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Nat Rev Endocrinol October 2018 PMID 30046148

Inflammaging: a new immune-metabolic viewpoint for age-related diseases.

Claudio Franceschi, Paolo Garagnani, Paolo Parini, Cristina Giuliani, Aurelia Santoro

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Mentions

118
Peak: 9 in Jan 2023
across 6 sources since Jul 2018

Extended reach

233,387
potential audience

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Jul 2018 – Dec 2025

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AI synopsis

What people are saying

Several social discussions highlight the importance of inflammaging in understanding aging processes, with some posts citing the article as a 'must-read' and discussing its implications for health strategies. The tone varies from casual mentions of the paper to more analytical comments about its mechanisms, showing both appreciation and curiosity for how this immune-metabolic perspective might shape future research and treatments.

AgreementModerate agreement

Most discussions support the significance of inflammaging, with many posts acknowledging it as a crucial factor in age-related diseases and referencing the publication as a valuable resource.

InterestHigh interest

Posts exhibit high curiosity, mentioning related topics like immunosenescence, lifestyle strategies to combat inflammaging, and emphasizing the relevance to aging and metabolic health.

EngagementModerate engagement

Participants show moderate to deep engagement by sharing summaries, commenting on mechanisms, and referencing further readings and talks, suggesting thoughtful consideration of the publication's ideas.

ImpactModerate impact

Overall, the discussions reflect recognition of the publication's potential influence on future aging research and clinical approaches, though some posts focus on awareness rather than proposing immediate applications.

Abstract in brief

  • Inflammaging is a low-grade, chronic inflammation that develops with age and contributes to age-related diseases, driven by various stimuli like pathogens, cell debris, and microbiota interacting with immune receptors.
  • Metaflammation, or metabolic inflammation caused by nutrient excess, shares mechanisms with inflammaging, and the gut microbiota plays a key role in both processes by releasing inflammatory products and interacting with other organs.
  • The authors suggest that chronic diseases not only result from aging and inflammaging but also accelerate aging, and propose new biomarkers like DNA methylation and metabolomics to better distinguish biological from chronological age.]
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Top posts

Most liked on X and Bluesky
Pluchino lab - Regenerative Neuroimmunology
@Pluchinolab · X

Inflammaging: a new immune–metabolic viewpoint for age-related diseases | Nature Reviews Endocrinology https://t.co/EjryDGjtbp

Jan 17, 2023 · 29 likes · 4 shares · 4,745 followers View post →
Julia B.
@JuliaB_fitness · X

@carlesvillapla1 @roxaneanquetil @ruixiang_tan @eduardo85979835 @Kelly69020986 @AntiAgify @danielsil44 @cynanthrope @MBerdock @MarkCTest @Aging_Advice @foundmyfitness @RogerSeheult Pretty good paper. Inflammaging: a new immune–metabolic viewpoint for age-related diseases. 2018 (#inflammaging is it (for humans). Everything converges on chronic/unresolved /systemic inflammation. https://t.co/boLe0Lv8Cm

May 13, 2021 · 24 likes · 8 shares · 2,272 followers View post →
Agingdoc
@agingdoc1 · X

Inflammaging: a new immune–metabolic viewpoint for age-related diseases (2018) https://t.co/am3qXnIaAN @NatureRevEndo

Jan 16, 2023 · 17 likes · 2 shares · 41,388 followers View post →
Agingdoc
@agingdoc1 · X

Inflammaging: a new immune–metabolic viewpoint for age-related diseases (2018) https://t.co/am3qXnIIql @NatureRevEndo https://t.co/kA1kcyWjBm

Apr 24, 2023 · 17 likes · 2 shares · 41,388 followers View post →
David
@davidbautistaqf · X

Teso. (Inflammaging: a new immune–metabolic viewpoint for age-related diseases) https://t.co/6fSDCvIvgk

Feb 23, 2021 · 12 likes · 11,046 followers View post →
Tushar Banerjee
@bnrjt07 · X

Further reading following Dr Akbar's talk on #immunosenescence and #inflammageing #EAACI2021 "Inflammaging: a new immune–metabolic viewpoint for age-related diseases | Nature Reviews Endocrinology" https://t.co/8YB1z2KQuX

Jul 11, 2021 · 6 likes · 1 share · 931 followers View post →

All mentions

Fay
@fay90028966 · X

RT @agingdoc1: Inflammaging: a new immune–metabolic viewpoint for age-related diseases (2018) https://t.co/am3qXnIIql @NatureRevEndo https…

Apr 25, 2023 · 2 shares · 142 followers View post →
Phenomics
@Phenomics_J · X

RT @agingdoc1: Inflammaging: a new immune–metabolic viewpoint for age-related diseases (2018) https://t.co/am3qXnIIql @NatureRevEndo https…

Apr 24, 2023 · 2 shares · 1,528 followers View post →
Agingdoc
@agingdoc1 · X

Inflammaging: a new immune–metabolic viewpoint for age-related diseases (2018) https://t.co/am3qXnIIql @NatureRevEndo https://t.co/kA1kcyWjBm

Apr 24, 2023 · 17 likes · 2 shares · 41,388 followers View post →
Carlo V. Caballero
@carvicab · X

Inflammaging: a new immune–metabolic viewpoint for age-related diseases https://t.co/UGDYHMGT9L #RotReuma #ClaseMMD

Jan 31, 2023 · 2 likes · 6,510 followers View post →
biotech archives
@bot_biotech · X

RT @Pluchinolab: Inflammaging: a new immune–metabolic viewpoint for age-related diseases | Nature Reviews Endocrinology https://t.co/EjryDG…

Jan 18, 2023 · 4 shares · 162 followers View post →
Sevgi Bağışlar Bremang
@SevgiBB_PhD · X

RT @Pluchinolab: Inflammaging: a new immune–metabolic viewpoint for age-related diseases | Nature Reviews Endocrinology https://t.co/EjryDG…

Jan 18, 2023 · 4 shares · 24 followers View post →
Jeffrey Gross, M.D.
@DrJeffreyGross · X

RT @agingdoc1: Inflammaging: a new immune–metabolic viewpoint for age-related diseases (2018) https://t.co/am3qXnIaAN @NatureRevEndo

Jan 18, 2023 · 2 shares · 47 followers View post →
JاMاL
@AlQasemJamal · X

RT @Pluchinolab: Inflammaging: a new immune–metabolic viewpoint for age-related diseases | Nature Reviews Endocrinology https://t.co/EjryDG…

Jan 18, 2023 · 4 shares · 515 followers View post →
Violetta Zujovic
@ViolettaZujovic · X

RT @Pluchinolab: Inflammaging: a new immune–metabolic viewpoint for age-related diseases | Nature Reviews Endocrinology https://t.co/EjryDG…

Jan 17, 2023 · 4 shares · 286 followers View post →
Pluchino lab - Regenerative Neuroimmunology
@Pluchinolab · X

Inflammaging: a new immune–metabolic viewpoint for age-related diseases | Nature Reviews Endocrinology https://t.co/EjryDGjtbp

Jan 17, 2023 · 29 likes · 4 shares · 4,745 followers View post →
Sandra Tapia
@mi_otrotuit · X

RT @agingdoc1: Inflammaging: a new immune–metabolic viewpoint for age-related diseases (2018) https://t.co/am3qXnIaAN @NatureRevEndo

Jan 17, 2023 · 2 shares · 770 followers View post →
Agingdoc
@agingdoc1 · X

Inflammaging: a new immune–metabolic viewpoint for age-related diseases (2018) https://t.co/am3qXnIaAN @NatureRevEndo

Jan 16, 2023 · 17 likes · 2 shares · 41,388 followers View post →
Julia B.
@JuliaB_fitness · X

RT @JuliaB_fitness: @carlesvillapla1 @roxaneanquetil @ruixiang_tan @eduardo85979835 @Kelly69020986 @AntiAgify @danielsil44 @cynanthrope @MB…

May 3, 2022 · 8 shares · 2,272 followers View post →
Nigel Ten Fleming
@TenFleming · X

Fragment from nature for this weekend focuses on an article titled ‘Inflammaging: a new immune–metabolic viewpoint for age-related diseases.’ https://t.co/gfP7d9VJU8

Oct 9, 2021 · 2,226 followers View post →
Trym Rogg
@RoggTrym · X

RT @JuliaB_fitness: @carlesvillapla1 @roxaneanquetil @ruixiang_tan @eduardo85979835 @Kelly69020986 @AntiAgify @danielsil44 @cynanthrope @MB…

Aug 23, 2021 · 8 shares · 94 followers View post →
Tushar Banerjee
@bnrjt07 · X

Further reading following Dr Akbar's talk on #immunosenescence and #inflammageing #EAACI2021 "Inflammaging: a new immune–metabolic viewpoint for age-related diseases | Nature Reviews Endocrinology" https://t.co/8YB1z2KQuX

Jul 11, 2021 · 6 likes · 1 share · 931 followers View post →
AntiAgify - Science will set you free
@AntiAgify · X

RT @JuliaB_fitness: @carlesvillapla1 @roxaneanquetil @ruixiang_tan @eduardo85979835 @Kelly69020986 @AntiAgify @danielsil44 @cynanthrope @MB…

May 23, 2021 · 8 shares · 1,353 followers View post →
Robin H. Gunster
@rhg_1 · X

RT @JuliaB_fitness: @carlesvillapla1 @roxaneanquetil @ruixiang_tan @eduardo85979835 @Kelly69020986 @AntiAgify @danielsil44 @cynanthrope @MB…

May 23, 2021 · 8 shares · 631 followers View post →
Sinch Health
@SinchHealth · X

RT @JuliaB_fitness: @carlesvillapla1 @roxaneanquetil @ruixiang_tan @eduardo85979835 @Kelly69020986 @AntiAgify @danielsil44 @cynanthrope @MB…

May 17, 2021 · 8 shares · 28 followers View post →
m73fitness
@m73fitness · X

RT @JuliaB_fitness: @carlesvillapla1 @roxaneanquetil @ruixiang_tan @eduardo85979835 @Kelly69020986 @AntiAgify @danielsil44 @cynanthrope @MB…

May 15, 2021 · 8 shares · 169 followers View post →
Julia B.
@JuliaB_fitness · X

RT @JuliaB_fitness: @carlesvillapla1 @roxaneanquetil @ruixiang_tan @eduardo85979835 @Kelly69020986 @AntiAgify @danielsil44 @cynanthrope @MB…

May 13, 2021 · 8 shares · 2,272 followers View post →
Orlando_uy
@Orlando_uy · X

RT @JuliaB_fitness: @carlesvillapla1 @roxaneanquetil @ruixiang_tan @eduardo85979835 @Kelly69020986 @AntiAgify @danielsil44 @cynanthrope @MB…

May 13, 2021 · 8 shares · 692 followers View post →
Julia B.
@JuliaB_fitness · X

@carlesvillapla1 @roxaneanquetil @ruixiang_tan @eduardo85979835 @Kelly69020986 @AntiAgify @danielsil44 @cynanthrope @MBerdock @MarkCTest @Aging_Advice @foundmyfitness @RogerSeheult Pretty good paper. Inflammaging: a new immune–metabolic viewpoint for age-related diseases. 2018 (#inflammaging is it (for humans). Everything converges on chronic/unresolved /systemic inflammation. https://t.co/boLe0Lv8Cm

May 13, 2021 · 24 likes · 8 shares · 2,272 followers View post →
David
@davidbautistaqf · X

Teso. (Inflammaging: a new immune–metabolic viewpoint for age-related diseases) https://t.co/6fSDCvIvgk

Feb 23, 2021 · 12 likes · 11,046 followers View post →
Mario
@Beteljuice · X

@yugoslavcivic @mscarnivore I don't have any major problems - my motivation is simply to ward off "inflammaging" down the road, i.e., incorporate it into my lifestyle now, not later when problems arise. https://t.co/VS1ajmoyKy

Jan 9, 2021 · 1 like · 1,999 followers View post →
Amaya Lopez-Pascual
@amayalpzp · X

RT @NatureRevEndo: #MustRead Review from Claudio Franceschi et al - #Inflammaging: a new #immune–#metabolic viewpoint for age-related disea…

Nov 28, 2019 · 2 shares · 274 followers View post →
Giovanni E Mann
@mann_ivel · X

RT @NatureRevEndo: #MustRead Review from Claudio Franceschi et al - #Inflammaging: a new #immune–#metabolic viewpoint for age-related disea…

Nov 27, 2019 · 2 shares · 1,171 followers View post →
Nature Reviews Endocrinology
@NatureRevEndo · X

#MustRead Review from Claudio Franceschi et al - #Inflammaging: a new #immune–#metabolic viewpoint for age-related diseases (£) https://t.co/qDOhUYxQHA https://t.co/cxzo2M5Tfh

Nov 27, 2019 · 5 likes · 2 shares · 35,369 followers View post →
Coralie Sengenès
@CoraSen · X

RT @NatureRevEndo: #MustRead Review - #Inflammaging: a new #immune–#metabolic viewpoint for age-related diseases (£) https://t.co/qDOhUYxQH…

Sep 12, 2019 · 2 shares · 103 followers View post →
Nature Reviews Endocrinology
@NatureRevEndo · X

#MustRead Review - #Inflammaging: a new #immune–#metabolic viewpoint for age-related diseases (£) https://t.co/qDOhUYxQHA https://t.co/JkCtLgLCOb

Sep 12, 2019 · 1 like · 2 shares · 35,369 followers View post →
Nature Reviews Endocrinology
@NatureRevEndo · X

#MustRead - #Inflammaging: a new #immune–#metabolic viewpoint for age-related diseases (£) https://t.co/qDOhUYxQHA https://t.co/mCCKtl6cNt

Jul 25, 2019 · 1 like · 35,369 followers View post →
Jessica Grace
@Endocrine2019 · X

Inflammaging: a new immune–metabolic viewpoint for age-related diseases Know more at https://t.co/IST1BvqmRs #endocrinologyconference #endocrinologycongress #endocrinologymetabolism #metabolismevent #diabetesmeeting #diabetes https://t.co/KXrH2c9g69

Jan 3, 2019 · 1 like · 44 followers View post →
Marcus Böhme
@boehmemarcus.bsky.social · Bluesky

#Inflammaging: a new immune–metabolic viewpoint for age-related diseases https://www.nature.com/articles/s41574-018-0059-4

Jul 27, 2018 View post →