Nat Cell Biol October 2018 PMID 30224760

Single particle trajectories reveal active endoplasmic reticulum luminal flow.

David Holcman, Pierre Parutto, Joseph E Chambers, Marcus Fantham, Laurence J Young, Stefan J Marciniak, Clemens F Kaminski, David Ron, Edward Avezov

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Mentions

Peak: 2 in Feb 2019

across 4 sources since Feb 2019

Extended reach

4,296

potential audience

Total likes

Video views

344

Mentions per month

Feb 2019 – Jun 2019

Where it's discussed

X / Twitter3 posts
YouTube2 videos
Facebook2 posts
News2 articles

AI synopsis

What people are saying

The discussions reflect strong interest and moderate agreement, with posts noting the importance of active luminal flow and referencing recent advances in microscopy, such as 'new from #The_MRC' and mentions of ER organization influencing transport. The tone combines excitement about the discovery with cautious recognition of its scientific significance, highlighting the potential for deeper understanding of cellular processes.

AgreementModerate agreement

Most posters appear to agree with the significance of the findings, emphasizing the novelty of active flow in the ER and its implications.

InterestHigh interest

Posts demonstrate high interest by highlighting the discovery of active transport mechanisms and referencing related literature and techniques.

EngagementModerate engagement

Discussion shows moderate depth, with some mentioning methodological details and potential biological impacts.

ImpactModerate impact

While the findings are acknowledged as important, there is some hesitation about immediate practical applications, resulting in a moderate impact score.

Abstract in brief

The endoplasmic reticulum (ER) is crucial for producing and transporting proteins and substances within cells, but its efficiency goes beyond mere diffusion.
Recent advancements in super-resolution microscopy showed that the organization of the ER influences how its contents move, with different transport modes observed in its various structures.
Findings of active flow in the ER, linked to energy-dependent contractions, highlight its role in ensuring effective distribution of materials in cells, especially in neurons that require extensive ER networks.

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All mentions

Molecular Trajectories Reveal Active Flow in Endoplasmic Reticulum

The smooth endoplasmic reticulum is revealed by single particle trajectories obtained by superresolution microscopy. Recent findings highlight how ER organization influences luminal transport modes and active flow…

David Holcman · Feb 9, 2019 287 views

Modeling ER Trafficking with Network and Particle Tracking Analysis

This is the third and final short introduction about ER analysis using SPTs analysis and network reconstruction. Recent studies reveal active, energy-dependent luminal flow within the ER, which enhances content…

David Holcman · Jun 16, 2019 57 views

Nano IJ

@nanomicroscopy · X

Single particle trajectories reveal active endoplasmic reticulum luminal flow. https://t.co/AqNfqhbWYj

Apr 16, 2019 · 594 followers View post →

Europe PMC articles

@EuropePMC · X

New from #The_MRC https://t.co/aPcel5rIjW Single particle trajectories reveal active Endoplasmic Reticulum luminal flow

Apr 2, 2019 · 1,552 followers View post →

Zeynep Öztürk, PhD

@zeyzeygen · X

Single particle trajectories reveal active endoplasmic reticulum luminal flow #ER_literature https://t.co/GdsC1HltHp

Feb 13, 2019 · 1 like · 1,807 followers View post →