N Engl J Med December 2018 PMID 30280640

Transcatheter Mitral-Valve Repair in Patients with Heart Failure.

Gregg W Stone, JoAnn Lindenfeld, William T Abraham, Saibal Kar, D Scott Lim, Jacob M Mishell, Brian Whisenant, Paul A Grayburn, Michael Rinaldi, Samir R Kapadia, Vivek Rajagopal, Ian J Sarembock, Andreas Brieke, Steven O Marx, David J Cohen

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Mentions

292

Peak: 25 in Feb 2021

across 6 sources since Dec 2018

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AI synopsis

What people are saying

Numerous discussions emphasize specific results, such as the COAPT trial showing significant reductions in heart failure-related hospitalizations and overall mortality among those treated. Phrases like 'extraordinary results,' '40% reduction in death,' and 'sustained improvements' underscore the enthusiastic and impactful nature of the findings. The discussions’ tone, marked by positive language and specific references to clinical outcomes, illustrates a robust engagement with the material and a belief in its potential to influence medical practice.

AgreementModerate agreement

Many discussions indicate support for the findings of the publication, highlighting positive outcomes associated with transcatheter mitral-valve repair.

InterestHigh interest

There is a noticeable curiosity among posters, with many expressing an eagerness to explore more about the trial and results.

EngagementHigh engagement

Several users delve deeply into specifics from the trials, referencing protocols, methodologies, and results, showcasing a high level of engagement.

ImpactHigh impact

The perceived impact is substantial, as users discuss the significance of the study in improving patient outcomes, suggesting that the findings could transform treatment approaches.

Abstract in brief

Transcatheter mitral valve repair was studied in heart failure patients with significant mitral regurgitation, showing it might enhance clinical outcomes.
In a trial with 614 patients, those receiving the repair along with medical therapy had fewer heart failure-related hospitalizations compared to those on medication alone.
The procedure also led to a significantly lower risk of device-related complications and reduced overall mortality within 24 months.

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All mentions

Mitral Valve Repair Improves Outcomes in Heart Failure Patients

Transcatheter mitral valve repair was studied in heart failure patients with significant mitral regurgitation. The procedure combined with medical therapy resulted in fewer hospitalizations and reduced overall mortality…

Rapid Rounding | MedEd · Jun 11, 2025 1,766 views

Key Cardiological Trials Impacting 2018 Outcomes

This video reviews the top 10 cardiology trials of 2018, highlighting significant studies including those on PCI strategies in cardiogenic shock and the effects of various treatments on cardiovascular outcomes. Discover…

CardioLearning · Jan 8, 2019 969 views

Transcatheter Mitral Valve Repair and Cardiology Updates

The CafÃ© com Journal delivers updates on recent cardiology publications each week. This session discusses innovative studies, including the impact of transcatheter mitral valve repair in heart failure patients…

CardioLearning · Dec 18, 2018 356 views

手取りすくな

@summerbody321 · X

https://t.co/uApeAoN7vJ https://t.co/1Q1EeYK29M

Jan 10, 2025 · 81 followers View post →

HB1961

@hakkibolukoglu · X

Reshaping the Use of Transcatheter Mitral Valve Repair in Patients With Heart Failure: the RESHAPE-HF2 Trial - American College of Cardiology https://t.co/1T5anCHmHW

Dec 12, 2024 · 366 followers View post →

Takuya Kishi @ねこ好き循環器内科医

@tkishi_cardiol · X

RT @KagiyamaNobu: なかなかFMRには良い治療がないなあ。。。となっていたところで、まさかのとんでもない治療効果を見せつけたのが2018年のCOAPT めちゃくちゃ開いたKM curveに、これはもうFMRの治療は = MitraClipだろ、という雰囲気が漂い…

Aug 31, 2024 · 1 share · 14,694 followers View post →

Nobu Kagiyama@Heart doctor

@KagiyamaNobu · X

なかなかFMRには良い治療がないなあ。。。となっていたところで、まさかのとんでもない治療効果を見せつけたのが2018年のCOAPT めちゃくちゃ開いたKM curveに、これはもうFMRの治療は = MitraClipだろ、という雰囲気が漂います ⬇️ https://t.co/EzF8W5NZkX https://t.co/jZvoZJWMoG

Aug 31, 2024 · 3 likes · 1 share · 7,024 followers View post →

Zach Rogers

@zachywac · X

@RealAaronWiles @DanielCalhoun36 @BroadStBoss @JohnFetterman https://t.co/4wKYfNXDSE https://t.co/Yz2YRGdOfj https://t.co/GhXzMuj3wj with a seemingly niche use device, hard to get concrete answers on its medical usefulness. but for objectivity sake its not as clear cut as you think

Oct 24, 2022 · 1 like · 24 followers View post →

Linda

@wordfinga · X

RT @wordfinga: @ovidiogarciav @GreggWStone @rahatheart1 @rafasadaba @djc795 @FaisalBakaeen @VictorDayan1 @yreddyhf @RMSSAA @pomyers @JoeSab…

Jul 31, 2022 · 1 share · 4,595 followers View post →

Linda

@wordfinga · X

@ovidiogarciav @GreggWStone @rahatheart1 @rafasadaba @djc795 @FaisalBakaeen @VictorDayan1 @yreddyhf @RMSSAA @pomyers @JoeSabik @Migas2001 https://t.co/wC6iBM86gF Are there any other COAPT Trial papers by Stone et al, that cover in great detail, the control and device arms GDMT protocols?

Jul 31, 2022 · 3 likes · 1 share · 4,595 followers View post →

Rahat Warraich PhD

@rahatheart1 · X

RT @rafasadaba: @GreggWStone @VictorDayan1 @yreddyhf @djc795 @wordfinga @ovidiogarciav @RMSSAA @pomyers @FaisalBakaeen @JoeSabik @Migas2001…

Jul 28, 2022 · 2 shares · 10,786 followers View post →

Linda

@wordfinga · X

RT @rafasadaba: @GreggWStone @VictorDayan1 @yreddyhf @djc795 @wordfinga @ovidiogarciav @RMSSAA @pomyers @FaisalBakaeen @JoeSabik @Migas2001…

Jul 27, 2022 · 2 shares · 4,595 followers View post →

Linda

@wordfinga · X

RT @rafasadaba: @GreggWStone @VictorDayan1 @yreddyhf @djc795 @wordfinga @ovidiogarciav @RMSSAA @pomyers @FaisalBakaeen @JoeSabik @Migas2001…

Jul 27, 2022 · 2 shares · 4,595 followers View post →

Ovidio García

@ovidiogarciav · X

RT @rafasadaba: @GreggWStone @VictorDayan1 @yreddyhf @djc795 @wordfinga @ovidiogarciav @RMSSAA @pomyers @FaisalBakaeen @JoeSabik @Migas2001…

Jul 27, 2022 · 2 shares · 3,520 followers View post →

Rafa Sádaba

@rafasadaba · X

@GreggWStone @VictorDayan1 @yreddyhf @djc795 @wordfinga @ovidiogarciav @RMSSAA @pomyers @FaisalBakaeen @JoeSabik @Migas2001 and BTW, the online NEJM paper takes you to version 1 of the protocol: https://t.co/58DezBTlXs

Jul 27, 2022 · 3 likes · 2 shares · 2,484 followers View post →

Rafa Sádaba

@rafasadaba · X

@GreggWStone @VictorDayan1 @yreddyhf @djc795 @wordfinga @ovidiogarciav @RMSSAA @pomyers @FaisalBakaeen @JoeSabik @Migas2001 It is true…”Subjects in this trial must have moderate-to-severe (3+) or severe (4+) functional mitral regurgitation and be likely to benefit from MR reduction, but are deemed too high risk to undergo mitral valve surgery”. It’s in your paper…https://t.co/am20Hgqh8C

Jul 27, 2022 · 6 likes · 2 shares · 2,484 followers View post →

Valva Mitralis

@Mitrovalvology · X

RT @Ankyba: Transcatheter Mitral Valve Repair in Patients with Heart Failure https://t.co/BD0mQ1ZQ1Y a través de @YouTube @mjack2050

Apr 9, 2022 · 1 share · 4,135 followers View post →

Anita

@Ankyba · X

Transcatheter Mitral Valve Repair in Patients with Heart Failure https://t.co/BD0mQ1ZQ1Y a través de @YouTube @mjack2050

Apr 9, 2022 · 3 likes · 1 share · 20 followers View post →

Valva Mitralis

@Mitrovalvology · X

RT @DianaZapataGar2: Transcatheter Mitral-Valve Repair in Patients with Heart Failure Diana Zapata Garcia https://t.co/Bchc3j9e4r

Mar 30, 2022 · 1 share · 4,135 followers View post →

Diana Zapata García

@DianaZapataGar2 · X

Transcatheter Mitral-Valve Repair in Patients with Heart Failure Diana Zapata Garcia https://t.co/Bchc3j9e4r

Mar 29, 2022 · 1 like · 1 share View post →

Valva Mitralis

@Mitrovalvology · X

RT @DianaZapataGar2: Transcatheter Mitral-Valve Repair in Patients with Heart Failure Diana Zapata https://t.co/zHUPPbHZRw

Mar 26, 2022 · 1 share · 4,135 followers View post →

Diana Zapata García

@DianaZapataGar2 · X

Transcatheter Mitral-Valve Repair in Patients with Heart Failure Diana Zapata https://t.co/zHUPPbHZRw

Mar 25, 2022 · 1 share View post →

Valva Mitralis

@Mitrovalvology · X

RT @TomShimoda: Is Mitra-clip a suitable option for functional mitral regurgitation? An interesting read. https://t.co/SNmEwsZ3OS

Mar 11, 2022 · 1 share · 4,135 followers View post →

@MTcardiac · X

RT @plum_blaclaw: GDMTにより重症MRのうち40％は消失し, 予後改善が期待できるという論文の紹介も！（単施設研究） https://t.co/Aru4Y6vDSt COAPTはこちら https://t.co/THzzVVqcoe #22JCS

Mar 11, 2022 · 4 shares · 31 followers View post →

Yoichiro.S@循環器内科医

@cardio_dr_ys · X

Mar 11, 2022 · 4 shares · 3,425 followers View post →

Misako TOKI

@misako_desu · X

Mar 11, 2022 · 4 shares · 939 followers View post →

Takuya Kishi @ねこ好き循環器内科医

@tkishi_cardiol · X

Mar 11, 2022 · 4 shares · 14,694 followers View post →

ぷらむん

@plum_blaclaw · X

GDMTにより重症MRのうち40％は消失し, 予後改善が期待できるという論文の紹介も！（単施設研究） https://t.co/Aru4Y6vDSt COAPTはこちら https://t.co/THzzVVqcoe #22JCS

Mar 11, 2022 · 11 likes · 4 shares · 244 followers View post →

Tomonari Maximilian Shimoda, MD

@TomShimoda · X

Is Mitra-clip a suitable option for functional mitral regurgitation? An interesting read. https://t.co/SNmEwsZ3OS

Mar 7, 2022 · 3 likes · 1 share · 656 followers View post →

Valva Mitralis

@Mitrovalvology · X

Age-Related Outcomes After Transcatheter Mitral Valve Repair in Patients With Heart Failure: Analysis From COAPT https://t.co/NRp6q8mBqq

Feb 4, 2022 · 1 like · 4,135 followers View post →

MasMaz

@MasMazCom · X

Age-Related Outcomes After Transcatheter Mitral Valve Repair in Patients With Heart Failure: Analysis From COAPT - https://t.co/KmhC7qYdw9

Jan 31, 2022 · 168 followers View post →

Dataemia

@Dataemia · X

Age-Related Outcomes After Transcatheter Mitral Valve Repair in Patients With Heart Failure: Analysis From COAPT - https://t.co/2HTUnd1nuQ

Jan 31, 2022 · 967 followers View post →

Vibha Amblihalli MD MPH

@vibha_md · X

RT @iamritu: @ash71us @ASE360 @edwardagill @EGarciaSayan @CASEfromASE @JamesDThomasMD1 @ErinMichos @RigolinVera @VLSorrellImages @GWhalleyP…

May 25, 2021 · 5 shares · 481 followers View post →

Abbas (Reza) Emaminia

@RezaEmaminia · X

RT @iamritu: @ash71us @ASE360 @edwardagill @EGarciaSayan @CASEfromASE @JamesDThomasMD1 @ErinMichos @RigolinVera @VLSorrellImages @GWhalleyP…

May 25, 2021 · 5 shares · 5,077 followers View post →

American Society of Echocardiography

@ASE360 · X

RT @iamritu: @ash71us @ASE360 @edwardagill @EGarciaSayan @CASEfromASE @JamesDThomasMD1 @ErinMichos @RigolinVera @VLSorrellImages @GWhalleyP…

May 25, 2021 · 5 shares · 33,750 followers View post →

CV Case Journal

@CASEfromASE · X

RT @iamritu: @ash71us @ASE360 @edwardagill @EGarciaSayan @CASEfromASE @JamesDThomasMD1 @ErinMichos @RigolinVera @VLSorrellImages @GWhalleyP…

May 25, 2021 · 5 shares · 5,705 followers View post →

Ashish Aneja MD FACC FAHA FASE FSCMR

@ash71us · X

RT @iamritu: @ash71us @ASE360 @edwardagill @EGarciaSayan @CASEfromASE @JamesDThomasMD1 @ErinMichos @RigolinVera @VLSorrellImages @GWhalleyP…

May 25, 2021 · 5 shares · 4,935 followers View post →

Ritu Thamman MD

@iamritu · X

@ash71us @ASE360 @edwardagill @EGarciaSayan @CASEfromASE @JamesDThomasMD1 @ErinMichos @RigolinVera @VLSorrellImages @GWhalleyPhD @DavidWienerMD @LucySafi @onco_cardiology @purviparwani @DocStrom @mswami001 In #Coapt volumetric calculations were thrown out because the LV volumes were significantly underestimated https://t.co/fYtDBLrl2k @JaeKOh2 @JamesDThomasMD1 #ASEchoJC https://t.co/Qx3RKgNl4K

May 25, 2021 · 8 likes · 5 shares · 31,677 followers View post →

ANGiiE

@AnGii_a · X

Transcatheter Mitral-Valve Repair in Patients with Heart Failure https://t.co/3tr4j6au0P a través de @YouTube Hola amigos , me ayudarían dando un Like y comentando , es un Trabajo de la Universidad , de antemano Gracias .

May 20, 2021 · 6 likes · 92 followers View post →

emily

@emily24829695 · X

May 15, 2021 · 18 likes · 12 followers View post →

Robert Alarcon

@robert_alarconc · X

3-Year Outcomes of Transcatheter Mitral Valve Repair in Patients With Heart Failure - ScienceDirect https://t.co/LDF8B5mx6k

Apr 18, 2021 · 189 followers View post →

Valva Mitralis

@Mitrovalvology · X

RT @PracUpCardio: 3-Year Outcomes of Transcatheter Mitral Valve Repair in Patients With Heart Failure https://t.co/qyNdNMCaF2 #cardiology

Mar 22, 2021 · 1 share · 4,135 followers View post →

Cardiology

@PracUpCardio · X

3-Year Outcomes of Transcatheter Mitral Valve Repair in Patients With Heart Failure https://t.co/qyNdNMCaF2 #cardiology

Mar 19, 2021 · 1 share · 884 followers View post →

Karsten Schenke

@kaschenke · X

RT @MCoylewright: Proud to offer Mitraclip with an outstanding team @erlangerhealth that optimizes medications/CRT first & follows with sha…

Mar 11, 2021 · 4 shares · 4,479 followers View post →

Valva Mitralis

@Mitrovalvology · X

RT @MCoylewright: Proud to offer Mitraclip with an outstanding team @erlangerhealth that optimizes medications/CRT first & follows with sha…

Mar 11, 2021 · 4 shares · 4,135 followers View post →

Valva Mitralis

@Mitrovalvology · X

RT @XavierPrida: Even delayed TMVr can save lives and improve QOL. Also, noteworthy 0 occurence of MS. 3-Year Outcomes of Transcatheter Mi…

Mar 11, 2021 · 1 share · 4,135 followers View post →

Valva Mitralis

@Mitrovalvology · X

RT @ArieBlitzMD: 3-Year Outcomes of Transcatheter Mitral Valve Repair in Patients With Heart Failure confirm intermediate-term superiority…

Mar 11, 2021 · 2 shares · 4,135 followers View post →

Anjan Gupta

@ACSCardiology · X

3-Year Outcomes of Transcatheter Mitral Valve Repair in Patients With Heart Failure: https://t.co/Xcix5PYJSw

Mar 7, 2021 · 430 followers View post →

Erlanger Health System

@erlangerhealth · X

RT @MCoylewright: Proud to offer Mitraclip with an outstanding team @erlangerhealth that optimizes medications/CRT first & follows with sha…

Mar 5, 2021 · 4 shares · 11,233 followers View post →

Dawn Freeman Pittman

@dfpittman · X

RT @MCoylewright: Proud to offer Mitraclip with an outstanding team @erlangerhealth that optimizes medications/CRT first & follows with sha…

Mar 4, 2021 · 4 shares · 302 followers View post →

megan coylewright md mph

@MCoylewright · X

Mar 4, 2021 · 21 likes · 4 shares · 1,992 followers View post →

Matthew J. Chung

@MatthewChungMD · X