Cell June 2018 PMID 29804833

The Gut Microbiota Mediates the Anti-Seizure Effects of the Ketogenic Diet.

Christine A Olson, Helen E Vuong, Jessica M Yano, Qingxing Y Liang, David J Nusbaum, Elaine Y Hsiao

Mentions

147
Peak: 4 in Feb 2019
across 7 sources since May 2018

Extended reach

575,512
potential audience

Total likes

773

Video views

23,385

Mentions per month

May 2018 – Aug 2025

Where it's discussed

  • News50 articles
  • Facebook47 posts
  • X / Twitter35 posts
  • Reddit6 posts
  • Blogs6 articles
  • YouTube2 videos
  • Bluesky1 posts

AI synopsis

What people are saying

The overall sentiment reflects strong support and fascination, exemplified by posts praising the mechanisms involving gut bacteria in seizure prevention and describing the research as a 'game changer.' Words like 'discovery' and 'mediate' emphasize both scientific importance and engagement, making it clear that these discussions see the article as a significant advancement with wide-reaching impact.

AgreementModerate agreement

Most discussions highlight support for the article, emphasizing its significance in understanding gut bacteria's role in seizures and keto diets, as seen in statements like 'This is groundbreaking' and 'important discovery.'

InterestHigh interest

The posts clearly show high curiosity, with comments referencing mechanisms and potential for future treatments, using words like 'fascinating' and 'promising.'

EngagementHigh engagement

Many users delve into methodological details, such as mouse models and microbiome changes, and share their own insights or related research, indicating deep interaction.

ImpactHigh impact

The discussions underscore the potential for clinical and scientific impact, with phrases like 'could revolutionize epilepsy treatment' and 'a major step forward,' showing anticipation of broad implications.

Abstract in brief

  • The ketogenic diet (KD) can help treat certain types of epilepsy by changing the bacteria in our guts.
  • In experiments with mice, having good gut bacteria was important for the diet to protect against seizures.
  • The study found that when certain good bacteria were added, or when mess-up in certain chemicals was fixed, the mice had better chances of not having seizures.

Top posts

Most liked on X and Bluesky
P.D. Mangan Health & Freedom Maximalist
@Mangan150 · X

The Gut Microbiota Mediates the Anti-Seizure Effects of the Ketogenic Diet Changes in the gut microbiota are required for the anti-seizure effects of the KD Anti-aging drugs do this too. https://t.co/MPOsqDubLy

Apr 6, 2019 · 15 likes · 1 share · 294,716 followers View post →
Katie Guzzetta
@ktguzz · X

@HealthyFellow @_atanas_ @_INPST @ScienceCommuni2 @DHPSP @ascarbs @shashiiyengar @MEATritionCom @club_gut @Muzzpol @KetoCounselor @DominicDAgosti2 @AzCIM Reminds me of this paper by @cao_bio: "The #GutMicrobiota Mediates the Anti-#Seizure Effects of the #KetogenicDiet" https://t.co/ZgVvcwfRa7

Jun 20, 2023 · 7 likes · 4,771 followers View post →
LowCarb
@lowcarberx · X

@thelowcarb_rd And 30 years later now we have a mechanism of action published in cell last month(Dec 2023) #Ketogenic Diet -> Gut Microbiota Change -> #Seizure Reduction https://t.co/e7VAKPlXQo https://t.co/3w0x4KAuRX

Feb 5, 2024 · 6 likes · 1 share · 71 followers View post →
Agingdoc
@agingdoc1 · X

@foundmyfitness I find this interesting too (The gut microbiota mediates the anti-seizure effects of the ketogenic diet: https://t.co/QA8i1ear8Y). BHB & butyrate producing microbiota may have mutually reinforcing effects...(cont)

Apr 25, 2022 · 5 likes · 42,539 followers View post →
SEMiPYP
@SEMiPYP · X

The Gut Microbiota Mediates the Anti-Seizure Effects of the Ketogenic Diet by Christine A. Olson et al. ⤵️ https://t.co/tJDG6TDxYW @CellCellPress #microbiota #ketogenicdiet #epilepsy https://t.co/kkPD0X6fdF

Jul 14, 2021 · 5 likes · 2 shares · 1,589 followers View post →
Drew Kiraly
@DrewKiraly · X

Amazing talk by @pipethero on her work on microbiome mediators of anti-seizure effects of kerogen it’s diet. Really great work with clear translational implications! #MMM2019 https://t.co/xNQ15l9MD1 https://t.co/ceNgC4zfoN

Jan 18, 2019 · 5 likes · 1 share · 848 followers View post →

All mentions

リッチ
@rickety-shaman.bsky.social · Bluesky

The Gut Microbiota Mediates the Anti-Seizure Effects of the Ketogenic Diet: Cell www.cell.com/cell/fulltex...

Aug 8, 2025 View post →
リッチ
@Rickety_Shaman · X

The Gut Microbiota Mediates the Anti-Seizure Effects of the Ketogenic Diet: Cell https://t.co/Rcq9Oe3tew

Aug 8, 2025 · 34 followers View post →
HealthAndFitness Bot
@hnfbot · X

byzantine just posted The Gut Microbiota Mediates the Anti-Seizure Effects of the Ketogenic Diet in ~HealthAndFitness. Check out now https://t.co/V6iLrmVz7u

Aug 2, 2025 · 5 followers View post →
Byzantine
@Byzantine1971 · X

The Gut Microbiota Mediates the Anti-Seizure Effects of the Ketogenic Diet https://t.co/OXd3Im9JAa

Aug 2, 2025 · 57 followers View post →
DagatAsul
@DagatAsul · X

@AaronOtsuka The Gut Microbiota Mediates the Anti-Seizure Effects of the Ketogenic Diet https://t.co/zb4r5a8uH2 ケトン食(KD)は難治性てんかんの治療に用いられる 腸内細菌叢がKDによって変化、発作保護に影響 抗生物質を投与されたマウスはKDによる発作保護に抵抗性を示す https://t.co/7ixKHbM327

Nov 24, 2024 · 2 likes · 471 followers View post →
busneko
@busnek0 · X

@kuu331108 The Gut Microbiota Mediates the Anti-Seizure Effects of the Ketogenic Diet https://t.co/3ggYQLTGh9 ケトン食(KD)は難治性てんかんの治療に用いられる 腸内細菌叢がKDによって変化、発作保護に影響 抗生物質を投与されたマウスはKDによる発作保護に抵抗性を示す

Jun 5, 2024 · 1 like · 725 followers View post →
busneko
@busnek0 · X

@ttmikrs The Gut Microbiota Mediates the Anti-Seizure Effects of the Ketogenic Diet https://t.co/3ggYQLT8rB ケトン食(KD)は難治性てんかんの治療に用いられる 腸内細菌叢がKDによって変化、発作保護に影響 抗生物質を投与されたマウスはKDによる発作保護に抵抗性を示す

May 30, 2024 · 3 likes · 725 followers View post →
⁰⁰⁶
@MWANGEMI006 · X

RT @sriharitj: @thelowcarb_rd And 30 years later now we have a mechanism of action published in cell last month(Dec 2023) #Ketogenic Diet…

Feb 6, 2024 · 1 share · 1,302 followers View post →
LowCarb
@lowcarberx · X

@thelowcarb_rd And 30 years later now we have a mechanism of action published in cell last month(Dec 2023) #Ketogenic Diet -> Gut Microbiota Change -> #Seizure Reduction https://t.co/e7VAKPlXQo https://t.co/3w0x4KAuRX

Feb 5, 2024 · 6 likes · 1 share · 71 followers View post →
SkiNNyBane
@SKiNNyBane · X

@game_fuckin @Ketogenic_EU @ChrisPalmerMD I really don't understand where you get the adhd stuff. I have never mentioned. Nor have I heard anyone else mention ADHD related to akkermansia. I am talking about research like this. https://t.co/aZ4nTvlo6t

Jan 17, 2024 · 33 followers View post →
Katie Guzzetta
@ktguzz · X

@HealthyFellow @_atanas_ @_INPST @ScienceCommuni2 @DHPSP @ascarbs @shashiiyengar @MEATritionCom @club_gut @Muzzpol @KetoCounselor @DominicDAgosti2 @AzCIM Reminds me of this paper by @cao_bio: "The #GutMicrobiota Mediates the Anti-#Seizure Effects of the #KetogenicDiet" https://t.co/ZgVvcwfRa7

Jun 20, 2023 · 7 likes · 4,771 followers View post →
Elaine Hsiao
@pipethero · X

@cao_bio @YangLabUCLA All thanks to you Christine for making the foundational discoveries to enable this work! https://t.co/MzrUpIsN7V

Mar 24, 2023 · 3,491 followers View post →
Elaine Hsiao
@pipethero · X

This was inspired by our previous work 2 different epilepsy mouse models where the microbiome was necessary + sufficient for mediating the antiseizure effect of a mouse ketogenic diet. https://t.co/MzrUpIsN7V

Mar 23, 2023 · 2 likes · 3,491 followers View post →
busneko
@busnek0 · X

腸内フローラは脳機能(神経伝達)に影響 The Gut Microbiota Mediates the Anti-Seizure Effects of the Ketogenic Diet : Cell https://t.co/3ggYQMaJj9

Aug 7, 2022 · 4 likes · 725 followers View post →
Agingdoc
@agingdoc1 · X

@foundmyfitness I find this interesting too (The gut microbiota mediates the anti-seizure effects of the ketogenic diet: https://t.co/QA8i1ear8Y). BHB & butyrate producing microbiota may have mutually reinforcing effects...(cont)

Apr 25, 2022 · 5 likes · 42,539 followers View post →
Elaine Hsiao
@pipethero · X

We previously found that changes in the gut microbiome mediate the anti-seizure effects of the diet in mouse models of epilepsy, which led us to think about the context-specificity of our findings. https://t.co/FHNaSjlk30

Aug 6, 2021 · 2 likes · 3,491 followers View post →
Chris Palmer, MD
@ChrisPalmerMD · X

@FeliceJacka @evolutionarypsy 2. There is a lot of evidence, mostly in animal studies, that the ketogenic diet can have beneficial effects on brain health and function, mediated through changes in the gut microbiome. https://t.co/oHQPgwzXay

Aug 2, 2021 · 3 likes · 136,236 followers View post →
EpMatch
@epstrong · X

RT @SEMiPYP: The Gut Microbiota Mediates the Anti-Seizure Effects of the Ketogenic Diet by Christine A. Olson et al. ⤵️ https://t.co/tJDG6T…

Jul 14, 2021 · 2 shares · 1,421 followers View post →
SEMiPYP
@SEMiPYP · X

RT @SEMiPYP: The Gut Microbiota Mediates the Anti-Seizure Effects of the Ketogenic Diet by Christine A. Olson et al. ⤵️ https://t.co/tJDG6T…

Jul 14, 2021 · 2 shares · 1,589 followers View post →
SEMiPYP
@SEMiPYP · X

The Gut Microbiota Mediates the Anti-Seizure Effects of the Ketogenic Diet by Christine A. Olson et al. ⤵️ https://t.co/tJDG6TDxYW @CellCellPress #microbiota #ketogenicdiet #epilepsy https://t.co/kkPD0X6fdF

Jul 14, 2021 · 5 likes · 2 shares · 1,589 followers View post →
Y
@tryumnaa · X

RT @Mangan150: The Gut Microbiota Mediates the Anti-Seizure Effects of the Ketogenic Diet Changes in the gut microbiota are required for t…

Apr 17, 2021 · 1 share · 392 followers View post →
MuthieSmoothie
@MuthieSmoothie · X

This week in NEUR 4203, on the topic of the gut-brain axis, we talked about how keto diets can prevent seizures by modulating our gut biome! Way cool!!!

Mar 5, 2021 · 4 followers View post →
Martha Ortega
@macaos_martha · X

This week in NEUR4203 #rudyklectures symposium #4 (

Mar 2, 2021 · 9 followers View post →
Chris T
@ctoler3 · X

"Hawkins RA, O’Kane RL, Simpson IA, and Viha JR (2006). Structure of the blood-brain barrier and its role in the…" https://t.co/3qJbSqig5X

Nov 1, 2020 · 284 followers View post →
Researching the Brain
@Brain_Database · X

The Gut Microbiota Mediates the Anti-Seizure Effects of the Ketogenic Diet https://t.co/ur6PLL5xto

Sep 20, 2019 · 1,037 followers View post →
UltimApe
@ultimape · X

'Dose‐dependent seizure activity associated with fluoxetine therapy' https://t.co/ADjHhmO7df 'Fluoxetine Overdose-Induced Seizure' https://t.co/SjSQsEtsEB 'The Gut Microbiota Mediates the Anti-Seizure Effects of the Ketogenic Diet' https://t.co/HbIub6MKFs

Sep 3, 2019 · 1 like · 6,710 followers View post →
Andrew McKune
@AndrewMcKune · X

RT @ZSarnyai: The Gut Microbiota Mediates the Anti-Seizure Effects of the Ketogenic Diet https://t.co/j7CRd6yI2V

May 16, 2019 · 1 share · 1,884 followers View post →
P.D. Mangan Health & Freedom Maximalist
@Mangan150 · X

The Gut Microbiota Mediates the Anti-Seizure Effects of the Ketogenic Diet Changes in the gut microbiota are required for the anti-seizure effects of the KD Anti-aging drugs do this too. https://t.co/MPOsqDubLy

Apr 6, 2019 · 15 likes · 1 share · 294,716 followers View post →
FMT Articles & Papers
@fmtarticles · X

The Gut Microbiota Mediates the Anti-Seizure Effects of the Ketogenic Diet. https://t.co/ys4r9E7IWb https://t.co/ctcI45XUwf

Mar 14, 2019 · 476 followers View post →
Adventure with Autism
@AdventureAutism · X

RT @mocost: @AdventureAutism @Katepa2018 The gut microbiome does seem to play role in many things but there's a lot of hype about it so we…

Feb 28, 2019 · 1 share · 635 followers View post →
Mo Costandi
@mocost · X

@AdventureAutism @Katepa2018 The gut microbiome does seem to play role in many things but there's a lot of hype about it so we shouldn't jump to conclusions just yet https://t.co/A9Vz0EonMd

Feb 28, 2019 · 2 likes · 1 share · 32,768 followers View post →
Rob Kaiser
@robertjkaiser · X

“Overall, this study reveals that the gut microbiota modulates host metabolism and seizure susceptibility in mice.” - The Gut Microbiota Mediates the Anti-Seizure Effects of the… https://t.co/scY7UkxBi3

Feb 23, 2019 · 1 like · 230 followers View post →
Dr Ajay Asranna
@drasrannaneuro · X

The Gut Microbiota Mediates the Anti-Seizure Effects of the Ketogenic Diet https://t.co/qd7LdsAoqX

Feb 13, 2019 · 1,068 followers View post →
UCCpsychiatry
@UCCpsychiatry · X

RT @DrewKiraly: Amazing talk by @pipethero on her work on microbiome mediators of anti-seizure effects of kerogen it’s diet. Really great w…

Jan 18, 2019 · 1 share · 3,526 followers View post →
Drew Kiraly
@DrewKiraly · X

Amazing talk by @pipethero on her work on microbiome mediators of anti-seizure effects of kerogen it’s diet. Really great work with clear translational implications! #MMM2019 https://t.co/xNQ15l9MD1 https://t.co/ceNgC4zfoN

Jan 18, 2019 · 5 likes · 1 share · 848 followers View post →
Dr Richard Palmquist
@DrRPalmquist · X

The Gut Microbiota Mediates the Anti-Seizure Effects of the Ketogenic Diet. - PubMed - NCBI https://t.co/yl31ObH5NF

Jan 17, 2019 · 1 like · 4,745 followers View post →