A polygenic p factor for major psychiatric disorders https://t.co/Jgtn5dmm2W
A polygenic p factor for major psychiatric disorders.
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Mar 2019 – Oct 2020Where it's discussed
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YouTube9 videos
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X / Twitter4 posts
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What people are saying
The collective discussions reflect a positive attitude toward the study, often referencing it as a significant development in psychiatric genetics, with phrases like 'consistently shows' and 'supports the existence,' indicating a recognition of the research's robustness and potential impact.
Most discussions show general support or acknowledgment of the study's findings, such as mentions of the polygenic p factor being consistently demonstrated.
The discussions indicate a moderate level of curiosity, mainly centered on the implications of the research.
Participants reference the methods and significance, like the use of genome-wide studies and PCA, suggesting some depth of engagement.
The debates suggest the research could have meaningful implications for understanding psychiatric genetics, though not universally labeled as transformative.
Abstract in brief
- Recent research suggests that a single "p factor" may explain a person's overall liability to major psychiatric disorders, based on high genetic correlations between different disorders.
- The study compared genetic correlations obtained from various methods, including family studies, genome-wide analyses, and polygenic score analyses, all supporting the existence of a genetic p factor.
- Principal component analysis revealed that all disorders loaded positively on the first component, which explained a significant portion of the variance, indicating that a genetic p factor underlies the genetic architecture of psychopathology.
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Most liked on X and BlueskyA polygenic p factor for major psychiatric disorders https://t.co/IY2itZOo5k
A polygenic p factor for major psychiatric disorders published as: https://t.co/j6Jyi8ht6B @nature #biorxiv
RT @SaskiaSelzam: Our new paper in Translational Psychiatry consistently shows a polygenic p factor for major psychiatric disorders using f…
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A polygenic p factor for major psychiatric disorders published as: https://t.co/j6Jyi8ht6B @nature #biorxiv
A polygenic p factor for major psychiatric disorders https://t.co/Jgtn5dmm2W
A polygenic p factor for major psychiatric disorders https://t.co/IY2itZOo5k
RT @SaskiaSelzam: Our new paper in Translational Psychiatry consistently shows a polygenic p factor for major psychiatric disorders using f…