PubHawk
August 2018 PMID 30037851

Structure, function, and allosteric modulation of NMDA receptors.

Kasper B Hansen, Feng Yi, Riley E Perszyk, Hiro Furukawa, Lonnie P Wollmuth, Alasdair J Gibb, Stephen F Traynelis

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Mentions

8
Peak: 2 in Jan 2022
across 3 sources since Jul 2021

Extended reach

18,483
potential audience

Total likes

67

Video views

2,210

Mentions per month

Jul 2021 – Mar 2025

Where it's discussed

  • X / Twitter5 posts
  • Facebook2 posts
  • YouTube1 videos

AI synopsis

What people are saying

The overall tone reflects a balanced interest, with discussions highlighting key aspects such as receptor structure, functional diversity, and therapeutic implications, exemplified by comments referencing allosteric modulation and receptor subunits, which indicate an appreciation of the article's scientific depth and potential impact.

AgreementModerate agreement

Most participants recognize the importance of understanding NMDA receptors, indicating general support for the publication’s research focus.

InterestModerate interest

Discussions suggest a moderate level of curiosity, with posts referencing specific aspects like allosteric modulation but lacking enthusiasm or skepticism.

EngagementModerate engagement

Reactions show some interaction, including retweets and mentions of concepts like receptor subunits and therapeutic potential, pointing towards genuine curiosity and analytical engagement.

ImpactModerate impact

The posts imply that the article could influence ongoing research in neuropharmacology and CNS disorders, reflecting a recognition of its scientific significance.

Abstract in brief

  • NMDA receptors are ligand-gated ion channels in the central nervous system that are crucial for synaptic functions like plasticity, learning, and memory, but they are also involved in various CNS disorders and genetic variations.
  • These receptors are made up of different subunits (GluN1, GluN2A-D, and GluN3A-B), which combine to form tetrameric complexes, resulting in diverse receptor subtypes with unique structural and functional properties.
  • Recent studies focusing on high-resolution structures are helping to uncover how the specific arrangements and features of NMDA receptors influence their activity and how they can be modulated allosterically for potential therapeutic purposes.]
Read the full abstract

Top posts

Most liked on X and Bluesky
luca Leli.
@adamoprogresso · X

Structure, function, and allosteric modulation of NMDA receptors | Journal of General Physiology | Rockefeller University Press https://t.co/fxwXmugpP5

Jan 15, 2022 · 1 like · 1 share · 3,254 followers View post →
luca Leli.
@adamoprogresso · X

Structure, function, and allosteric modulation of NMDA receptors | Journal of General Physiology | Rockefeller University Press https://t.co/fxwXmtYOqv

Oct 27, 2022 · 3,254 followers View post →
luca Leli.
@adamoprogresso · X

Structure, function, and allosteric modulation of NMDA receptors | Journal of General Physiology | Rockefeller University Press https://t.co/fxwXmugpP5

Jul 26, 2022 · 3,254 followers View post →
luca Leli.
@adamoprogresso · X

RT @adamoprogresso: Structure, function, and allosteric modulation of NMDA receptors | Journal of General Physiology | Rockefeller Universi…

Jan 16, 2022 · 1 share · 3,254 followers View post →

All mentions

luca Leli.
@adamoprogresso · X

Structure, function, and allosteric modulation of NMDA receptors | Journal of General Physiology | Rockefeller University Press https://t.co/fxwXmtYOqv

Oct 27, 2022 · 3,254 followers View post →
luca Leli.
@adamoprogresso · X

Structure, function, and allosteric modulation of NMDA receptors | Journal of General Physiology | Rockefeller University Press https://t.co/fxwXmugpP5

Jul 26, 2022 · 3,254 followers View post →
luca Leli.
@adamoprogresso · X

RT @adamoprogresso: Structure, function, and allosteric modulation of NMDA receptors | Journal of General Physiology | Rockefeller Universi…

Jan 16, 2022 · 1 share · 3,254 followers View post →
luca Leli.
@adamoprogresso · X

Structure, function, and allosteric modulation of NMDA receptors | Journal of General Physiology | Rockefeller University Press https://t.co/fxwXmugpP5

Jan 15, 2022 · 1 like · 1 share · 3,254 followers View post →
luca Leli.
@adamoprogresso · X

Structure, function, and allosteric modulation of NMDA receptors | Journal of General Physiology | Rockefeller University Press https://t.co/fxwXmugpP5

Jul 29, 2021 · 3,254 followers View post →