Ⓜ️Ⓜ️T
@Tonmapu · X

#2 Scientific Tweet for @BioProtocol and @Aubrai_ "An epigenetic biomarker of aging for lifespan and healthspan" - DNAm PhenoAge, a DNA methylation (DNAm)-based biomarker that outperforms nearly all previous measures (Horvath, Hannum) in predicting morbidity and mortality https://t.co/MxwjBhIqHQ https://t.co/MWb41hlybM

Sep 23, 2025 · 40 likes · 2,208 followers View post →
加藤浩晃
@HiroakiKato · X

2.Levine M. et al. (2018). “An epigenetic biomarker of aging for lifespan and healthspan.” Aging (Albany NY). ・血中DNAメチル化に基づく新たな老化指標「DNAm PhenoAge」を開発した研究(第2世代エピジェネティッククロック)。 https://t.co/tyH2MOspXa

Jun 17, 2025 · 3 likes · 19,047 followers View post →
赤い炊飯ジャー(shin1_s)
@shin1_s · X

An epigenetic biomarker of aging for lifespan and healthspan - PMC https://t.co/5yFv2IIT52

Mar 11, 2025 · 197 followers View post →
John Sigmon
@JohnSigmon · X

its based on a paper from 2018 where they found strong correlation between these standard markers and all cause mortality. paper -> https://t.co/9FijKbP82q

Feb 17, 2025 · 3 likes · 1,483 followers View post →
luis hernan graffe
@hernangraffe · X

RT @hernangraffe: https://t.co/EtX99cWdil

Jan 1, 2025 · 1 share · 3,150 followers View post →
luis hernan graffe
@hernangraffe · X

https://t.co/EtX99cWdil

Dec 27, 2024 · 1 share · 3,150 followers View post →
Manoj Mayogi Mishra
@mayogisense · X

RT @gglinskii: An epigenetic biomarker of aging for lifespan and healthspan https://t.co/WX95Jz5ZcG

Aug 4, 2024 · 1 share · 572 followers View post →
Dr. Gennadi Glinsky, MD, Ph.D.
@gglinskii · X

An epigenetic biomarker of aging for lifespan and healthspan https://t.co/WX95Jz5ZcG

Aug 4, 2024 · 3 likes · 1 share · 2,063 followers View post →
Salvador Macip, MD, PhD
@DrMacip · X

Proud to have our paper on CUDC-907 as a new senolytic as one of @AgingJrnl's Top 10 Papers in 2023 https://t.co/4WPb3WuQlh

Feb 19, 2024 · 24 likes · 5 shares · 6,606 followers View post →
Aging Journal
@AgingJrnl · X

Watch an #agingshort video of Aging's top 10 #papers in 2023, based on the number of times a DOI is successfully resolved (Crossref data). https://t.co/D6XfiHlBQZ #aging #oa #research #publication #lifespan #healthspan #gerontology #longevity #countdown #list #top10 #youtube

Feb 15, 2024 · 1 share · 4,683 followers View post →
Aging and Disease
@ISOAD2018 · X

RT @AgingJrnl: Join us daily as we count down the 10 most popular Aging papers in 2023 (based on Crossref resolutions). #2023YearinReview…

Feb 13, 2024 · 3 shares · 89 followers View post →
YMED-X
@YmedX269 · X

RT @AgingJrnl: Join us daily as we count down the 10 most popular Aging papers in 2023 (based on Crossref resolutions). #2023YearinReview…

Feb 13, 2024 · 3 shares · 229 followers View post →
Dechao Feng
@DechaoF · X

RT @AgingJrnl: Join us daily as we count down the 10 most popular Aging papers in 2023 (based on Crossref resolutions). #2023YearinReview…

Feb 13, 2024 · 3 shares · 941 followers View post →
Aging-US
@AgingJrnl · X

Join us daily as we count down the 10 most popular Aging papers in 2023 (based on Crossref resolutions). #2023YearinReview #2: "An epigenetic biomarker of aging for lifespan and healthspan" DOI: https://t.co/xYPTdJ83Qw https://t.co/1JpCQ30QyN

Feb 13, 2024 · 7 likes · 3 shares · 4,377 followers View post →
VAUBAN Sébastien Le Prestre
@Vauban059 · X

RT @AlexSamTG: Commençons donc. Premier intervenant à la barre "Morgane Levine" qui propose un test nommé "Horvath-Levine"... Il s'appuie s…

Jun 1, 2023 · 3 shares · 537 followers View post →
luis hernan graffe
@hernangraffe · X

RT @hernangraffe: https://t.co/EtX99cVFsN

Mar 4, 2023 · 1 share · 3,150 followers View post →
luis hernan graffe
@hernangraffe · X

https://t.co/EtX99cVFsN

Mar 3, 2023 · 1 share · 3,150 followers View post →
luis hernan graffe
@hernangraffe · X

RT @agingdoc1: Obviously there are tradeoffs WRT predictive value vs. other desirable aging biomarker attributes

Mar 3, 2023 · 2 shares · 3,150 followers View post →
Bayar Jaff
@JaffBayar · X

RT @agingdoc1: Obviously there are tradeoffs WRT predictive value vs. other desirable aging biomarker attributes

Mar 3, 2023 · 2 shares · 606 followers View post →
Agingdoc
@agingdoc1 · X

Obviously there are tradeoffs WRT predictive value vs. other desirable aging biomarker attributes

Mar 3, 2023 · 5 likes · 2 shares · 41,700 followers View post →
Calen P. Ryan
@CalenRyan · X

Papers reporting each of the clocks are here: https://t.co/81qRT9HD23 https://t.co/twaRXLdCiX https://t.co/39AYUr8VV8

Feb 9, 2023 · 3 likes · 655 followers View post →
Andrew Steele
@statto · X

I’ve seen this ‘focus on a single measure’ in some biohackers. eg @DrMorganLevine et al. made this clock by finding blood tests that predict biological age first. This means you can calculate your bio age just with (fairly standard) test results… https://t.co/M3xEu9QK7J

Jan 27, 2023 · 2 likes · 12,403 followers View post →
Julian Mutz
@julianmutz · X

"An epigenetic biomarker of aging for lifespan and healthspan" Important 2018 paper by @DrMorganLevine & colleagues in @AgingJrnl https://t.co/CJIdtm8wfH #aging https://t.co/cWfIFcM4WY

Jan 16, 2023 · 1 like · 513 followers View post →
Aude Smith
@AudeSmith5 · X

RT @AlexSamTG: Commençons donc. Premier intervenant à la barre "Morgane Levine" qui propose un test nommé "Horvath-Levine"... Il s'appuie s…

Dec 17, 2022 · 3 shares · 1,840 followers View post →
Vicieux \o/
@Anonyme_Vicieux · X

RT @AlexSamTG: Commençons donc. Premier intervenant à la barre "Morgane Levine" qui propose un test nommé "Horvath-Levine"... Il s'appuie s…

Dec 17, 2022 · 3 shares · 336 followers View post →
Alexander Samuel
@AlexSamTG · X

Commençons donc. Premier intervenant à la barre "Morgane Levine" qui propose un test nommé "Horvath-Levine"... Il s'appuie sur une publication qu'elle a faite sous la direction de Steve Horvath : https://t.co/hYo0MYn31M ⬇️ https://t.co/rHeXEtTcYr

Dec 17, 2022 · 52 likes · 3 shares · 20,253 followers View post →
Raúl F. Pastor
@Pastorvinosalud · X

https://t.co/coXb4W3DdW

Aug 9, 2022 · 2 likes · 86 followers View post →
luis hernan graffe
@hernangraffe · X

RT @ZaneKoch6: Biological clocks, a la PhenoAge (@DrMorganLevine) and GrimAge, are more accurate predictors of age-related deterioration a…

Jun 23, 2022 · 1 share · 3,150 followers View post →
Zane Koch
@zanehkoch · X

Biological clocks, a la PhenoAge (@DrMorganLevine) and GrimAge, are more accurate predictors of age-related deterioration and offer more interpretable predictions. For clinical applications these are the way forward. phenoAge: 10.18632/aging.101414 grimAge: 10.18632/aging.101684

Jun 23, 2022 · 3 likes · 1 share · 640 followers View post →
David Adams
@david_adams22 · X

9 blood measures to estimate biological age https://t.co/tiPT6JP2Q1 https://t.co/IWa4vZL1sB https://t.co/aEu9PiLr9z https://t.co/yTM6dWPE1u

May 8, 2022 · 1 like · 309 followers View post →
agepapers
@agepapers · X

An epigenetic biomarker of aging for lifespan and healthspan https://t.co/CZ1l3QdzSn

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@agepapers · X

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@agepapers · X

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@agepapers · X

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@agepapers · X

An epigenetic biomarker of aging for lifespan and healthspan https://t.co/KZjoaXSGuY

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Fay
@fay90028966 · X

RT @agingdoc1: An epigenetic biomarker of aging for lifespan and healthspan (2018) https://t.co/gHH7SSbjha

Mar 18, 2022 · 4 shares · 142 followers View post →
The Phoenix Lab
@The_Phoenix_Lab · X

RT @agingdoc1: An epigenetic biomarker of aging for lifespan and healthspan (2018) https://t.co/gHH7SSbjha

Mar 17, 2022 · 4 shares · 210 followers View post →
Ranjan Nanda
@RanjanN2022 · X

RT @agingdoc1: An epigenetic biomarker of aging for lifespan and healthspan (2018) https://t.co/gHH7SSbjha

Mar 17, 2022 · 4 shares · 384 followers View post →
Agingdoc
@agingdoc1 · X

An epigenetic biomarker of aging for lifespan and healthspan (2018) https://t.co/gHH7SSbjha

Mar 17, 2022 · 8 likes · 4 shares · 41,700 followers View post →
agepapers
@agepapers · X

An epigenetic biomarker of aging for lifespan and healthspan https://t.co/Qslf2JQpMo

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@agepapers · X

An epigenetic biomarker of aging for lifespan and healthspan https://t.co/uV4aiNXJR3

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@agepapers · X

An epigenetic biomarker of aging for lifespan and healthspan https://t.co/jThIYUpvcM

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@agepapers · X

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An epigenetic biomarker of aging for lifespan and healthspan https://t.co/gsnuIaeLAk

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Jason Jin
@jasonljin · X

@Alex_HPL @davidasinclair @DrAdamBat @DrCaseysKitchen @hubermanlab @PeterAttiaMD @agingdoc1 Big fan of Steve Horvath’s work on epigenetic aging https://t.co/7tYI3z8AQR

Jan 12, 2022 · 6 likes · 3,091 followers View post →
Curious Always
@learningaddict2 · X

@elonmusk Suggested changes to your tweet, Elon: Let’s set a (biological) age limit after which you can’t run for political office, perhaps a number just below (62). Ref: An epigenetic biomarker of aging for lifespan and healthspan Aging (Albany NY). April 17, 2018. https://t.co/sLuUV8IJ7S

Dec 2, 2021 · 39 followers View post →
Nathan Owens
@NathanEqualsOne · X

@richcollins @mike_lustgarten CMP + CBC + hsCRP, based on "An epigenetic biomarker of aging for lifespan and healthspan", Aging (Albany NY) 10(4) 573-591 (2018 Apr 18).

Nov 10, 2021 · 2 likes · 2,113 followers View post →
Orlando_uy
@Orlando_uy · X

An epigenetic biomarker of aging for lifespan and healthspan https://t.co/aUApRZsogQ

Jun 3, 2021 · 4 likes · 694 followers View post →
Matthew Lake
@Matthew_Lake182 · X

@Jess67335463 @davidasinclair Here's the paper from Morgan Levine An epigenetic biomarker of aging for lifespan and healthspan https://t.co/pnZ3PS77CY Ageless RX calculator is based on this.

May 17, 2021 · 885 followers View post →
Gastón F Rodríguez
@GastonFRodrigu1 · X

Envejecimiento | Un biomarcador epigenético del envejecimiento para la vida y la esperanza de salud - Texto Completo https://t.co/5CHi9gAm0y

May 1, 2021 · 1,154 followers View post →
Natalia Szejko
@Natalia99510427 · X

Very cool, epigenetic biomarkers of Aging: https://t.co/z8q2lQ5xX0

Apr 26, 2021 · 278 followers View post →
Ole Marius Tidemann
@oltidema · X

RT @agingdoc1: @foundmyfitness GrimmAge esp. (Horvath pub) shows promise: https://t.co/1o2JVX1nF3 but the best clock will depend on precise…

Dec 15, 2020 · 1 share · 28 followers View post →
Agingdoc
@agingdoc1 · X

@foundmyfitness GrimmAge esp. (Horvath pub) shows promise: https://t.co/1o2JVX1nF3 but the best clock will depend on precisely what this surrogate variable is targeting. @DrMorganLevine is doing some great comparative work here as well: https://t.co/yg4kslhS9C https://t.co/gHH7SSbjha -@agingdoc1

Dec 15, 2020 · 8 likes · 1 share · 41,700 followers View post →
Pathfinder
@Nordic_Nog · X

@GuruAnaerobic 100%, but there are far better approaches An epigenetic biomarker of aging for lifespan and healthspan https://t.co/WDb8L7G67r

Sep 21, 2019 · 543 followers View post →
nacho
@Beastmaaster001 · X

An epigenetic biomarker of aging for lifespan and healthspan https://t.co/5I4E1DjhV6

Jun 22, 2019 · 421 followers View post →
Science
@Long_life_sci · X

RT @biorxiv_pubd: An epigenetic biomarker of aging for lifespan and healthspan published as: https://t.co/3sRTrPm2vO @AgingJrnl #biorxiv

Apr 3, 2019 · 2 shares · 33 followers View post →
Aging-US
@AgingJrnl · X

RT @biorxiv_pubd: An epigenetic biomarker of aging for lifespan and healthspan published as: https://t.co/3sRTrPm2vO @AgingJrnl #biorxiv

Mar 27, 2019 · 2 shares · 4,377 followers View post →
bioRxiv Published
@biorxiv_pubd · X

An epigenetic biomarker of aging for lifespan and healthspan published as: https://t.co/3sRTrPm2vO @AgingJrnl #biorxiv

Mar 26, 2019 · 5 likes · 2 shares · 2,906 followers View post →
Lifeboat Foundation
@LifeboatHQ · X

RT @LifeboatHQ: Morgan E. Levine, coauthor of “An epigenetic biomarker of aging for lifespan and healthspan”, joins our Life Extension Boar…

Jan 16, 2019 · 1 share · 31,611 followers View post →
Lifeboat Foundation
@LifeboatHQ · X

Morgan E. Levine, coauthor of “An epigenetic biomarker of aging for lifespan and healthspan”, joins our Life Extension Board. https://t.co/rljMWzhWQ6 https://t.co/Z0VRpwXh7Z

Jan 15, 2019 · 1 like · 1 share · 31,611 followers View post →
Wojciech Branicki
@WBranicki · X

Chcesz wiedzieć w jakim tempie starzeje się Twój organizm? Zapytaj genetyka. Analiza 513 cytozyn w genomie człowieka daje precyzyjną informację o tempie starzenia się organizmu i tak zwanym wieku fenotypowym. https://t.co/aouM8LDAer

Jan 13, 2019 · 152 followers View post →
Mike Lustgarten, PhD
@mike_lustgarten · X

An epigenetic biomarker of aging for lifespan and healthspan. - PubMed - NCBI https://t.co/IzHIRSTAMH

Jan 5, 2019 · 1 like · 9,724 followers View post →