Acta Psychiatr Scand November 2018 PMID 29923178

Effects of psilocybin therapy on personality structure.

D Erritzoe, L Roseman, M M Nour, K MacLean, M Kaelen, D J Nutt, R L Carhart-Harris

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Mentions

49
Peak: 5 in Jul 2021
across 7 sources since Jun 2018

Extended reach

146,720
potential audience

Total likes

53

Video views

1,031

Mentions per month

Jun 2018 – Sep 2025

Where it's discussed

  • X / Twitter20 posts
  • Facebook10 posts
  • News10 articles
  • Blogs4 articles
  • YouTube2 videos
  • Reddit2 posts
  • Bluesky1 posts

AI synopsis

What people are saying

Discussions express broad support and curiosity about the research's significance, exemplified by comments like 'Fascinating implications!' and mentions of personality traits changing, which demonstrate a mixture of agreement and interest. The tone varies from enthusiastic to cautious, reflecting nuanced engagement with the potential societal and scientific impacts.

AgreementModerate agreement

Most discussants acknowledge the positive findings regarding personality changes due to psilocybin, highlighting decreases in neuroticism and increases in openness and extraversion.

InterestHigh interest

Posts show high curiosity about the potential implications of these findings, with discussions about cultural consequences and neuroscience.

EngagementModerate engagement

Though some posts briefly mention the results, others explore broader implications, suggesting moderate engagement and reflection.

ImpactModerate impact

There is a recognition that these findings could have meaningful impacts on mental health treatments and cultural perceptions, though some remain skeptical.

Abstract in brief

  • Psilocybin therapy, combined with psychological support, was found to significantly reduce neuroticism and increase extraversion and openness in patients with treatment-resistant depression, with changes persisting at 3 months.
  • The degree of insight experienced during the psilocybin session predicted the extent of personality change, suggesting a link between subjective psychedelic experiences and long-term personality shifts.
  • These personality changes are similar to those seen with traditional antidepressants, but the notable increases in extraversion and openness might be unique effects of psychedelic therapy, warranting further research into underlying brain mechanisms.

Top posts

Most liked on X and Bluesky
Reset.Me
@resetmenews · X

#Psilocybin mushrooms prompt the brain to create new brain cells, a process known as #neurogenesis: https://t.co/rVVFQ0ZaDE 2. Psilocybin use results in personality changes, including increased openness: https://t.co/kdlQf5XYZr 3. https://t.co/HNPoevPKGj

May 14, 2021 · 6 likes · 2 shares · 13,319 followers View post →
Ben Smith
@curiouskiwicat · X

@MichaelDPlant putting aside cures for addiction and mental illness (it seems like that isn't your focus), one study studying personality change using the Big-5 scale reports decreases in Neuroticism and increases in Extraversion and Openness... https://t.co/8BZyTzq4F1 ...

Oct 21, 2022 · 5 likes · 636 followers View post →
Ander Retolaza
@AnderRetolaza · X

#Psilocibina para la #Depresión Resistente: Disminuye el Neuroticismo, Aumenta la Extroversión. Vía ⁦@SEPsiqLegal⁩ https://t.co/Bavi5Qiarp

Jul 26, 2021 · 4 likes · 4 shares · 695 followers View post →
Robin Carhart-Harris
@RCarhartHarris · X

@conradomr @jordanbpeterson The group level results are quite consistently a decrease in neuroticism with psychedelics - eg: https://t.co/4gNZTWMSLA https://t.co/RBl2xBjan6

Dec 21, 2022 · 1 like · 65,411 followers View post →
Pete
@extramuros_pete · X

@_alice_evans Some evidence that psilocybin increases openness (from big-5 personality traits) reported: https://t.co/oprMWtMVVb https://t.co/HgPXVidhbv Seems likely that would have cultural consequences. Also wondering about women's roles related to various cultures' use of psychedelics.

Apr 3, 2022 · 1 like · 49 followers View post →
Stephen Pimentel
@StephenPiment · X

Effects of psilocybin therapy on personality structure https://t.co/k9d9SJDtCM

Jul 9, 2019 · 12,815 followers View post →

All mentions

Mind_Jump
@Mind_Works101 · X

Fascinating implications! Effects of psilocybin therapy on personality structure - Erritzoe - 2018 - Acta Psychiatrica Scandinavica - Wiley Online Library https://t.co/ot9Cs2eRab

Sep 5, 2025 · 291 followers View post →
Yahia
@YahiaAlajori · X

https://t.co/1aSpa3spcD

Feb 23, 2023 · 241 followers View post →
Robin Carhart-Harris
@RCarhartHarris · X

@conradomr @jordanbpeterson The group level results are quite consistently a decrease in neuroticism with psychedelics - eg: https://t.co/4gNZTWMSLA https://t.co/RBl2xBjan6

Dec 21, 2022 · 1 like · 65,411 followers View post →
Ben Smith
@curiouskiwicat · X

@MichaelDPlant putting aside cures for addiction and mental illness (it seems like that isn't your focus), one study studying personality change using the Big-5 scale reports decreases in Neuroticism and increases in Extraversion and Openness... https://t.co/8BZyTzq4F1 ...

Oct 21, 2022 · 5 likes · 636 followers View post →
Pete
@extramuros_pete · X

@_alice_evans Some evidence that psilocybin increases openness (from big-5 personality traits) reported: https://t.co/oprMWtMVVb https://t.co/HgPXVidhbv Seems likely that would have cultural consequences. Also wondering about women's roles related to various cultures' use of psychedelics.

Apr 3, 2022 · 1 like · 49 followers View post →
Carlos Mirapeix.
@psicopeix · X

Esto nos lo tenemos que tomar en serio. Siempre lo mire con reticencia, pero hay un incesante incremento en las investigaciones. Ahora, que cambie la personalidad, me cuesta creerlo. Serán efectos puntuales, pero ¡ya veremos¡ https://t.co/v0vktj8gRv

Jul 26, 2021 · 4,339 followers View post →
Anxo Fernández Dopico
@Carnaina · X

RT @AnderRetolaza: #Psilocibina para la #Depresión Resistente: Disminuye el Neuroticismo, Aumenta la Extroversión. Vía ⁦@SEPsiqLegal⁩ http…

Jul 26, 2021 · 4 shares · 6,160 followers View post →
SANIDAD TE QUIERO
@SanidadQ · X

RT @AnderRetolaza: #Psilocibina para la #Depresión Resistente: Disminuye el Neuroticismo, Aumenta la Extroversión. Vía ⁦@SEPsiqLegal⁩ http…

Jul 26, 2021 · 4 shares · 391 followers View post →
pacotraver
@pacotraver · X

RT @AnderRetolaza: #Psilocibina para la #Depresión Resistente: Disminuye el Neuroticismo, Aumenta la Extroversión. Vía ⁦@SEPsiqLegal⁩ http…

Jul 26, 2021 · 4 shares · 9,619 followers View post →
Ander Retolaza
@AnderRetolaza · X

#Psilocibina para la #Depresión Resistente: Disminuye el Neuroticismo, Aumenta la Extroversión. Vía ⁦@SEPsiqLegal⁩ https://t.co/Bavi5Qiarp

Jul 26, 2021 · 4 likes · 4 shares · 695 followers View post →
Reset.Me
@resetmenews · X

#Psilocybin mushrooms prompt the brain to create new brain cells, a process known as #neurogenesis: https://t.co/rVVFQ0ZaDE 2. Psilocybin use results in personality changes, including increased openness: https://t.co/kdlQf5XYZr 3. https://t.co/HNPoevPKGj

May 14, 2021 · 6 likes · 2 shares · 13,319 followers View post →
François Booream
@BooraemFrancois · X

https://t.co/RLeGGqXAmw

Aug 23, 2020 · 717 followers View post →
Alex Garcia
@alex_here_now · X

@JacksonKernion Give em shrooms “Openness scores ... significantly increased following psilocybin ...” https://t.co/THiYe5ZIEB

Jan 31, 2020 · 2,306 followers View post →
Jan Jozef
@JJ_Kisters · X

@TomVED @wierdduk Nogal veel mensen hebben daar 'last' van. https://t.co/E5tIWUMstJ

Jan 20, 2020 · 5,365 followers View post →
Stephen Pimentel
@StephenPiment · X

Effects of psilocybin therapy on personality structure https://t.co/k9d9SJDtCM

Sep 11, 2019 · 12,815 followers View post →
Stephen Pimentel
@StephenPiment · X

Effects of psilocybin therapy on personality structure https://t.co/k9d9SJDtCM

Jul 9, 2019 · 12,815 followers View post →
Natural Detox
@naturaldetox102 · X

Effects of psilocybin therapy on personality structure. #healthy https://t.co/b80DWIhknm

Jan 18, 2019 · 259 followers View post →
techami
@techami31 · X

Effects of psilocybin therapy on personality structure. ~ Naturopath https://t.co/4xnxKTqDcq

Jan 18, 2019 · 744 followers View post →
techami
@techami31 · X

Effects of psilocybin therapy on personality structure. -- https://t.co/tmYZilxfmB

Jan 18, 2019 · 744 followers View post →
OccuWorld
@OccuWorld · X

Effects of psilocybin therapy on personality structure. https://t.co/DBk1fpwMV3

Jan 18, 2019 · 8,738 followers View post →
Society for the Study of Addiction
@addiction-ssa.org · Bluesky

Effects of psilocybin therapy on personality structure. - PubMed - NCBI https://buff.ly/2tsS6Ur

Jun 22, 2018 View post →