Publications by authors named "David Ron"

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ISRIB Blunts the Integrated Stress Response by Allosterically Antagonising the Inhibitory Effect of Phosphorylated eIF2 on eIF2B.
Alisa F Zyryanova, Kazuhiro Kashiwagi, Claudia Rato, Heather P Harding, Ana Crespillo-Casado, Luke A Perera, Ayako Sakamoto, Madoka Nishimoto, Mayumi Yonemochi, Mikako Shirouzu

Mol Cell· January 2021

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Single particle trajectories reveal active endoplasmic reticulum luminal flow.
David Holcman, Pierre Parutto, Joseph E Chambers, Marcus Fantham, Laurence J Young, Stefan J Marciniak, Clemens F Kaminski, David Ron, Edward Avezov

Nat Cell Biol· October 2018

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A structural basis for chaperone repression of stress signaling from the endoplasmic reticulum.
Lisa Neidhardt, Joanne Tung, Miriam Kuchersky, Jakub Milczarek, Vasileios Kargas, David Ron

Mol Cell· November 2025

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Translon: a single term for translated regions.
Michał I Świrski, Jack A S Tierney, M Mar Albà, Dmitry E Andreev, Julie L Aspden, David Ron

Nat Methods· October 2025

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Protocol for iterative enrichment of integrated sgRNAs via derivative CRISPR-Cas9 libraries from genomic DNA of sorted fixed cells.
Adriana Ordóñez, David Ron, Heather P Harding

STAR Protoc· December 2024

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Alternating binding and p97-mediated dissociation of SDS22 and I3 recycles active PP1 between holophosphatases.
Anja F Kueck, Johannes van den Boom, Sandra Koska, David Ron, Hemmo Meyer

Proc Natl Acad Sci U S A· September 2024

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A genome-wide CRISPR/Cas9 screen identifies calreticulin as a selective repressor of ATF6α.
Joanne Tung, Lei Huang, Ginto George, Heather P Harding, David Ron

Elife· July 2024

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Substrate recruitment via eIF2γ enhances catalytic efficiency of a holophosphatase that terminates the integrated stress response.
Yahui Yan, Maithili Shetty, Heather P Harding, Ginto George, Alisa Zyryanova, David Ron

Proc Natl Acad Sci U S A· April 2024

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The IRE1β-mediated unfolded protein response is repressed by the chaperone AGR2 in mucin producing cells.
Lisa Neidhardt, Eva Cloots, Natalie Friemel, Caroline A M Weiss, Heather P Harding, David Ron

EMBO J· March 2024

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J-domain proteins: From molecular mechanisms to diseases.
Jaroslaw Marszalek, Paolo De Los Rios, Douglas Cyr, Matthias P Mayer, Vasista Adupa, David Ron

Cell Stress Chaperones· February 2024

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AMPylation and Endoplasmic Reticulum Protein Folding Homeostasis.
Luke A Perera, David Ron

Cold Spring Harb Perspect Biol· March 2023

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Infancy-onset diabetes caused by de-regulated AMPylation of the human endoplasmic reticulum chaperone BiP.
Luke A Perera, Andrew T Hattersley, Heather P Harding, Matthew N Wakeling, Sarah E Flanagan, David Ron

EMBO Mol Med· March 2023

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Basic science under threat: Lessons from the Skirball Institute.
Agnel Sfeir, Gord Fishell, Alexander F Schier, Michael L Dustin, Wen-Biao Gan, David Ron

Cell· March 2022

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Pharmacological targeting of endoplasmic reticulum stress in disease.
Stefan J Marciniak, Joseph E Chambers, David Ron

Nat Rev Drug Discov· February 2022

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Fluorescence Intensity-Based eIF2B's Guanine Nucleotide-Exchange Factor Activity Assay.
Yusuke Sekine, David Ron, Alisa F Zyryanova

Methods Mol Biol· February 2022

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Higher-order phosphatase-substrate contacts terminate the integrated stress response.
Yahui Yan, Heather P Harding, David Ron

Nat Struct Mol Biol· October 2021

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Structures of a deAMPylation complex rationalise the switch between antagonistic catalytic activities of FICD.
Luke A Perera, Steffen Preissler, Nathan R Zaccai, Sylvain Prévost, Juliette M Devos, David Ron

Nat Commun· August 2021

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Cargo receptor-assisted endoplasmic reticulum export of pathogenic α1-antitrypsin polymers.
Adriana Ordóñez, Heather P Harding, Stefan J Marciniak, David Ron

Cell Rep· May 2021

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Calcium depletion challenges endoplasmic reticulum proteostasis by destabilising BiP-substrate complexes.
Steffen Preissler, Claudia Rato, Yahui Yan, Luke A Perera, Aron Czako, David Ron

Elife· December 2020

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Correction: Thioredoxin-related protein 32 is an arsenite-regulated thiol reductase of the proteasome 19 S particle.
R Luke Wiseman, King-Tung Chin, Cole M Haynes, Ariel Stanhill, Chong-Feng Xu, David Ron

J Biol Chem· July 2020

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De Novo Mutations in Affecting eIF2 Signaling Cause Neonatal/Early-Onset Diabetes and Transient Hepatic Dysfunction.
Elisa De Franco, Richard Caswell, Matthew B Johnson, Matthew N Wakeling, Amnon Zung, David Ron

Diabetes· March 2020

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GDF15 mediates the effects of metformin on body weight and energy balance.
Anthony P Coll, Michael Chen, Pranali Taskar, Debra Rimmington, Satish Patel, David Ron

Nature· February 2020

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Publisher Correction: GDF15 mediates the effects of metformin on body weight and energy balance.
Anthony P Coll, Michael Chen, Pranali Taskar, Debra Rimmington, Satish Patel, David Ron

Nature· February 2020

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Is There Room for Personalized Medicine in Small-Cell Lung Cancer (SCLC)? Remarkable Activity of Pazopanib in Refractory FGFR1-Amplified ED-SCLC.
Alessandro Russo, David Arias Ron, Marika Rasschaert, Hans Prenen, Ranee Mehra

JCO Precis Oncol· December 2019

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Unstructured regions in IRE1α specify BiP-mediated destabilisation of the luminal domain dimer and repression of the UPR.
Niko Amin-Wetzel, Lisa Neidhardt, Yahui Yan, Matthias P Mayer, David Ron

Elife· December 2019

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The ribosomal P-stalk couples amino acid starvation to GCN2 activation in mammalian cells.
Heather P Harding, Adriana Ordonez, Felicity Allen, Leopold Parts, Alison J Inglis, David Ron

Elife· November 2019

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