ACS Nano July 2018 PMID 29924591

Epigenetic Optical Mapping of 5-Hydroxymethylcytosine in Nanochannel Arrays.

Tslil Gabrieli, Hila Sharim, Gil Nifker, Jonathan Jeffet, Tamar Shahal, Rani Arielly, Michal Levi-Sakin, Lily Hoch, Nissim Arbib, Yael Michaeli, Yuval Ebenstein

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Mentions

Peak: 9 in Aug 2021

across 2 sources since Jun 2020

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14,645

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213

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Jun 2020 – Sep 2021

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The group discusses the technical achievement of mapping 5hmC across the genome, highlighting phrases like 'mapped the human genome' and 'using an additional color' to emphasize the innovative methods. The tone conveys scientific curiosity and recognition of the technology’s potential, with appreciation reflected in messages like 'Thanks' and references to combining methylation and hydroxymethylation detection, illustrating active engagement and acknowledgment of its significance.

AgreementModerate agreement

Most responses express positive recognition of the technological advancement in mapping 5-hydroxymethylcytosine, indicating agreement with the publication's importance.

InterestModerate interest

Discussions show genuine interest, with mentions of mapping the human genome and the potential for analyzing epigenetic markers.

EngagementModerate engagement

Users actively engage by thanking and referencing specific methods and potential applications, suggesting a moderate to deep level of involvement.

ImpactModerate impact

The posts imply that this new technology could significantly influence epigenetics research and genome analysis, though direct claims about revolutionary impact are cautious.

Abstract in brief

This study introduces a new ultra-sensitive optical mapping technology that can analyze the distribution of 5hydroxymethylcytosine (5hmC), an important epigenetic marker linked to gene regulation and cancer, across entire chromosomes on single DNA molecules.
Unlike traditional sequencing methods, which struggle with noise and limited insights into complex or low-5hmC regions, this long-read approach generates continuous profiles spanning up to 1 million base pairs, revealing detailed epigenetic landscapes in variable regions like the HLA gene complex.
The research shows that 5hmC levels detected by this technique correlate with gene activity and provide insights into long-range epigenetic patterns at the single-molecule level, advancing understanding of epigenetic variation within and between cells.]

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Innovative Optical Mapping for Epigenetic Marker Analysis in Genomics

This study introduces a highly sensitive optical mapping technology that analyzes 5-hydroxymethylcytosine distribution across chromosomes at the single-molecule level, revealing detailed epigenetic landscapes and gene…

Auspicious dissenT · Aug 28, 2021 2,883 views

Advanced Optical Mapping of 5-Hydroxymethylcytosine in Chromosomes

This study introduces a sensitive optical mapping technology that analyzes 5hydroxymethylcytosine distribution across chromosomes on single DNA molecules, offering detailed epigenetic profiles linked to gene regulation…

Vilella Genomics · Jun 24, 2020 20 views

DRAX$

@Jay93231852 · X

RT @hagenom: @MoMgenomics @bach_warren @methylnick @nanopore Thanks @MoMgenomics :) We mapped the human genome for hydroxymethylation as w…

Sep 26, 2021 · 2 shares · 510 followers View post →

Jose Velazquez

@12JoseVelazquez · X

RT @MoMgenomics: $BNGO

Aug 28, 2021 · 6 shares · 233 followers View post →

IronCat

@IBHenryJ · X

RT @hagenom: @MoMgenomics @bach_warren @methylnick @nanopore Thanks @MoMgenomics :) We mapped the human genome for hydroxymethylation as w…

Aug 28, 2021 · 2 shares · 1,478 followers View post →

KakaPlog

@RiskTaker7275 · X

RT @MoMgenomics: $BNGO

Aug 27, 2021 · 6 shares · 12 followers View post →

Thinker

@goldentouch73 · X

RT @MoMgenomics: $BNGO

Aug 27, 2021 · 6 shares · 2,536 followers View post →

Joey Sales

@sales_js · X

RT @MoMgenomics: $BNGO

Aug 27, 2021 · 6 shares · 1,042 followers View post →

Gary Beane

@pollinus66 · X

RT @MoMgenomics: $BNGO

Aug 27, 2021 · 6 shares · 2,014 followers View post →

MessengerOfMoistville

@MoMgenomics · X

$BNGO

Aug 27, 2021 · 29 likes · 6 shares · 826 followers View post →

Yuval Ebenstein

@hagenom · X

@MoMgenomics @bach_warren @methylnick @nanopore Thanks @MoMgenomics :) We mapped the human genome for hydroxymethylation as well

Aug 27, 2021 · 20 likes · 2 shares · 626 followers View post →

Taco Jesse

@TJesse62 · X

RT @hagenom: @PDevaux_FD @bionanogenomics Hi Pierre, in addition to methylation we can also map 5hmC using an additional color. https://t.c…

Jun 21, 2020 · 1 share · 1,752 followers View post →

Yuval Ebenstein

@hagenom · X

@PDevaux_FD @bionanogenomics Hi Pierre, in addition to methylation we can also map 5hmC using an additional color. https://t.co/E7KCXR7BOd https://t.co/VQTrf4jgow

Jun 21, 2020 · 3 likes · 1 share · 626 followers View post →

Epigenetic Optical Mapping of 5-Hydroxymethylcytosine in Nanochannel Arrays.

Mentions per month

Where it's discussed

What people are saying

Abstract in brief

Top posts

All mentions

Innovative Optical Mapping for Epigenetic Marker Analysis in Genomics

Advanced Optical Mapping of 5-Hydroxymethylcytosine in Chromosomes