The overall reactions demonstrate high interest and agreement, with comments referring to the power of cryo-electron microscopy, revolutionary insights into cellular stress, and the potential for new therapeutics. Words like 'impressive,' 'powerful,' and phrases such as 'new paper' and 'reveal how' highlight their engagement and the perceived significance of the publication.
AgreementStrong agreement
Most discussions convey strong support and enthusiasm for the findings, emphasizing the significance of ISRIB in modulating the stress response.
InterestHigh interest
The posts show high curiosity, highlighting the novelty of the research and its potential implications.
EngagementHigh engagement
Several posts delve into the molecular mechanisms and potential applications, indicating active engagement.
ImpactHigh impact
The discussions suggest that this research could have a transformative effect on understanding stress responses and developing therapies.
Abstract in brief
ISRIB works by interfering with the integrated stress response (ISR) by binding to eIF2B in a way that prevents phosphorylated eIF2 (eIF2P) from inhibiting it.
The molecule enhances eIF2B's activity mainly when eIF2P is present, which is part of how it reduces the stress response; this interaction is influenced by mutations that make eIF2B less sensitive to eIF2P.
CryoEM studies reveal that when eIF2P molecules bind to eIF2B, they cause structural changes that weaken ISRIB's binding, demonstrating that ISRIB and eIF2P compete through allosteric mechanisms to regulate eIF2B's activity.]
ISRIB Blunts the Integrated Stress Response by Allosterically Antagonising the Inhibitory Effect of Phosphorylated eIF2 on eIF2B https://t.co/oMCDRj3B3E
Jan 7, 2021 · 35 likes · 9 shares · 143,980 followersView post →
MC
Molecular Cell
@MolecularCell · X
Online Now: ISRIB Blunts the Integrated Stress Response by Allosterically Antagonising the Inhibitory Effect of Phosphorylated eIF2 on eIF2B https://t.co/K8qVuxVmEP
Nov 24, 2020 · 19 likes · 4 shares · 143,980 followersView post →
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FrezzaLab
@FrezzaLab · X
ISRIB Blunts the Integrated Stress Response by Allosterically Antagonising the Inhibitory Effect of Phosphorylated eIF2 on eIF2B https://t.co/j3jCgo6vom
Jan 7, 2021 · 8 likes · 2 shares · 26,945 followersView post →
Nov 20, 2020 · 2 likes · 7,004 followersView post →
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RIKEN BDR
@BDR_RIKEN · X
PUBLICATION
K Kashiwagi, T Ito (Lab for Translation Structural Biology) & collaborators @TheCIMR reveal how the drug-like molecule ISRIB antagonizes the integrated stress response, whose chronic activity has pathological effects on cells.
In @MolecularCell
https://t.co/dYBPzUU0iA
Nov 24, 2020 · 1 like · 1,402 followersView post →
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Atsuo T. Sasaki, Ph.D.｜GTP-Sasaki Lab
@gtpgeeks · X
The impressive power of Cryo-EM!
Molecular Cell paper from Drs. Takuhiko Ito's and David Ron's groups:
ISRIB Blunts the Integrated Stress Response by Allosterically Antagonising the Inhibitory Effect of Phosphorylated eIF2 on eIF2B
https://t.co/UXGwBAJXiv https://t.co/YhiIMzOAot
ISRIB blunts the integrated stress response by allosterically antagonising the inhibitory effect of phosphorylated eIF2 on eIF2B. This interaction influences cellular stress management and has implications for…
ISRIB interferes with the integrated stress response by binding to eIF2B, preventing phosphorylated eIF2 from inhibiting it. This enhances eIF2B activity and reduces cellular stress, as revealed through cryoEM studies…
ISRIB interferes with the integrated stress response by binding to eIF2B, preventing phosphorylation of eIF2 from inhibiting it, thus reducing stress signaling. CryoEM studies show structural changes influence ISRIB's…
ISRIB Blunts the Integrated Stress Response by Allosterically Antagonising the Inhibitory Effect of Phosphorylated eIF2 on eIF2B.
Molecular cell(2021)
#Biotechnology #Science
https://t.co/C3gKjvCYzA
@grokの解説⬇️
RT @westminstercolo: ISRIB Blunts the Integrated Stress Response by Allosterically Antagonising the Inhibitory Effect of Phosphorylated eIF…
Aug 25, 2025 · 1 share · 1,115 followersView post →
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@westminstercolo · X
ISRIB Blunts the Integrated Stress Response by Allosterically Antagonising the Inhibitory Effect of Phosphorylated eIF2 on eIF2B
[2021. @Cambridge_Uni. RIKEN Center for Biosystems Dynamics Research]
https://t.co/5YmtzukkYn
RT @MolecularCell: ISRIB Blunts the Integrated Stress Response by Allosterically Antagonising the Inhibitory Effect of Phosphorylated eIF2…
Jan 7, 2021 · 9 shares · 1,766 followersView post →
MC
Molecular Cell
@MolecularCell · X
ISRIB Blunts the Integrated Stress Response by Allosterically Antagonising the Inhibitory Effect of Phosphorylated eIF2 on eIF2B https://t.co/oMCDRj3B3E
Jan 7, 2021 · 35 likes · 9 shares · 143,980 followersView post →
GB
Glenn Bantug
@gbantug2000 · X
RT @FrezzaLab: ISRIB Blunts the Integrated Stress Response by Allosterically Antagonising the Inhibitory Effect of Phosphorylated eIF2 on e…
RT @FrezzaLab: ISRIB Blunts the Integrated Stress Response by Allosterically Antagonising the Inhibitory Effect of Phosphorylated eIF2 on e…
Jan 7, 2021 · 2 shares · 1,239 followersView post →
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FrezzaLab
@FrezzaLab · X
ISRIB Blunts the Integrated Stress Response by Allosterically Antagonising the Inhibitory Effect of Phosphorylated eIF2 on eIF2B https://t.co/j3jCgo6vom
Jan 7, 2021 · 8 likes · 2 shares · 26,945 followersView post →
VH
Vasili Hauryliuk
@hauryliuk · X
RT @MolecularCell: Online Now: ISRIB Blunts the Integrated Stress Response by Allosterically Antagonising the Inhibitory Effect of Phosphor…
Nov 25, 2020 · 4 shares · 3,159 followersView post →
YS
Yuichi Shichino
@u1_7no · X
RT @MolecularCell: Online Now: ISRIB Blunts the Integrated Stress Response by Allosterically Antagonising the Inhibitory Effect of Phosphor…
Nov 24, 2020 · 4 shares · 802 followersView post →
PK
P Kritsiligkou
@Parikki · X
RT @MolecularCell: Online Now: ISRIB Blunts the Integrated Stress Response by Allosterically Antagonising the Inhibitory Effect of Phosphor…
Nov 24, 2020 · 4 shares · 761 followersView post →
MC
Molecular Cell
@MolecularCell · X
Online Now: ISRIB Blunts the Integrated Stress Response by Allosterically Antagonising the Inhibitory Effect of Phosphorylated eIF2 on eIF2B https://t.co/K8qVuxVmEP
Nov 24, 2020 · 19 likes · 4 shares · 143,980 followersView post →
RB
RIKEN BDR
@BDR_RIKEN · X
PUBLICATION
K Kashiwagi, T Ito (Lab for Translation Structural Biology) & collaborators @TheCIMR reveal how the drug-like molecule ISRIB antagonizes the integrated stress response, whose chronic activity has pathological effects on cells.
In @MolecularCell
https://t.co/dYBPzUU0iA
Nov 24, 2020 · 1 like · 1,402 followersView post →
SS
@sabrina-solley.bsky.social
@sabrina_solley · X
RT @TheCIMR: New paper from David Ron’s Lab @TheCIMR and Takuhiro Ito’s Lab @riken_en: ISRIB blunts the Integrated Stress Response by allos…
Nov 23, 2020 · 4 shares · 153 followersView post →
JA
Jonny Nixon-Abell
@AbellJonny · X
RT @TheCIMR: New paper from David Ron’s Lab @TheCIMR and Takuhiro Ito’s Lab @riken_en: ISRIB blunts the Integrated Stress Response by allos…
Nov 23, 2020 · 4 shares · 1,510 followersView post →
ML
Marciniak Lab
@MarciniakLab · X
RT @TheCIMR: New paper from David Ron’s Lab @TheCIMR and Takuhiro Ito’s Lab @riken_en: ISRIB blunts the Integrated Stress Response by allos…
Nov 23, 2020 · 4 shares · 2,273 followersView post →
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Javier Santoyo
@jsantoyo · X
ISRIB Blunts the Integrated Stress Response by Allosterically Antagonising the Inhibitory Effect of Phosphorylated eIF2 on eIF2B. @MolecularCell
https://t.co/OmtUxHwhSe
The impressive power of Cryo-EM!
Molecular Cell paper from Drs. Takuhiko Ito's and David Ron's groups:
ISRIB Blunts the Integrated Stress Response by Allosterically Antagonising the Inhibitory Effect of Phosphorylated eIF2 on eIF2B
https://t.co/UXGwBAJXiv https://t.co/YhiIMzOAot
ISRIB blunts the integrated stress response by allosterically antagonising the inhibitory effect of phosphorylated eIF2 on eIF2B https://t.co/IBfZO3qmNB
ISRIB blunts the integrated stress response by allosterically antagonising the inhibitory effect of phosphorylated eIF2 on eIF2B https://t.co/2awWzH74sR #bioRxiv
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