Transl Psychiatry October 2018 PMID 30279410

A polygenic p factor for major psychiatric disorders.

Saskia Selzam, Jonathan R I Coleman, Avshalom Caspi, Terrie E Moffitt, Robert Plomin

Mentions

18
Peak: 4 in Jan 2020
across 3 sources since Mar 2019

Extended reach

98,016
potential audience

Total likes

2,289

Video views

66,626

Mentions per month

Mar 2019 – Oct 2020

Where it's discussed

  • YouTube9 videos
  • News5 articles
  • X / Twitter4 posts

AI synopsis

What people are saying

The collective discussions reflect a positive attitude toward the study, often referencing it as a significant development in psychiatric genetics, with phrases like 'consistently shows' and 'supports the existence,' indicating a recognition of the research's robustness and potential impact.

AgreementModerate agreement

Most discussions show general support or acknowledgment of the study's findings, such as mentions of the polygenic p factor being consistently demonstrated.

InterestModerate interest

The discussions indicate a moderate level of curiosity, mainly centered on the implications of the research.

EngagementModerate engagement

Participants reference the methods and significance, like the use of genome-wide studies and PCA, suggesting some depth of engagement.

ImpactModerate impact

The debates suggest the research could have meaningful implications for understanding psychiatric genetics, though not universally labeled as transformative.

Abstract in brief

  • Recent research suggests that a single "p factor" may explain a person's overall liability to major psychiatric disorders, based on high genetic correlations between different disorders.
  • The study compared genetic correlations obtained from various methods, including family studies, genome-wide analyses, and polygenic score analyses, all supporting the existence of a genetic p factor.
  • Principal component analysis revealed that all disorders loaded positively on the first component, which explained a significant portion of the variance, indicating that a genetic p factor underlies the genetic architecture of psychopathology.

Top posts

Most liked on X and Bluesky
hbd chick
@hbdchick · X

A polygenic p factor for major psychiatric disorders https://t.co/Jgtn5dmm2W

Feb 10, 2020 · 4 likes · 15,552 followers View post →
Stephen Pimentel
@StephenPiment · X

A polygenic p factor for major psychiatric disorders https://t.co/IY2itZOo5k

Jan 24, 2020 · 12,655 followers View post →
bioRxiv Published
@biorxiv_pubd · X

A polygenic p factor for major psychiatric disorders published as: https://t.co/j6Jyi8ht6B @nature #biorxiv

Oct 16, 2020 · 2,904 followers View post →
Jaroslav Točík
@lvm93n · X

RT @SaskiaSelzam: Our new paper in Translational Psychiatry consistently shows a polygenic p factor for major psychiatric disorders using f…

Mar 24, 2019 · 54 shares · 174 followers View post →

All mentions

bioRxiv Published
@biorxiv_pubd · X

A polygenic p factor for major psychiatric disorders published as: https://t.co/j6Jyi8ht6B @nature #biorxiv

Oct 16, 2020 · 2,904 followers View post →
hbd chick
@hbdchick · X

A polygenic p factor for major psychiatric disorders https://t.co/Jgtn5dmm2W

Feb 10, 2020 · 4 likes · 15,552 followers View post →
Stephen Pimentel
@StephenPiment · X

A polygenic p factor for major psychiatric disorders https://t.co/IY2itZOo5k

Jan 24, 2020 · 12,655 followers View post →
Jaroslav Točík
@lvm93n · X

RT @SaskiaSelzam: Our new paper in Translational Psychiatry consistently shows a polygenic p factor for major psychiatric disorders using f…

Mar 24, 2019 · 54 shares · 174 followers View post →