PLoS Biol May 2018 PMID 29738529

Identifying novel strategies for treating human hair loss disorders: Cyclosporine A suppresses the Wnt inhibitor, SFRP1, in the dermal papilla of human scalp hair follicles.

Nathan J Hawkshaw, Jonathan A Hardman, Iain S Haslam, Asim Shahmalak, Amos Gilhar, Xinhong Lim, Ralf Paus

Download social card

Mentions

Peak: 9 in Jan 2019

across 5 sources since May 2018

Extended reach

117,094

potential audience

Total likes

5,675

Video views

107,672

Mentions per month

May 2018 – Feb 2024

Where it's discussed

X / Twitter22 posts
News7 articles
YouTube2 videos
Blogs2 articles
Reddit1 posts

AI synopsis

What people are saying

Many discussions highlight the significance of recent scientific discoveries, such as advances in medicine and environmental sustainability, using words like 'hope,' 'big steps,' and 'good news,' which convey a generally positive tone. Some mentions of the research article focus on its innovative approach to hair loss by targeting SFRP1, seen as a promising but still evolving strategy, contributing to a cautiously optimistic overall sentiment.

AgreementModerate agreement

Many discussions express optimism and support for scientific advances, including the potential of targeting SFRP1 for hair growth. However, some posts remain neutral or cautious, indicating general interest without full endorsement.

InterestModerate interest

The topics attract moderate curiosity, with discussions about scientific discoveries and their implications, but many comments lack deep technical engagement or detailed analysis.

EngagementModerate engagement

Posts include sharing videos, referencing discoveries, and encouraging reflection, showing a willingness to engage with the subject, but few comments delve into detailed scientific critique or exploration.

ImpactModerate impact

The overall tone suggests these discussions are seen as promising and potentially impactful, especially by highlighting positive societal advances and medical research, though without asserting immediate revolutionary change.

Abstract in brief

This study investigates new ways to treat hair loss by focusing on how Cyclosporine A (CsA), a drug known to induce hair growth, works at a molecular level, specifically by reducing the activity of the Wnt inhibitor SFRP1 in hair follicles.
Researchers found that lowering SFRP1 increases Wnt signaling, which is crucial for hair growth, and demonstrated that blocking SFRP1 with a drug called WAY316606 enhances hair production and prevents hair follicle regression in human tissue samples.
The findings suggest that targeting SFRP1 to boost Wnt activity could be a safe and effective new strategy for promoting hair growth, potentially avoiding risks linked to prolonged Wnt pathway activation, such as cancer.

Read the full abstract

All mentions

Innovative Strategies for Hair Loss Treatment Targeting Wnt Signaling

This video explores new approaches for treating hair loss by focusing on Cyclosporine A's impact on the Wnt inhibitor SFRP1 in hair follicles. Findings highlight how reducing SFRP1 can enhance hair growth through…

Just Mick · Jan 8, 2019 74,985 views

Cyclosporine's Role in Promoting Hair Growth via Wnt Pathway Activation

This video explores how Cyclosporine A induces hair growth by suppressing the Wnt inhibitor SFRP1 in hair follicles, increasing Wnt signaling, and potentially offering new treatments for hair loss.

Haircafe · Jun 23, 2022 32,687 views

ナンティコッタ(　ﾟдﾟ)

@AU41nkWaS69G87W · X

次は発毛薬として有名なシクロスポリン。臓器移植後の免疫抑制のために処方される薬なんだけど、患者さんで多毛症の報告があるやつだね。下記のurlでは、シクロスポリンの成分で脱毛症の治療薬を作ろうなんて研究も始まってた(今はもう諦めたのかな？)。https://t.co/rH486sAG3U https://t.co/XEPootai4x

Feb 28, 2024 · 22 followers View post →

Alby

@alby83fox · X

L'umanità nel 2018 (Cos'è accaduto in un anno di scoperte) https://t.co/M7EgtxGUue via @YouTube

Oct 13, 2019 · 51 followers View post →

Bordó

@AliceBordi · X

https://t.co/be7tc4uXPq

Aug 29, 2019 · 92 followers View post →

12 Ruote in Movimento #nogreenpass

@12ruoteinmovim · X

L'umanità nel 2018 https://t.co/Xaex6qHzBb Video di inizio anno. In descrizione ci sono i link delle notizie. Ciò fa pensare, ossia il fatto che i media ed i politici ci hanno raccontato o nascosto molte cose. Spegnete i tg, informatevi e riflettete! #informazione #justmick

Aug 24, 2019 · 105 followers View post →

Raffaele Sena

@raffaele_sena · X

Una botta di ottimismo che voglio regalare a chiunque abbia voglia di ascoltare per qualche minuto. Ah, se ne vale la pena! https://t.co/dhDqTQUIGu

Jun 13, 2019 · 238 followers View post →

blind

@emmezetaJ · X

Tolto il riferimento al consumo di carne (per me imprescindibile) e in generale un'aura un po' troppo new age per i miei gusti, video interessante e che infonde ottimismo, consigliato

May 9, 2019 · 1,097 followers View post →

Claudio Buosi

@ClaudioKlaBuosi · X

Humanity in 2018 (What happened in a year of discoveries) https://t.co/S6zVcrEupq

May 2, 2019 · 16 followers View post →

Mazinga

@Mazinga12971328 · X

Cosa è successo nel 2018? https://t.co/gzIhtltNeX

Apr 27, 2019 · 1 like · 7 followers View post →

Mario Penco

@mario_penco · X

Humanity in 2018 (What happened in a year of discoveries) https://t.co/yS5llxli5X

Apr 24, 2019 · 37 followers View post →

dermatologyf

@dermatologyf · X

Identifying novel strategies for treating human hair loss disorders: Cyclosporine A suppresses the Wnt inhibitor, SFRP1, in the dermal papilla of human scalp hair follicles. https://t.co/llMR2C9tPt

Apr 22, 2019 · 88 followers View post →

MFT Libraries

@mftlibraries · X

#PLOSBiology: Identifying novel strategies for treating human hair loss disorders: Cyclosporine A suppresses ... @manchesterBRC #openaccess https://t.co/KLlYST1tjU

Mar 28, 2019 · 2,218 followers View post →

Guida Italia

@GuidaItalia · X

Scoperte e invenzioni del 2018 https://t.co/4pOLnMVr3g https://t.co/hnwy0uVb7d

Mar 14, 2019 · 2 followers View post →

Nicola Scoppio

@altro_computer · X

Un po' di buone notizie che riguardano la sostenibilità del mondo intero. Se guardassimo meno tg zeppi dei piccoli problemi italiani, scopriremmo che un ambiente più pulito è possibile e saremmo meno negativi e fatalisti. https://t.co/VqwWfcHi27

Feb 5, 2019 · 5 followers View post →

Hernán

@ham19773 · X

@KentArgentina @GustavoNofal https://t.co/G1OLkIuAuZ

Feb 2, 2019 · 1 like · 752 followers View post →

jenuty

@jenuty · X

RT @mickodelli: Primo episodio del 2019! L'umanità nel 2018 - Cos'è accaduto in un anno di scoperte su https://t.co/QTmMppsATq o direttamen…

Jan 10, 2019 · 1 share · 293 followers View post →

RDX

@riccardodelsal · X

L'umanità nel 2018 (Cos'è accaduto in un anno di scoperte) https://t.co/ybSKmC9GgZ via @YouTube “tra i vari casini che facciamo siamo una razza veramente figa”

Jan 9, 2019 · 171 followers View post →

Mick Odelli

@mickodelli · X

Jan 8, 2019 · 2 likes · 1 share · 737 followers View post →

Gabriele Rossi

@gabryredKP · X

Mi è piaciuto un video di @YouTube: https://t.co/5ANJhMEUEb L'umanità nel 2018 (Cos'è accaduto in un anno di scoperte)

Jan 8, 2019 · 18 followers View post →

ivan frattina

@ivanfrattina · X

Mi è piaciuto un video di @YouTube: https://t.co/vpyujb2PRB L'umanità nel 2018 (Cos'è accaduto in un anno di scoperte)

Jan 8, 2019 · 59 followers View post →

Sabina Viezzoli

@la_mouche · X

RT @mickodelli: L'umanità nel 2018 (Cos'è accaduto in un anno di scoperte): https://t.co/3SN0RF3tGD tramite @YouTube

Jan 8, 2019 · 1 share · 603 followers View post →

DinaMite

@DinaMite___ · X

Ecco, non siamo poi così disastrosi Ecco tutto il buono fatto nel mondo nel 2018 Sembrano passi da gigante #BuongiornoATutti https://t.co/C0j7GltUqi

Jan 8, 2019 · 1 like · 1,967 followers View post →

Mick Odelli

@mickodelli · X

L'umanità nel 2018 (Cos'è accaduto in un anno di scoperte): https://t.co/3SN0RF3tGD tramite @YouTube

Jan 8, 2019 · 2 likes · 1 share · 737 followers View post →

Haarausfall: Substanz mit neuem Wirkmechanismus gefunden

News

DOI: 10.1371/journal.pbio.2003705. 15.05.2018 l PZ. Foto: Fotolia/Africa Studio. loading... Frag die KI. Die experimentelle KI von PZ und PTA-Forum.

Dec 13, 2025 View →

Senescent Cells in Skin Contribute to the Formation of Age Spots ...

Blogs

Our first open-access journal International Journal of Medical ... 10.1371/journal.pbio.2003705. 2020 has been billed as the year when ...

Oct 5, 2018 View →

Osteoporosis drug found to stimulate hair follicle growth - Juta ...

News

[link url="http://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.2003705"]PLOS Biology abstract[/link]. Tags; androgenetic ...

May 16, 2018 View →

Androgenetische Alopezie: SFRP1-Inhibitor lässt Haare sprießen ...

News

In PLoS Biology (2018; doi: 10.1371/journal.pbio.2003705) berichten sie außerdem, dass ein ursprünglich für die Behandlung der Osteoporose ...

May 10, 2018 View →

Immunosuppressants Side Effect May Benefit People With Hair Loss

News

... journal PLOS Biology (2018) https://doi.org/10.1371/journal.pbio.2003705 · Hair Loss - (https://en.wikipedia.org/wiki/Hair_loss). Source ...

May 9, 2018 View →

Neuer Wirkstoff gegen Haarausfall? - Nebenwirkung eines alten ...

News

... 10.1371/journal.pbio.2003705). (University of Manchester, 09.05.2018 – NPO). 9. Mai 2018. Keine Meldungen mehr verpassen – mit unserem ...

May 9, 2018 View →

Baldness treatment using a medication for osteoporosis

Blogs

Reference: http://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.2003705. Currently rated 4.3 by 4 people. Posted in: Medical ...

May 9, 2018 View →

A potential new treatment for baldness has been discovered using a ...

... 10.1371/journal.pbio.2003705. Abstract. Hair growth disorders often ... 10.1371/journal.pbio.2003705. Abstract. Hair growth disorders often ...

May 9, 2018 View →

Fringe benefits: Drug side effects could treat human hair loss ...

News

PLOS Biology, 2018; 16 (5): e2003705 DOI: 10.1371/journal.pbio.2003705. Cite This Page: MLA; APA; Chicago. University of Manchester. "Fringe ...

May 8, 2018 View →

Fringe benefits: Side effects of an immunosuppressant lead to ...

News

DOI. 10.1371/journal.pbio.2003705. Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases ...

May 8, 2018 View →

Identifying novel strategies for treating human hair loss disorders: Cyclosporine A suppresses the Wnt inhibitor, SFRP1, in the dermal papilla of human scalp hair follicles.

Mentions per month

Where it's discussed

What people are saying

Abstract in brief

Top posts

All mentions

Innovative Strategies for Hair Loss Treatment Targeting Wnt Signaling

Cyclosporine's Role in Promoting Hair Growth via Wnt Pathway Activation