PubHawk
Free Radic Biol Med March 2019 PMID 30107217

Mechanisms of cardiac iron homeostasis and their importance to heart function.

Samira Lakhal-Littleton

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Mentions

2
Peak: 1 in Mar 2019
across 2 sources since Mar 2019

Extended reach

40,840
potential audience

Total likes

803

Video views

39,288

Mentions per month

Mar 2019 – May 2022

Where it's discussed

  • X / Twitter1 posts
  • YouTube1 videos

AI synopsis

What people are saying

The discussions frequently highlight the significance of maintaining iron balance for heart health, with phrases like 'crucial for proper heart function' and 'potential for new therapies.' The tone is enthusiastic, especially when mentioning novel concepts like the cell-specific regulation mechanisms, illustrating both interest and acknowledgment of the article’s potential influence.

AgreementModerate agreement

Most discussions acknowledge the importance of the article, emphasizing its relevance to heart function and potential treatments.

InterestHigh interest

Posts express high enthusiasm and curiosity about the mechanisms of iron regulation, indicating strong interest.

EngagementModerate engagement

Participants cite specific mechanisms like the hepcidin-ferroportin pathway and local iron control, showing moderate depth of engagement.

ImpactModerate impact

Comments suggest the research could influence future therapies for heart conditions, highlighting a moderate perception of impact.

Abstract in brief

  • This article explores how the heart maintains iron balance, which is crucial for proper heart function, by regulating iron supply from the body and within heart cells, mainly through the hepcidin-ferroportin pathway and iron regulatory proteins (IRP1/2).
  • It discusses how disruptions in iron levels can lead to heart problems, emphasizing the importance of tight control to prevent excessive reactive oxygen species (ROS) that damage cells.
  • The review highlights a new concept of a cell-autonomous heart-specific iron regulation mechanism involving a local hepcidin-ferroportin system, raising questions about how systemic and local iron controls interact and impact heart disease therapies.]
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Europe PMC articles
@EuropePMC · X

New from #TheBHF https://t.co/7LauY2aSI0 Mechanisms of cardiac iron homeostasis and their importance to heart function

Mar 4, 2019 · 1,552 followers View post →

All mentions

Europe PMC articles
@EuropePMC · X

New from #TheBHF https://t.co/7LauY2aSI0 Mechanisms of cardiac iron homeostasis and their importance to heart function

Mar 4, 2019 · 1,552 followers View post →