JAMA Intern Med August 2018 PMID 29971406

The Carbohydrate-Insulin Model of Obesity: Beyond "Calories In, Calories Out".

David S Ludwig, Cara B Ebbeling

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Mentions

138
Peak: 5 in Feb 2022
across 6 sources since May 2020

Extended reach

316,215
potential audience

Total likes

533

Video views

41,621

Mentions per month

May 2020 – Sep 2025

Where it's discussed

  • Facebook63 posts
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AI synopsis

What people are saying

The group demonstrates a strong interest in the Carbhohydrate-Insulin Model, referencing its historical context and scientific basis, as seen in phrases like 'well described here' and mention of detailed physiological processes. The tone indicates respectful debate and clarification, highlighting a community deeply engaged in understanding this model's significance and implications.

AgreementModerate agreement

Most discussions show support or acknowledgment of the Carbhohydrate-Insulin Model, with some emphasizing its established presence in literature.

InterestHigh interest

The discussions are highly engaged, reflecting curiosity and effort to understand or clarify aspects of the model.

EngagementModerate engagement

Participants reference specific concepts like 'postprandial hyperinsulinemia' and cite literature, indicating active engagement.

ImpactModerate impact

While the influence is noteworthy among those involved, it remains primarily within academic and interested circles, with limited broader societal impact.

Abstract in brief

  • The Carbohydrate-Insulin Model suggests that high-glycemic load processed carbohydrates cause hormonal changes that promote fat storage, increase hunger, and decrease energy expenditure, contributing to obesity.
  • Evidence from animal studies and meta-analyses indicates that diets lower in glycemic load can lead to better weight loss outcomes compared to low-fat diets, although long-term adherence remains challenging.
  • The CIM offers a framework for understanding how various dietary and non-dietary factors influence hormones and fat metabolism, proposing low-glycemic load diets as a practical alternative to traditional calorie-restricted approaches.

Top posts

Most liked on X and Bluesky
Kevin Hall
@KevinH_PhD · X

The prior CIM posits “high-carb diets…produce postprandial hyperinsulinemia, promotes deposition of calories in fat cells instead of oxidation in lean tissues, & thereby predisposes to weight gain through increased hunger, slowing metabolic rate, or both” https://t.co/wGO69hQzgw

Feb 4, 2022 · 48 likes · 4 shares · 37,728 followers View post →
Kevin Hall
@KevinH_PhD · X

@DNSWilson Do you think my description of the carb-insulin model differs from that described in this reference cited in the manuscript? https://t.co/wGO69hyYoY

May 6, 2020 · 5 likes · 1 share · 37,728 followers View post →
Kevin Hall
@KevinH_PhD · X

@JimJohnsonSci @JohnSpeakman4 @CaATiER_Chop_ER @davidludwigmd @garytaubes A reminder that the CIM was previously repeatedly described in the academic literature as well as in several books. Happy to see that the CIM has evolved since then and I’m looking forward to reading its “first full formulation”! https://t.co/gaSwgbIZ1s https://t.co/Cvck421u21

Jul 25, 2021 · 4 likes · 1 share · 37,728 followers View post →
Samuele Marcora
@SamueleMarcora · X

@garytaubes @JimJohnsonSci @KevinH_PhD @CarpentierAndr3 This kind of things take effort: https://t.co/um02vfjGK0 The CIM of obsity is well described here https://t.co/sKJTzn2Jsc and it is not so difficult to understand for somebody with a basic knowledge of human physiology. https://t.co/eSIYuKEwXS

Apr 9, 2021 · 1 like · 1 share · 10,035 followers View post →
thalesnemo
@thalesnemo · X

@nicknorwitz @AlambushaS @janvyjidak CR is CICO which has long been debunked as a tautology ! CR has been proven NOT to work 1️⃣ https://t.co/gFUM8u9ajD 2️⃣ https://t.co/BzjsR7zIev 3️⃣ https://t.co/Vf74Dd6DXy 4️⃣ https://t.co/xV7kpSwo1J 5️⃣ https://t.co/4P6O5cO6S9

Jul 16, 2021 · 1 like · 1,115 followers View post →
joshua
@BlackJJosh · X

@ChuckWardTweets @garytaubes @JohnSpeakman @whsource https://t.co/f0VIcXH1Tl

Jan 7, 2021 · 1 like · 1 share · 118 followers View post →

All mentions

user634987
@user634987 · X

@RuudGit @RealRafito @MichaelAArouet If caloric intake was lower in the ketogenic diet group, you would almost certainly see differences in physical markers, but those are absent. https://t.co/dxQ7RY0hGI https://t.co/s0p6VCg5Co https://t.co/MLZ3wM28NS

Sep 23, 2025 · 5 followers View post →
Beta Hydroxybutyrate Enjoyer
@BHBEnjoyer · X

@DavidMe17661988 They didn't, I went over that specific paper in that slide and in the abstract itself they specify: "high–glycemic-load", you're just trying to misquote them. Why don't you do basic due diligence instead of making such claims? https://t.co/PuspZ5I3UW

Jun 6, 2024 · 527 followers View post →
evian
@matthew_balI · X

@Player425 @sdnufo666 @jlkittybsh @BMOBananafish @Ol_levina а вот что говорят на сайте к которому ты ссылался https://t.co/3VnS6oyZDb

Nov 5, 2022 · 29 followers View post →
τσου
@dirfelixx · X

RT @KevinH_PhD: The prior CIM posits “high-carb diets…produce postprandial hyperinsulinemia, promotes deposition of calories in fat cells i…

Jul 29, 2022 · 4 shares · 870 followers View post →
Dr. Woodall
@DrWoodallND · X

RT @KevinH_PhD: The prior CIM posits “high-carb diets…produce postprandial hyperinsulinemia, promotes deposition of calories in fat cells i…

Feb 7, 2022 · 4 shares · 676 followers View post →
Maples the Syrup Frog
@Maples46014332 · X

RT @KevinH_PhD: The prior CIM posits “high-carb diets…produce postprandial hyperinsulinemia, promotes deposition of calories in fat cells i…

Feb 4, 2022 · 4 shares · 2,801 followers View post →
John Speakman
@JohnSpeakman4 · X

RT @KevinH_PhD: The prior CIM posits “high-carb diets…produce postprandial hyperinsulinemia, promotes deposition of calories in fat cells i…

Feb 4, 2022 · 4 shares · 11,852 followers View post →
Kevin Hall
@KevinH_PhD · X

The prior CIM posits “high-carb diets…produce postprandial hyperinsulinemia, promotes deposition of calories in fat cells instead of oxidation in lean tissues, & thereby predisposes to weight gain through increased hunger, slowing metabolic rate, or both” https://t.co/wGO69hQzgw

Feb 4, 2022 · 48 likes · 4 shares · 37,728 followers View post →
John Speakman
@JohnSpeakman4 · X

RT @KevinH_PhD: @JimJohnsonSci @JohnSpeakman4 @CaATiER_Chop_ER @davidludwigmd @garytaubes A reminder that the CIM was previously repeatedly…

Jul 25, 2021 · 1 share · 11,852 followers View post →
Kevin Hall
@KevinH_PhD · X

@JimJohnsonSci @JohnSpeakman4 @CaATiER_Chop_ER @davidludwigmd @garytaubes A reminder that the CIM was previously repeatedly described in the academic literature as well as in several books. Happy to see that the CIM has evolved since then and I’m looking forward to reading its “first full formulation”! https://t.co/gaSwgbIZ1s https://t.co/Cvck421u21

Jul 25, 2021 · 4 likes · 1 share · 37,728 followers View post →
thalesnemo
@thalesnemo · X

@nicknorwitz @AlambushaS @janvyjidak CR is CICO which has long been debunked as a tautology ! CR has been proven NOT to work 1️⃣ https://t.co/gFUM8u9ajD 2️⃣ https://t.co/BzjsR7zIev 3️⃣ https://t.co/Vf74Dd6DXy 4️⃣ https://t.co/xV7kpSwo1J 5️⃣ https://t.co/4P6O5cO6S9

Jul 16, 2021 · 1 like · 1,115 followers View post →
Samuele Marcora
@SamueleMarcora · X

@JimJohnsonSci @JohnSpeakman4 @DanielJDrucker @KevinH_PhD Jim can you tell us what is the CIM of obesity you are talking about? This one https://t.co/sKJTzn2Jsc or another one? If another one, ref please

May 7, 2021 · 10,035 followers View post →
Bhopender Thakur
@TheBhupiThakur · X

RT @SamueleMarcora: @garytaubes @JimJohnsonSci @KevinH_PhD @CarpentierAndr3 This kind of things take effort: https://t.co/um02vfjGK0 The CI…

Apr 9, 2021 · 1 share · 1,376 followers View post →
Samuele Marcora
@SamueleMarcora · X

@garytaubes @JimJohnsonSci @KevinH_PhD @CarpentierAndr3 This kind of things take effort: https://t.co/um02vfjGK0 The CIM of obsity is well described here https://t.co/sKJTzn2Jsc and it is not so difficult to understand for somebody with a basic knowledge of human physiology. https://t.co/eSIYuKEwXS

Apr 9, 2021 · 1 like · 1 share · 10,035 followers View post →
JAMA Internal Medicine
@JAMAInternalMed · X

https://t.co/SAJDalkmQW

Mar 20, 2021 · 108,133 followers View post →
Bhopender Thakur
@TheBhupiThakur · X

RT @BlackJJosh: @ChuckWardTweets @garytaubes @JohnSpeakman @whsource https://t.co/f0VIcXH1Tl

Jan 7, 2021 · 1 share · 1,376 followers View post →
joshua
@BlackJJosh · X

@ChuckWardTweets @garytaubes @JohnSpeakman @whsource https://t.co/f0VIcXH1Tl

Jan 7, 2021 · 1 like · 1 share · 118 followers View post →
ilk insan
@HSapiensIdaltu · X

@Earthling637 7. Bu konuda David Ludwig'i takip edebilirsin [1, 2]. Bir de Ludwig'e karşı olan kalori dengesini savunan Kevin Hall, Stephen Guyenet var. Bunların karşılıklı atışmaları çift yönlü olarak oldukça katkı verici olabilir. [1] https://t.co/vvhrlvnHck [2] https://t.co/DU7jaxZhMg

Dec 9, 2020 · 341 followers View post →
Matthew McClellan
@Matthew_Mc · X

RT @KevinH_PhD: @DNSWilson Do you think my description of the carb-insulin model differs from that described in this reference cited in the…

May 14, 2020 · 1 share · 215 followers View post →
Kevin Hall
@KevinH_PhD · X

@DNSWilson Do you think my description of the carb-insulin model differs from that described in this reference cited in the manuscript? https://t.co/wGO69hyYoY

May 6, 2020 · 5 likes · 1 share · 37,728 followers View post →