Proc Natl Acad Sci U S A September 2018 PMID 30201705

Universal method for robust detection of circadian state from gene expression.

Rosemary Braun, William L Kath, Marta Iwanaszko, Elzbieta Kula-Eversole, Sabra M Abbott, Kathryn J Reid, Phyllis C Zee, Ravi Allada

Mentions

115
Peak: 11 in Jul 2021
across 6 sources since Jun 2020

Extended reach

537,758
potential audience

Total likes

20,975

Video views

517,551

Mentions per month

Jun 2020 – May 2023

Where it's discussed

  • News74 articles
  • X / Twitter12 posts
  • Facebook12 posts
  • Blogs12 articles
  • Reddit3 posts
  • YouTube2 videos

AI synopsis

What people are saying

The discussions reflect a positive reception, with posts emphasizing the method's robust and universal nature, like the mention of TimeSignature's performance across datasets. The tone combines curiosity about biological clocks, with some posts exploring practical implications for aging and medicine, demonstrating both interest and recognition of potential significance.

AgreementModerate agreement

Most discussions acknowledge the significance of the new method, with comments highlighting TimeSignature's advantages over existing techniques.

InterestHigh interest

Posts demonstrate strong curiosity about circadian rhythms and their relation to aging, showing active engagement with the topic.

EngagementModerate engagement

Comments include references to specific studies and viewers engaging with the biological implications, indicating moderate thoughtful interaction.

ImpactModerate impact

Posts imply the research could influence future circadian studies and clinical applications, but real-world impact remains to be fully seen.

Abstract in brief

  • The study introduces TimeSignature, a new algorithm that accurately determines a person's circadian (biological) time based on gene expression data, even across different measurement platforms and datasets.
  • TimeSignature outperforms existing methods by consistently estimating circadian time within 2 hours for most samples, and it can be applied to new data without the need for re-training or data normalization.
  • This approach overcomes a major challenge in biomarker development by providing a universal, reliable tool for assessing circadian rhythms, which can improve diagnosis and treatment timing for sleep and health disorders.]

Top posts

Most liked on X and Bluesky
Eleanor Sheekey
@EleanorSheekey · X

How are circadian rhythms connected with #aging and can this knowledge be exploited for circadian medicine? Well, i explore in this weeks video --> https://t.co/1IDIKkBqlH #circadianrhythm #circadianclocks #scicomm #AcademicYouTube @LongevityTech https://t.co/pLuuL1V06u

Jul 2, 2021 · 22 likes · 7 shares · 4,889 followers View post →
Jonathan Cedernaes
@JCedernaes · X

"High-accuracy determination of internal circadian time from a single blood sample" Nicole Wittenbrink et al. https://t.co/p4WCYIbTGv "Universal method for robust detection of circadian state from gene expression" Rosemary Braun et al. https://t.co/RORXL7XJXC -->

Jun 2, 2020 · 4 likes · 3,124 followers View post →
Jonathan Cedernaes
@JCedernaes · X

@ProfKantermann @SleepAndSports I agree DLMO is tricky, but 1-to-2 sample blood tests – there is also TimeSignature by Allada and colleauges https://t.co/mkCo8vbbMs – are not (as far as I know) as well characterized across different conditions/populations (?) (first validation in their JCI study was in n=28)

May 4, 2023 · 1 like · 3,124 followers View post →
Gohsuke Takama
@gohsuket · X

|・ω・`)フムフム "Circadian rhythms and aging." on YouTube - https://t.co/wwGlb4BaNd

Jul 3, 2021 · 2,991 followers View post →
Academic YouTubers
@YTacademics · X

RT @EleanorSheekey: How are circadian rhythms connected with #aging and can this knowledge be exploited for circadian medicine? Well, i e…

Jul 2, 2021 · 7 shares · 2,102 followers View post →
Brian Hodge
@Brian_Hodge_ · X

RT @EleanorSheekey: How are circadian rhythms connected with #aging and can this knowledge be exploited for circadian medicine? Well, i e…

Jul 2, 2021 · 7 shares · 1,289 followers View post →

All mentions

Jonathan Cedernaes
@JCedernaes · X

@ProfKantermann @SleepAndSports I agree DLMO is tricky, but 1-to-2 sample blood tests – there is also TimeSignature by Allada and colleauges https://t.co/mkCo8vbbMs – are not (as far as I know) as well characterized across different conditions/populations (?) (first validation in their JCI study was in n=28)

May 4, 2023 · 1 like · 3,124 followers View post →
Knowledgica
@knowledgica · X

RT @EleanorSheekey: How are circadian rhythms connected with #aging and can this knowledge be exploited for circadian medicine? Well, i e…

Jul 12, 2021 · 7 shares · 274 followers View post →
No Know Universe, Lot-num.ber si.x.t.nine
@Franky53659510 · X

Circadian rhythms and aging. https://t.co/uFk0grVkdX via @YouTube

Jul 7, 2021 · 1,060 followers View post →
Gohsuke Takama
@gohsuket · X

|・ω・`)フムフム "Circadian rhythms and aging." on YouTube - https://t.co/wwGlb4BaNd

Jul 3, 2021 · 2,991 followers View post →
Amador Romero Franco
@amaromfra · X

RT @EleanorSheekey: How are circadian rhythms connected with #aging and can this knowledge be exploited for circadian medicine? Well, i e…

Jul 2, 2021 · 7 shares · 230 followers View post →
Paola Svd
@Pao_23 · X

RT @EleanorSheekey: How are circadian rhythms connected with #aging and can this knowledge be exploited for circadian medicine? Well, i e…

Jul 2, 2021 · 7 shares · 415 followers View post →
Neurometabolism
@Neurometabolis1 · X

RT @EleanorSheekey: How are circadian rhythms connected with #aging and can this knowledge be exploited for circadian medicine? Well, i e…

Jul 2, 2021 · 7 shares · 559 followers View post →
Alex Freeman
@alex__freeman · X

RT @EleanorSheekey: How are circadian rhythms connected with #aging and can this knowledge be exploited for circadian medicine? Well, i e…

Jul 2, 2021 · 7 shares · 39 followers View post →
Brian Hodge
@Brian_Hodge_ · X

RT @EleanorSheekey: How are circadian rhythms connected with #aging and can this knowledge be exploited for circadian medicine? Well, i e…

Jul 2, 2021 · 7 shares · 1,289 followers View post →
Academic YouTubers
@YTacademics · X

RT @EleanorSheekey: How are circadian rhythms connected with #aging and can this knowledge be exploited for circadian medicine? Well, i e…

Jul 2, 2021 · 7 shares · 2,102 followers View post →
Eleanor Sheekey
@EleanorSheekey · X

How are circadian rhythms connected with #aging and can this knowledge be exploited for circadian medicine? Well, i explore in this weeks video --> https://t.co/1IDIKkBqlH #circadianrhythm #circadianclocks #scicomm #AcademicYouTube @LongevityTech https://t.co/pLuuL1V06u

Jul 2, 2021 · 22 likes · 7 shares · 4,889 followers View post →
Jonathan Cedernaes
@JCedernaes · X

"High-accuracy determination of internal circadian time from a single blood sample" Nicole Wittenbrink et al. https://t.co/p4WCYIbTGv "Universal method for robust detection of circadian state from gene expression" Rosemary Braun et al. https://t.co/RORXL7XJXC -->

Jun 2, 2020 · 4 likes · 3,124 followers View post →