May 2018 PMID 29727683

Fasting Activates Fatty Acid Oxidation to Enhance Intestinal Stem Cell Function during Homeostasis and Aging.

Maria M Mihaylova, Chia-Wei Cheng, Amanda Q Cao, Surya Tripathi, Miyeko D Mana, Khristian E Bauer-Rowe, Monther Abu-Remaileh, Laura Clavain, Aysegul Erdemir, Caroline A Lewis, Elizaveta Freinkman, Audrey S Dickey, Albert R La Spada, Yanmei Huang, George W Bell

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Mentions

115
Peak: 3 in Sep 2019
across 7 sources since Jun 2018

Extended reach

183,131
potential audience

Total likes

351

Video views

8,901

Mentions per month

Jun 2018 – Sep 2025

Where it's discussed

  • News66 articles
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  • Blogs14 articles
  • X / Twitter9 posts
  • Reddit5 posts
  • YouTube4 videos
  • Bluesky1 posts

AI synopsis

What people are saying

The overall tone reflects a positive reception, with excerpts such as mentioning the activation of fatty acid oxidation and its benefits for intestinal stem cells, and people referencing the study's recognition on prestigious lists, indicating high regard and curiosity about fasting's role in health and aging. The use of words like 'enhancement,' 'activation,' and 'top publication' underscores the perceived significance and impact of the research.

AgreementModerate agreement

Most discussions express strong support or positive recognition of the research, highlighting the significance of fasting and fatty acid oxidation in stem cell health.

InterestModerate interest

Participants show curiosity and value the findings, with mentions of the potential health benefits and the importance of this work in aging and tissue regeneration.

EngagementModerate engagement

Conversations demonstrate active participation, referencing specific mechanisms like FAO, enzymes like Cpt1a, and implications for health, indicating thoughtful engagement.

ImpactModerate impact

The publication is seen as influential, with some discussions describing it as a 'game changer' or a top publication, emphasizing its importance in the field of aging and stem cell research.

Abstract in brief

  • Diet significantly impacts tissue regeneration across different species, with low caloric states like intermittent fasting showing benefits for overall health and aging-related tissue function.
  • A 24-hour fast enhances intestinal stem cell (ISC) function in both young and aged mice by triggering a fatty acid oxidation (FAO) program, and stimulating FAO pharmacologically can replicate fasting effects.
  • Disruption of the enzyme Cpt1a, crucial for FAO, negates fasting's benefits on ISCs, while long-term removal of Cpt1a reduces ISC numbers and function, indicating FAO's importance in ISC maintenance and intestinal regeneration.

Top posts

Most liked on X and Bluesky
Craig Kent
@KCraigKentMD · X

.@MariaMMihaylova, PHD’s “Fasting Activates Fatty Acid Oxidation to Enhance Intestinal Stem Cell Function during Homeostasis & Aging,” has been named to @CellStemCell’s list of top publications from 2018. We recruit leaders in all fields to join our world-class faculty #OSUCOM https://t.co/ID2NdJdcKs

Sep 13, 2019 · 10 likes · 1,668 followers View post →
Cell Press
@CellPressNews · X

Fasting Activates Fatty Acid Oxidation to Enhance Intestinal Stem Cell Function during Homeostasis and Aging @ohyilmaz ? #ISSCR19 https://t.co/Zv2CDyS6R2

Jun 29, 2019 · 4 likes · 1 share · 160,833 followers View post →
Pluchino lab - Regenerative Neuroimmunology
@Pluchinolab · X

Fasting Activates Fatty Acid Oxidation to Enhance Intestinal Stem Cell Function during Homeostasis and Aging: Cell Stem Cell https://t.co/HrKeeMSskd

Jan 25, 2020 · 4 likes · 1 share · 4,736 followers View post →
Johana Tello
@JOHANATELLO · X

Fasting Activates Fatty Acid Oxidation to Enhance Intestinal Stem Cell Function during Homeostasis and Aging https://t.co/EOfe495cqS

Jan 25, 2020 · 4 likes · 309 followers View post →
tune
@keisuke4713 · X

断食 OxPhos,autophagy⬆️,解糖,glutamin分解阻害⇨mitochondria活動改善 "正常"幹細胞の再生を訓練 https://t.co/MUFL3UYgCU 断食⇨脂肪酸酸化(FAO) ⇨若い

Jan 15, 2025 · 3,742 followers View post →
MyDoctorWellness
@jezamoraj · X

Ayuno 72h: Apaga el Hambre, ENCIENDE tu Cerebro mira el video aquí

Sep 4, 2025 · 1,921 followers View post →

All mentions

MyDoctorWellness
@jezamoraj · X

Ayuno 72h: Apaga el Hambre, ENCIENDE tu Cerebro mira el video aquí

Sep 4, 2025 · 1,921 followers View post →
tune
@keisuke4713 · X

断食 OxPhos,autophagy⬆️,解糖,glutamin分解阻害⇨mitochondria活動改善 "正常"幹細胞の再生を訓練 https://t.co/MUFL3UYgCU 断食⇨脂肪酸酸化(FAO) ⇨若い

Jan 15, 2025 · 3,742 followers View post →
Gabriel_s
@FPgabriel1 · X

@npaokano 2. Mihaylova, Maria M. et. al. “Fasting Activates Fatty Acid Oxidation to Enhance Intestinal Stem Cell Function during Homeostasis and Aging.” Cell Stem Cell. 2018 May, Volume 22, Issue 5, p769–778.

Mar 18, 2020 · 136 followers View post →
Ferda
@WinderFerda · X

RT @Pluchinolab: Fasting Activates Fatty Acid Oxidation to Enhance Intestinal Stem Cell Function during Homeostasis and Aging: Cell Stem Ce…

Jan 25, 2020 · 1 share · 345 followers View post →
Pluchino lab - Regenerative Neuroimmunology
@Pluchinolab · X

Fasting Activates Fatty Acid Oxidation to Enhance Intestinal Stem Cell Function during Homeostasis and Aging: Cell Stem Cell https://t.co/HrKeeMSskd

Jan 25, 2020 · 4 likes · 1 share · 4,736 followers View post →
Johana Tello
@JOHANATELLO · X

Fasting Activates Fatty Acid Oxidation to Enhance Intestinal Stem Cell Function during Homeostasis and Aging https://t.co/EOfe495cqS

Jan 25, 2020 · 4 likes · 309 followers View post →
Craig Kent
@KCraigKentMD · X

.@MariaMMihaylova, PHD’s “Fasting Activates Fatty Acid Oxidation to Enhance Intestinal Stem Cell Function during Homeostasis & Aging,” has been named to @CellStemCell’s list of top publications from 2018. We recruit leaders in all fields to join our world-class faculty #OSUCOM https://t.co/ID2NdJdcKs

Sep 13, 2019 · 10 likes · 1,668 followers View post →
NeuroStemCells
@NeuroStemCell · X

Fasting Activates Fatty Acid Oxidation to Enhance Intestinal Stem Cell Function during Homeostasis and Aging. https://t.co/pbz7cqRMoM #Neuralstemcells

Sep 7, 2019 · 536 followers View post →
Cell Press
@CellPressNews · X

Fasting Activates Fatty Acid Oxidation to Enhance Intestinal Stem Cell Function during Homeostasis and Aging @ohyilmaz ? #ISSCR19 https://t.co/Zv2CDyS6R2

Jun 29, 2019 · 4 likes · 1 share · 160,833 followers View post →
Allen Tien, MD, MHS mdlogix.com 94,698 田一彦
@allentien.bsky.social · Bluesky

https://www.cell.com/cell-stem-cell/fulltext/S1934-5909(18)30163-2 Fasting Activates Fatty Acid Oxidation to Enhance Intestinal Stem Cell Function during Homeostasis and Aging

Jun 9, 2018 View post →