J Physiol October 2018 PMID 30089335

Short-term feeding of a ketogenic diet induces more severe hepatic insulin resistance than an obesogenic high-fat diet.

Gerald Grandl, Leon Straub, Carla Rudigier, Myrtha Arnold, Stephan Wueest, Daniel Konrad, Christian Wolfrum

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Mentions

57
Peak: 11 in Jun 2020
across 6 sources since Jan 2019

Extended reach

186,900
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2,386

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Jan 2019 – Nov 2025

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AI synopsis

What people are saying

The group expresses strong agreement with the research, often citing studies and scientific terminology, demonstrating a serious and analytical approach. Their language shifts from neutral explanations to critical remarks about common misconceptions, reflecting a high level of interest and engagement that could shape perceptions about ketogenic diets' health effects.

AgreementModerate agreement

Most discussions acknowledge and support the findings of the publication, highlighting consensus about ketogenic diets causing insulin resistance.

InterestHigh interest

Posts show high interest, with many referencing scientific studies and engaging in detailed analysis of the mechanisms involved.

EngagementModerate engagement

Several discussions delve into specifics, such as hepatic glucose output and studies on rodents, indicating a moderate level of analytical engagement.

ImpactHigh impact

Many imply that this research could influence how ketogenic diets are viewed, especially regarding health risks, showing a high potential impact.

Abstract in brief

  • Short-term ketogenic diet (KD) causes more severe liver insulin resistance than an obesogenic high-fat diet (HFD), leading to increased glucose production despite animals appearing metabolically healthy in the fasting state.
  • Both KD and HFD result in glucose intolerance, which is linked to increased lipid oxidation and a lower respiratory exchange ratio, but KD's insulin resistance is specifically due to hepatic glucose output.
  • The study highlights that even a brief period of carbohydrate restriction can induce hepatic insulin resistance, emphasizing the complex effects of different high-fat diets on glucose metabolism and the development of conditions like type 2 diabetes.]

Top posts

Most liked on X and Bluesky
Shivam Joshi, MD
@sjoshimd · X

Short-term Feeding of a Ketogenic Diet Induces More Severe Hepatic Insulin Resistance Than an Obesogenic High-Fat D… https://t.co/ZQ8UIh3Z3R

Jun 21, 2020 · 16 likes · 10 shares · 3,695 followers View post →
Pinky (@pinkypascoe@ohai.social)
@PascoePinky · X

@agentmangeek @BadMedicalTakes Here are a couple studies pertaining to keto diets and insulin resistance (there's not much research yet, mostly rodent studies at this point) https://t.co/2ZOpu36vmt https://t.co/9VBlDSVjzq Read about gluconeogenesis also for more detail on how protein gets turned into glucose

Oct 22, 2021 · 6 likes · 203 followers View post →
Dr. Kara Fitzgerald
@kfitzgeraldnd · X

A recent study found that two groups of animals fed the ketogenic rodent chow and the high fat diet rodent chow experienced higher rather than lower glucose intolerance. Link to study: https://t.co/lXQGVtVxfE https://t.co/1x4ERirrfo

Aug 13, 2021 · 4 likes · 5,680 followers View post →
dyd medicina int
@dydmedicinaint · X

Short‐term feeding of a ketogenic diet induces more severe hepatic insulin resistance than an obesogenic high‐fat diet - Grandl - 2018 - The Journal of Physiology - Wiley Online Library https://t.co/6rtMdT31Mv

Mar 18, 2019 · 2 likes · 1 share · 1,605 followers View post →
村元信之介
@muramo10GP · X

一般論としてHCHF食は肥りLCHF(ケトン)食は痩せる。マウスにケトン食を与えて3日後に糖負荷試験をしたら、HCHF食よりも耐糖能が低下した。その原因は筋肉組織の糖の取込低下ではなく、肝臓の糖新生を抑制できないことであった。ケトン食はT2Dのリスクになるかも。(覚書) https://t.co/nP3ltwwCRb

Jan 18, 2023 · 2 likes · 248 followers View post →
Abd Tahrani
@AbdTahrani · X

@MacroFour @Dr__Guess @BrownAdey And in rodents studies Keto did not reduce the risk of T2D https://t.co/2hhJB1YVMW

Sep 3, 2021 · 1 like · 7,572 followers View post →

All mentions

づーあわ
@Awazu_Kitchen · X

参考: ・https://t.co/drC65U82v6 ・https://t.co/DqyT1BLVsh ・https://t.co/jib4wwkyeW

Oct 1, 2023 · 187 followers View post →
村元信之介
@muramo10GP · X

一般論としてHCHF食は肥りLCHF(ケトン)食は痩せる。マウスにケトン食を与えて3日後に糖負荷試験をしたら、HCHF食よりも耐糖能が低下した。その原因は筋肉組織の糖の取込低下ではなく、肝臓の糖新生を抑制できないことであった。ケトン食はT2Dのリスクになるかも。(覚書) https://t.co/nP3ltwwCRb

Jan 18, 2023 · 2 likes · 248 followers View post →
joseph anya
@josephanyaa · X

this research paper is often cited as proof that a ketogenic diet causes insulin resistance and it’s kinda funny tbh it’s sad that people only read the title and abstract and make deductions from it https://t.co/8kqBwM51Ei

Dec 15, 2022 · 1 like · 3,974 followers View post →
Rich Collins
@richcollins · X

A relevant study: “Hyperinsulinaemic–euglycaemic clamps with double tracer show that the effect of KD is a result of hepatic insulin resistance and increased glucose output but not impaired glucose clearance or tissue glucose uptake in other tissues.” https://t.co/luCHuCBXaq

Oct 21, 2022 · 1 like · 2,094 followers View post →
Augusto
@e_augusto31 · X

@K_A_M_____ @spacetankie @SoldAndVinegar @OrwellNGoode Whoever wrote that is clearly just speaking out of their ass. https://t.co/iGJfjRmta5 https://t.co/Qjs7CXGKt6 It is very accepted among the keto community that it does indeed cause insulin resistance in healthy people, and they do know that this is not a bad thing.

Aug 7, 2022 · 171 followers View post →
Pinky (@pinkypascoe@ohai.social)
@PascoePinky · X

@agentmangeek @BadMedicalTakes Here are a couple studies pertaining to keto diets and insulin resistance (there's not much research yet, mostly rodent studies at this point) https://t.co/2ZOpu36vmt https://t.co/9VBlDSVjzq Read about gluconeogenesis also for more detail on how protein gets turned into glucose

Oct 22, 2021 · 6 likes · 203 followers View post →
Abd Tahrani
@AbdTahrani · X

@MacroFour @Dr__Guess @BrownAdey And in rodents studies Keto did not reduce the risk of T2D https://t.co/2hhJB1YVMW

Sep 3, 2021 · 1 like · 7,572 followers View post →
Dr. Kara Fitzgerald
@kfitzgeraldnd · X

A recent study found that two groups of animals fed the ketogenic rodent chow and the high fat diet rodent chow experienced higher rather than lower glucose intolerance. Link to study: https://t.co/lXQGVtVxfE https://t.co/1x4ERirrfo

Aug 13, 2021 · 4 likes · 5,680 followers View post →
identity¿
@edacikcikcik · X

karbonhidratı kesmenin uzun vadede insülin direncine ve onu takiben diyabete sebep olduğunu söyleyen çalışmalar mevcut. https://t.co/NFEO3MUrWl mesela ketojenik diyet kilo verdiriyor olabilir ama bu yüzden önerilmiyor.

Aug 9, 2021 · 279 followers View post →
Rivka Freeman RPh aka Nutrition Pharmacist
@rivkafreeman · X

RT @sjoshimd: Short-term Feeding of a Ketogenic Diet Induces More Severe Hepatic Insulin Resistance Than an Obesogenic High-Fat D… https://…

Jun 23, 2020 · 10 shares · 1,957 followers View post →
Tushar Mehta
@EcoDocTush · X

RT @sjoshimd: Short-term Feeding of a Ketogenic Diet Induces More Severe Hepatic Insulin Resistance Than an Obesogenic High-Fat D… https://…

Jun 22, 2020 · 10 shares · 587 followers View post →
Evan Allen
@EAllen0417 · X

RT @sjoshimd: Short-term Feeding of a Ketogenic Diet Induces More Severe Hepatic Insulin Resistance Than an Obesogenic High-Fat D… https://…

Jun 22, 2020 · 10 shares · 2,798 followers View post →
Antonio Soler
@antoniosoler · X

RT @sjoshimd: Short-term Feeding of a Ketogenic Diet Induces More Severe Hepatic Insulin Resistance Than an Obesogenic High-Fat D… https://…

Jun 21, 2020 · 10 shares · 346 followers View post →
Jan
@janrouxx · X

RT @sjoshimd: Short-term Feeding of a Ketogenic Diet Induces More Severe Hepatic Insulin Resistance Than an Obesogenic High-Fat D… https://…

Jun 21, 2020 · 10 shares · 154 followers View post →
Dr. Shashank Joshi
@AskDrShashank · X

RT @sjoshimd: Short-term Feeding of a Ketogenic Diet Induces More Severe Hepatic Insulin Resistance Than an Obesogenic High-Fat D… https://…

Jun 21, 2020 · 10 shares · 32,625 followers View post →
Livingguy
@Livingguy1 · X

RT @sjoshimd: Short-term Feeding of a Ketogenic Diet Induces More Severe Hepatic Insulin Resistance Than an Obesogenic High-Fat D… https://…

Jun 21, 2020 · 10 shares · 216 followers View post →
Plant Based Health Professionals UK
@plantbasedhpuk · X

RT @sjoshimd: Short-term Feeding of a Ketogenic Diet Induces More Severe Hepatic Insulin Resistance Than an Obesogenic High-Fat D… https://…

Jun 21, 2020 · 10 shares · 3,907 followers View post →
Joel "Heart Prevention" Kahn MD, FACC
@drjkahn · X

RT @sjoshimd: Short-term Feeding of a Ketogenic Diet Induces More Severe Hepatic Insulin Resistance Than an Obesogenic High-Fat D… https://…

Jun 21, 2020 · 10 shares · 32,184 followers View post →
Selvam
@Selkrish98 · X

RT @sjoshimd: Short-term Feeding of a Ketogenic Diet Induces More Severe Hepatic Insulin Resistance Than an Obesogenic High-Fat D… https://…

Jun 21, 2020 · 10 shares · 984 followers View post →
Shivam Joshi, MD
@sjoshimd · X

Short-term Feeding of a Ketogenic Diet Induces More Severe Hepatic Insulin Resistance Than an Obesogenic High-Fat D… https://t.co/ZQ8UIh3Z3R

Jun 21, 2020 · 16 likes · 10 shares · 3,695 followers View post →
DERC
@DERC · X

Here's the study that the last tweet was based on: Short‐term feeding of a ketogenic diet induces more severe hepatic insulin resistance than an obesogenic high‐fat diet https://t.co/6G11pg8EtJ

Mar 28, 2019 · 285 followers View post →
DYD P.N.A©
@dydpna · X

RT @dydmedicinaint: Short‐term feeding of a ketogenic diet induces more severe hepatic insulin resistance than an obesogenic high‐fat diet…

Mar 24, 2019 · 1 share · 70 followers View post →
dyd medicina int
@dydmedicinaint · X

Short‐term feeding of a ketogenic diet induces more severe hepatic insulin resistance than an obesogenic high‐fat diet - Grandl - 2018 - The Journal of Physiology - Wiley Online Library https://t.co/6rtMdT31Mv

Mar 18, 2019 · 2 likes · 1 share · 1,605 followers View post →
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... this area particularly, to humans. Link to study: https://physoc.onlinelibrary.wiley.com/doi/10.1113/JP275173".

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