PubHawk
BMC Biol August 2018 PMID 30068331

Species comparison of liver proteomes reveals links to naked mole-rat longevity and human aging.

Ivonne Heinze, Martin Bens, Enrico Calzia, Susanne Holtze, Oleksandr Dakhovnik, Arne Sahm, Joanna M Kirkpatrick, Karol Szafranski, Natalie Romanov, Sai Nagender Sama, Kerstin Holzer, Stephan Singer, Maria Ermolaeva, Matthias Platzer, Thomas Hildebrandt

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Mentions

28
Peak: 2 in Jan 2020
across 4 sources since Sep 2018

Extended reach

34
potential audience

Total likes

0

Video views

35

Mentions per month

Sep 2018 – Jan 2020

Where it's discussed

  • News21 articles
  • Blogs4 articles
  • YouTube2 videos
  • Bluesky1 posts

AI synopsis

What people are saying

The discussions reflect a positive outlook on the research, with comments like 'reveals links to longevity' and 'metabolic features associated with aging,' which underscore the scientific importance of the findings. The tone and choice of words like 'unique', 'discovery', and 'new detoxification pathway' convey excitement about the potential implications for understanding aging and developing interventions.

AgreementModerate agreement

Most discussions acknowledge the significance of the study linking molecular mechanisms to longevity, indicating general support.

InterestHigh interest

Posts demonstrate high interest by highlighting the potential implications for aging research and pointing out specific findings related to mitochondrial functions.

EngagementModerate engagement

Several discussions delve into the methods used and potential applications, reflecting a moderate level of thoughtful engagement.

ImpactModerate impact

The discussions suggest that the publication could influence future aging studies and therapeutic approaches, though the overall impact is still speculative.

Abstract in brief

  • The study compares liver proteins of long-lived naked mole-rats (NMRs) and shorter-lived guinea pigs, revealing that NMRs have unique mitochondrial protein expressions that lead to distinct metabolic features, such as reduced respiration rates and increased fatty acid utilization.
  • Findings show that the molecular changes in NMRs' aging process are similar to those in humans, suggesting a direct link to their remarkable longevity and aging resistance.
  • The research also discovered a new detoxification pathway associated with longevity, confirmed its role in nematodes, and highlights the importance of combining proteomic and transcriptomic data for cross-species insights into aging.
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Top posts

Most liked on X and Bluesky
Marcus Böhme
@boehmemarcus.bsky.social · Bluesky

Species comparison of liver proteomes reveals links to naked mole-rat longevity and human aging #longevity #JenAge https://bmcbiol.biomedcentral.com/articles/10.1186/s12915-018-0547-y#Sec9

Sep 5, 2018 View post →

All mentions

Marcus Böhme
@boehmemarcus.bsky.social · Bluesky

Species comparison of liver proteomes reveals links to naked mole-rat longevity and human aging #longevity #JenAge https://bmcbiol.biomedcentral.com/articles/10.1186/s12915-018-0547-y#Sec9

Sep 5, 2018 View post →