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The discussions demonstrate strong agreement with the research, supported by references to prior studies on somatic mosaicism, and expressions of curiosity about its biological significance, with users engaging actively by comparing findings and suggesting implications for health and aging.
Most discussions acknowledge and support the findings, emphasizing the significance of age-related somatic mutations in normal tissue.
The topic sparks high interest, with users referencing related studies and expressing curiosity about the broader implications.
Participants actively analyze the research, comparing it with previous data and discussing its biological relevance, indicating moderate engagement.
Many believe this research has high impact, highlighting its importance for understanding aging and potential cancer development, with some comments suggesting it could influence future studies and medicine.
Also see related work by @imartincorena Somatic mutant clones colonize the human esophagus with age https://t.co/wbLEdm9ZvC. They did not report #PPM1D mutations- perhaps fewer subjects with a similar extent of lifestyle impact? (or British beer is not so unhealthy?!)
@rosslevinemd @TaylorJ_MD @DavidSteensma @calliecoombsmd @KellyLBolton @nancykgillis @md_padron https://t.co/trQZ8T7Y0P the more data that comes out, the more I believe somatic mosaicism is a feature of biology, Not a bug…. Pick your favorite organ I’m sure there is some clonal process there
Kourosh Saeb-Parsy @KSaebParsy from our Aerodigestive Programme contributed to the "Somatic mutant clones colonize the human esophagus with age" publication... https://t.co/RBhMLlrcoX
Aquí os dejo la bibliografía: https://t.co/Luuv95Rc8X https://t.co/lILtPpYfza https://t.co/QpQTUWntYG
@DrGrahamLJ @ClareWilsonMed @newscievents @newscientist For example https://t.co/NgPensVX7v and https://t.co/06ZEZjYPK6 and other work from the Sanger Institute mapping somatic mutations in healthy tissue
31/ #365papers "Somatic mutant clones colonize the human esophagus with age", Martincorena et al. 2018 https://t.co/DhetxLVfrm 32/ "Age-related remodelling of oesophageal epithelia by mutated cancer drivers", Yokoyama et al. 2019 https://t.co/HBCUB5MOs3
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This video explores the relationship between diabetes mellitus and cause-specific death rates, highlighting recent research findings. It provides insights into the implications of fasting glucose levels and their…
In 2018 we reported that the same phenomenon occurs at even greater extent in normal oesophagus. By middle age, much of the oesophageal epithelium has been colonised by clones carrying mutations in key cancer genes. 3/n https://t.co/wYVI1mN1Xo https://t.co/Z7WaTl2BQX
@rosslevinemd @TaylorJ_MD @DavidSteensma @calliecoombsmd @KellyLBolton @nancykgillis @md_padron https://t.co/trQZ8T7Y0P the more data that comes out, the more I believe somatic mosaicism is a feature of biology, Not a bug…. Pick your favorite organ I’m sure there is some clonal process there
@DrGrahamLJ @ClareWilsonMed @newscievents @newscientist For example https://t.co/NgPensVX7v and https://t.co/06ZEZjYPK6 and other work from the Sanger Institute mapping somatic mutations in healthy tissue
RT @RuxandraTeslo: @kishel_m @phil49472744 https://t.co/N3x0KKNtj7
@kishel_m @phil49472744 https://t.co/N3x0KKNtj7
@AdamsBioAging Probably not mutations. https://t.co/gY3Sc3qsMG The paradox of mutations and cancer. 2018 https://t.co/nE5ENBikfU
RT @oncoscientia: Aquí os dejo la bibliografía: https://t.co/Luuv95Rc8X https://t.co/lILtPpYfza https://t.co/QpQTUWntYG
Aquí os dejo la bibliografía: https://t.co/Luuv95Rc8X https://t.co/lILtPpYfza https://t.co/QpQTUWntYG
Somatic mutant clones colonize the human esophagus with age. https://t.co/ekBb46yPiA
New from #CR_UK https://t.co/cu8bwkIlhl Somatic mutant clones colonize the human esophagus with age
New from #wellcometrust https://t.co/cu8bwkIlhl Somatic mutant clones colonize the human esophagus with age
New from #The_MRC https://t.co/cu8bwkIlhl Somatic mutant clones colonize the human esophagus with age
Kourosh Saeb-Parsy @KSaebParsy from our Aerodigestive Programme contributed to the "Somatic mutant clones colonize the human esophagus with age" publication... https://t.co/RBhMLlrcoX
31/ #365papers "Somatic mutant clones colonize the human esophagus with age", Martincorena et al. 2018 https://t.co/DhetxLVfrm 32/ "Age-related remodelling of oesophageal epithelia by mutated cancer drivers", Yokoyama et al. 2019 https://t.co/HBCUB5MOs3
RT @Goodell_Lab: Also see related work by @imartincorena Somatic mutant clones colonize the human esophagus with age https://t.co/wbLEdm9Zv…
Also see related work by @imartincorena Somatic mutant clones colonize the human esophagus with age https://t.co/wbLEdm9ZvC. They did not report #PPM1D mutations- perhaps fewer subjects with a similar extent of lifestyle impact? (or British beer is not so unhealthy?!)