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Clin Pharmacokinet December 2018 PMID 30019172

Clinical Pharmacokinetics and Pharmacodynamics of Propofol.

Marko M Sahinovic, Michel M R F Struys, Anthony R Absalom

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Mentions

11
Peak: 2 in Dec 2023
across 3 sources since Jul 2021

Extended reach

1,181,294
potential audience

Total likes

38,520

Video views

1,169,274

Mentions per month

Jul 2021 – May 2025

Where it's discussed

  • News7 articles
  • X / Twitter2 posts
  • YouTube2 videos

AI synopsis

What people are saying

The discussions include mentions of compartmental models and references to authoritative texts like Miller’s anesthesia, reflecting a neutral stance focused on informational exchange. Words like 'new' and references to existing literature suggest curiosity rather than strong engagement or endorsement.

AgreementNeither agree nor disagree

There is limited explicit support or disagreement with the publication, indicating neutral or cautious views.

InterestModerate interest

The discussion shows some curiosity, mainly around the new models and the mention of specific references.

EngagementNeutral engagement

Most contributors mention or reference models and publications but do not dive deeply into critique or analysis.

ImpactNeutral impact

The discussion appears to be informational without indicating a significant shift in opinion or practice.

Abstract in brief

  • Propofol is a widely used intravenous anesthetic that works by enhancing the inhibitory effects of GABA, but it can cause cardiopulmonary side effects, so it should only be administered by trained professionals.
  • Numerous pharmacokinetic (PK) and pharmacodynamic (PD) models exist to guide dosing, with recent models like the Eleveld model designed for broader patient populations; however, prospective validation is still needed.
  • Propofol interacts with other drugs such as hypnotics and opioids, often additively or synergistically, and tools like response surface modeling help clinicians understand these complex interactions to optimize dosing and reduce adverse effects.]
Read the full abstract

Top posts

Most liked on X and Bluesky
Diego Ketamino
@DiegoEscarraman · X

@d_llanten Reves JG, Glass P, Lubarsky DA. Intravenous anesthetics. In Miller RD, Eriksson LI, Fleischer LA, et al, editors: Miller’s anesthesia, ed 7. Philadelphia, 2010, Churchill Livingstone, pp 719-768. https://t.co/9vFjdtAesA

May 20, 2022 · 2 likes · 11,918 followers View post →
Liam Skoda
@LiamSkoda · X

New Video: Compartmental Models. https://t.co/wEasb9PRE6

Dec 9, 2023 · 1 like · 32 followers View post →

All mentions

How Anesthesia Works in the Body Explained

Anesthesia causes temporary loss of sensation, absence of pain, and unconsciousness. This video explains how anesthetic drugs like Propofol enhance GABA effects and act on the body, highlighting safety considerations…

La Hiperactina · May 20, 2025 1,168,050 views
Liam Skoda
@LiamSkoda · X

New Video: Compartmental Models. https://t.co/wEasb9PRE6

Dec 9, 2023 · 1 like · 32 followers View post →
Diego Ketamino
@DiegoEscarraman · X

@d_llanten Reves JG, Glass P, Lubarsky DA. Intravenous anesthetics. In Miller RD, Eriksson LI, Fleischer LA, et al, editors: Miller’s anesthesia, ed 7. Philadelphia, 2010, Churchill Livingstone, pp 719-768. https://t.co/9vFjdtAesA

May 20, 2022 · 2 likes · 11,918 followers View post →
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1007/s40262-018-0672-3. 65. Orser BA, Canning K, MacDonald JF. Mechanisms 78 ... 7d. drome. Anaesthesist. 2004; 53:1009–22. doi:10.1007/ 167. Axon AD, Hunter JM, ...

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Combination of propofol and nasal sufentanil or intravenous ...
News

doi: 10.1007/s40262-018-0672-3. 15. Baykal Tutal Z, Gulec H, Derelı N, et al. Propofol-ketamine combination: a choice with less ...

Jul 1, 2021 View →